Downmodulation of TGF-α protein expression with antisense oligonucleotides inhibits proliferation of head and neck squamous carcinoma but not normal mucosal epithelial cells

Journal of Cellular Biochemistry

Volumn 69, Issue 1, 1998, Pages 55-62

  Grandis, Jennifer Rubin ^a,b   Chakraborty, Arup ^a   Zeng, Qing ^a   Melhem, Mona F ^a   Tweardy, David J ^a  

^a UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^b UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

Antisense oligonucleotides; Head and neck cancer; TGF

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; EPIDERMAL GROWTH FACTOR RECEPTOR; TRANSFORMING GROWTH FACTOR ALPHA;

ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; GENE OVEREXPRESSION; GROWTH INHIBITION; HEAD AND NECK CANCER; HUMAN; HUMAN CELL; MOUTH CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BINDING; SQUAMOUS CELL CARCINOMA;

BASE SEQUENCE; CARCINOMA, SQUAMOUS CELL; CELL DIVISION; CELL TRANSFORMATION, NEOPLASTIC; DOWN-REGULATION; EPITHELIAL CELLS; HEAD AND NECK NEOPLASMS; HUMANS; MUCOUS MEMBRANE; OLIGONUCLEOTIDES, ANTISENSE; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR ALPHA; TUMOR CELLS, CULTURED;

EID: 0032053944     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4644(19980401)69:1<55::AID-JCB6>3.0.CO;2-U     Document Type: Article

References (43)

