Voltage-Gated Sodium Channels and Hyperalgesia

Annual Review of Pharmacology and Toxicology

Volumn 44, Issue , 2004, Pages 371-397

  Lai, Josephine ^a   Porreca, Frank ^a   Hunter, John C ^b   Gold, Michael S ^c,d  

^a UNIVERSITY OF ARIZONA   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

^c UNIVERSITY OF MARYLAND   (United States)

^d UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

Antiarrhythmics; Anticonvulsant; Inflammation; Local anesthetics; Neuropathic pain; Sensory neuron

Indexed keywords

ADENOSINE; ADENOSINE TRIPHOSPHATE; ADRENALIN; ANTIARRHYTHMIC AGENT; ANTICONVULSIVE AGENT; ANTISENSE OLIGODEOXYNUCLEOTIDE; ARACHIDONIC ACID; BRADYKININ; BRAIN DERIVED NEUROTROPHIC FACTOR; CAPSAICIN; CARRAGEENAN; CYTOKINE; ENDOTHELIN 1; FREUND ADJUVANT; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); GUANOSINE TRIPHOSPHATE; LIDOCAINE; LOCAL ANESTHETIC AGENT; NERVE GROWTH FACTOR; NEUROTROPHIC FACTOR; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN DERIVATIVE; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE INHIBITOR; SEROTONIN; SODIUM CHANNEL BLOCKING AGENT; TETRODOTOXIN; TUMOR NECROSIS FACTOR ALPHA; UNINDEXED DRUG; VOLTAGE GATED SODIUM CHANNEL;

CENTRAL NERVOUS SYSTEM; CHRONIC PAIN; HUMAN; HYPERALGESIA; INFLAMMATION; MUSCLE SPINDLE AFFERENT NERVE; NERVE CELL EXCITABILITY; NEUROPATHIC PAIN; NONHUMAN; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; REVIEW; SYNDROME;

ANALGESICS; ANESTHETICS, LOCAL; ANIMALS; ANTICONVULSANTS; HUMANS; HYPERALGESIA; INFLAMMATION; ION CHANNEL GATING; NEURONS, AFFERENT; PAIN; PERIPHERAL NERVOUS SYSTEM DISEASES; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; TETRODOTOXIN;

EID: 1342302379     PISSN: 03621642     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.pharmtox.44.101802.121627     Document Type: Review

References (184)

1. Cantrell AR, Catterall WA. 2001. Neuromodulation of Na+ channels: an unexpected form of cellular plasticity. Nat. Rev. Neurosci. 2:397-407
2. Isom LL. 2001. Sodium channel beta subunits: anything but auxiliary. Neuroscientist 7:42-54
3. Goldin AL, Barchi RL, Caldwell JH, Hofmann F, Howe JR, et al. 2000. Nomenclature of voltage-gated sodium channels. Neuron 28:365-68
4. Catterall WA. 2002. Molecular mechanisms of gating and drug block of sodium channels. Novartis. Found. Symp. 241:206-18, discussion 218-32
5. Yu FH, Catterall WA. 2003. Overview of the voltage-gated sodium channel family. Genome Biol. 4:207
6. Meyer RA, Campbell JN, Raja SN. 1994. Peripheral neural mechanisms of nociception. In Textbook of Pain, ed. PD Wall, R Melzack, pp. 13-56. New York: Churchill Livingstone
7. Schmelz M, Schmid R, Handwerker HO, Torebjork HE. 2000. Encoding of burning pain from capsaicin-treated human skin in two categories of unmyelinated nerve fibres. Brain 123(Pt. 3):560-71
8. Djouhri L, Newton R, Levinson SR, Berry CM, Carruthers B, Lawson SN. 2003. Sensory and electrophysiological properties of guinea-pig sensory neurones expressing Na(v)1.7 (PN1) Na(+) channel alphasubunit protein. J. Physiol. 546:565-76
9. Fang X, Djouhri L, Okuse K, Wood JN, Lawson SN. 2001. Sensory and electrophysiological properties of DRG neurones with SNS-like immunoreactivity (SNS-Li) in rats. Soc. Neurosci. Abstr. 27:Program 819.815
10. Fang X, Djouhri L, Black JA, Dib-Hajj SD, Waxman SG, Lawson SN. 2002. The presence and role of the tetrodotoxin-resistant sodium channel Na(v) 1.9 (NaN) in nociceptive primary afferent neurons. J. Neurosci. 22:7425-33
11. Quasthoff S, Grosskreutz J, Schroder JM, Schneider U, Grafe P. 1995. Calcium potentials and tetrodotoxin-resistant sodium potentials in unmyelinated C fibres of biopsied human sural nerve. Neuroscience 69:955-65
12. Brock JA, McLachlan EM, Belmonte C. 1998. Tetrodotoxin-resistant impulses in single nociceptor nerve terminals in guinea-pig cornea. J. Physiol. (London) 512:211-17
13. Scroggs RS, Fox AP. 1992. Calcium current variation between acutely isolated adult rat dorsal root ganglion neurons of different size. J. Physiol. 445:639-58
14. Baccaglini PI, Hogan PG. 1983. Some rat sensory neurons in culture express characteristics of differentiated pain sensory cells. Proc. Natl. Acad Sci. USA 80:594-98
