Interleukin-1β in immune cells of the abdominal vagus nerve: A link between the immune and nervous systems?

Journal of Neuroscience

Volumn 19, Issue 7, 1999, Pages 2799-2806

  Goehler, Lisa E ^a   Gaykema, Ron P A ^a   Nguyen, Kien T ^a   Lee, Jacqueline E ^a   Tilders, Fred J H ^b   Maier, Steven F ^a   Watkins, Linda R ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

Cytokines; Dendritic cells; ELISA; Endotoxin; Immunohistochemistry; Macrophages; Rat; Vagus

Indexed keywords

CYTOKINE; ENDOTOXIN; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; HLA ANTIGEN CLASS 2; INTERLEUKIN 1;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; GASTROINTESTINAL TRACT; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MALE; NEUROIMMUNOLOGY; NONHUMAN; PRIORITY JOURNAL; RAT; VAGUS NERVE; ABDOMEN; ANIMAL; CYTOLOGY; DRUG EFFECT; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNOLOGY; IMMUNOMODULATION; INNERVATION; SPRAGUE DAWLEY RAT;

ABDOMEN; ANIMALS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE; HISTOCOMPATIBILITY ANTIGENS CLASS II; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-1; MALE; NEUROIMMUNOMODULATION; RATS; RATS, SPRAGUE-DAWLEY; VAGUS NERVE;

EID: 0033106495     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.19-07-02799.1999     Document Type: Article

References (34)

