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Volumn 116, Issue 5, 2005, Pages 949-959

Role of regulatory T cells in human diseases

Author keywords

Allergy; Autoimmunity; Dysregulation polyendocrinopathy enteropathy X linked; Foxp3; IgE; Immunotherapy; Lymphoproliferation; Regulatory T cells; X linked autoimmunity allergic dysregulation

Indexed keywords

ALLERGEN; AUTOANTIGEN; COLECALCIFEROL; CORTICOSTEROID; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; PROBIOTIC AGENT; TRANSCRIPTION FACTOR FOXP3;

EID: 27644433355     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2005.08.047     Document Type: Review
Times cited : (240)

References (121)
  • 1
    • 0037364804 scopus 로고    scopus 로고
    • Natural versus adaptive regulatory T cells
    • J.A. Bluestone, and A.K. Abbas Natural versus adaptive regulatory T cells Nat Rev Immunol 3 2003 253 257
    • (2003) Nat Rev Immunol , vol.3 , pp. 253-257
    • Bluestone, J.A.1    Abbas, A.K.2
  • 2
    • 0041735102 scopus 로고    scopus 로고
    • Regulatory T cells control the development of allergic disease and asthma
    • D.T. Umetsu, O. Akbari, and R.H. Dekruyff Regulatory T cells control the development of allergic disease and asthma J Allergy Clin Immunol 112 2003 480 488
    • (2003) J Allergy Clin Immunol , vol.112 , pp. 480-488
    • Umetsu, D.T.1    Akbari, O.2    Dekruyff, R.H.3
  • 3
    • 2442484053 scopus 로고    scopus 로고
    • Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses
    • S. Sakaguchi Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses Annu Rev Immunol 22 2004 531 562
    • (2004) Annu Rev Immunol , vol.22 , pp. 531-562
    • Sakaguchi, S.1
  • 4
    • 0034679567 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation
    • S. Read, V. Malmstrom, and F. Powrie Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation J Exp Med 192 2000 295 302
    • (2000) J Exp Med , vol.192 , pp. 295-302
    • Read, S.1    Malmstrom, V.2    Powrie, F.3
  • 5
    • 0034679560 scopus 로고    scopus 로고
    • Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
    • T. Takahashi, T. Tagami, S. Yamazaki, T. Uede, J. Shimizu, and N. Sakaguchi Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4 J Exp Med 192 2000 303 310
    • (2000) J Exp Med , vol.192 , pp. 303-310
    • Takahashi, T.1    Tagami, T.2    Yamazaki, S.3    Uede, T.4    Shimizu, J.5    Sakaguchi, N.6
  • 6
    • 0036195161 scopus 로고    scopus 로고
    • CD4(+)CD25(+) immunoregulatory T cells: Gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor
    • R.S. McHugh, M.J. Whitters, C.A. Piccirillo, D.A. Young, E.M. Shevach, and M. Collins CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor Immunity 16 2002 311 323
    • (2002) Immunity , vol.16 , pp. 311-323
    • McHugh, R.S.1    Whitters, M.J.2    Piccirillo, C.A.3    Young, D.A.4    Shevach, E.M.5    Collins, M.6
  • 7
    • 0036170938 scopus 로고    scopus 로고
    • Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance
    • J. Shimizu, S. Yamazaki, T. Takahashi, Y. Ishida, and S. Sakaguchi Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance Nat Immunol 3 2002 135 142
    • (2002) Nat Immunol , vol.3 , pp. 135-142
    • Shimizu, J.1    Yamazaki, S.2    Takahashi, T.3    Ishida, Y.4    Sakaguchi, S.5
  • 8
    • 0347785480 scopus 로고    scopus 로고
    • Control of regulatory T cell development by the transcription factor Foxp3
    • S. Hori, T. Nomura, and S. Sakaguchi Control of regulatory T cell development by the transcription factor Foxp3 Science 299 2003 1057 1061
    • (2003) Science , vol.299 , pp. 1057-1061
    • Hori, S.1    Nomura, T.2    Sakaguchi, S.3
  • 9
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • S. Sakaguchi, N. Sakaguchi, M. Asano, M. Itoh, and M. Toda Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases J Immunol 155 1995 1151 1164
    • (1995) J Immunol , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 10
    • 0036597371 scopus 로고    scopus 로고
    • CD4+ CD25+ suppressor T cells: More questions than answers
    • E.M. Shevach CD4+ CD25+ suppressor T cells: more questions than answers Nat Rev Immunol 2 2002 389 400
    • (2002) Nat Rev Immunol , vol.2 , pp. 389-400
    • Shevach, E.M.1
  • 11
    • 0031821875 scopus 로고    scopus 로고
    • CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
    • A.M. Thornton, and E.M. Shevach CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production J Exp Med 188 1998 287 296
    • (1998) J Exp Med , vol.188 , pp. 287-296
    • Thornton, A.M.1    Shevach, E.M.2
  • 12
    • 0037220923 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T cells suppress differentiation and functions of Th1 and Th2 cells, Leishmania major infection, and colitis in mice
    • D. Xu, H. Liu, M. Komai-Koma, C. Campbell, C. McSharry, and J. Alexander CD4+CD25+ regulatory T cells suppress differentiation and functions of Th1 and Th2 cells, Leishmania major infection, and colitis in mice J Immunol 170 2003 394 399
    • (2003) J Immunol , vol.170 , pp. 394-399
    • Xu, D.1    Liu, H.2    Komai-Koma, M.3    Campbell, C.4    McSharry, C.5    Alexander, J.6
  • 13
    • 2942709797 scopus 로고    scopus 로고