15. Gold MS, Dastmalchi S, Levine JD. 1996. Co-expression of nociceptor properties in dorsal root ganglion neurons from the adult rat in vitro. Neuroscience 71:265-75
16. Stucky C, Lewin GR. 1999. Isolectin B(4)-positive and -negative nociceptors are functionally distinct. J. Neurosci. 19:6497-505
17. Petruska JC, Cooper BY, Gu JG, Rau KK, Johnson RD. 2000. Distribution of P2X1, P2X2, and P2X3 receptor subunits in rat primary afferents: relation to population markers and specific cell types. J. Chem. Neuroanat. 20:141-62
18. Petruska JC, Cooper BY, Johnson RD, Gu JG. 2000. Distribution patterns of different P2x receptor phenotypes in acutely dissociated dorsal root ganglion neurons of adult rats. Exp. Brain Res. 134:126-32
19. Petruska JC, Napaporn J, Johnson RD, Gu JG, Cooper BY. 2000. Subclassified acutely dissociated cells of rat DRG: histochemistry and patterns of capsaicin-, proton-, and ATP-activated currents. J. Neurophysiol. 84:2365-79
20. Petruska JC, Napaporn J, Johnson RD, Cooper BY. 2002. Chemical responsiveness and histochemical phenotype of electrophysiologically classified cells of the adult rat dorsal root ganglion. Neuroscience 115:15-30
21. Harper AA, Lawson SN. 1985. Conduction velocity is related to morphological cell type in rat dorsal root ganglion neurones. J. Physiol. 359:31-46
22. Lee KH, Chung K, Chung JM, Coggeshall RE. 1986. Correlation of cell body size, axon size, and signal conduction velocity for individually labeled dorsal root ganglion cells in the cat. J. Comp. Neurol. 243:335-46
23. Lawson SN, Perry MJ, Prabhakar E, McCarthy PW. 1993. Primary sensory neurones: neurofilament, neuropeptides, and conduction velocity. Brain Res. Bull. 30:239-43
24. Ritter AM, Mendell LM. 1992. Somal membrane properties of physiologically identified sensory neurons in the rat: effects of nerve growth factor. J. Neurophysiol. 68:2033-41
25. Black JA, Dib-Hajj S, McNabola K, Jeste S, Rizzo MA, et al. 1996. Spinal sensory neurons express multiple sodium channel alpha-subunit mRNAs. Brain Res. Mol. Brain Res. 43:117-31
26. Renganathan M, Dib-Hajj S, Waxman SG. 2002. Na(v)1.5 underlies the third TTX-R sodium current' in rat small DRG neurons. Brain Res. Mol. Brain Res. 106:70-82
27. Shah BS, Stevens EB, Gonzalez MI, Bramwell S, Pinnock RD, et al. 2000. Beta3, a novel auxiliary subunit for the voltage-gated sodium channel, is expressed preferentially in sensory neurons and is upregulated in the chronic constriction injury model of neuropathic pain. Eur. J. Neurosci. 12:3985-90
28. Kazen-Gillespie KA, Ragsdale DS, D'Andrea MR, Mattei LN, Rogers KE, Isom LL. 2000. Cloning, localization, and functional expression of sodium channel beta1A subunits. J. Biol. Chem. 275:1079-88
29. Waxman SG, Kocsis JD, Black JA. 1994. Type III sodium channel mRNA is expressed in embryonic but not adult spinal sensory neurons, and is reexpressed following axotomy. J. Neurophysiol. 72:466-70
30. Caldwell JH, Schaller KL, Lasher RS, Peles E, Levinson SR. 2000. Sodium channel Na(v)1.6 is localized at nodes of ranvier, dendrites, and synapses. Proc. Natl. Acad. Sci. USA 97:5616-20
31. Toledo AJ, Brehm P, Halegoua S, Mandel G. 1995. A single pulse of nerve growth factor triggers long-term neuronal excitability through sodium channel gene induction. Neuron 14:607-11
32. Fjell J, Hjelmstrom P, Hormuzdiar W, Milenkovic M, Aglieco F, et al. 2000. Localization of the tetrodotoxin-resistant sodium channel NaN in nociceptors. Neuroreport 11:199-202
33. Ogata N, Tatebayashi H. 1993. Kinetic analysis of two types of Na+ channels in rat dorsal root ganglia. J. Physiol. (London) 466:9-37
34. Cummins TR, Waxman SG. 1997. Downregulation of tetrodotoxin-resistant sodium currents and upregulation of a rapidly repriming tetrodotoxin-sensitive sodium current in small spinal sensory neurons after nerve injury. J. Neurosci. 17:3503-14
35. Rush AM, Brau ME, Elliott AA, Elliott JR. 1998. Electrophysiological properties of sodium current subtypes in small cells from adult rat dorsal root ganglia. J. Physiol. (London) 511:771-89
36. Scholz A, Appel N, Vogel W. 1998. Two types of TTX-resistant and one TTX-sensitive Na+ channel in rat dorsal root ganglion neurons and their blockade by halothane. Suppl. Eur. J. Neurosci. 10:2547-56
