The dermatofibrosarcoma protuberans-associated collagen type Iα1/platelet-derived growth factor (PDGF) B-chain fusion gene generates a transforming protein that is processed to functional PDGF-BB

Cancer Research

Volumn 59, Issue 15, 1999, Pages 3719-3723

  Shimizu, Akira ^a   O'Brien, Kevin P ^b   Sjöblom, Tobias ^a   Pietras, Kristian ^a   Buchdunger, Elisabeth ^c   Collins, V Peter ^d   Heldin, Carl Henrik ^a   Dumanski, Jan P ^b   Östman, Arne ^a  

^a LUDWIG INSTITUTE FOR CANCER RESEARCH   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c NOVARTIS PHARMA AG   (Switzerland)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; HYBRID PROTEIN; PLATELET DERIVED GROWTH FACTOR B;

ANIMAL CELL; ARTICLE; CELL GROWTH; CELL STRAIN 3T3; CHIMERA; DERMATOFIBROSARCOMA PROTUBERANS; FUSION GENE; INTRON; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN STRUCTURE;

3T3 CELLS; ANIMALS; ANTINEOPLASTIC AGENTS; CELL TRANSFORMATION, NEOPLASTIC; COSMIDS; DERMATOFIBROSARCOMA; ENZYME INHIBITORS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM PROTEINS; ONCOGENE PROTEINS, FUSION; PIPERAZINES; PLATELET-DERIVED GROWTH FACTOR; PYRIMIDINES; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA; RECEPTORS, PLATELET-DERIVED GROWTH FACTOR; SKIN NEOPLASMS;

