GABA(B) receptors inhibit mechanosensitivity of primary afferent endings

Journal of Neuroscience

Volumn 19, Issue 19, 1999, Pages 8597-8602

  Page, Amanda J ^a   Blackshaw, L Ashley ^a  

^a ROYAL ADELAIDE HOSPITAL   (Australia)

Author keywords

Esophagus; Ferret; GABA(B) receptors; Mechanoreceptors; Vagal afferents; Visceral afferents

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; 4 AMINOBUTYRIC ACID B RECEPTOR STIMULATING AGENT; BACLOFEN; GUANINE NUCLEOTIDE BINDING PROTEIN;

ANIMAL TISSUE; ARTICLE; DRUG MECHANISM; FERRET; MECHANICAL STIMULATION; MECHANORECEPTOR; NONHUMAN; PRIORITY JOURNAL; RECEPTOR DENSITY; SENSORY NERVE CONDUCTION; VAGUS NERVE STIMULATION;

EID: 0033215989     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.19-19-08597.1999     Document Type: Article

References (36)

1. Andrews PLR, Bingham S, Wood KL (1987) Modulation of the vagal drive to the intramural cholinergic and non-cholinergic neurones in the ferret stomach by baclofen. J Physiol (Lond) 388:25-39.
2. Awapara J, Landua AJ, Fuerst R, Scale B (1950) Free γ-aminobutyric acid in brain. J Biol Chem 187:35-39.
3. Bakhle YS, Bell C (1995) Neurokinin A and substance P vary independently in different regions of rat sensory neurons. Neuropeptides 28:237-241.
4. B-receptors. Br J Pharmacol 97:1225-1231.
5. Berthoud H-R, Powley TL (1992) Vagal afferent innervation of the rat fundic stomach: morphological characterization of the gastric tension receptor. J Comp Neurol 319:261-276.
6. B receptors: drugs meet clones. Curr Opin Neurobiol 8:345-350.
7. B receptor agonists. Am J Physiol, in press.
8. Bolser C, Blythin DJ, Chapman RW, Egan RW, Hey JA, Rizzo C, Kuo S-C, Kreutner W (1995) The pharmacology of SCH50911: a novel, orally-active GABA-B receptor antagonist. J Pharmacol Exp Ther 274:1393-1398.
9. Bolser DC, DeGennaro FC, O'Reilly S, Chapman RW, Kreutner W, Egan RW, Hey JA (1994) Peripheral and central sites of action of GABA-B agonists to inhibit the cough reflex in the cat and guinea-pig. Br J Pharmacol 113:1344-1348.
10. B receptor pharmacology. Annu Rev Pharmacol Toxicol 33:109-147.
11. B receptors as targets for drug action. Drug Res 42:215-223.
12. Bowery NG, Hill DR, Hudson AL, Doble A, Middlemiss DN, Shaw J, Turnbull M (1980) (-)Baclofen decreases neurotransmitter release in the mammalian CNS by an action at a novel GABA receptor. Nature 283:92-94.
13. Brooks PA, Glaum SR, Miller RJ, Spyer KM (1992) The actions of baclofen on the neurones and synaptic transmission in the nucleus tractus solitarii of the rat in vitro. J Physiol (Lond) 457:115-129.
14. Capaday C (1995) The effects of baclofen on the stretch reflex parameters of the cat. Exp Brain Res 104:287-296.
15. Chelyshev YA, Gataullin RR (1983) Effect of morphine and leucine-enkephalin on the electrophysiological responses of pacinian corpuscles of the cat. Neurosci Lett 39:165-168.
16. Curtis DR, Johnston GAR (1974) Aminoacid transmitters in the mammalian central nervous system. Rev Physiol Biochem Exp Pharamacol 69:97-188.
17. Davidoff RA, Sears E (1974) The effects of Lioresal on synaptic activity in the isolated spinal cord. Neurology 24:957-963.
18. Erdö SL, Rosdy B, Szporny C (1982) Higher GABA concentrations in fallopian tube than in brain of the rat. J Neurochem 38:1174-1176.
19. Green KA, Cottrell GA (1988) Actions of baclofen on components of the Ca-current in rat and mouse DRG neurones in culture. Br J Pharmacol 94:235-245.
20. Heppelmann B, Pawlak M (1997) Inhibitory effect of somatostatin on the mechanosensitivity of articular afferents in normal and inflamed knee joints of the rat. Pain 73:377-382.
21. Jessen KR, Hills JM, Saffery MJ (1986) Immunohistochemical demonstration of GABAergic neurons in the enteric nervous system. J Neurosci 6:1628-1634.
22. Kato M, Waldmann U, Murakami S (1978) Effects of baclofen on spinal neurones of cats. Neuropharmacology 17:827-833.
23. Kleinrok A, Kilbinger H (1983) γ-Aminobutyric acid and cholinergic transmission in the guinea-pig ileum. Naunyn Schmiedebergs Arch Pharmacol 322:216-220.
24. Knutsson E, Lindblom U, Martensson A (1974) Plasma and cerebrospinal fluid levels of baclofen (Lioresal) at optimal therapeutic responses in spastic paresis. J Neurol Sci 23:473-484.
25. B agonist baclofen inhibits transient lower oesophageal sphincter relaxations and gastroesophageal reflux in normal human subjects. Gastroenterology, in press.
26. B receptors in guinea distal colon. Eur J Pharmacol 230:187-193.
27. Newberry NR, Nicoll RA (1985) Comparison of the action of baclofen with γ-aminobutyric acid on rat hippocampal pyramidal cells in vitro. J Physiol (Lond) 360:161-185.
28. Nicoll RA, Malenka RC, Kauer JA (1990) Functional comparison of neurotransmitter receptor subtypes in mammalian central nervous system. Physiol Rev 70:513-565.
29. Page AJ, Blackshaw LA (1998) An in vitro study of the properties of vagal afferent fibres innervating the ferret oesophagus and stomach. J Physiol (Lond) 512:907-916.
30. Roberts E, Frankel S (1950) γ-Aminobutyric acid in brain: its formation from glutamic acid. J Biol Chem 187:55-63.
31. +-evoked release of sensory CGRP from the guinea-pig urinary bladder. Life Sci 48:169-172.
32. Silva Carvalho L, Dawid Milner MS, Spyer KM (1995) The pattern of excitatory inputs to the nucleus tractus solitarii evoked on stimulation in the hypothalamic defence area of the cat. J Physiol (Lond) 487:727-737.
33. Su X, Sengupta JN, Gebhart GF (1997) Effects of κ opioid receptor-selective agonists on responses of pelvic nerve afferents to noxious colorectal distension. J Neurophysiol 78:1003-1012.
34. Tanaka C (1985) γ-Aminobutyric acid in peripheral tissues. Life Sci 37:2221-2235.
35. Trippenbach T (1995) Baclofen-induced block of the Hering-Breuer expiratory-promoting reflex in rats. Can J Physiol Pharmacol 73:706-713.
36. Udenfriend S (1950) Identification of γ-aminobutyric acid in brain by the isotope derivative method. J Biol Chem 187:65-69.