37. Kostyuk PG, Veselovsky NS, Fedulova SA, Tsyndrenko AY. 1981. Ionic currents in the somatic membrane of rat dorsal root ganglion neurons-I. Sodium currents. Neuroscience 6:2424-30
38. Roy ML, Narahashi T. 1992. Differential properties of tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels in rat dorsal root ganglion neurons. J. Neurosci. 12:2104-11
39. Elliott AA, Elliott JR. 1993. Characterization of TTX-sensitive and TTX-resistant sodium currents in small cells from adult rat dorsal root ganglia. J. Physiol. (London) 463:39-56
40. Cummins TR, Dib-Hajj SD, Black JA, Akopian AN, Wood JN, Waxman SG. 1999. A novel persistent tetrodotoxin-resistant sodium current in SNS-null and wild-type small primary sensory neurons. J. Neurosci. 19:1-6
41. Akopian AN, Souslova V, England S, Okuse K, Ogata N, et al. 1999. The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways. Nat. Neurosci. 2:541-48
42. Baker MD, Chandra SY, Ding Y, Waxman SG, Wood JN. 2003. GTP-induced tetrodotoxin-resistant Na+ current regulates excitability in mouse and rat small diameter sensory neurones. J. Physiol. (London) 548:373-82
43. Herzog RI, Cummins TR, Waxman SG. 2001. Persistent TTX-resistant Na+ current affects resting potential and response to depolarization in simulated spinal sensory neurons. J. Neurophysiol. 86:1351-64
44. Dib-Hajj SD, Tyrrell L, Black JA, Waxman SG. 1998. NaN, a novel voltage-gated Na channel, is expressed preferentially in peripheral sensory neurons and down-regulated after axotomy. Proc. Natl. Acad. Sci. USA 95:8963-68
45. Tate S, Benn S, Flick C, Trezise D, John V, et al. 1998. Two sodinm channels contribute to TTX-R sodium current in primary sensory neurons. Nat. Neurosci. 1:653-55
46. Brau ME, Elliott JR. 1998. Local anaesthetic effects on tetrodotoxin-resistant Na+ currents in rat dorsal root ganglion neurones. Eur. J. Anaesthesiol. 15:80-88
47. Gold MS, Thut PD. 2001. Lithium increases potency of lidocaine-induced block of voltage-gated Na(+) currents in rat sensory neurons in vitro. J. Pharmacol. Exp. Ther. 299:705-11
48. Gold MS, Weinreich D, Kim CS, Wang R, Treanor J, et al. 2003. Redistribution of Na(V)1.8 in uninjured axons enables neuropathic pain. J. Neurosci. 23:158-66
49. England S, Bevan S, Docherty RJ. 1996. PGE2 modulates the tetrodotoxin-resistant sodium current in neonatal rat dorsal root ganglion neurons via the cyclic AMP-protein kinase A cascade. J. Physiol. (London) 495:429-40
50. Blair NT, Bean BP. 2002. Roles of tetrodotoxin TTX-sensitive Na+ current, TTX-resistant Na+ current, and Ca2+ current in the action potentials of nociceptive sensory neurons. J. Neurosci. 22:10277-90
51. Brock JA, Pianova S, Belmonte C. 2001. Differences between nerve terminal impulses of polymodal nociceptors and cold sensory receptors of the guinea-pig cornea. J. Physiol. 533:493-501
52. Carr RW, Pianova S, Brock JA. 2002. The effects of polarizing current on nerve terminal impulses recorded from polymodal and cold receptors in the guinea-pig cornea. J. Gen. Physiol. 120:395-405
53. Gu JG, MacDermott AB. 1997. Activation of ATP P2X receptors elicits glutamate release from sensory neuron synapses. Nature 389:749-53
54. Samad TA, Sapirstein A, Woolf CJ. 2002. Prostanoids and pain: unraveling mechanisms and revealing therapeutic targets. Trends Mol. Med. 8:390-96
55. Ferreira SH. 1972. Prostaglandins, aspirin-like drugs and analgesia. Nat. New Biol. 240:200-3
56. Handwerker HO. 1976. Influences of algogenic substances and prostaglandins on the discharges of unmyelinated cutaneous nerve fibers identified as nociceptors. Adv. Pain Res. Ther. 1:41-45
57. Chahl LA, Iggo A. 1977. The effects of bradykinin and prostaglandin E1 on rat cutaneous afferent nerve activity. Br. J. Pharmacol. 59:343-47
58. Khasar SG, Gold MS, Levine JD. 1998. A tetrodotoxin-resistant sodium current mediates inflammatory pain in the rat. Neurosci. Lett. 256:17-20
59. Gold MS, Reichling DB, Shuster MJ, Levine JD. 1996. Hyperalgesic agents increase a tetrodotoxin-resistant Na+ current in nociceptors. Proc. Natl. Acad. Sci. USA 93:1108-12
60. Cardenas LM, Cardenas CG, Scroggs RS. 2001. 5HT increases excitability of nociceptor-like rat dorsal root ganglion neurons via cAMP-coupled TTX-resistant Na+ channels. J. Neurophysiol. 86:241-48
