Pathologic correlates of nondemented aging, mild cognitive impairment, and early-stage Alzheimer's disease

Journal of Molecular Neuroscience

Volumn 17, Issue 2, 2001, Pages 101-118

  Morris, John C ^a   Price, Joseph L ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aging; Alzheimer's disease; Amyloid plaques; Mild cognitive impairment

Indexed keywords

ADULT; AGED; AGING; ALZHEIMER DISEASE; ARTICLE; CLINICAL ARTICLE; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; DEGENERATIVE DISEASE; HUMAN; NERVE CELL DEGENERATION; NEUROFIBRILLARY TANGLE; NEUROLOGIC DISEASE; NEUROPATHOLOGY; SENILE PLAQUE;

AGED; AGING; ALZHEIMER DISEASE; CEREBRAL CORTEX; DIAGNOSIS, DIFFERENTIAL; DISEASE PROGRESSION; HUMANS; MIDDLE AGED; NEUROFIBRILLARY TANGLES; SENILE PLAQUES;

EID: 0035168927     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1385/JMN:17:2:101     Document Type: Article

References (110)

1. Ber eine eigenartige erkrankung der hirnrinde
2. Distribution of Alzheimer-type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer's disease
3. Neuronal loss, neurofibrillary tangles and granulovacular degeneration in the hippocampus with aging and dementia. A quantitative study
4. Clinicopathologic studies in cognitively healthy aging and Alzheimer disease: Relation of histologic markers to dementia severity, age, sex, and apolipoprotein E genotype
5. Neocortical neurofibrillary tangles correlate with dementia severity in Alzheimer's disease
6. The association between quantitative measures of dementia and of senile change in the cerebral grey matter of the elderly subjects
7. Memory complaints in older adults: Fact or fiction?
8. Episodic memory changes are associated with the APOE-Σ4 allele in nondemented older adults
9. Progression to dementia in patients with isolated memory loss
10. Neuropathological stageing of Alzheimer-related changes
11. Frequency of stages of Alzheimer-related lesions in different age categories
12. Memory decline in healthy older people Implications for identifying mild cognitive impairment
13. Memory functions in normal aging
14. Age-associated memory impairment: Proposed diagnostic criteria and measures of clinical change: Report of a National Institute of Mental Health work group
15. Population-based norms for the Mini-Mental State Examination by age and education level
16. Clinico-pathologic studies in dementia: Nondemented subjects with pathologically confirmed Alzheimer's disease
17. β-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease
18. Predicting conversion to Alzheimer disease using standardized clinical information
19. Is the "preamyloid" of diffuse plaques in Alzheimer's disease really nonfibrillar?
20. Retrospective postmortem dementia assessment: Validation of a new clinical interview to assist neuropathologic study
21. β A4 deposits are constant in the brain of the oldest old: An immunocytochemical study of 20 French centenarians
22. Peripheral anti-Aβ antibody alters CNS and plasma Aβ clearance and decreases brain Aβ burden in a mouse model of Alzheimer's disease
23. Identification of normal and pathological aging in prospectively studied nondemented elderly humans
24. APOE-Σ4 is associated with memory decline in cognitively impaired elderly
25. Cognitive performance on the Alzheimer's disease assessment scale: Effect of education
26. Prevalence, incidence and duration of Braak's stages in the general population: Can we know?
27. The preclinical phase of Alzheimer disease. A 22-year prospective study of the Faminham cohort
28. Aging and disease
29. Mild cognitive impairment in the elderly: Predictors of dementia
30. Minimental state: A practical method for grading the cognitive state of patients for the clinicians
31. Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein
32. Cognitive stability over 2 years in a rural elderly population: The MOVIES project
33. Zur kenntnis der hirnever nderungen bei der normalen altersinvolution
34. Cerebral cortex pathology in aging and Alzheimer's disease: A quantitative survery of large hospital-based geriatric and psychiatric cohorts
35. Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
36. Absence of cognitive impairment or decline in preclinical Alzheimer's disease
37. Mild cognitive impairment: Identifying and treating the earliest stages of Alzheimer's disease
38. Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer's disease
39. Prevalence and severity of cognitive impairment with and without dementia in an elderly population
40. Memory impairment on free and cued selective reminding predicts dementia
41. The role of APOE Σ4 in modulating effects of other risk factors for cognitive decline in elderly persons
42. Regional distribution of neuritic plaques in the nondemented elderly and subjects with very mild Alzheimer disease
43. Neurofibrillary tangles in nondemented elderly subjects and mild Alzheimer disease
44. APOE-Σ4 predicts incident AD in Japanese-American men: The Honolulu-Asia aging study
45. Cognitive markers preceding Alzheimer's dementia in the healthy oldest old
46. A new clinical scale for the staging of dementia
47. Neuropathological and neuropsychological changes in "normal" aging: Evidence for preclinical Alzheimer disease in cognitively normal individuals
48. Prediction of AD with MRI-based hippocampal volume in mild cognitive impairment