1. Berenson JR, Yang J, Mickel RA (1989): Frequent amplification of the bcl-1 locus in head and neck squamous cell carcinomas. Oncogene 4:1111-1116.
2. Boyle JO, Hakim J, Koch W (1993): The incidence of p53 mutations increases with progression of head and neck cancer. Cancer Res 53:4477-4480.
3. Brachman R, Lindquist PB, Nagashima M, Kohr W, Lipari T, Napier M, Derynck R (1989): Transmembrane TGF-α precursors activate EGF/TGF-α receptors. Cell 56:691-700.
4. Callender T, El-Naggar AK, Lee MS, Frankenthaler R, Luna MA, Batsakis JG (1994): PRAD-1 (CCND1)/Cyclin D1 oncogene amplification in primary head and neck squamous cell carcinomas. Cancer 74:152-158.
5. Cammilleri S, Sanrajrang S, Perdeau B, Brixy F, Calvo F, Bazin H, Magdelenat H (1996): Biodistribution of iodine-125 tyramine transforming growth factor alpha and anti-sense oligonucleotide in athymic mice with a human mammary tumour xenograft following intratumoral injection. Eur J Nuc Med 23(4):448-452.
6. Derynck R (1992): The physiology of transforming growth factor-α. Adv Cancer Res 58:27-52.
7. DeVries N, Snow GB (1988): Prevention of second primary cancers in head and neck cancer patients: new perspective. Am J Otolaryngol 9:151-154.
8. Duddy SK, Earp HS, Russell WE, Smith GJ, Grisham JW (1995): Differential dependence of the tumorigenicity of chemically transformed rat liver epithelial cells on autocrine production of transforming growth factor alpha. Cell Growth and Differentiation 6(3):251-261.
9. Heo DS, Snyderman CH, Gollin SM, Walker PE, Deka R, Barnes EL, Johnson JT, Herberman RB, Whiteside TL (1989): Biology, cytogenetics, and sensitivity to immunological effector cells of new head and neck squamous cell carcinoma lines. Cancer Res 49:5167-5175.
10. Howell GM, Ziobe BL, Humphrey LE, Wilson JK, Sun I, Lynch M, Brattain MG (1995): Regulation of autocrine gastrin expression by the TGF alpha autocrine loop. J Cell Physiol 162(2):256-265.
11. Jacobovits EB, Schlokat V, Vannice JL, Derynck R, Levinson AO (1988): The human transforming growth factor alpha promoter directs transcription initiation from a single site in the absence of a TATA sequence. Mol Cell Biol 8:5549-5554.
12. Jones AS, Morar P, Phillips DE (1995): Second primary tumors in patients with head and neck squamous cell carcinoma. Cancer 75:1343-1353.
13. Karnes WE Jr, Walsh JH, Wu SV, Kim RS, Martin MG, Wong HC (1992): Autonomous proliferation of colon cancer cells that coexpress transforming growth factor alpha and its receptor. Variable effects of receptor-blocking antibody. Gastroenterology 2:474-485.
14. Maestro R, Gasparotto D, Vukosavljevic T, Barzan L, Sulfaro S, Boiocchi M (1993): Three discrete regions of deletion at 3p in head and neck cancers. Cancer Res 53:5775-5779.
15. Mashberg A, Bofetta P, Winkelman R (1993): Tobacco smoking, alcohol drinking and cancer of the oral cavity and oropharynx among U.S. Veterans. Cancer 72:1369-1375.
16. Minna JD (1989): Genetic events in the pathogenesis of lung cancer. Chest 96(suppl):17s-23s.
17. Murthy U, Rieman DJ, Rodeck U (1990): Inhibition of TGF-α induced second messengers by anti-EGF receptor antibody-425. Biochem Biophy Res Comm 172(2):471-476.
18. Nawroz H, van der Riet P, Hruban RH, Koch W, Ruppert JM, Sidransky D (1994): Allelotype of head and neck squamous cell carcinoma. Cancer Res 54:1152-1155.
19. Rubenstein M, Mirochnik Y, Chou P, Guinan P (1996): Antisense oligonucleotide intralesional therapy for human PC-3 prostate tumors carried in athymic nude mice. J Surg Onc 62(3):194-200.
20. Rubin Grandis J, Melhem MF, Barnes EL, Tweardy DJ (1996b): Quantitative immunohistochemical analysis of transforming growth factor-α and epidermal growth factor receptor in patients with squamous cell carcinoma of the head and neck. Cancer 78(6):1284-1292.
21. Rubin Grandis J, Tweardy DT (1993): Elevated levels of transforming growth factor α and epidermal growth factor receptor messenger RNA are early markers of carcinogenesis in head and neck cancer. Cancer Res 53:3579-3584.
22. Rubin Grandis J, Zeng Q, Tweardy DJ (1996a): Retinoic acid normalizes the elevated gene transcription rate of TGF-α and EGFR in head and neck cancer cell lines. Nature Med 2:237-240.
23. Sacchi M, Snyderman CH, Heo DS, Johnson JT, d'Amico F, Herberman RB, Whiteside TL (1990): Local adoptive immunotherapy of human head and neck cancer xenografts in nude mice with lymphokine-activated killer cells and interleukin 2. Cancer Res 50:3113-3118.
24. Saranath D, Panchal RG, Nair R, Mehta AR, Sanghavi V, Sumegi J (1989): Oncogene amplification in squamous cell carcinoma of the oral cavity. Jpn J Cancer Res 80:430-437.
25. Schultz-Hector S, Haghayegh S (1993): Beta-fibroblast growth factor expression in human and murine squamous cell carcinomas and its relationship to regional endothelial cell proliferation. Cancer Res 53:1444-1449.
26. Schuuring E, Verhoeven E, Mooi WJ, Michalides RJ (1992): Identification and cloning of two over-expressed genes U21B31/PRD 1 and EMS 1, within the amplified chromosome 11q13 region in human carcinomas. Oncogene 7: 355-361.
27. Schwab G, Siegall CB, Aarden LA, Neckers L, Nordan RP (1991): Characterization of an interleukin-6-mediated autocrine growth loop in the human multiple myeloma cell line, U266. Blood 77:587-593.
28. Sizeland AM, Burgess AW (1992): Anti-sense transforming growth factor a oligonucleotides inhibit autocrine stimulated proliferation of a colon carcinoma cell line. Mol Biol Cell 3:1235-1243.
29. Slaughter DP, Southwick HW, Smejkal W (1953): Field cancerization in oral stratified squamous epithelium: Clinical implications of multicentric origin. Cancer 6:963-968.
30. Somers KD, Cartwright SL, Schechter GL (1990): Amplification of the int-2 gene in human head and neck squamous cell carcinomas. Oncogene 5:915-920.
31. Sporn MB, Roberts AB (1985): Autocrine growth factors and cancer. Nature 13:745-747.
32. Thomas GR, Tubb EE, Sessions RB, Cullen KJ (1993): Growth factor mRNA expression in human head and neck malignant tumors. Arch Otolaryngol Head Neck Surg 119:1247-1252.
33. Tkatch LS, Rubin KA, Ziegler SF, Tweardy DJ (1995): Modulation of human G-CSF receptor mRNA and protein in normal and leukemic myeloid cells by G-CSF and retinoic acid. J Leukoc Biol 57:964-971.
34. Todd R, Chou MY, Matossian K, Gallagher GT, Danoff RB, Wong DTW (1991): Cellular sources of transforming growth factor alpha in human oral cancer. J Dent Res 70:917-923.
35. Todd R, Donoff BR, Gertz R, Chang ALC, Chow P, Matossian K (1989): TGF-α and EGF-receptor mRNAs in human oral cancers. Carcinogenesi 10:1553-1556.
36. Trojan J, Blossey BK, Johnson TR, Rudin SD, Tykocinski M, Ilan J, Ilan J (1992): Loss of tumorigenicity of rat glioblastoma directed by episome-based antisense cDNA transcription of insulin-like growth factor I. Proc Natl Acad Sci USA 89:4874-4878.
37. Trojan J, Johnson TR, Rudin SD, Ilan J, Tykocinski ML (1993): Treatment and prevention of rat glioblastoma by immunogenic C6 cells expressing antisense insulin-like growth factor I RNA. Science 259:94-97.
38. Waldmann TA, White JD, Goldman CK (1993): The interleukin-2 receptor: a target for monoclonal antibody treatment of human T-cell lymphotrophic virus I-induced adult T-cell leukemia. Blood 82:1701-1712.
39. Wickstrom EL, Bacon TA, Gonzalez A, Freeman DL, Lyman GH, Wickstrom E (1988): Human promyelocytic leukemia HL-60 cell proliferation and c-myc protein expression are inhibited by an antisense pentadecadeoxynucleotide targeted against c-myc mRNA. Proc Natl Acad Sci USA 85:1028-1032.
40. Williams ME, Gaffey MJ, Weiss LM, Wilzynski SP, Schuuring E, Levine PA (1993): Chromosome 11Q13 amplification in head and neck squamous cell carcinoma. Arch Otolaryngol Head Neck Surg 119:1238-1243.
41. Wong ST, Winchell LF, McCune BK, Earp HS, Teixide J, Massague J, Herman B, Lee DC (1989): The TGF-alpha precursor expressed on the cell surface binds to the EGF receptor on adjacent cells, leading to signal transduction. Cell 56:495-506.
42. Yokota J, Yamamoto T, Toyoshima K, Terada M, Sugimura T, Battifora H (1986): Amplification of c-erbB-2 oncogene in human adenocarcinomas in vivo. Lancet 1(8484):765-767.
43. Ziober BL, Wilson JKV, Humphrey LE, Childress-Fields K, Brattain MG (1993): Autocrine transforming growth factor-α is associated with progression of transformed properties in human colon cancer cells. J Biol Chem 268:691-698.