61. Okamoto K, Imbe H, Morikawa Y, Itoh M, Sekimoto M, et al. 2002. 5-HT2A receptor subtype in the peripheral branch of sensory fibers is involved in the potentiation of inflammatory pain in rats. Pain 99:133-43
62. D'Alcantara P, Cardenas LM, Swillens S, Scroggs RS. 2002. Reduced transition between open and inactivated channel states underlies 5-HT increased INa+ in rat nociceptors. Biophys. J. 83:5-21
63. Cui M, Nicol GD. 1995. Cyclic AMP mediates the prostaglandin E2-induced potentiation of bradykinin excitation in rat sensory neurons. Neuroscience 66:459-66
64. Zhou Z, Davar G, Strichartz G. 2002. Endothelin-1 (ET-1) selectively enhances the activation gating of slowly inactivating tetrodotoxin-resistant sodium currents in rat sensory neurons: a mechanism for the pain-inducing actions of ET-1. J. Neurosci. 22:6325-30
65. Ferreira SH, Romitelli M, de Nucci G. 1989. Endothelin-1 participation in overt and inflammatory pain. J. Cardiovasc. Pharmacol. 13(Suppl. 5):S220-22
66. Griswold DE, Douglas SA, Martin LD, Davis TG, Davis L, et al. 1999. Endothelin B receptor modulates inflammatory pain and cutaneous inflammation. Mol. Pharmacol. 56:807-12
67. Piovezan AP, D'Orleans-Juste P, Souza GE, Rae GA. 2000. Endothelin-1-induced ET(A) receptor-mediated nociception, hyperalgesia and oedema in the mouse hind-paw: modulation by simultaneous ET(B) receptor activation. Br. J. Pharmacol. 129:961-68
68. Gokin AP, Fareed MU, Pan HL, Hans G, Strichartz GR, Davar G. 2001. Local injection of endothelin-1 produces pain-like behavior and excitation of nociceptors in rats. J. Neurosci. 21:5358-66
69. Khasar SG, McCarter G, Levine JD. 1999. Epinephrine produces a beta-adrenergic receptor-mediated mechanical hyperalgesia and in vitro sensitization of rat nociceptors. J. Neurophysiol. 81:1104-12
70. Lewin GR, Ritter AM, Mendell GR. 1993. Nerve growth factor-induced hyperalgesia in the neonatal and adult rat. J. Neurosci. 13:2136-48
71. Shu X, Mendell GR. 1999. Nerve growth factor acutely sensitizes the response of adult rat sensory neurons to capsaicin. Neurosci. Lett. 274:159-62
72. Winston J, Toma H, Shenoy M, Pasricha PJ. 2001. Nerve growth factor regulates VR-1 mRNA levels in cultures of adult dorsal root ganglion neurons. Pain 89:181-86
73. Bielefeldt K, Ozaki N, Gebhart GF. 2003. Role of nerve growth factor in modulation of gastric afferent neurons in the rat. Am. J. Physiol. Gastro. Liver Physiol. 284:G499-507
74. Zhang YH, Vasko MR, Nicol GD. 2002. Ceramide, a putative second messenger for nerve growth factor, modulates the TTX-resistant Na+ current and delayed rectifier K+ current in rat sensory neurons. J. Physiol. 544:385-402
75. Fjell J, Cummins TR, Dib-Hajj SD, Fried K, Black JA, Waxman SG. 1999. Differential role of GDNF and NGF in the maintenance of two TTX-resistant sodium channels in adult DRG neurons. Mol. Brain Res. 67:267-82
76. Cho HJ, Kim SY, Park MJ, Kim DS, Kim JK, Chu MY. 1997. Expression of mRNA for brain-derived neurotrophic factor in the dorsal root ganglion following peripheral inflammation. Brain Res. 749:358-62
77. Kafitz KW, Rose CR, Thoenen H, Konnerth A. 1999. Neurotrophin-evoked rapid excitation through TrkB receptors. Nature 401:918-21
78. Blum R, Kafitz KW, Konnerth A. 2002. Neurotrophin-evoked depolarization requires the sodium channel Na(V)1.9. Nature 419:687-93
79. Waxman SG, Dib-Hajj S, Cummins TR, Black JA. 1999. Sodium channels and pain. Proc. Natl. Acad. Sci. USA 96:7635-39
80. Gould HJ 3rd, England JD, Liu ZP, Levinson SR. 1998. Rapid sodium channel augmentation in response to inflammation induced by complete Freund's adjuvant. Brain Res. 802:69-74
81. Tanaka M, Cummins TR, Ishikawa K, Dib-Hajj SD, Black JA, Waxman SG. 1998. SNS Na+ channel expression increases in dorsal root ganglion neurons in the carrageenan inflammatory pain model. Neuroreport 9:967-72
82. Weskamp G, Otten U. 1987. An enzyme-linked immunoassay for nerve growth factor (NGF): a tool for studying regulatory mechanisms involved in NGF production in brain and in peripheral tissues. J. Neurochem. 48:1779-86