    • Differential regulatory capacity of CD25+ T regulatory cells and preactivated CD25+ T regulatory cells on development, functional activation, and proliferation of Th2 cells
    • M. Stassen, H. Jonuleit, C. Muller, M. Klein, C. Richter, and T. Bopp Differential regulatory capacity of CD25+ T regulatory cells and preactivated CD25+ T regulatory cells on development, functional activation, and proliferation of Th2 cells J Immunol 173 2004 267 274
    • (2004) J Immunol , vol.173 , pp. 267-274
    • Stassen, M.1    Jonuleit, H.2    Muller, C.3    Klein, M.4    Richter, C.5    Bopp, T.6
  • 14
    • 0141449974 scopus 로고    scopus 로고
    • CD4+CD25+ T cells regulate virus-specific primary and memory CD8+ T cell responses
    • S. Suvas, U. Kumaraguru, C.D. Pack, S. Lee, and B.T. Rouse CD4+CD25+ T cells regulate virus-specific primary and memory CD8+ T cell responses J Exp Med 198 2003 889 901
    • (2003) J Exp Med , vol.198 , pp. 889-901
    • Suvas, S.1    Kumaraguru, U.2    Pack, C.D.3    Lee, S.4    Rouse, B.T.5
  • 15
    • 16844362608 scopus 로고    scopus 로고
    • Mechanisms of suppression by suppressor T cells
    • H. von Boehmer Mechanisms of suppression by suppressor T cells Nat Immunol 6 2005 338 344
    • (2005) Nat Immunol , vol.6 , pp. 338-344
    • Von Boehmer, H.1
  • 16
    • 5644302161 scopus 로고    scopus 로고
    • Human T regulatory cells can use the perforin pathway to cause autologous target cell death
    • W.J. Grossman, J.W. Verbsky, W. Barchet, M. Colonna, J.P. Atkinson, and T.J. Ley Human T regulatory cells can use the perforin pathway to cause autologous target cell death Immunity 21 2004 589 601
    • (2004) Immunity , vol.21 , pp. 589-601
    • Grossman, W.J.1    Verbsky, J.W.2    Barchet, W.3    Colonna, M.4    Atkinson, J.P.5    Ley, T.J.6
  • 17
    • 0141703239 scopus 로고    scopus 로고
    • CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes
    • E.A. Green, L. Gorelik, C.M. McGregor, E.H. Tran, and R.A. Flavell CD4+CD25+ T regulatory cells control anti-islet CD8+ T cells through TGF-beta-TGF-beta receptor interactions in type 1 diabetes Proc Natl Acad Sci U S A 100 2003 10878 10883
    • (2003) Proc Natl Acad Sci U S a , vol.100 , pp. 10878-10883
    • Green, E.A.1    Gorelik, L.2    McGregor, C.M.3    Tran, E.H.4    Flavell, R.A.5
  • 19
    • 17144400393 scopus 로고    scopus 로고
    • TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells
    • J.C. Marie, J.J. Letterio, M. Gavin, and A.Y. Rudensky TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells J Exp Med 201 2005 1061 1067
    • (2005) J Exp Med , vol.201 , pp. 1061-1067
    • Marie, J.C.1    Letterio, J.J.2    Gavin, M.3    Rudensky, A.Y.4
  • 20
    • 0029788211 scopus 로고    scopus 로고
    • Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation
    • M. Asano, M. Toda, N. Sakaguchi, and S. Sakaguchi Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation J Exp Med 184 1996 387 396
    • (1996) J Exp Med , vol.184 , pp. 387-396
    • Asano, M.1    Toda, M.2    Sakaguchi, N.3    Sakaguchi, S.4
  • 21
    • 0033988289 scopus 로고    scopus 로고
    • Anergy and suppression regulate CD4(+) T cell responses to a self peptide
    • M.S. Jordan, M.P. Riley, H. von Boehmer, and A.J. Caton Anergy and suppression regulate CD4(+) T cell responses to a self peptide Eur J Immunol 30 2000 136 144
    • (2000) Eur J Immunol , vol.30 , pp. 136-144
    • Jordan, M.S.1    Riley, M.P.2    Von Boehmer, H.3    Caton, A.J.4
  • 23
    • 0036568942 scopus 로고    scopus 로고
    • Generation of CD4(+)CD25(+) regulatory T cells from autoreactive T cells simultaneously with their negative selection in the thymus and from nonautoreactive T cells by endogenous TCR expression
    • K. Kawahata, Y. Misaki, M. Yamauchi, S. Tsunekawa, K. Setoguchi, and J. Miyazaki Generation of CD4(+)CD25(+) regulatory T cells from autoreactive T cells simultaneously with their negative selection in the thymus and from nonautoreactive T cells by endogenous TCR expression J Immunol 168 2002 4399 4405
    • (2002) J Immunol , vol.168 , pp. 4399-4405
    • Kawahata, K.1    Misaki, Y.2    Yamauchi, M.3    Tsunekawa, S.4    Setoguchi, K.5    Miyazaki, J.6
  • 24
    • 0036345337 scopus 로고    scopus 로고
    • Origin of regulatory T cells with known specificity for antigen
    • I. Apostolou, A. Sarukhan, L. Klein, and H. von Boehmer Origin of regulatory T cells with known specificity for antigen Nat Immunol 3 2002 756 763
    • (2002) Nat Immunol , vol.3 , pp. 756-763
    • Apostolou, I.1    Sarukhan, A.2    Klein, L.3    Von Boehmer, H.4
  • 25
    • 9244244736 scopus 로고    scopus 로고
    • Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells
    • H.M. van Santen, C. Benoist, and D. Mathis Number of T reg cells that differentiate does not increase upon encounter of agonist ligand on thymic epithelial cells J Exp Med 200 2004 1221 1230
    • (2004) J Exp Med , vol.200 , pp. 1221-1230
    • Van Santen, H.M.1    Benoist, C.2    Mathis, D.3
  • 27
    • 17044430217 scopus 로고    scopus 로고
    • Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter
    • Y.Y. Wan, and R.A. Flavell Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter Proc Natl Acad Sci U S A 102 2005 5126 5131
    • (2005) Proc Natl Acad Sci U S a , vol.102 , pp. 5126-5131
