Generation of immunity to the HER-2/neu oncogenic protein in patients with breast and ovarian cancer using a peptide-based vaccine

Clinical Cancer Research

Volumn 5, Issue 6, 1999, Pages 1289-1297

  Disis, Mary L ^a,c   Grabstein, Kenneth H ^b   Sleath, Paul R ^b   Cheever, Martin A ^b  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b GLAXOSMITHKLINE   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER VACCINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; PEPTIDE; TUMOR ANTIGEN;

ANTIGEN EXPRESSION; ARTICLE; BREAST CANCER; CELLULAR IMMUNITY; CLINICAL ARTICLE; CLINICAL TRIAL; HELPER CELL; HUMAN; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOLOGICAL TOLERANCE; INTRADERMAL DRUG ADMINISTRATION; LYMPHOCYTIC INFILTRATION; ONCOGENE NEU; OVARY CANCER; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; TUMOR IMMUNITY;

ADJUVANTS, IMMUNOLOGIC; BREAST NEOPLASMS; CANCER VACCINES; CD4-POSITIVE T-LYMPHOCYTES; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITOPES; FEMALE; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; HYPERSENSITIVITY, DELAYED; IMMUNITY, CELLULAR; OVARIAN NEOPLASMS; PEPTIDE FRAGMENTS; RECEPTOR, ERBB-2;

EID: 0033048807     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Nanda, N. K., and Sercarz, E. E. Induction of anti-self-immunity to cure cancer. Cell, 82: 13-17, 1995.
2. Sercarz, E. E., Lehmann, P. V., Ametani, A., Benichou, G., Miller, A., and Moudgil, K. Dominance and crypticity of T cell antigenic determinants. Annu. Rev. Immunol., 11: 729-766, 1993.
3. Disis, M. L., Gralow, J. R., Bernhard, H., Hand, S. L., Rubin, W. D., and Cheever, M. A. Peptide-based, but not whole protein, vaccines elicit immunity to HER-2/neu, an oncogenic self-protein. J. Immunol., 156: 3151-3158, 1996.
4. Bernards, R., Destree, A., McKenzie, S., Gordon, E., Weinberg, R. A., and Panicali, D. Effective tumor immunotherapy directed against an oncogene-encoded product using a vacinnia virus vector. Proc. Natl. Acad. Sci. USA, 84: 6854-6858, 1987.
5. Disis, M. L., Bernhard, H., Shiota, F. M., Hand, S. L., Gralow, J. R., Huseby, E. S., Gillis, S., and Cheever, M. A. Granulocyte-macrophage colony-stimulating factor: an effective adjuvant for protein and peptide-based vaccines. Blood, 88: 202-210, 1996.
6. Kaplan, G., Walsh, G., Guido, L. S., Meyn, P., Burkhardt, R. A., Abalos, R. M., Barker, J., Frindt, P. A., Fajardo, T. T., Celona, R., and Cohn, Z. A. Novel responses of human skin to intradermal recombinant granulocyte/macrophage-colony-stimulating factor: Langerhans cell recruitment, keratinocyte growth, and enhanced wound healing. J. Exp. Med., 175: 1717-1728, 1992.
7. Disis, M., and Cheever, M. HER-2/neu oncogenic protein: issues in vaccine development. Crit. Rev. Immunol., 18: 37-45, 1998.
8. Greenberg, P. D. Adoptive T cell therapy of tumors: mechanisms operative in the recognition and elimination of tumor cells. Adv. Immunol., 49: 281-355, 1991.
9. Klarnet, J. P., Matis, L. A., Kern, D. E., Mizuno, M. T., Peace, D. J., Thompson, J. A., Greenberg, P. D., and Cheever, M. A. Antigen-driven T cell clones can proliferate in vivo, eradicate disseminated leukemia, and provide specific immunologic memory. J. Immunol., 138: 4012-4017, 1987.
10. Reece, J. C., Geysen, H. M., and Rodda, S. J. Mapping the major human T helper epitopes of tetanus toxin. The emerging picture. J. Immunol., 151: 6175-6184, 1993.
11. Broman, K., Speed, T., and Tigges, M. Estimation of antigen-responsive T cell frequencies in PBMC from human subjects. J. Immunol. Methods, 198: 119-132, 1996.
12. Rinn, K., Schiffman, K., Otero, H., and Disis, M. Antigen-specific recall urticaria to a tumor vaccine. J. Allergy Clin. Immunol., in press, 1999.
13. Gjertsen, M. K., Bakka, A., Breivik, J., Saeterdal, I., Solheim, B. G., Soreide, O., Thorsby, E., and Gaudernack, G. Vaccination with mutant ras peptides and induction of T-cell responsiveness in pancreatic carcinoma patients carrying the corresponding RAS mutation. Lancet, 346: 1399-1400, 1995.
14. Feller, D., and Cruz, D. L. Identifying antigenic T cell sites. Nature (Lond.), 349: 720-721, 1991.
15. Roscoe, D. M., Jung, S. H., Benhar, I., Pai, L., Lee, B. K., and Pastan, I. Primate antibody response to immunotoxin: serological and computer-aided analysis of epitopes on a truncated form of Pseudomonas exotoxin. Infect. Immun., 62: 5055-5065, 1994.
16. Bisset, L. R., and Fierz, W. Using a neural network to identify potential HLA-DR1 binding sites within proteins. J. Mol. Recognit, 6: 41-48, 1993.
17. Ioannides, C., Ioannides, M., and O'Brian, C. T cell recognition of oncogene products: a new strategy for immunotherapy. Mol. Carcinog., 6: 77-82, 1992.
18. Disis, M. L., Calenoff, E., McLaughlin, G., Murphy, A. E., Chen, W., Groner, B., Jeschke, M., Lydon, N., McGlynn, E., Livingston, R. B., Moe, R., and Cheever, M. A. Existent T-cell and antibody immunity to HER-2/neu protein in patients with breast cancer. Cancer Res., 54: 16-20, 1994.
19. Leitzel, K., Teramoto, Y., Sampson, E., Mauceri, J., Langton, B., Demers, L., Podczaski, E., Harvey, H., Shambaugh, S., Volas, G., Weaver, S., and Lipton, A. Elevated soluble c-erb-2 antigen levels in the serum and effusions of a proportion of breast cancer patients. J. Clin. Oncol., 10: 1436-1443, 1992.
20. Bernhard, H., Disis, M. L., Heimfeld, S., Hand, S., Gralow, J. R., and Cheever, M. A. Generation of immunostimulatory dendritic cells from human CD34+ hematopoietic progenitor cells of the bone marrow and peripheral blood. Cancer Res., 55: 1099-1104, 1995.
21. Reid, C. D. L., Fryer, P. R., Clifford, C., Kirk, A., Tikerpae, J., and Knight, S. C. Identification of hematopoietic progenitors of macrophages and dendritic Langerhans cells (DL-CFU) in human bone marrow and peripheral blood. Blood, 76: 1139-1149, 1990.
22. Lehmann, P. V., Forsthuber, T., Miller, A., and Sercarz, E. E. Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen. Nature (Lond.), 358: 155-157, 1992.
23. Lehmann, P. V., Sercarz, E. E., Forsthuber, T., Dayan, C. M., and Gammon, G. Determinant spreading and the dynamics of the autoimmune T-cell repertoire. Immunol. Today, 14: 203-208, 1993.
24. Elson, C. J., Barker, R. N., Thompson, S. J., and Williams, N. A. Immunologically ignorant autoreactive T cells, epitope spreading and repertoire limitation. Immunol. Today, 16: 71-76, 1995.