83. Woolf CJ, Safieh-Garabedian B, Ma QP, Crilly P, Winter J. 1994. Nerve growth factor contributes to the generation of inflammatory sensory hypersensitivity. Neuroscience 62:327-31
84. Bielefeldt K, Ozaki N, Gebhart GF. 2002. Experimental ulcers alter voltage-sensitive sodium currents in rat gastric sensory neurons. Gastroenterology 122:394-405
85. Porreca F, Lai J, Bian D, Wegert S, Ossipov MH, et al. 1999. A comparison of the potential role of the tetrodotoxin-insensitive sodium channels, PN3/SNS and NaN/SNS2, in rat models of chronic pain. Proc. Natl. Acad. Sci. USA 96:7640-44
86. Yoshimura N, Seki S, Novakovic SD, Tzoumaka E, Erickson VL, et al. 2001. The involvement of the tetrodotoxin-resistant sodium channel Nav1.8 (PN3/SNS) in a rat model of visceral pain. J. Neurosci. 21:8690-96
87. Toledo-Aral JJ, Moss BL, He ZJ, Koszowski AG, Whisenand T, et al. 1997. Identification of PN1, a predominant voltage-dependent sodium channel expressed principally in peripheral neurons. Proc. Natl. Acad. Sci. USA 94:1527-32
88. Devor M, Keller CH, Deerinck TJ, Ellisman MH. 1989. Na+ channel accumulation on axolemma of afferent endings in nerve end neuromas in Apteronotus. Neurosci. Lett. 102:149-54
89. England JD, Happel LT, Kline DG, Gamboni F, Thouron CL, et al. 1996. Sodium channel accumulation in humans with painful neuromas. Neurology 47:272-76
90. Devor M. 1994. In Textbook of Pain, ed. PD Walls, R Melzack, pp. 79-101. Edinburgh: Churchill Livingstone
91. Waxman SG, Kocsis JD, Black JA. 1994. Type III sodium channel mRNA is expressed in embryonic but not adult spinal sensory neurons, and is reexpressed following axotomy. J. Neurophysiol. 72:466-70
92. Black JA, Cummins TR, Plumpton C, Chen YH, Hormuzdiar W, et al. 1999. Upregulation of a silent sodium channel after peripheral, but not central, nerve injury in DRG neurons. J. Neurophysiol. 82:2776-85
93. Everill B, Cummins TR, Waxman SG, Kocsis JD. 2001. Sodium currents of large (Aβ type) adult cutaneous afferent dorsal root ganglion neurons display rapid recovery from inactivation before and after axotomy. Neuroscience 106:161-69
94. Sleeper AA, Cummins TR, Dib-Hajj SD, Hormuzdiar W, Tyrrell L, et al. 2000. Changes in expression of two tetrodotoxin-resistant sodium channels and their currents in dorsal root ganglion neurons after sciatic nerve injury but not rhizotomy. J. Neurosci. 20:7279-89
95. Decosterd I, Ji RR, Abdi S, Tate S, Woolf CJ. 2002. The pattern of expression of the voltage-gated sodium channels Nav1.8 and Nav1.9 does not change in uninjured primary sensory neurons in experimental neuropathic pain models. Pain 96:269-77
96. Lancaster E, Weinreich D. 2001. Sodium channels in vagotomized primary afferent neurons of the rat. J. Physiol. 536:445-58
97. Kim SH, Chung JM. 1992. An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain 50:355-63
98. Bennet GJ, Xie YK. 1988. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 33:87-107
99. Decosterd I, Woolf CJ. 2000. Spared nerve injury: an animal model of persistent peripheral neuropathic pain. Pain 87:149-58
100. Seltzer Z, Dubner R, Shir Y. 1990. A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury. Pain 43:205-18
101. Winkelstein BA, Rutkowski MD, Weinstein JN, DeLeo JA. 2001. Quantification of neural tissue injury in a rat radiculopathy model: comparison of local deformation, behavioral outcomes, and spinal cytokine mRNA for two surgeons. J. Neurosci. Methods 111:49-57
102. Liu X, Eschenfelder S, Blenk KH, Janig W, Habler HJ. 2000. Spontaneous activity of axotomized afferent neurons after L5 spinal nerve injury in rats. Pain 84:309-18
103. Liu CN, Wall PD, Ben-Dor E, Michaelis M, Amir R, Devor M. 2000. Tactile allodynia in the absence of C-fiber activation: altered firing properties of DRG neurons following spinal nerve injury. Pain 85:503-21
104. Han HC, Lee DH, Chung JM. 2000. Characteristics of ectopic discharges in a rat neuropathic pain model. Pain 84:253-61
105. Boucher TJ, Okuse K, Bennett DL, Munson JB, Wood JN, McMahon SB. 2000. Potent analgesic effects of GDNF in neuropathic pain states. Science 290:124-27
106. Kim CH, Oh Y, Chung JM, Chung K. 2001. The changes in expression of three subtypes of TTX-sensitive sodium channels in sensory neurons after spinal nerve ligation. Mol. Brain Res. 95:153-61