    • Wan, Y.Y.1    Flavell, R.A.2
  • 28
    • 4544241811 scopus 로고    scopus 로고
    • Tolerance, not immunity, crucially depends on IL-2
    • T.R. Malek, and A.L. Bayer Tolerance, not immunity, crucially depends on IL-2 Nat Rev Immunol 4 2004 665 674
    • (2004) Nat Rev Immunol , vol.4 , pp. 665-674
    • Malek, T.R.1    Bayer, A.L.2
  • 29
    • 0348223787 scopus 로고    scopus 로고
    • Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
    • W. Chen, W. Jin, N. Hardegen, K.J. Lei, L. Li, and N. Marinos Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3 J Exp Med 198 2003 1875 1886
    • (2003) J Exp Med , vol.198 , pp. 1875-1886
    • Chen, W.1    Jin, W.2    Hardegen, N.3    Lei, K.J.4    Li, L.5    Marinos, N.6
  • 30
    • 1242290580 scopus 로고    scopus 로고
    • Natural and induced CD4+CD25+ cells educate CD4+CD25- cells to develop suppressive activity: The role of IL-2, TGF-beta, and IL-10
    • S.G. Zheng, J.H. Wang, J.D. Gray, H. Soucier, and D.A. Horwitz Natural and induced CD4+CD25+ cells educate CD4+CD25- cells to develop suppressive activity: the role of IL-2, TGF-beta, and IL-10 J Immunol 172 2004 5213 5221
    • (2004) J Immunol , vol.172 , pp. 5213-5221
    • Zheng, S.G.1    Wang, J.H.2    Gray, J.D.3    Soucier, H.4    Horwitz, D.A.5
  • 31
    • 2142645808 scopus 로고    scopus 로고
    • Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7
    • M.C. Fantini, C. Becker, G. Monteleone, F. Pallone, P.R. Galle, and M.F. Neurath Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7 J Immunol 172 2004 5149 5153
    • (2004) J Immunol , vol.172 , pp. 5149-5153
    • Fantini, M.C.1    Becker, C.2    Monteleone, G.3    Pallone, F.4    Galle, P.R.5    Neurath, M.F.6
  • 33
    • 8344275995 scopus 로고    scopus 로고
    • Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells
    • H. Yagi, T. Nomura, K. Nakamura, S. Yamazaki, T. Kitawaki, and S. Hori Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells Int Immunol 16 2004 1643 1656
    • (2004) Int Immunol , vol.16 , pp. 1643-1656
    • Yagi, H.1    Nomura, T.2    Nakamura, K.3    Yamazaki, S.4    Kitawaki, T.5    Hori, S.6
  • 34
    • 2542420993 scopus 로고    scopus 로고
    • In vivo instruction of suppressor commitment in naive T cells
    • I. Apostolou, and H. von Boehmer In vivo instruction of suppressor commitment in naive T cells J Exp Med 199 2004 1401 1408
    • (2004) J Exp Med , vol.199 , pp. 1401-1408
    • Apostolou, I.1    Von Boehmer, H.2
  • 36
    • 0035576221 scopus 로고    scopus 로고
    • The amount of scurfin protein determines peripheral T cell number and responsiveness
    • R. Khattri, D. Kasprowicz, T. Cox, M. Mortrud, M.W. Appleby, and M.E. Brunkow The amount of scurfin protein determines peripheral T cell number and responsiveness J Immunol 167 2001 6312 6320
    • (2001) J Immunol , vol.167 , pp. 6312-6320
    • Khattri, R.1    Kasprowicz, D.2    Cox, T.3    Mortrud, M.4    Appleby, M.W.5    Brunkow, M.E.6
  • 37
    • 0026178213 scopus 로고
    • X-linked lymphoreticular disease in the scurfy (sf) mutant mouse
    • V.L. Godfrey, J.E. Wilkinson, and L.B. Russell X-linked lymphoreticular disease in the scurfy (sf) mutant mouse Am J Pathol 138 1991 1379 1387
    • (1991) Am J Pathol , vol.138 , pp. 1379-1387
    • Godfrey, V.L.1    Wilkinson, J.E.2    Russell, L.B.3
  • 38
    • 0025317650 scopus 로고
    • The scurfy mouse mutant has previously unrecognized hematological abnormalities and resembles Wiskott-Aldrich syndrome
    • M.F. Lyon, J. Peters, P.H. Glenister, S. Ball, and E. Wright The scurfy mouse mutant has previously unrecognized hematological abnormalities and resembles Wiskott-Aldrich syndrome Proc Natl Acad Sci U S A 87 1990 2433 2437
    • (1990) Proc Natl Acad Sci U S a , vol.87 , pp. 2433-2437
    • Lyon, M.F.1    Peters, J.2    Glenister, P.H.3    Ball, S.4    Wright, E.5
  • 39
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
    • J.D. Fontenot, M.A. Gavin, and A.Y. Rudensky Foxp3 programs the development and function of CD4+CD25+ regulatory T cells Nat Immunol 4 2003 330 336
    • (2003) Nat Immunol , vol.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 42
    • 0035162560 scopus 로고    scopus 로고
    • Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
    • M.E. Brunkow, E.W. Jeffery, K.A. Hjerrild, B. Paeper, L.B. Clark, and S.A. Yasayko Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse Nat Genet 27 2001 68 73
    • (2001) Nat Genet , vol.27 , pp. 68-73
    • Brunkow, M.E.1    Jeffery, E.W.2    Hjerrild, K.A.3    Paeper, B.4    Clark, L.B.5    Yasayko, S.A.6
  • 43
    • 0034526617 scopus 로고    scopus 로고
    • JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome
    • T.A. Chatila, F. Blaeser, N. Ho, H.M. Lederman, C. Voulgaropoulos, and C. Helms JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome J Clin Invest 106 2000 R75 R81
    • (2000) J Clin Invest , vol.106
    • Chatila, T.A.1    Blaeser, F.2    Ho, N.3    Lederman, H.M.4    Voulgaropoulos, C.5    Helms, C.6
  • 44
    • 0035163909 scopus 로고    scopus 로고
    • X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy
    • R.S. Wildin, F. Ramsdell, J. Peake, F. Faravelli, J.L. Casanova, and N. Buist X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy Nat Genet 27 2001 18 20
    • (2001) Nat Genet , vol.27 , pp. 18-20
    • Wildin, R.S.1    Ramsdell, F.2    Peake, J.3    Faravelli, F.4    Casanova, J.L.5    Buist, N.6
  • 45
    • 0035167967 scopus 로고    scopus 로고
    • The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
    • C.L. Bennett, J. Christie, F. Ramsdell, M.E. Brunkow, P.J. Ferguson, and L. Whitesell The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3 Nat Genet 27 2001 20 21
    • (2001) Nat Genet , vol.27 , pp. 20-21
    • Bennett, C.L.1    Christie, J.2    Ramsdell, F.3    Brunkow, M.E.4    Ferguson, P.J.5    Whitesell, L.6
  • 46
    • 0036346861 scopus 로고    scopus 로고
    • Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome
    • R.S. Wildin, S. Smyk-Pearson, and A.H. Filipovich Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome J Med Genet 39 2002 537 545
    • (2002) J Med Genet , vol.39 , pp. 537-545
    • Wildin, R.S.1    Smyk-Pearson, S.2    Filipovich, A.H.3
  • 47
    • 13144261691 scopus 로고    scopus 로고
    • FOXP3 acts as a rheostat of the immune response
    • H.D. Ochs, S.F. Ziegler, and T.R. Torgerson FOXP3 acts as a rheostat of the immune response Immunol Rev 203 2005 156 164
    • (2005) Immunol Rev , vol.203 , pp. 156-164
    • Ochs, H.D.1    Ziegler, S.F.2    Torgerson, T.R.3
  • 48
    • 11144355358 scopus 로고    scopus 로고
    • Dermatologic and immunologic findings in the immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome
    • D.S. Nieves, R.P. Phipps, S.J. Pollock, H.D. Ochs, Q. Zhu, and G.A. Scott Dermatologic and immunologic findings in the immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome Arch Dermatol 140 2004 466 472
    • (2004) Arch Dermatol , vol.140 , pp. 466-472
    • Nieves, D.S.1    Phipps, R.P.2    Pollock, S.J.3    Ochs, H.D.4    Zhu, Q.5    Scott, G.A.6
  • 49
    • 0035821985 scopus 로고    scopus 로고
    • Treatment of the immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) by allogeneic bone marrow transplantation
    • O. Baud, O. Goulet, D. Canioni, F. Le Deist, I. Radford, and D. Rieu Treatment of the immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) by allogeneic bone marrow transplantation N Engl J Med 344 2001 1758 1762
    • (2001) N Engl J Med , vol.344 , pp. 1758-1762
    • Baud, O.1    Goulet, O.2    Canioni, D.3    Le Deist, F.4    Radford, I.5    Rieu, D.6
  • 51
    • 0042591396 scopus 로고    scopus 로고
    • Multiple domains define the expression and regulatory properties of Foxp1 forkhead transcriptional repressors
    • B. Wang, D. Lin, C. Li, and P. Tucker Multiple domains define the expression and regulatory properties of Foxp1 forkhead transcriptional repressors J Biol Chem 278 2003 24259 24268
    • (2003) J Biol Chem , vol.278 , pp. 24259-24268
    • Wang, B.1    Lin, D.2    Li, C.3    Tucker, P.4
  • 52
    • 0347986673 scopus 로고    scopus 로고
    • Transcriptional and DNA binding activity of the Foxp1/2/4 family is modulated by heterotypic and homotypic protein interactions
    • S. Li, J. Weidenfeld, and E.E. Morrisey Transcriptional and DNA binding activity of the Foxp1/2/4 family is modulated by heterotypic and homotypic protein interactions Mol Cell Biol 24 2004 809 822
    • (2004) Mol Cell Biol , vol.24 , pp. 809-822
    • Li, S.1    Weidenfeld, J.2    Morrisey, E.E.3
  • 53
    • 0035813231 scopus 로고    scopus 로고
    • Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation
    • L.A. Schubert, E. Jeffery, Y. Zhang, F. Ramsdell, and S.F. Ziegler Scurfin (FOXP3) acts as a repressor of transcription and regulates T cell activation J Biol Chem 276 2001 37672 37679
    • (2001) J Biol Chem , vol.276 , pp. 37672-37679
    • Schubert, L.A.1    Jeffery, E.2    Zhang, Y.3    Ramsdell, F.4    Ziegler, S.F.5
  • 54
    • 17044393922 scopus 로고    scopus 로고
    • Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells
    • E. Bettelli, M. Dastrange, and M. Oukka Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells Proc Natl Acad Sci U S A 102 2005 5138 5143
    • (2005) Proc Natl Acad Sci U S a , vol.102 , pp. 5138-5143
    • Bettelli, E.1    Dastrange, M.2    Oukka, M.3
  • 56
    • 0028171297 scopus 로고
    • CD4+CD8- T cells are the effector cells in disease pathogenesis in the scurfy (sf) mouse
    • P.J. Blair, S.J. Bultman, J.C. Haas, B.T. Rouse, J.E. Wilkinson, and V.L. Godfrey CD4+CD8- T cells are the effector cells in disease pathogenesis in the scurfy (sf) mouse J Immunol 153 1994 3764 3774
    • (1994) J Immunol , vol.153 , pp. 3764-3774
    • Blair, P.J.1    Bultman, S.J.2    Haas, J.C.3    Rouse, B.T.4    Wilkinson, J.E.5    Godfrey, V.L.6
  • 57
    • 0037385314 scopus 로고    scopus 로고
    • An essential role for Scurfin in CD4+CD25+ T regulatory cells
    • R. Khattri, T. Cox, S.A. Yasayko, and F. Ramsdell An essential role for Scurfin in CD4+CD25+ T regulatory cells Nat Immunol 4 2003 337 342
    • (2003) Nat Immunol , vol.4 , pp. 337-342
    • Khattri, R.1    Cox, T.2    Yasayko, S.A.3    Ramsdell, F.4
  • 58
    • 0035008978 scopus 로고    scopus 로고
    • SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN-gamma and IL-4 signaling in vivo