EID: 0033178762     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Enzinger, F. M., and Weiss, S. W. Soft tissue tumors, St. Louis: C. V. Mosby Co., 1995.
2. Fish, F. S. Soft tissue sarcomas in dermatology. Dermatol. Surg., 22: 268-273, 1996.
3. Simon, M-P., Pedeutour, F., Sirvent, N., Grosgeorge, J., Minoletti, F., Coindre, J-M., Terrier-Lacombe, M-J., Mandahl, N., Craver, R. D., Blin, N., Sozzi, G., Turc-Carel, C., O'Brien, K. P., Kedra, D., Fransson, I., Guilbaud, C., and Dumanski, J. P. Deregulation of the platelet-derived growth factor B-chain gene via fusion with collagen gene COLIA1 in dermatofibrosarcoma protuberans and giant-cell fibroblastoma, Nat. Genet., 15: 95-98, 1997.
4. O'Brien, K. P., Seroussi, E., Dal Cin, P., Sciot, R., Mandahl, N., Fletcher, J. A., Turc-Carel, C., and Dumanski, J. P. Various regions within the α-helical domain of the COLIA1 gene are fused to the second exon of the PDGFB gene in dermatofibrosarcomas and giant-cell fibroblastomas. Genes Chromosomes Cancer, 23: 187-193, 1998.
5. Dolittle, R. F., Hunkapiller, M. W., Hood, L. E., Devare, S. G., Robbins, K. C., Aaronson, S. A., and Antoniades, H. N. Simian sarcoma virus one gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor. Science (Washington DC), 221: 275-277, 1983.
6. sis of simian sarcoma virus. Nature (Lond.), 304: 35-39, 1983.
7. Heldin, C.-H., Östman, A., and Rönnstrand, L. Signal transduction via platelet-derived growth factor receptors, Biochim. Biophys. Acta, 1378: F79-F113, 1998.
8. Claesson-Welsh, L. Platelet-derived growth factor receptor signals. J. Biol. Chem., 269: 32023-32026, 1994.
9. Heldin, C-H., and Rönnstrand, L. Growth factor receptors in cell transformation. In: G. Peters and K. Vousden (eds.), Frontiers in Molecular Biology: Oncogenes and Tumor Suppressor Genes, pp. 55-85. Oxford: Oxford University Press, 1997.
10. Carroll, M., Tomasson, M. H., Barker, G. P., Golub, T. R., and Gilliland, D. G. The TEL/platelet-derived growth factor β receptor (PDGFβR) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGFβR kinase-dependent signaling pathways. Proc. Natl. Acad. Sci. USA, 93: 14845-14850, 1996.
11. Golub, T. R., Barker, G. F., Lovett, M., and Gilliland, D. G. Fusion of PDGF receptor β to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. Cell, 77: 307-316, 1994.
12. Greco, A., Fusetti, L., Villa, R., Sozzi, G., Minoletti, F., Mauri, P., and Pierotti, M. A. Transforming activity of the chimeric sequence formed by the fusion of collagen gene COLIA1 and the platelet derived growth factor b-chain gene in dermatofibrosarcoma protuberans. Oncogene, 17: 1313-1319, 1998.
13. Gisselsson, D., Höglund, M., O'Brien, K. P., Dumanski, J. P., Mertens, F., and Mandahl, N. A case of dermatofibrosarcoma protuberans with a ring chromosome 5 and a rearranged chromosome 22 containing amplified COLIA1 and PDGFB sequences. Cancer Lett., 133: 129-134, 1999.
14. Chomczynski, P., and Sacchi, N. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem., 162: 156-159, 1987.
15. Buehdunger, E., Zimmermann, J., Mett, H., Meyer, T., Muller, M., Druker, B. J., and Lydon, N. B. Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative. Cancer Res., 56: 100-104, 1996.
16. Thyberg, J., Östman, A., Bäckström, G., Westermark, B., and Heldin, C-H. Localization of platelet-derived growth factor (PDGF) in CHO cells transfected with PDGF A- or B-chain cDNA: retention of PDGF-BB in the endoplasmlc reticulum and Golgi complex. J. Cell Sci., 97: 219-229, 1990.
17. Östman, A., Rall, L., Kammacher, A., Wormstead, M. A., Coit, D., Valenzuela, P., Betsholtz, C., Westermark, B., and Heldin, C-H. Synthesis and assembly of a functionally active recombinant platelet-derived growth factor AB heterodimer. J. Biol. Chem., 263: 16202-16208, 1988.
18. Claesson-Welsh, L., Eriksson, A., Morén, A., Severinsson, L., Ek, B., Östman, A., Betsholtz, C., and Heldin, C-H. cDNA cloning and expression of a human platelet-derived growth factor (PDGF) receptor specific for B-chain-containing PDGF molecules. Mol. Cell. Biol., 8: 3476-3486, 1988.
19. Sorkin, A., Westermark, B., Heldin, C-H., and Claesson-Welsh, L. Effect of receptor kinase inactivation on the rate of internalization and degradation of PDGF and the PDGF β-receptor. J. Cell Biol., 112: 469-478, 1991.
20. Östman, A., Thyberg, J., Westermark, B., and Heldin, C-H. PDGF-AA and PDGF-BB biosynthesis. Proprotein processing in the Golgi complex and lysosomal degradation of PDGF-BB retained intracellularly. J. Cell Biol., 118: 509-519, 1992.
21. Beckmann, M. P., Betsholtz, C., Heldin, C-H., Westermark, B., Di Marco, E., Di Fiore, P. P., Robbins, K. C., and Aaronson, S. A. Comparison of biological properties and transforming potential of human PDGF-A and PDGF-B chains. Science (Washington DC), 241: 1346-1349, 1988.
22. Bywater, M., Rorsman, F., Bongcam-Rudloff, E., Mark, G., Kammacher, A., Heldin, C-H., Westermark, B., and Betsholtz, C. Expression of recombinant platelet-derived growth factor A- and B-chain homodimers in Rat-1 cells and human fibroblasts reveals differences in protein processing and autocrine effects. Mol. Cell. Biol., 8: 2753-2762, 1988.
23. Pedeutour, F., Simon, M. P., Monoletti, F., Sozzi, G., Pierotti, M. A., Hect, F., and Turc-Carel, C. Ring 22 chromosomes in dermatofibrosarcoma protuberans are low level amplifiers of chromosome 17 and 22 sequences. Cancer Res., 55: 2400-2403, 1995.
24. Allan, A. E., Tsou, H. C., Harrington, A., Stasko, T., Lee, X., Si, S. P., Grande, D. J., and Peacocke, M. Clonal origin of dermatofibrosarcoma protuberans. Invest. Dermatol., 100: 99-102, 1993.
25. Bedalov, A., Breault, D. T., Sokolov, B. P., Lichtler, A. C., Bedalov, I., Clark, S. H., Mack, K., Khillan, J. S., Woody, C. O., and Kream, B. E. Regulation of the α1(I) collagen promoter in vascular smooth muscle cells. Comparison with other α1(I) collagen-producing cells in transgenic animals and cultured cells. J. Biol. Chem., 269: 4903-4909, 1994.
26. Smits, A., Funa, K., Vassbotn, F. S., Beausang-Linder, M., af-Ekenstam, F., Heldin, C-H., Westermark, B., and Nistér, M. Expression of platelet-derived growth factor and its receptors in proliferative disorders of fibroblastic origin. Am. J. Pathol., 140: 639-648, 1992.
27. Westermark, B., and Sorg, C. E. Biology of Platelet-Derived Growth Factor. Cytokines. Basel: S. Karger AG, 1993.
28. Östman, A., Thyberg, J., Westermark, B., and Heldin, C-H. PDGF-AA and -BB biosynthesis. Proprotein processing in the Golgi complex and lysosomal degradation of PDGF-BB retained intracellularly. J. Cell Biol., 118: 509-519, 1993.
29. Robbins, K. C., Antoniades, H. N., Devare, S. G., Hunkapiller, M. W., and Aaronson, S. A. Structural and immunological similarities between simian sarcoma virus gene product(s) and human platelet-derived growth factor. Nature (Lond.), 305: 605-609, 1983.
30. Fleming, T. P., Matsui, T., Molloy, C. J., Robbins, K. C., and Aaronson, S. A. Autocrine mechanism for v-sis transformation requires cell surface localization of internally activated growth factor receptors. Proc. Natl. Acad. Sci. USA, 86: 8063-8067, 1989.
31. Rao, C. D., Pech, M., Robbins, K. C., and Aaronson, S. A. The 5′ untranslated sequence of the c-sis/platelet-derived growth factor 2 transcript is a potent translational inhibitor. Mol. Cell. Biol., 8: 284-292, 1988.
32. Kikuchi, K., Soma, Y., Fujimoto, M., Kadano, T., Sato, S., Abe, M., Ohhara, K., and Takehara, K. Dermatofibrosarcoma protuberans: increased growth response to platelet-derived growth factor BB in cell culture. Biochem. Biophys. Res. Commun., 196: 409-415, 1993.