Excitation of rat colonic afferent fibres by 5-HT3 receptors

Journal of Physiology

Volumn 544, Issue 3, 2002, Pages 861-869

  Hicks, Gareth A ^a   Coldwell, Jonathan R ^b   Schindler, Marcus ^a   Bland Ward, Philip A ^a   Jenkins, David ^a   Lynn, Penny A ^b   Humphrey, Patrick P A ^a   Blackshaw, Ashley L ^b,c  

^a GLAXOSMITHKLINE   (United Kingdom)

^b UNIVERSITY OF ADELAIDE   (Australia)

^c HANSON INSTITUTE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHYLSEROTONIN; ALOSETRON; SEROTONIN; SEROTONIN 3 RECEPTOR; SEROTONIN AGONIST; SEROTONIN ANTAGONIST; SEROTONIN 3 ANTAGONIST; 2 METHYL 5 HT; 2-METHYL-5-HT; DRUG DERIVATIVE; SEROTONIN RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL LABELING; CELL STIMULATION; CONTROLLED STUDY; IMMUNOREACTIVITY; INFERIOR MESENTERIC GANGLION; INHIBITION KINETICS; INTESTINE CELL; INTESTINE MUCOSA; MUSCLE SPINDLE AFFERENT NERVE; NERVE ENDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SENSORY NERVE CELL; SEROSA; SPINAL GANGLION; SPLANCHNIC NERVE; STIMULUS RESPONSE; ADULT; CELL BODY; COLONIC AFFERENT FIBER; DESCENDING COLON; DORSAL ROOT GANGLIA; DOSE RESPONSE; FEMALE; LUMBAR SPLANCHNIC NERVE BUNDLE; MUCOSAL AFFERENT; NERVE CELL STIMULATION; PERCEPTIVE THRESHOLD; SENSORY GANGLION; ANIMAL; COLON; CYTOLOGY; DRUG EFFECT; IMMUNOHISTOCHEMISTRY; INNERVATION; NERVE FIBER; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; COLON; GANGLIA, SPINAL; IMMUNOHISTOCHEMISTRY; NERVE FIBERS; NEURONS, AFFERENT; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT3; SEROTONIN; SEROTONIN ANTAGONISTS;

EID: 0036849547     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2002.025452     Document Type: Article

References (33)