    • T. Naka, H. Tsutsui, M. Fujimoto, Y. Kawazoe, H. Kohzaki, and Y. Morita SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN-gamma and IL-4 signaling in vivo Immunity 14 2001 535 545
    • (2001) Immunity , vol.14 , pp. 535-545
    • Naka, T.1    Tsutsui, H.2    Fujimoto, M.3    Kawazoe, Y.4    Kohzaki, H.5    Morita, Y.6
  • 59
    • 0035873731 scopus 로고    scopus 로고
    • Genetic regulation of autoimmune disease: BALB/c background TGF-beta 1-deficient mice develop necroinflammatory IFN-gamma-dependent hepatitis
    • J.D. Gorham, J.T. Lin, J.L. Sung, L.A. Rudner, and M.A. French Genetic regulation of autoimmune disease: BALB/c background TGF-beta 1-deficient mice develop necroinflammatory IFN-gamma-dependent hepatitis J Immunol 166 2001 6413 6422
    • (2001) J Immunol , vol.166 , pp. 6413-6422
    • Gorham, J.D.1    Lin, J.T.2    Sung, J.L.3    Rudner, L.A.4    French, M.A.5
  • 60
    • 0347993107 scopus 로고    scopus 로고
    • Mutational analysis of the FOXP3 gene and evidence for genetic heterogeneity in the immunodysregulation, polyendocrinopathy, enteropathy syndrome
    • C.J. Owen, C.E. Jennings, H. Imrie, A. Lachaux, N.A. Bridges, and T.D. Cheetham Mutational analysis of the FOXP3 gene and evidence for genetic heterogeneity in the immunodysregulation, polyendocrinopathy, enteropathy syndrome J Clin Endocrinol Metab 88 2003 6034 6039
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 6034-6039
    • Owen, C.J.1    Jennings, C.E.2    Imrie, H.3    Lachaux, A.4    Bridges, N.A.5    Cheetham, T.D.6
  • 61
    • 0036669298 scopus 로고    scopus 로고
    • CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2
    • T.R. Malek, A. Yu, V. Vincek, P. Scibelli, and L. Kong CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice. Implications for the nonredundant function of IL-2 Immunity 17 2002 167 178
    • (2002) Immunity , vol.17 , pp. 167-178
    • Malek, T.R.1    Yu, A.2    Vincek, V.3    Scibelli, P.4    Kong, L.5
  • 62
    • 2542461255 scopus 로고    scopus 로고
    • Molecular defects in human severe combined immunodeficiency and approaches to immune reconstitution
    • R.H. Buckley Molecular defects in human severe combined immunodeficiency and approaches to immune reconstitution Annu Rev Immunol 22 2004 625 655
    • (2004) Annu Rev Immunol , vol.22 , pp. 625-655
    • Buckley, R.H.1
  • 63
    • 0028783963 scopus 로고
    • Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells
    • B. Sadlack, J. Lohler, H. Schorle, G. Klebb, H. Haber, and E. Sickel Generalized autoimmune disease in interleukin-2-deficient mice is triggered by an uncontrolled activation and proliferation of CD4+ T cells Eur J Immunol 25 1995 3053 3059
    • (1995) Eur J Immunol , vol.25 , pp. 3053-3059
    • Sadlack, B.1    Lohler, J.2    Schorle, H.3    Klebb, G.4    Haber, H.5    Sickel, E.6
  • 64
    • 0027369395 scopus 로고
    • Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene
    • B. Sadlack, H. Merz, H. Schorle, A. Schimpl, A.C. Feller, and I. Horak Ulcerative colitis-like disease in mice with a disrupted interleukin-2 gene Cell 75 1993 253 261
    • (1993) Cell , vol.75 , pp. 253-261
    • Sadlack, B.1    Merz, H.2    Schorle, H.3    Schimpl, A.4    Feller, A.C.5    Horak, I.6
  • 65
    • 0028784289 scopus 로고
    • Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment
    • D.M. Willerford, J. Chen, J.A. Ferry, L. Davidson, A. Ma, and F.W. Alt Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment Immunity 3 1995 521 530
    • (1995) Immunity , vol.3 , pp. 521-530
    • Willerford, D.M.1    Chen, J.2    Ferry, J.A.3    Davidson, L.4    Ma, A.5    Alt, F.W.6
  • 66
    • 0029028363 scopus 로고
    • Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta
    • H. Suzuki, T.M. Kundig, C. Furlonger, A. Wakeham, E. Timms, and T. Matsuyama Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta Science 268 1995 1472 1476
    • (1995) Science , vol.268 , pp. 1472-1476
    • Suzuki, H.1    Kundig, T.M.2    Furlonger, C.3    Wakeham, A.4    Timms, E.5    Matsuyama, T.6
  • 67
    • 0242580058 scopus 로고    scopus 로고
    • Loss of tolerance and autoimmunity affecting multiple organs in STAT5A/5B-deficient mice
    • J.W. Snow, N. Abraham, M.C. Ma, B.G. Herndier, A.W. Pastuszak, and M.A. Goldsmith Loss of tolerance and autoimmunity affecting multiple organs in STAT5A/5B-deficient mice J Immunol 171 2003 5042 5050
    • (2003) J Immunol , vol.171 , pp. 5042-5050
    • Snow, J.W.1    Abraham, N.2    Ma, M.C.3    Herndier, B.G.4    Pastuszak, A.W.5    Goldsmith, M.A.6
  • 68
    • 0034965185 scopus 로고    scopus 로고
    • Control of T cell hyperactivation in IL-2-deficient mice by CD4(+)CD25(-) and CD4(+)CD25(+) T cells: Evidence for two distinct regulatory mechanisms
    • M. Wolf, A. Schimpl, and T. Hunig Control of T cell hyperactivation in IL-2-deficient mice by CD4(+)CD25(-) and CD4(+)CD25(+) T cells: evidence for two distinct regulatory mechanisms Eur J Immunol 31 2001 1637 1645
    • (2001) Eur J Immunol , vol.31 , pp. 1637-1645
    • Wolf, M.1    Schimpl, A.2    Hunig, T.3
  • 69
    • 0030903027 scopus 로고    scopus 로고
    • Human immune disorder arising from mutation of the alpha chain of the interleukin-2 receptor
