Neurotrophin-4 deficient mice have a loss of vagal intraganglionic mechanoreceptors from the small intestine and a disruption of short-term satiety

Journal of Neuroscience

Volumn 21, Issue 21, 2001, Pages 8602-8615

  Fox, Edward A ^a   Phillips, Robert J ^a   Baronowsky, Elizabeth A ^a   Byerly, Mardi S ^a   Jones, Sarahlouise ^a   Powley, Terry L ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

Autonomic nervous system; Food intake; Gastrointestinal tract; Intraganglionic laminar endings; Knock out mice; Meal pattern; Myenteric neurons; Vagus nerve; Visceral afferents

Indexed keywords

NEUROTROPHIN 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AUTONOMIC NERVOUS SYSTEM; INTESTINE INNERVATION; KNOCKOUT MOUSE; MECHANORECEPTOR; MOUSE; MYENTERIC PLEXUS; NONHUMAN; PRIORITY JOURNAL; SATIETY; SMALL INTESTINE; VAGUS NERVE;

EID: 0035503048     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-21-08602.2001     Document Type: Article

References (78)

1. Primary sensory afferents in the inferior mesenteric ganglion and related nerves of the guinea pig. An experimental study with anterogradely transported wheat germ agglutinin-horseradish peroxidase conjugate
2. Perception and reflex relaxation of the stomach in response to gut distention
3. Vagal afferent innervation of the rat fundic stomach: Morphological characterization of the gastric tension receptor
4. Distribution and structure of vagal afferent intraganglionic laminar endings (IGLEs) in the rat gastrointestinal tract
5. Capsaicin-resistant vagal afferent fibers in the rat gastrointestinal tract: Anatomical identification and functional integrity
6. BDNF is a target-derived survival factor for arterial baroreceptor and chemoafferent primary sensory neurons
7. The survival of NGF-dependent but not BDNF-dependent cranial sensory neurons is promoted by several different neurotrophins early in their development
8. A quantitative investigation of the effects of neonatal capsaicin treatment on vagal afferent neurons in the rat
9. Chemical lesion of visceral afferents causes transient overconsumption of unfamiliar highfat diets in rats
10. Methods for determining numbers of cells and synapses: A case for more uniform standards of review
11. Neuronal deficits, not involving motor neurons, in mice lacking BDNF and/or NT4
12. Molecular and cellular aspects of patterning sensory neurone connections in the vertebrate nervous system
13. Neurotrophin-4/5 is a mammalian-specific survival factor for distinct populations of sensory neurons
14. Neurotrophin-3 and neurotrophin receptor immunoreactivity in peptidergic enteric neurons
15. Reflex gastric relaxation in response to distention of the duodenum
16. Relaxatory responses of canine proximal stomach to esophageal and duodenal distension. Importance of vagal pathways
17. The splanchnic nerve and food intake regulation
18. Requirement of neurotrophin-3 for the survival of proliferating trigeminal ganglion progenitor cells
19. Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 complement and cooperate with each other sequentially during visceral neuron development
20. Mice lacking brain-derived neurotrophic factor exhibit visceral sensory neuron losses distinct from mice lacking NT4 and display a severe developmental deficit in control of breathing
21. Cells expressing messenger-RNA for neurotrophins and their receptors during embryonic rat development
22. Mice lacking brain-derived neurotrophic factor develop with sensory deficits
23. A neuronal subpopulation in the mammalian enteric nervous system expresses TrkA and TrkC neurotrophin receptor-like proteins
24. Knocking the NT4 gene into the BDNF locus rescues BDNF deficient mice and reveals distinct NT4 and BDNF activities
25. Lack of neurotrophin-3 results in death of spinal sensory neurons and premature differentiation of their precursors
26. Vagal afferent innervation of smooth muscle in the stomach and duodenum of the mouse: Morphology and topography
27. C-Kit mutant mice have a selective loss of vagal intramuscular mechanoreceptors that innervate gastric smooth muscle
28. Quantification without pontification: Choosing a method for counting objects in sectioned tissues
29. Specific, selective, and complete staining of neurons of the myenteric plexus, using cuprolinic blue
30. Axonal transport of neurotrophins by visceral afferent and efferent neurons of the vagus nerve of the rat
31. BDNF supports mammalian chemoafferent neurons in vitro and following peripheral target removal in vivo
32. Localization of neurotrophins and their high-affinity receptors during human enteric nervous system development
33. Cuprolinic blue (quinolinic phthalocyanine) counterstaining of enteric neurons for peroxidase immunocytochemistry
