Imatinib GIST keeps finding new indications: Successful treatment of dermatofibrosarcoma protuberans by targeted inhibition of the platelet-derived growth factor receptor

Journal of Clinical Oncology

Volumn 20, Issue 17, 2002, Pages 3568-3569

  Sawyers, Charles L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMATINIB; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN TYROSINE KINASE;

ANTINEOPLASTIC ACTIVITY; DERMATOFIBROSARCOMA PROTUBERANS; DRUG EFFICACY; DRUG INDICATION; DRUG TARGETING; EDITORIAL; HUMAN; PRIORITY JOURNAL;

EID: 0036731703     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.2002.20.17.3568     Document Type: Editorial

References (10)

1. Chronic myeloid leukemia
2. Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors
3. Molecular targeting of platelet-derived growth factor B by imatinib mesylate in a patient with metastatic dermatofibrosarcoma protuberans
4. Deregulation of the platelet-derived growth factor B-chain gene via fusion with collagen gene COL1A1 in dermatofibrosarcoma protuberans and giant-cell fibroblastoma
5. Various regions within the alpha-helical domain of the COL1A1 gene are fused to the second exon of the PDGFB gene in dermatofibrosarcomas and giant-cell fibroblastomas
6. The dermatofibrosarcoma protuberans-associated collagen type Ialpha1/platelet-derived growth factor (PDGF) B-chain fusion gene generates a transforming protein that is processed to functional PDGF-BB
7. Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation
8. Activity of ST1571 in chronic myelomonocytic leukemia with a platelet-derived growth factor b-receptor fusion
9. Effect of the tyrosine kinase inhibitor STI571 in a patient with a metastatic gastro-intestinal stromal tumor
10. ZD1839 (Iressa) as a single agent for the treatment of metastatic non-small-cell lung cancer