1. ANDREWS, P. L. R., DAVIS, C. J., BINGHAM, S., DAVIDSON, H. I. M., HAWTHORN, J. & MASKELL, L. (1990). The abdominal visceral innervation and the emetic reflex: pathways, pharmacology, and plasticity. Canadian Journal of Physiology and Pharmacology 68, 325-345.
2. BARON, R., JANIG, W. & KOLLMANN, W. (1988). Sympathetic and afferent somata projecting in hindlimb nerves and the anatomical organization of the lumbar sympathetic nervous system of the rat. Journal of Comparative Neurology 275, 460-468.
3. BEARCROFT, C. P., PERRETT, D. & FARTHING, M. J. (1998). Postprandial plasma 5-hydroxytryptamine in diarrhoea predominant irritable bowel syndrome: a pilot study. Gut 42, 42-46.
4. BERTHOUD, H. R., LYNN, P. A. & BLACKSHAW, L. A. (2001). Vagal and spinal mechanosensors in the rat stomach and colon have multiple receptive fields. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology 280, R1371-1381.
5. BERTRAND, P. P., KUNZE, W. A., FURNESS, J. B. & BORNSTEIN, J. C. (2000). The terminals of myenteric intrinsic primary afferent neurons of the guinea-pig ileum are excited by 5-hydroxytryptamine acting at 5-hydroxytryptamine-3 receptors. Neuroscience 101, 459-469.
6. BLACKSHAW, L. A. & GRUNDY, D. (1993a). Effects of 5-hydroxytryptamine (5-HT) on the discharge of vagal mechanoreceptors and motility in the upper gastrointestinal tract of the ferret. Journal of the Autonomic Nervous System 45, 51-59.
7. BLACKSHAW, L. A. & GRUNDY, D. (1993b) Effects of 5-hydroxytryptamine on discharge of vagal mucosal afferent fibres from the upper gastrointestinal tract of the ferret. Journal of the Autonomic Nervous System 45, 41-50.
8. BLUMBERG, H., HAUPT, P., JANIG, W. & KOHLER, W. (1983). Encoding of visceral noxious stimuli in the discharge patterns of visceral afferent fibres from the colon. Pflügers Archiv 398, 33-40.
9. CAMILLERI, M. (2001). Management of the irritable bowel syndrome. Gastroenterology 120, 652-668.
10. CAMILLERI, M., NORTHCUTT, A. R., KONG, S., DUKES, G. E., MCSORLEY, D. & MANGEL, A. W. (2000). Efficacy and safety of alosetron in women with irritable bowel syndrome: a randomised, placebo-controlled trial. Lancet 355, 1035-1040.
11. CARDENAS, C. G., MAR, L. P., VYSOKANOV, A. V., ARNOLD, P. B., CARDENAS, L. M., SURMEIER, D. J. & SCROGGS, R. S. (1999). Serotonergic modulation of hyperpolarization-activated current in acutely isolated rat dorsal root ganglion neurons. Journal of Physiology 518, 507-523.
12. CHEN, J. J., VASKO, M. R., WU, X., STAEVA, T. P., BAEZ, M., ZGOMBICK, J. M. & NELSON, D. L. (1998). Multiple subtypes of serotonin receptors are expressed in rat sensory neurons in culture. Journal of Pharmacology and Experimental Therapeutics 287, 1119-1127.
13. 3 receptors in activation of abdominal sympathetic C fibre afferents during ischaemia in cats. Journal of Physiology 509, 729-740.
14. FURNESS, J. B., KOOPMANS, H. S., ROBBINS, H. L. & LIN, H. C. (2000). Identification of intestinofugal neurons projecting to the coeliac and superior mesenteric ganglia in the rat. Autonomic Neuroscience 83, 81-85.
15. 4 receptor agonists stimulate small intestinal transit but do not have direct visceral antinociceptive effects in the rat. Gastroenterology 120, A6.
16. HICKS, G. A., HURLE, M., SAVAGE, T. J., MAZZIA, C., CLERC, N. G. & HUMPHREY, P. P. A. (2001b). Enterochromaffin cells of the human, rat and guinea-pig colon: lack of evidence for the presence of 5-HT3 receptors. Gastroenterology 120, A171.
17. HILLSLEY, K., KIRKUP, A. J. & GRUNDY, D. (1998). Direct and indirect actions of 5-hydroxytryptamine on the discharge of mesenteric afferent fibres innervating the rat jejunum. Journal of Physiology 506, 551-561.
18. HOUGHTON, L. A., WHITAKER, P., ATKINSON, W., WHORWELL, P. J., FRICKER, J., RIMMER, M., JACQUES, L. & MILLS, J. (2001). Increased platelet stores of 5-hydroxytryptamine (5-HT) in female patients with diarrhoea predominant irritable bowel syndrome. Gastroenterology 120, A636.
19. KIRCHGESSNER, A. L., TAMIR, H. & GERSHON, M. D. (1992). Identification and stimulation by serotonin of intrinsic sensory neurons of the submucosal plexus of the guinea pig gut: activity-induced expression of Fos immunoreactivity. Journal of Neuroscience 12, 235-248.
20. KOZLOWSKI, C. M., GREEN, A., GRUNDY, D., BOISSONADE, F. M. & BOUNTRA, C. (2000). The 5-HT(3) receptor antagonist alosetron inhibits the colorectal distention induced depressor response and spinal c-fos expression in the anaesthetised rat. Gut 46, 474-480.
21. LEMBO, T., MUNAKATA, J., MERTZ, H., NIAZI, N., KODNER, A., NIKAS, V. & MAYER, E. A. (1994). Evidence for the hypersensitivity of lumbar splanchnic afferents in irritable bowel syndrome. Gastroenterology 107, 1686-1696.
22. LUCKENSMEYER, G. B. & KEAST, J. R. (1995). Distribution and morphological characterization of viscerofugal projections from the large intestine to the inferior mesenteric and pelvic ganglia of the male rat. Neuroscience 66, 663-671
23. LYNN, P. A. & BLACKSHAW, L. A. (1999). In vitro recordings of afferent fibres with receptive fields in the serosa, muscle and mucosa of rat colon. Journal of Physiology 518, 271-282.
24. MAZZIA, C. J. & CLERC, N. G. (2001). Localization of 5-HT3 receptor immunoreactivity in enteric nervous system of rat colon. Gastroenterology 120, A335.
25. NESS, T. J. & GEBHART, G. F. (1988). Characterization of neurons responsive to noxious colorectal distension in the T13-L2 spinal cord of the rat. Journal of Neurophysiology 60, 1419-1438.
26. PAINTAL, A. S. (1954). The response of gastric stretch receptors and certain other abdominal and thoracic vagal receptors to some drugs. Journal of Physiology 126, 271-285.
27. PAN, H. & GERSHON, M. D. (2000). Activation of intrinsic afferent pathways in submucosal ganglia of the guinea pig small intestine. Journal of Neuroscience 20, 3295-3309.
28. PIERCE, P. A., XIE, G. X., LEVINE, J. D. & PEROUTKA, S. J. (1996). 5-Hydroxytryptamine receptor subtype messenger RNAs in rat peripheral sensory and sympathetic ganglia: a polymerase chain reaction study. Neuroscience 70, 553-559.
29. SPIER, A. D., WOTHERSPOON, G., NAYAK, S. V., NICHOLS, R. A., PRIESTLEY, J. V. & LUMMIS, S. C. (1999). Antibodies against the extracellular domain of the 5-HT3 receptor label both native and recombinant receptors. Brain Research. Molecular Brain Research 67, 221-230.
30. SPILLER, R. C., JENKINS, D., THORNLEY, J. P., HEBDEN, J. M., WRIGHT, T., SKINNER, M. & NEAL, K. R. (2000). Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome. Gut 47, 804-811.
31. 3 subtype of serotonin receptor contributes to nociceptive processing via a novel subset of myelinated and unmyelinated nociceptors. Journal of Neuroscience 22, 1010-1019.
32. ZHAI, J., GERSHON, M. D., WALSH, J. H., WONG, H. C. & KIRCHGESSNER, A. L. (1999). Inward currents in neurons from newborn guinea pig intestine: mediation by 5-hydroxytryptamine type 3 receptors. Journal of Pharmacology and Experimental Therapeutics 291, 374-382.
33. ZHU, J. X., ZHU, X. Y., OWYANG, C. & LI, Y. (2001). Intestinal serotonin acts as a paracrine substance to mediate vagal signal transmission evoked by luminal factors in the rat. Journal of Physiology