KIT activation is a ubiquitous feature of gastrointestinal stromal tumors

Cancer Research

Volumn 61, Issue 22, 2001, Pages 8118-8121

  Rubin, B P ^a   Singer, S ^a   Tsao, C ^a   Duensing, A ^a   Lux, M L ^a   Ruiz, R ^a   Hibbard, M K ^a   Chen, C J ^a   Xiao, S ^a   Tuveson, D A ^a   Demetri, G D ^a   Fletcher, C D M ^a   Fletcher, J A ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN KIT; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG;

ADULT; AGED; AMINO ACID SUBSTITUTION; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; GASTROINTESTINAL TUMOR; GENE MUTATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; STROMA;

ADULT; AGED; AGED, 80 AND OVER; AMINO ACID SEQUENCE; DNA, COMPLEMENTARY; DNA, NEOPLASM; ENZYME ACTIVATION; FEMALE; GASTROINTESTINAL NEOPLASMS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MUTATION; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-KIT; SEQUENCE HOMOLOGY, AMINO ACID; STROMAL CELLS;

EID: 0035890740     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Gastrointestinal pacemaker cell tumor (GIPACT): Gastrointestinal stromal tumors show phenotypic characteristics of the interstitial cells of Cajal
2. Interstitial cells of Cajal as precursors of gastrointestinal stromal tumors
3. Embryonic form of smooth muscle myosin heavy chain (SMemb/MHC-B) in gastrointestinal stromal tumor and interstitial cells of Cajal
4. Gastrointestinal stromal tumors may originate from a subset of CD34-positive interstitial cells of Cajal
5. Developmental origin and Kit-dependent development of the interstitial cells or' of Cajal in the mammalian small intestine
6. Blockade of kit signaling induces transdifferentiation of interstitial cells of Cajal to a smooth muscle phenotype
7. W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity
8. Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors
9. KIT mutation portends poor prognosis in gastrointestinal stromal/smooth muscle tumors
10. Mutations of c-kit JM domain are found in a minority of human gastrointestinal stromal tumors
11. Mutations in exon II of c-Kit occur preferentially in malignant versus benign gastrointestinal stromal tumors and do not occur in leiomyomas or leiomyosarcomas
12. Effect of c-kit mutation on prognosis of gastrointestinal stromal tumors
13. From white spots to stem cells: The role of the Kit receptor in mammalian development
14. Hereditary anemias of the mouse: A review for geneticists
15. Decreased production of mast cells in S1/SId anemic mice
16. Disturbed intestinal movement, bile reflux to the stomach, and deficiency of c-kit-expressing cells in Ws/Ws mutant rats
17. Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product
18. Ligand-independent activation of c-kit receptor tyrosine kinase in a murine mastocytoma cell line P-815 generated by a point mutation
19. Substitution of an aspartic acid results in constitutive activation of c-kit receptor tyrosine kinase in a rat tumor mast cell line RBL-2H3
20. Constitutive activation of c-kit in FMA3 murine mastocytoma cells caused by deletion of seven amino acids at the juxtamembrane domain
21. c-kit point mutation of extracellular domain in patients with myeloproliferative disorders
22. Activating c-kit gene mutations in human germ cell tumors
23. A novel gain-of-function mutation of c-kit gene in gastrointestinal stromal tumors
24. Gastrointestinal stromal tumours: Correlation of immunophenotype with clinicopathological features
25. KIT extracellular and kinase domain mutations in gastrointestinal stromal tumors
26. TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors
27. Immunohistochemical spectrum of GISTs at different sites and their differential diagnosis with a reference to CD117 (KIT)
28. c-KIT receptor expression in cutaneous malignant melanoma and benign melanotic naevi
29. Proto-oncogene c-kit expression in malignant melanoma: Protein loss with tumor progression
30. Phosphatidylinositol 3 kinase contributes to the transformation of hematopoietic cells by the D816V c-Kit mutant
31. Signal transduction pathways in sarcoma as targets for therapeutic intervention
32. ST1571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: Biological and clinical implications
33. Effect of the tyrosine kinase inhibitor ST1571 in a patient with a metastatic gastrointestinal stromal tumor