    • N. Sharfe, H.K. Dadi, M. Shahar, and C.M. Roifman Human immune disorder arising from mutation of the alpha chain of the interleukin-2 receptor Proc Natl Acad Sci U S A 94 1997 3168 3171
    • (1997) Proc Natl Acad Sci U S a , vol.94 , pp. 3168-3171
    • Sharfe, N.1    Dadi, H.K.2    Shahar, M.3    Roifman, C.M.4
  • 70
    • 0033920789 scopus 로고    scopus 로고
    • Human IL-2 receptor alpha chain deficiency
    • C.M. Roifman Human IL-2 receptor alpha chain deficiency Pediatr Res 48 2000 6 11
    • (2000) Pediatr Res , vol.48 , pp. 6-11
    • Roifman, C.M.1
  • 72
    • 0028867420 scopus 로고
    • Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
    • E.A. Tivol, F. Borriello, A.N. Schweitzer, W.P. Lynch, J.A. Bluestone, and A.H. Sharpe Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4 Immunity 3 1995 541 547
    • (1995) Immunity , vol.3 , pp. 541-547
    • Tivol, E.A.1    Borriello, F.2    Schweitzer, A.N.3    Lynch, W.P.4    Bluestone, J.A.5    Sharpe, A.H.6
  • 73
  • 74
    • 2942738825 scopus 로고    scopus 로고
    • The emerging role of the CTLA-4 gene in autoimmune endocrinopathies
    • B. Vaidya, and S. Pearce The emerging role of the CTLA-4 gene in autoimmune endocrinopathies Eur J Endocrinol 150 2004 619 626
    • (2004) Eur J Endocrinol , vol.150 , pp. 619-626
    • Vaidya, B.1    Pearce, S.2
  • 75
    • 13144259647 scopus 로고    scopus 로고
    • Primary hemophagocytic syndromes point to a direct link between lymphocyte cytotoxicity and homeostasis
    • G. Menasche, J. Feldmann, A. Fischer, and G. de Saint Basile Primary hemophagocytic syndromes point to a direct link between lymphocyte cytotoxicity and homeostasis Immunol Rev 203 2005 165 179
    • (2005) Immunol Rev , vol.203 , pp. 165-179
    • Menasche, G.1    Feldmann, J.2    Fischer, A.3    De Saint Basile, G.4
  • 76
    • 85047692430 scopus 로고    scopus 로고
    • IL-10-producing and naturally occurring CD4+ Tregs: Limiting collateral damage
    • A. O'Garra, P.L. Vieira, P. Vieira, and A.E. Goldfeld IL-10-producing and naturally occurring CD4+ Tregs: limiting collateral damage J Clin Invest 114 2004 1372 1378
    • (2004) J Clin Invest , vol.114 , pp. 1372-1378
    • O'Garra, A.1    Vieira, P.L.2    Vieira, P.3    Goldfeld, A.E.4
  • 77
    • 0028158319 scopus 로고
    • High levels of interleukin 10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoietic stem cells
    • R. Bacchetta, M. Bigler, J.L. Touraine, R. Parkman, P.A. Tovo, and J. Abrams High levels of interleukin 10 production in vivo are associated with tolerance in SCID patients transplanted with HLA mismatched hematopoietic stem cells J Exp Med 179 1994 493 502
    • (1994) J Exp Med , vol.179 , pp. 493-502
    • Bacchetta, R.1    Bigler, M.2    Touraine, J.L.3    Parkman, R.4    Tovo, P.A.5    Abrams, J.6
  • 78
    • 0030704726 scopus 로고    scopus 로고
    • A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
    • H. Groux, A. O'Garra, M. Bigler, M. Rouleau, S. Antonenko, and J.E. de Vries A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis Nature 389 1997 737 742
    • (1997) Nature , vol.389 , pp. 737-742
    • Groux, H.1    O'Garra, A.2    Bigler, M.3    Rouleau, M.4    Antonenko, S.5    De Vries, J.E.6
  • 80
    • 0037018104 scopus 로고    scopus 로고
    • In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines
    • F.J. Barrat, D.J. Cua, A. Boonstra, D.F. Richards, C. Crain, and H.F. Savelkoul In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines J Exp Med 195 2002 603 616
    • (2002) J Exp Med , vol.195 , pp. 603-616
    • Barrat, F.J.1    Cua, D.J.2    Boonstra, A.3    Richards, D.F.4    Crain, C.5    Savelkoul, H.F.6
  • 81
    • 2442450433 scopus 로고    scopus 로고
    • IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cells
    • P.L. Vieira, J.R. Christensen, S. Minaee, E.J. O'Neill, F.J. Barrat, and A. Boonstra IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cells J Immunol 172 2004 5986 5993
    • (2004) J Immunol , vol.172 , pp. 5986-5993
    • Vieira, P.L.1    Christensen, J.R.2    Minaee, S.3    O'Neill, E.J.4    Barrat, F.J.5    Boonstra, A.6
  • 82
    • 0028037782 scopus 로고
    • Regulatory T cell clones induced by oral tolerance: Suppression of autoimmune encephalomyelitis
    • Y. Chen, V.K. Kuchroo, J. Inobe, D.A. Hafler, and H.L. Weiner Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis Science 265 1994 1237 1240
    • (1994) Science , vol.265 , pp. 1237-1240
    • Chen, Y.1    Kuchroo, V.K.2    Inobe, J.3    Hafler, D.A.4    Weiner, H.L.5
  • 83
    • 0035186416 scopus 로고    scopus 로고
    • Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells
    • H.L. Weiner Induction and mechanism of action of transforming growth factor-beta-secreting Th3 regulatory cells Immunol Rev 182 2001 207 214
    • (2001) Immunol Rev , vol.182 , pp. 207-214
    • Weiner, H.L.1
  • 85
    • 1642453559 scopus 로고    scopus 로고
    • Specialization in tolerance: Innate CD(4+)CD(25+) versus acquired TR1 and TH3 regulatory T cells
    • F. Cottrez, and H. Groux Specialization in tolerance: innate CD(4+)CD(25+) versus acquired TR1 and TH3 regulatory T cells Transplantation 77 suppl 2004 S12 S15
    • (2004) Transplantation , vol.77 , Issue.SUPPL.