107. Wang R, Guo W, Ossipov MH, Vanderah TW, Porreca F, Lai J. 2003. GDNF normalizes neurochemical changes in injured dorsal root ganglion neurons and prevents the expression of experimental neuropathic pain. Neuroscience. In press
108. Lyu YS, Park SK, Chung K, Chung JM. 2000. Low dose of tetrodotoxin reduces neuropathic pain behaviors in an animal model. Brain Res. 871:98-103
109. Chaplan SR, Bach FW, Pogrel JW, Chung JM, Yaksh TL. 1994. Quantitative assessment of tactile allodynia in the rat paw. J. Neurosci. Methods 53:55-63
110. V1.8. Pain 95:143-52
111. V 1.8 sodium channels to action potential electrogenesis in DRG neurons. J. Neurophysiol. 86:629-40
112. Wu G, Ringkamp M, Murinson BB, Pogatzki EM, Hartke TV, et al. Degeneration of myelinated efferent fibers induces spontaneous activity in uninjured C-fiber afferents. J. Neurosci. 22:7746-53
113. Li Y, Dorsi MJ, Meyer RA, Belzberg AJ. 2000. Mechanical hyperalgesia after an L5 spinal nerve lesion in the rat is not dependent on input from injured nerve fibers. Pain 85:493-502
114. Novakovic SD, Tzoumaka E, McGivern JG, Haraguchi M, Sangameswaran L, et al. 1998. Distribution of the tetrodotoxin-resistant sodium channel PN3 in rat sensory neurons in normal and neuropathic conditions. J. Neurosci. 18:2174-87
115. Coward K, Plumpton C, Facer P, Birch R, Carlstedt T, et al. 2000. Immunolocalization of SNS/PN3 and NaN/SNS2 sodium channels in human pain states. Pain 85:41-50
116. Bucknill AT, Coward K, Plumpton C, Tate, S, Bountra C, et al. 2002. Nerve fibers in lumbar spine structures and injured spinal roots express the sensory neuron-specific sodium channels SNS/PN3 and NaN/SNS2. Spine 27:135-40
117. V1.8 in NGF-induced hyperalgesia, but not neuropathic pain. Neuroreport 12:1-4
118. + channels: local anesthetics, antiarrhythmics and anticonvulsants. Trends Pharmacol. Sci. 8:57-65
119. Backonja MM. 1994. Local anesthetics as adjuvant analgesics. J. Pain Symp. Manage. 9:491-99
120. Tanelian DL, Victory RA. 1995. Sodium channel-blocking agents: their use in neuropathic pain conditions. Pain Forum 4:75-80
121. Ellemann K, Sjogren P, Banning AM, Jensen TS, Smith T, Geertsen P. 1989. Trial of intravenous lidocaine on painful neuropathy in cancer patients. Clin. J. Pain 5:291-94
122. Brose WG, Cousins MJ. 1991. Subcutaneous lidocaine for treatment of neuropathic cancer pain. Pain 45:145-48
123. Bruera E, Ripamonti C, Brenneis C, Macmillan K, Hanson J. 1992. A randomized double-blind crossover trial of intravenous lidocaine in the treatment of neuropathic cancer pain. J. Pain Symp. Manage. 7:138-40
124. Petersen P, Kastrup J. 1987. Dercum's disease (adiposis dolorosa). Treatment of the severe pain with intravenous lidocaine. Pain 28:77-80
125. Kaube H, Hoskin KL, Goadsby PJ. 1994. Lignocaine and headache: an electrophysiological study in the cat with supporting clinical observations in man. J. Neurol. 241:415-20
126. Kastrup J, Petersen P, Dejgard A, Angelo HR, Hilsted J. 1987. Intravenous lidocaine infusion - a new treatment of chronic painful diabetic neuropathy? Pain 28:69-75
127. Dejgard A, Petersen P, Kastrup J. 1988. Mexiletine for treatment of chronic painful diabetic neuropathy. Lancet 1:9-11
128. Bach FW, Jensen TS, Kastrup J, Stigsby B, Dejgard A. 1990. The effect of intravenous lidocaine on nociceptive processing in diabetic neuropathy. Pain 40:29-34
129. Lindstrom P, Lindblom U. 1987. The analgesic effect of tocainide in trigeminal neuralgia. Pain 28:45-50
130. Rowbotham MC, Reisner-Keller LA, Fields HL. 1991. Both intravenous lidocaine and morphine reduce the pain of postherpetic neuralgia. Neurology 41:1024-28
131. Rowbotham MC, Davies PS, Fields HL. 1995. Topical lidocaine gel relieves postherpetic neuralgia. Ann. Neurol. 37:246-53
132. Marchettini P, Lacerenza M, Marangoni C, Pellegata G, Sotgiu ML, Smirne S. 1992. Lidocaine test in neuralgia. Pain 48:377-82
133. Nagaro T, Shimizu C, Inoue H, Fujitani T, Adachi N, et al. 1995. The efficacy of intravenous lidocaine on various types of neuropathic pain. Jap. J. Anesth. 44:862-67
134. Ferrante FM, Paggioli J, Cherukuri S, Arthur GR. 1996. The analgesic response to intravenous lidocaine in the treatment of neuropathic pain. Anesth. Analg. 82:91-97
