Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor

Proceedings of the National Academy of Sciences of the United States of America

Volumn 95, Issue 20, 1998, Pages 12022-12027

  Fry, David W ^a   Bridges, Alexander J ^a   Denny, William A ^b   Doherty, Annette ^a   Greis, Kenneth D ^a   Hicks, James L ^a   Hook, Kenneth E ^a   Keller, Paul R ^a   Leopold, Wilbur R ^a   Loo, Joseph A ^a   Mcnamara, Dennis J ^a   Nelson, James M ^a   Sherwood, Veronika ^a   Smaill, Jeff B ^b   Trumpp Kallmeyer, Susanne ^a   Dobrusin, Ellen M ^a  

^a PFIZER INC   (United States)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; EPIDERMAL GROWTH FACTOR RECEPTOR; N [4 (3 BROMOANILINO) 6 QUINAZOLINYL]ACRYLAMIDE; ONCOPROTEIN; PD 160678; PD 160879; PD 174265; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CARCINOMA; CONTROLLED STUDY; DNA SEQUENCE; DRUG EFFICACY; DRUG RECEPTOR BINDING; ENZYME ASSAY; HUMAN; HUMAN CELL; MOLECULAR MODEL; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; SQUAMOUS CELL CARCINOMA;

ANIMALS; ANTINEOPLASTIC AGENTS; BINDING SITES; CELL LINE; CYSTEINE; ENZYME INHIBITORS; HUMANS; MICE; MICE, NUDE; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; NEOPLASM TRANSPLANTATION; NEOPLASMS, EXPERIMENTAL; PROTEIN CONFORMATION; PROTEIN-TYROSINE KINASES; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; RECOMBINANT FUSION PROTEINS; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 13144266690     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.95.20.12022     Document Type: Article

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