FGF and VEGF function in angiogenesis: Signalling pathways, biological responses and therapeutic inhibition

Trends in Pharmacological Sciences

Volumn 22, Issue 4, 2001, Pages 201-207

  Cross, Michael J ^a   Claesson Welsh, Lena ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR; PROTEIN TYROSINE KINASE; VASCULOTROPIN;

ANGIOGENESIS; ARTICLE; CANCER; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; ENDOTHELIUM CELL; HUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

EID: 0035313488     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-6147(00)01676-X     Document Type: Review

References (80)

1. Mechanisms of angiogenesis and arteriogenesis
2. Vascular-specific growth factors and blood vessel formation
3. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
4. Tumor angiogenesis: Past, present and the near future
5. Heparin affinity: Purification of a tumor-derived capillary endothelial cell growth factor
6. Fibroblast growth factor 2: Its structure and property, paracrine function, tumor angiogenesis, and prostate-related mitogenic and oncogenic functions
7. Extracellular sequestration and release of fibroblast growth factor: A regulatory mechanism?
8. FGFs, heparan sulfate and FGFRs: Complex interactions essential for development
9. Fibroblast growth factor receptor tyrosine kinases: Molecular analysis and signal transduction
10. Structural and functional diversity in the FGF receptor multigene family
11. Fibroblast growth factors as multifunctional signaling factors
12. Murine FGFR-1 is required for early postimplantation growth and axial organization
13. Fibroblast growth factor receptor 2 (FGFR2)-mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction
14. Maintenance of vascular integrity in the embryo requires signaling through the FGF receptor
15. Impaired cerebral cortex development and blood pressure regulation in FGF-2-deficient mice
16. Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3
17. Structural basis for FGF receptor dimerization and activation
18. Signal transduction by fibroblast growth factor receptors
19. Fibroblast growth factor receptor-1-mediated endothelial cell proliferation is dependent on the Src homology (SH) 2/SH3 domain-containing adaptor protein Crk
20. A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-γ1
21. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
22. Purification and characterization of a naturally occurring vascular endothelial growth factor-placenta growth factor heterodimer
23. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
24. Hypoxia regulatory elements of the human vascular endothelial growth factor gene
25. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
26. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
27. Structure and function of vascular endothelial growth factor receptor-1 and -2
28. Vascular endothelial growth factor receptor-3
29. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
30. Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
31. Increased hemangioblast commitment, not vascular disorganization, is the primary defect in flt-1 knock-out mice
32. Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice
33. Increased gene expression for VEGF and the VEGF receptors KDR/Flk and Flt in lungs exposed to acute or to chronic hypoxia. Modulation of gene expression by nitric oxide
34. VEGF, flk-1, and flt-1 expression in a rat myocardial infarction model of angiogenesis
35. Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia
36. Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor
37. Biological activity and phosphorylation sites of the bacterially expressed cytosolic domain of the KDR VEGFreceptor
38. Role of αvβ3 integrin in the activation of vascular endothelial growth factor receptor-2
39. The vascular endothelial growth factor receptor Flt-1 mediates biological activities. Implications for a functional role of placenta growth factor in monocyte activation and chemotaxis
40. Integrin αvβ3 requirement for sustained mitogen-activated protein kinase activity during angiogenesis
41. Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability
42. Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells
43. The ShcA phosphotyrosine docking protein sensitizes cardiovascular signaling in the mouse embryo
44. Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein
45. Endothelial apoptosis in Braf-deficient mice
46. Mekk3 is essential for early embryonic cardiovascular development
47. Current status of antiangiogenic factors
48. Antiangiogenic strategies and agents in clinical trials
49. Angiogenesis: New insights and therapeutic potential
50. Left ventricular electromechanical mapping to assess efficacy of phVEGF(165) gene transfer for therapeutic angiogenesis in chronic myocardial ischemia
51. Genes expressed in human tumor endothelium
52. Internalization of fibroblast growth factor receptor is inhibited by a point mutation at tyrosine 766
53. 2, phosphoinositide 3-kinase and cytoskeletal reorganisation in porcine aortic endothelial cells
54. Fibroblast growth factor receptor-1 mediates chemotaxis independently of direct SH2-domain protein binding
55. Novel recognition motif on fibroblast growth factor receptor mediates direct association and activation of SNT adapter proteins
56. A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway
57. Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation
58. Contribution of Src and Ras pathways in FGF-2 induced endothelial cell differentiation
59. Association of fibroblast growth factor receptor 1 with the adaptor protein Grb14. Characterization of a new receptor binding partner
60. Phosphatidylinositol 3′-kinase-independent p70 S6 kinase activation by fibroblast growth factor receptor-1 is important for proliferation but not differentiation of endothelial cells
61. p38 mitogen-activated protein kinase activation is required for fibroblast growth factor-2-stimulated cell proliferation but not differentiation
62. The Src homology 2 domain protein Shb transmits basic fibroblast growth factor- and nerve growth factor-dependent differentiation signals in PC12 cells
63. The 230 kDa mature form of KDR/Flk-1 (VEGF receptor-2) activates the PLC-γ pathway and partially induces mitotic signals in NIH3T3 fibroblasts
64. Interactions of FLT-1 and KDR with phospholipase C γ: Identification of the phosphotyrosine binding sites
65. VRAP is an adaptor protein that binds KDR, a receptor for vascular endothelial cell growth factor
66. The Shc-related adaptor protein, Sck, forms a complex with the vascular- endothelial-growth-factor receptor KDR in transfected cells
67. 2 in endothelial cells via p42/44 mitogen-activated protein kinase
68. Vascular endothelial growth factor/vascular permeability factor enhances vascular permeability via nitric oxide and prostacyclin
69. Roles of two VEGF receptors, Flt-1 and KDR, in the signal transduction of VEGF effects in human vascular endothelial cells
70. Utilization of distinct signaling pathways by receptors for vascular endothelial cell growth factor and other mitogens in the induction of endothelial cell proliferation
71. Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation
72. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt
73. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
74. Phosphorylation of the endothelial nitric oxide synthase at Ser-1177 is required for VEGF-induced endothelial cell migration
75. Vascular endothelial growth factor signals endothelial cell production of nitric oxide and prostacyclin through flk-1/KDR activation of c-Src
76. Vascular endothelial growth factor (VEGF)-driven actin-based motility is mediated by VEGFR2 and requires concerted activation of stress-activated protein kinase 2 (SAPK2/p38) and geldanamycin-sensitive phosphorylation of focal adhesion kinase
77. Vascular endothelial growth factor stimulates tyrosine phosphorylation and recruitment to new focal adhesions of focal adhesion kinase and paxillin in endothelial cells
78. Nitric oxide is an upstream signal of vascular endothelial growth factor-induced extracellular signal-related kinase 1/2 activation in postcapillary endothelium
79. Protein kinase G mediates vascular endothelial growth factor-induced Raf-1 activation and proliferation in human endothelial cells
80. VEGF receptor signaling in tumor angiogenesis