    • Cottrez, F.1    Groux, H.2
  • 86
    • 0242412365 scopus 로고    scopus 로고
    • A comparative study between T regulatory type 1 and CD4+CD25+ T cells in the control of inflammation
    • A. Foussat, F. Cottrez, V. Brun, N. Fournier, J.P. Breittmayer, and H. Groux A comparative study between T regulatory type 1 and CD4+CD25+ T cells in the control of inflammation J Immunol 171 2003 5018 5026
    • (2003) J Immunol , vol.171 , pp. 5018-5026
    • Foussat, A.1    Cottrez, F.2    Brun, V.3    Fournier, N.4    Breittmayer, J.P.5    Groux, H.6
  • 87
    • 10744226674 scopus 로고    scopus 로고
    • Human CD8+CD25+ thymocytes share phenotypic and functional features with CD4+CD25+ regulatory thymocytes
    • L. Cosmi, F. Liotta, E. Lazzeri, M. Francalanci, R. Angeli, and B. Mazzinghi Human CD8+CD25+ thymocytes share phenotypic and functional features with CD4+CD25+ regulatory thymocytes Blood 102 2003 4107 4114
    • (2003) Blood , vol.102 , pp. 4107-4114
    • Cosmi, L.1    Liotta, F.2    Lazzeri, E.3    Francalanci, M.4    Angeli, R.5    Mazzinghi, B.6
  • 88
    • 4344675302 scopus 로고    scopus 로고
    • Alloantigen specific CD8+CD28- FOXP3+ T suppressor cells induce ILT3+ ILT4+ tolerogenic endothelial cells, inhibiting alloreactivity
    • J.S. Manavalan, S. Kim-Schulze, L. Scotto, A.J. Naiyer, G. Vlad, and P.C. Colombo Alloantigen specific CD8+CD28- FOXP3+ T suppressor cells induce ILT3+ ILT4+ tolerogenic endothelial cells, inhibiting alloreactivity Int Immunol 16 2004 1055 1068
    • (2004) Int Immunol , vol.16 , pp. 1055-1068
    • Manavalan, J.S.1    Kim-Schulze, S.2    Scotto, L.3    Naiyer, A.J.4    Vlad, G.5    Colombo, P.C.6
  • 89
    • 8644240281 scopus 로고    scopus 로고
    • Identification of a novel natural regulatory CD8 T-cell subset and analysis of its mechanism of regulation
    • E. Xystrakis, A.S. Dejean, I. Bernard, P. Druet, R. Liblau, and D. Gonzalez-Dunia Identification of a novel natural regulatory CD8 T-cell subset and analysis of its mechanism of regulation Blood 104 2004 3294 3301
    • (2004) Blood , vol.104 , pp. 3294-3301
    • Xystrakis, E.1    Dejean, A.S.2    Bernard, I.3    Druet, P.4    Liblau, R.5    Gonzalez-Dunia, D.6
  • 90
    • 20844457916 scopus 로고    scopus 로고
    • Rat CD8(+) FOXP3(+) T suppressor cells mediate tolerance to allogeneic heart transplants, inducing PIR-B in APC and rendering the graft invulnerable to rejection
    • J. Liu, Z. Liu, P. Witkowski, G. Vlad, J.S. Manavalan, and L. Scotto Rat CD8(+) FOXP3(+) T suppressor cells mediate tolerance to allogeneic heart transplants, inducing PIR-B in APC and rendering the graft invulnerable to rejection Transpl Immunol 13 2004 239 247
    • (2004) Transpl Immunol , vol.13 , pp. 239-247
    • Liu, J.1    Liu, Z.2    Witkowski, P.3    Vlad, G.4    Manavalan, J.S.5    Scotto, L.6
  • 91
    • 3042594506 scopus 로고    scopus 로고
    • Allergen-responsive CD4+CD25+ regulatory T cells in children who have outgrown cow's milk allergy
    • M.R. Karlsson, J. Rugtveit, and P. Brandtzaeg Allergen-responsive CD4+CD25+ regulatory T cells in children who have outgrown cow's milk allergy J Exp Med 199 2004 1679 1688
    • (2004) J Exp Med , vol.199 , pp. 1679-1688
    • Karlsson, M.R.1    Rugtveit, J.2    Brandtzaeg, P.3
  • 92
    • 1942531991 scopus 로고    scopus 로고
    • T regulatory cells in atopic dermatitis and subversion of their activity by superantigens
    • L.S. Ou, E. Goleva, C. Hall, and D.Y. Leung T regulatory cells in atopic dermatitis and subversion of their activity by superantigens J Allergy Clin Immunol 113 2004 756 763
    • (2004) J Allergy Clin Immunol , vol.113 , pp. 756-763
    • Ou, L.S.1    Goleva, E.2    Hall, C.3    Leung, D.Y.4
  • 93
    • 0037504093 scopus 로고    scopus 로고
    • Induction of IL-10+CD4+CD25+ T cells by grass pollen immunotherapy
    • J.N. Francis, S.J. Till, and S.R. Durham Induction of IL-10+CD4+CD25+ T cells by grass pollen immunotherapy J Allergy Clin Immunol 111 2003 1255 1261
    • (2003) J Allergy Clin Immunol , vol.111 , pp. 1255-1261
    • Francis, J.N.1    Till, S.J.2    Durham, S.R.3
  • 94
    • 0038363534 scopus 로고    scopus 로고
    • IL-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy
    • M. Jutel, M. Akdis, F. Budak, C. Aebischer-Casaulta, M. Wrzyszcz, and K. Blaser IL-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy Eur J Immunol 33 2003 1205 1214
    • (2003) Eur J Immunol , vol.33 , pp. 1205-1214
    • Jutel, M.1    Akdis, M.2    Budak, F.3    Aebischer-Casaulta, C.4    Wrzyszcz, M.5    Blaser, K.6
  • 95
    • 2942685507 scopus 로고    scopus 로고
    • Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells
    • M. Akdis, J. Verhagen, A. Taylor, F. Karamloo, C. Karagiannidis, and R. Crameri Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells J Exp Med 199 2004 1567 1575
    • (2004) J Exp Med , vol.199 , pp. 1567-1575