1. Banchereau J, Steinman RM (1998) Dendritic cells and the control of immunity. Nature 392:425-252.
2. Berthoud H-R, Kressel M, Neuhuber WL (1995) Vagal afferent innervation of rat abdominal paraganglia as revealed by anterograde Diltracing and confocal microscopy. Acta Anat 152:127-132.
3. Bradford MM (1976) A rapid and sensitive method for quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
4. Bret-Dibat JL, Bluthé R-M, Kent S, Kelley K, Dantzer R (1495) Lipopolysaccharide and interleukin-1 depress food-motivated behavior in mice by a vagal-mediated mechanism. Brain Behav Immun 9:242-246.
5. Carlson DE (1997) Adrenocorticotropin correlates strongly with endotoxemia after intravenous but not after intraperitoncal inoculations of E. coli. Shock 7:65-99.
6. Cella M, Sallusto F, Lanxavecchia A (1997) Origin, maturation and antigen presenting function of dendritic cells. Curr Opin Immunol 9:10-16.
7. Clatworthy AL, Illich PA, Castro GA, Walters ET (1995) Role of periaxonal inflammation in the development of thermal hyperalgesia and guarding behavior in a rat model of neuropathic pain. Neurosci Lett 184:5-8.
8. Dunn AJ (1993) Role of cytokines in infection-induced stress. Ann NY Acad Sci 697:189-202.
9. Ericsson A, Arias C, Sawchenko PE (1997) Evidence for an intramedullary prostaglandin-dependcnt mechanism in the activation of stress-related neuroendocrine circuitry by intravenous interleukin-1. J Neurosci 17:7166-7179.
10. Gaykema RPA, Dijkstra I, Tilders FJH (1995) Subdiaphragmatic vagotomy suppresses endotoxin-induced activation of the hypothalamic corticotrophin-releasing hormone neurons and ACTH secretion. Endocrinology 136:4717-4720.
11. Gaykema RPA, Goehler LE, Tilders FJH, Bol JGJM, McGorry M, Fleshner M, Maier SF, Watkins LR (1998) Bacterial endotoxin induces Fos immunoreactivity in primary afferent neurons of the vagus nerve. Neuroimmunomodulation 5:234-240.
12. Goehler LE, Relton JK, Dripps D, Keichle R, Tartaglia N, Maier SF, Watkins LR (1997) Vagal paraganglia hind biotinylated interleukin-1 receptor antagonist: a possible mechanism for immune-to-brain communication. Brain Res Bull 43:357-364.
13. Goehler LE, Gaykema RPA, Hammack SE, Maier SF, Watkins LR (1998) Interleukin-1 induces c-Fos immunoreactivity in primary afferent neurons of the vagus nerve. Brain Res 804:306-310.
14. Goerdt S, Kodelja V, Schmuth M, Orfanos CE, Sorg C (1996) The mononuclear phagocyte-dendritic cell dichotomy: myths, facts, and a revised concept. Clin Exp Immunol 105:1-9.
15. Hansen MK, Krueger JM (1997) Subdiaphragmatic vagotomy blocks the sleep- and fever-promoting effects of interleukin-1β. Am J Physiol 273:R1246-R1253.
16. Hoek A, Allaerts W, Leenan PJN, Schoemaker J, Drexhage HA (1997) Dendritic cells and macrophages in the pituitary and gonads. Evidence for their role in the fine regulation of the reproductive endocrine response. Eur J Endocrinol 136:8-24.
17. Kluger MJ (1991) Fever: the role of pyrogens and cryogens. Physiol Rev 71:93-127.
18. Lenczowski MJP, Schmidt ED, Van Dam A-M, Gaykema RPA, Tilders FJH (1998) Individual variation in hypothalamus-pituitary-adrenal responsiveness of rats to endotoxin and IL-1β. Ann NY Acad Sci 856:139-147.
19. Maier SF, Wiertelak EP, Martin D, Watkins LR (1993) Interleukin-1 mediates the behavioral hyperalgesia produced by lithium chloride and endotoxin. Brain Res 623:321-324.
20. Mascarucci P, Perego C, Terrazino, S, De Simoni MG (1998) Glutamic acid release in the nucleus tractus solitarius induced by peripheral endotoxin and interleukin-1. Neuroscicnce 86:1285-1290.
21. Morgan M, Pack RJ, Howc A (1976) Structure of cells and nerve endings in abdominal vagal paraganglia of the rat. Cell Tissue Res 169:467-484.
22. Nguyen KT, Deak T, Owens SM, Kohno T, Fleshner M, Watkins LR, Maier SF (1998) Exposure to acute stress induces brain interleukin-1β protein in the rat. J Neurosci 18:2239-2246.
23. Ni K, O'Neill HC (1997) The role of dendritic cells in T cell activation. Immunol Cell Biol 75:223-230.
24. Prechtl JC, Powley TL (1987) A light and electron microscopic examination of the vagal hepatic branch of the rat. Anat Embryol 176:115-126.
25. Saper CB, Breder CD (1994) The neurological basis of fever. N Engl J Med 330:1880-1886.
26. Schaffar N, Rao H, Kessler JP, Jean A (1997) Immunohistochemical detection of glutamate in rat vagal sensory neurons. Brain Res 778:302-308.
27. Schotanus K, Tilders FJH, Berkenbosch F (1993) Human recombinant interleukin-1 receptor antagonist prevents ACTH, but not interleukin-6 responses to bacterial endotoxin in rats. Endocrinology 133:2461-2468.
28. Schotanus K, Holtkamp GM, Meloen RH, Puijk WC, Berkenbosch F, Tilders FJH (1995) Domains of rat interleukin-1b involved in type I receptor binding. Endocrinology 136:332-339.
29. Shu S, Ju G, Fan L (1988) The glucose oxidase-DAB-nickel method in peroxidase histochemistry of the nervous system. Neurosci Lett 85:169-171.
30. Steinman RM (1991) The dendritic cell system and its role in immunogenicity. Annu Rev Immunol 9:271-296.
31. Van Dam A-M, Brouns M, Louisse S, Berkenbosch F (1992) Appearance of interleukin-1 in macrophages and ramified microglia in the brain of endotoxin-treated rats: a pathway for the induction of non-specific symptoms of sickness? Brain Res 588:291-296.
32. Watkins LR, Weirtelak EP, Goehler LE, Smith KP, Martin D, Maier SF (1994) Characterization of cytokine induced hyperalgesia. Brain Res 654:15-26.
33. Watkins LR, Goehler LE, Relton JK, Tartaglia N, Silbert L, Martin D, Maier SF (1995a) Blockade of intcrleukin-1 induced hyperthermia by subdiaphragmatic vagotomy: evidence for vagal mediation of immune-brain communication. Neurosci Lett 183:17-31.
34. Watkins LR, Maier SF, Goehler LE (1995b) Cytokine-to-brain communication: a review and analysis of alternative mechanisms. Life Sci 57:1011-1026.