34. Neurotrophin-4 is a target-derived neurotrophic factor for neurons of the trigeminal ganglion
35. Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development
36. Regional differences in the number of neurons in the myenteric plexus of the guinea pig small intestine and colon: An evaluation of markers used to count neurons
37. Transient overconsumption of novel foods by deafferentated rats: Effects of novel diet composition
38. Effects of jejunoileal bypass on meal patterns in genetically obese and lean rats
39. Vagal innervation of the rat pylorus: An anterograde tracing study using carbocyanine dyes and laser scanning confocal microscopy
40. Dependence of developing group Ia afferents on neurotrophin-3
41. Neurotrophins and the specification of neuronal phenotype
42. Absence of sensory neurons before target innervation in brain-derived neurotrophic factor-, neurotrophin 3-, and TrkC-deficient embryonic mice
43. Sensory but not motor neuron deficits in mice lacking NT4 and BDNF
44. Abundant production of brain-derived neurotrophic factor by adult visceral epithelia. Implications for paracrine and target-derived neurotrophic functions
45. Differential effects of upper gastrointestinal fill on milk ingestion and nipple attachment in the suckling rat
46. Tetramethyl benzidine for horseradish peroxidase neurohistochemistry: A non-carcinogenic blue reaction product with superior sensitivity for visualizing neural afferents and efferents
47. Sensory vagal innervation of the rat esophagus and cardia: A light and electron microscopic anterograde tracing study
48. Afferent nerve endings in the ganglia of the intermuscular plexus of the dog's esophagus
49. A method for selective section of vagal afferent or efferent axons in the rat
50. Tension and stretch receptors in gastrointestinal smooth muscle: Re-evaluating vagal mechanoreceptor electrophysiology
51. Afferent innervation of gastrointestinal tract smooth muscle by the hepatic branch of the vagus
52. Three-dimensional reconstructions of autonomic projections to the gastrointestinal tract
53. Vegetative innervation of the esophagus. II. Intraganglionic laminar endings
54. Sensory vagal nature and anatomical access paths to esophagus laminar nerve endings in myenteric ganglia. Determination by surgical degeneration methods
55. Lack of neurotrophin-4 causes selective structural and chemical deficits in sympathetic ganglia and their preganglionic innervation
56. Growth factors and the development and plasticity of the enteric nervous system
57. The origin and development of the vagal and spinal innervation of the external muscle of the mouse esophagus
58. TrkB and neurotrophin-4 are important for development and maintenance of sympathetic preganglionic neurons innervating the adrenal medulla
59. Duodenal nutrient exposure elicits nutrient-specific gut motility and vagal afferent signals in rat
60. Gut vagal afferent lesions increase meal size but do not block gastric preloadinduced feeding suppression
61. Pregastric and gastric satiety
62. Afferent axons in abdominal vagus mediate satiety effect of cholecystokinin in rats
63. Functions of the neurotrophins during nervous system development: What the knockouts are teaching us
64. The meal pattern of genetically obese (ob/ob) mice
65. Neurotrophin 4 is required for the survival of a subclass of hair follicle receptors
66. Leukemia inhibitory factor and neurotrophins support overlapping populations of rat nodose sensory neurons in culture
67. Widespread and developmentally regulated expression of neurotrophin-4 mRNA in rat brain and peripheral tissues
68. Selective vagal rhizotomies: A new dorsal surgical approach used for intestinal deafferentations
69. Suppression of meal size by intestinal nutrients is eliminated by celiac vagal deafferentation
70. Topographic inventories of vagal afferents in gastrointestinal muscle
71. Neuronal and nonneuronal expression of neurotrophins and their receptors in sensory and sympathetic ganglia suggest new intercellular trophic interactions
72. Axonal outgrowth from adult mouse nodose ganglia in vitro is stimulated by neurotrophin-4 in a Trk receptor and mitogen-activated protein kinase-dependent way
73. Deficient long-term memory and long-lasting long-term potentiation in mice with a targeted deletion of neurotrophin-4 gene
74. Vagotomy attenuates suppression of sham feeding induced by intestinal nutrients
75. Transduction sites of vagal mechanoreceptors in the guinea pig esophagus
76. Presence and localization of neurotrophin receptor tyrosine kinase (TrkA, TrkB, TrkC) mRNAs in visceral afferent neurons of the nodose and petrosal ganglia
77. Neurochemistry of the nodose ganglion
78. Distribution of brain-derived neurotrophic factor in cranial and spinal ganglia