135. Edwards WT, Habib F, Burney RG, Begin G. 1985. Intravenous lidocaine in the management of various chronic pain states. A review of 211 cases. Reg. Anesth. 10:1-6
136. Galer BS, Miller KV, Rowbotham MC. 1993. Response to intravenous lidocaine infusion differs based on clinical diagnosis and site of nervous system injury. Neurology 43:1233-35
137. Wallace MS, Ridgeway BM, Leung AY, Gerayli A, Yaksh TL. 2000. Concentration-effect relationship of intravenous lidocaine on the allodynia of complex regional pain syndrome types I and II. Anesthesiology 92:75-83
138. Tanelian DL, Brose WG. 1991. Neuropathic pain can be relieved by drugs that are use-dependent sodium channel blockers: lidocaine, carbamazepine, and mexiletine. Anesthesiology 74:949-51
139. Chabal C, Jacobson L, Mariano A, Chaney E, Britell CW. 1992. The use of oral mexiletine for the treatment of pain after peripheral nerve injury. Anesthesiology 76:513-17
140. Chabal C, Jacobson L, Russell LC, Burchiel KJ. 1992. Pain response to perineuromal injection of normal saline, epinephrine, and lidocaine in humans. Pain 49:9-12
141. Galer BS, Harle J, Rowbotham MC. 1996. Response to intravenous lidocaine infusion predicts subsequent response to oral mexiletine: a prospective study. J. Pain Symp. Manage. 12:161-67
142. Kingery WS. 1997. A critical review of controlled clinical trials for peripheral neuropathic pain and complex regional pain syndromes. Pain 73:123-39
143. Covino BG, Wildsmith JAW. 1998. Clinical pharmacology of local anesthetic agents. In Neural Blockade in Clinical Anesthesia and Management of Pain, ed. MJ Cousins, PO Bridenbaugh, pp. 97-128. Philadelphia: Lippincott-Raven. 3rd ed.
144. Petersen P, Kastrup J, Zeeberg I, Boysen G. 1986. Chronic pain treatment with intravenous lidocaine. Neurol. Res. 8:189-90
145. Amer S, Lindblom U, Meyerson BA, Molander C. 1990. Prolonged relief of neuralgia after regional anesthetic blocks. A call for further experimental and systematic clinical studies. Pain 43:287-97
146. Sinnott C, Edmonds P, Cropley I, Hanks G, Dunlop RJ, et al. 1991. Flecainide in cancer nerve pain. Lancet 337:1347
147. Ichimata M, Ikebe H, Yoshitake S, Hattori S, Iwasaka H, Noguchi T. 2001. Analgesic effects of flecainide on postherapeutic neuralgia. Int. J. Clin. Pharmcol. Res. 21:15-19
148. Mao J, Chen LL. 2000. Systemic lidocaine for neuropathic pain relief. Pain 87:7-17
149. Abram SE, Yaksh TL. 1994. Systemic lidocaine blocks nerve injury-induced hyperalgesia and nociceptor-driven spinal sensitization in the rat. Anesthesiology 80:383-91
150. Koch BD, Faurot GF, McGuirk JR, Clarke DE, Hunter JC. 1996. Modulation of mechano-hyperalgesia by clinically effective analgesics in rats with a peripheral mononeuropathy. Analgesia 2:157-64
151. Chaplan SR, Bach FW, Shafer SL, Yaksh TL. 1995. Prolonged alleviation of tactile allodynia by intravenous lidocaine in neuropathic rats. Anesthesiology 83:775-85
152. Hedley LR, Martin B, Waterbury LD, Clarke DE, Hunter JC. 1995. A comparison of the action of mexilitine and morphine in rodent models of acute and chronic pain. Proc. West Pharmacol. Soc. 38:103-4
153. Jett MF, McGuirk J, Waligora D, Hunter JC. 1997. The effects of mexilitine, desipramine and fluoxetine in rat models involving central sensitization. Pain 69:161-69
154. Nozaki-Taguchi N, Chaplan SR, Higuera ES, Ajakwe RC, Yaksh TL. 2001. Vincristine-induced allodynia in the rat. Pain 93:69-76
155. Smith LJ, Shih A, Miletic G, Miletic V. 2002. Continual systemic infusion of lidocaine provides analgesia in an animal model of neuropathic pain. Pain 97:267-73
156. + channels. J. Neurophysiol. 72:349-59
157. Chabal C, Russell LC, Burchiel KJ. 1989. The effect of intravenous lidocaine, tocainide, and mexiletine on spontaneously active fibers originating in rat sciatic neuromas. Pain 38:333-38
158. Devor M, Wall PD, Catalan N. 1992. Systemic lidocaine silences ectopic neuroma and DRG discharge without blocking nerve conduction. Pain 48:261-68
159. Omana-Zapata I, Khabbaz M, Hunter JC, Bley KR. 1997. QX-314 inhibits ectopic nerve activity associated with neuropathic pain. Brain Res. 771:228-37