49. Neuropsychological detection and characterization of preclinical Alzheimer's disease
50. Clinicopathological analysis of dementia disorders in the elderly
51. Clinically diagnosed Alzheimer's disease: Autopsy results in 150 cases
52. Changes in cognitive functioning of the oldest old
53. Preclinical prediction of Alzheimer's disease using SPECT
54. 1H MRS study
55. Development of dementing illnesses in an 80-year-old volunteer cohort
56. Clinical, pathological, and neurochemical changes in dementia: A subgroup with preserved mental status and numerous neocortical plaques
57. Diagnosis of Alzheimer's disease
58. Use of structural magnetic resonance imaging to predict who will get Alzheimer's disease
59. Practice parameter: Diagnosis of dementia (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology
60. Loss and atrophy of layer II entorhinal cortex neurons in elderly people with mild cognitive impairment
61. Senescent forgetfulness: Benign and malignant
62. Aging-associated cognitive decline
63. The "preclinical phase" of probable Alzheimer's disease: A 13-year prospective study of the Framingham Cohort
64. Cognitive test performance among nondemented elderly African Americans and whites
65. The diagnosis of Alzheimer's disease
66. Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease
67. Neuropsychological prediction of dementia and the absence of dementia in healthy elderly persons
68. Interlaboratory comparison of neuropathology assessments in Alzheimer's disease: A study of the Consortium to Establish a Registry for Alzheimer's Disease (CERAD)
69. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease
70. The Clinical Dementia Rating (CDR): Current version and scoring rules
71. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part IV. Rates of cognitive change in the longitudinal assessment of probable Alzheimer's disease
72. Very mild Alzheimer's disease: Informant-based clinical, psychometric, and pathologic distinction from normal aging
73. Cerebral amyloid deposition and diffuse plaques in "normal" aging: Evidence for presymptomatic and very mild Alzheimer's disease
74. Mild cognitive impairment represents early-stage Alzheimer's disease
75. Does variability increase with age? An archival study of cognitive measures
76. Consensus recommendations for the postmortem diagnosis of Alzheimer's disease
77. Apolipoprotein E status as a predictor of the development of Alzheimer's disease in memory-impaired individuals
78. Mild cognitive impairment
79. Practice parameter: Early detection of dementia: Mild cognitive impairment (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology
80. The distribution of tangles, plaques and related immunohistochemical markers in healthy aging and Alzheimer's disease
81. Neuron number in the entorhinal cortex and CA1 in preclinical Alzheimer disease
82. Tangles and plaques in nondemented aging and "preclinical" Alzheimer's disease
83. Classification criteria for mild cognitive impairment A population-based validation study
84. Influence of age on clinical and psychometric assessment of subjects with very mild or mild dementia of the Alzheimer type
85. A prospective study of cognitive function and onset of dementia in cognitively healthy elders
86. What do adult age differences in the digit symbol substitution test reflect?
87. The aging of working memory
88. The hazards of cognitive aging
89. Immunization with amyloid-§ attenuates Alzheimer-disease-like pathology in the PDAPP mouse
90. Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
91. Preclinical AD revisited. Neuropathology of cognitively normal older adults
92. Frequency of stages of Alzheimer-related lesions in different age categories
93. The effects of preclinical dementia on estimates of normal cognitive functioning in aging
94. The course of cognitive impairment in preclinical Alzheimer disease. Three- and 6-year follow-up of a population-based sample
95. Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease
96. Volumetric MRI analysis of the amygdala and the hippocampus in subjects with age-associated memory impairment: Correlation to visual and verbal memory
97. Life span and synapses: Will there be a primary senile dementia?
98. Psychometric differentiation of dementia. Replication and extension of the findings of Storandt and coworkers
99. Prediction of probable Alzheimer's disease in memory-impaired patients: A prospective longitudinal study
100. A prospective study of the clinical utility of ApoE genotype in the prediction of outcome in patients with memory impairment
101. Observations on the brains of non-demented old people
102. Observations on the brains of demented old people
103. Neuropathology in controls and demented subjects from the Baltimore Longitudinal Study of Aging
104. Alzheimer changes in nondemented patients younger than sixty-five: Possible early stages of Alzheimer's disease and senile dementia of Alzheimer type
105. β-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
106. Differences in the pattern of hippocampal neuronal loss in normal aging and Alzheimer's disease
107. Change in cognitive function in older persons from a community population
108. Alzheimer β amyloid deposition enhanced by ApoE Σ4 gene precedes neurofibrillary pathology in the frontal association cortex of nondemented senior subjects
109. Radioiodinated styrylbenzenes and thioflavins as probes for amyloid aggregates