Ibuprofen blocks changes in nav 1.7 and 1.8 sodium channels associated with complete freund's adjuvant-induced inflammation in rat

Journal of Pain

Volumn 5, Issue 5, 2004, Pages 270-280

  Gould III, Harry J ^a   England, John D ^c   Soignier, R Denis ^a   Nolan, Porter ^a   Minor, Lerna D ^b   Liu, Z P ^a   Levinson, S Rock ^d   Paul, Dennis ^b  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LOUISIANA STATE UNIV HLTH SCI C   (United States)

^c Billings Clinic Red Lodge   (United States)

^d UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

COX 2 inhibition; hyperalgesia; ibuprofen; inflammatory pain; NS 398; Sodium channel

Indexed keywords

FREUND ADJUVANT; IBUPROFEN; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; SODIUM CHANNEL; SODIUM CHANNEL BLOCKING AGENT;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LABELING; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOCHEMISTRY; DRUG MECHANISM; DRUG SELECTIVITY; ENZYME INHIBITION; HYPERALGESIA; INFLAMMATION; MECHANICAL STIMULATION; NOCICEPTIVE STIMULATION; NONHUMAN; RAT; SPINAL GANGLION; THERMAL STIMULATION; UPREGULATION;

ANIMALS; CYCLOOXYGENASE INHIBITORS; FREUND'S ADJUVANT; IBUPROFEN; INFLAMMATION; NERVE TISSUE PROTEINS; PAIN MEASUREMENT; RATS; RATS, SPRAGUE-DAWLEY; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; UP-REGULATION;

EID: 3042791018     PISSN: 15265900     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpain.2004.04.005     Document Type: Article

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