160. Persaud N, Strichartz GR. 2002. Micromolar lidocaine selectively blocks propagating ectopic impulses at a distance from their site of origin. Pain 99:333-40
161. Swerdlow M. 1984. Anticonvulsant drugs and chronic pain. Clin. Neuropharmacol 7:51-82
162. Blom S. 1962. Trigeminal neuralgia: its treatment with a new anticonvulsant drug (G-32883). Lancet 1:839-40
163. McQuay H, Carroll D, Jadad AR, Wiffen P, Moore A. 1995. Anticonvulsant drugs for the management of pain: a systematic review. Br. Med. J. 311:1047-52
164. Campbell FG, Graham JG, Zilkha KJ. 1966. Clinical trial of carbamazepine (Tegretol) in trigeminal neuralgia. J. Neurol. Neurosurg. Psychiatry 29:265-67
165. Killian JM, Fromm GH. 1968. Carbamazepine in the treatment of neuralgia. Use of side-effects. Arch. Neurol. 19:129-36
166. Rull J, Quibrera R, Gonzalez-Millan H, Lozano Castenada O. 1969. Symptomatic treatment of peripheral diabetic neuropathy with carbamazepine: double-blind crossover study. Diabetologia 5:215-20
167. Saudek CD, Werns S, Reidenberg MM. 1977. Phenytoin in the treatment of diabetic symmetrical polyneuropathy. Clin. Pharmacol. Ther. 22:196-99
168. Chadda VS, Mathur MS. 1978. Double blind study of the effects of diphenylhydantoin sodium on diabetic neuropathy. J. Assoc. Physicians India 26:403-6
169. 2 and in the chronic hyperalgesia in rats with streptozotocin-induced diabetes. Pain 63:33-37
170. Fitton A, Goa KL. 1995. Lamotrigine. An update of its pharmacology and therapeutic use in epilepsy. Drugs 50:691-713
171. Leach MJ, Marden CM, Miller AA. 1986. Pharmacological studies on lamotrigine, a novel potential antiepileptic drug. II. Neurochemical studies on the mechanism of action. Epilepsia 27:490-97
172. Cheung H, Kamp D, Harris E. 1992. An in vitro investigation of the action of lamotrigine on neuronal voltage-activated sodium channels. Epilepsy Res. 13:107-12
173. Zakrzewska JM, Chaudhry Z, Nurmikko TJ, Patton DW, Mullens EL. 1997. Lamotrigine (Lamictal) in refractory trigeminal neuralgia: results from a double-blind placebo controlled crossover trial. Pain 73:223-30
174. Eisenberg E, Alon N, Yarnitsky D, Ishay A, Daoud D. 1996. Lamotrigine for the treatment of painful diabetic neuropathy. 8th World Congress on Pain Abstr., Vancouver, Canada. p. 372.
175. Harbison J, Dennehy F, Keating D. 1997. Lamotrigine for pain with hyperalgesia. Irish Med. J. 90:56
176. McCleane G. 1999. 200 mg daily of lamotrigine has no analgesic effect in neuropathic pain: a randomized, double-blind, placebo controlled trial. Pain 83:105-7
177. Hunter JC, Gogas KR, Hedley LR, Jacobson LO, Kassotakis L, et al. 1997. The effect of novel anti-epileptic drugs in rat experimental models of acute and chronic pain. Eur. J. Pharmacol. 324:153-60
178. Laughlin TM, Tram KV, Wilcox GL, Birnbaum AK. 2002. Comparison of antiepileptic drugs tiagabine, lamotrigine and gabapentin in mouse models of acute, prolonged and chronic nociception. J. Pharmacol. Exp. Ther. 302:1168-75
179. Lee TH, Wang CJ, Wu PC, Buerkle H, Lin SH, Yang LC. 2002. The thermal and mechanical anti-hyperalgesic effects of pre- versus post-intrathecal treatment with lamotrigine in a rat model of inflammatory pain. Life Sci. 70:3039-47
180. Galer BS, Jensen MP, Ma T, Davies PS, Rowbotham MC. 2002. The lidocaine patch 5% effectively treats all neuropathic pain qualities: results of a randomized, double-blind, vehicle-controlled, 3-week efficacy study with the use of the neuropathic pain scale. Clin. J. Pain 18:297-301
181. Gracely RH, Lynch SA, Bennett GJ. 1992. Painful neuropathy: altered central processing maintained dynamically by peripheral input. Pain 51:175-94
182. Koltzenburg M, Torebjork HE, Wahren LK. 1994. Nociceptor modulated central sensitization causes mechanical hyperalgesia in acute chemogenic and chronic neuropathic pain. Brain Res. 117:579-91
183. Fletcher D, Le Corre P, Guilbaud G, Le Verge R. 1997. Antinociceptive effect of bupivacaine encapsulated in poly(D,L):-lactide-co-glycolide microspheres in the acute inflammatory pain model of carrageenin-injected rats. Anesth. Analg. 84:90-4
184. Yoon YW, Na HS, Chung JM. 1996. Contributions of injured and intact afferents to neuropathic pain in an experimental rat model. Pain 64:27-36