Design of GFB-111, a platelet-derived growth factor binding molecule with antiangiogenic and anticancer activity against human tumors in mice

Nature Biotechnology

Volumn 18, Issue 10 SUPPL., 2000, Pages 1065-1070

  Blaskovich, Michelle A ^a   Lin, Qing ^b   Delarue, Frederic L ^a   Sun, Jiazhi ^a   Park, Hyung Soon ^b   Coppola, Domenico ^a   Hamilton, Andrew D ^a   Sebti, Saïd M ^a  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^b YALE UNIVERSITY   (United States)

Author keywords

Angiogenesis; Cancer drug discovery; Oncogenesis; Platelet derived growth factor

Indexed keywords

ACIDIC FIBROBLAST GROWTH FACTOR; BASIC FIBROBLAST GROWTH FACTOR; EPIDERMAL GROWTH FACTOR; GFB 111; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; SOMATOMEDIN BINDING PROTEIN 1; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; AUTOPHOSPHORYLATION; CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; ENZYME INHIBITION; IC 50; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

ANGIOGENESIS INHIBITORS; ANIMALS; ANTINEOPLASTIC AGENTS; CELL DIVISION; CELL LINE; DNA; DRUG DESIGN; ENDOTHELIAL GROWTH FACTORS; ENZYME ACTIVATION; GLIOBLASTOMA; HUMANS; INHIBITORY CONCENTRATION 50; LYMPHOKINES; MICE; MICE, NUDE; MITOGEN-ACTIVATED PROTEIN KINASES; NEOPLASM TRANSPLANTATION; NEOVASCULARIZATION, PATHOLOGIC; PEPTIDES, CYCLIC; PHOSPHORYLATION; PLATELET-DERIVED GROWTH FACTOR; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTORS, GROWTH FACTOR; RECEPTORS, PLATELET-DERIVED GROWTH FACTOR; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; SUBSTRATE SPECIFICITY; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0033772236     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/80257     Document Type: Article

References (8)

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