    • Akdis, M.1    Verhagen, J.2    Taylor, A.3    Karamloo, F.4    Karagiannidis, C.5    Crameri, R.6
  • 96
    • 4344696812 scopus 로고    scopus 로고
    • Fluticasone propionate increases CD4CD25 T regulatory cell suppression of allergen-stimulated CD4CD25 T cells by an IL-10-dependent mechanism
    • X. Dao Nguyen, and D.S. Robinson Fluticasone propionate increases CD4CD25 T regulatory cell suppression of allergen-stimulated CD4CD25 T cells by an IL-10-dependent mechanism J Allergy Clin Immunol 114 2004 296 301
    • (2004) J Allergy Clin Immunol , vol.114 , pp. 296-301
    • Dao Nguyen, X.1    Robinson, D.S.2
  • 97
    • 0036278230 scopus 로고    scopus 로고
    • Suppression of airway eosinophilia by killed Mycobacterium vaccae-induced allergen-specific regulatory T-cells
    • C. Zuany-Amorim, E. Sawicka, C. Manlius, A. Le Moine, L.R. Brunet, and D.M. Kemeny Suppression of airway eosinophilia by killed Mycobacterium vaccae-induced allergen-specific regulatory T-cells Nat Med 8 2002 625 629
    • (2002) Nat Med , vol.8 , pp. 625-629
    • Zuany-Amorim, C.1    Sawicka, E.2    Manlius, C.3    Le Moine, A.4    Brunet, L.R.5    Kemeny, D.M.6
  • 98
    • 0036681632 scopus 로고    scopus 로고
    • Long-term protective and antigen-specific effect of heat-killed Mycobacterium vaccae in a murine model of allergic pulmonary inflammation
    • C. Zuany-Amorim, C. Manlius, A. Trifilieff, L.R. Brunet, G. Rook, and G. Bowen Long-term protective and antigen-specific effect of heat-killed Mycobacterium vaccae in a murine model of allergic pulmonary inflammation J Immunol 169 2002 1492 1499
    • (2002) J Immunol , vol.169 , pp. 1492-1499
    • Zuany-Amorim, C.1    Manlius, C.2    Trifilieff, A.3    Brunet, L.R.4    Rook, G.5    Bowen, G.6
  • 99
    • 0037323748 scopus 로고    scopus 로고
    • Impact of Mycobacterium vaccae immunization on lung histopathology in a murine model of chronic asthma
    • C. Ozdemir, T. Akkoc, N.N. Bahceciler, D. Kucukercan, I.B. Barlan, and M.M. Basaran Impact of Mycobacterium vaccae immunization on lung histopathology in a murine model of chronic asthma Clin Exp Allergy 33 2003 266 270
    • (2003) Clin Exp Allergy , vol.33 , pp. 266-270
    • Ozdemir, C.1    Akkoc, T.2    Bahceciler, N.N.3    Kucukercan, D.4    Barlan, I.B.5    Basaran, M.M.6
  • 100
    • 0035094643 scopus 로고    scopus 로고
    • Intradermal administration of a killed Mycobacterium vaccae suspension (SRL 172) is associated with improvement in atopic dermatitis in children with moderate-to-severe disease
    • P.D. Arkwright, and T.J. David Intradermal administration of a killed Mycobacterium vaccae suspension (SRL 172) is associated with improvement in atopic dermatitis in children with moderate-to-severe disease J Allergy Clin Immunol 107 2001 531 534
    • (2001) J Allergy Clin Immunol , vol.107 , pp. 531-534
    • Arkwright, P.D.1    David, T.J.2
  • 101
    • 12244290348 scopus 로고    scopus 로고
    • The effects of Mycobacterium vaccae on allergen-induced airway responses in atopic asthma
    • L. Camporota, A. Corkhill, H. Long, J. Lordan, L. Stanciu, and N. Tuckwell The effects of Mycobacterium vaccae on allergen-induced airway responses in atopic asthma Eur Respir J 21 2003 287 293
    • (2003) Eur Respir J , vol.21 , pp. 287-293
    • Camporota, L.1    Corkhill, A.2    Long, H.3    Lordan, J.4    Stanciu, L.5    Tuckwell, N.6
  • 102
    • 0347518970 scopus 로고    scopus 로고
    • Pilot study of the safety and effect of intranasal delipidated acid-treated Mycobacterium vaccae in adult asthma
    • P.M. Shirtcliffe, A. Goldkorn, M. Weatherall, P.L. Tan, and R. Beasley Pilot study of the safety and effect of intranasal delipidated acid-treated Mycobacterium vaccae in adult asthma Respirology 8 2003 497 503
    • (2003) Respirology , vol.8 , pp. 497-503
    • Shirtcliffe, P.M.1    Goldkorn, A.2    Weatherall, M.3    Tan, P.L.4    Beasley, R.5
  • 103
    • 0042074304 scopus 로고    scopus 로고
    • Mycobacterium vaccae administration during allergen sensitization or challenge suppresses asthmatic features
    • J.J. Smit, H. Van Loveren, M.O. Hoekstra, M.A. Schijf, G. Folkerts, and F.P. Nijkamp Mycobacterium vaccae administration during allergen sensitization or challenge suppresses asthmatic features Clin Exp Allergy 33 2003 1083 1089
    • (2003) Clin Exp Allergy , vol.33 , pp. 1083-1089
    • Smit, J.J.1    Van Loveren, H.2    Hoekstra, M.O.3    Schijf, M.A.4    Folkerts, G.5    Nijkamp, F.P.6
  • 104
    • 0034886143 scopus 로고    scopus 로고
    • Toll-like receptors: Critical proteins linking innate and acquired immunity
    • S. Akira, K. Takeda, and T. Kaisho Toll-like receptors: critical proteins linking innate and acquired immunity Nat Immunol 2 2001 675 680
    • (2001) Nat Immunol , vol.2 , pp. 675-680
    • Akira, S.1    Takeda, K.2    Kaisho, T.3
  • 105
    • 0037450804 scopus 로고    scopus 로고
    • Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide
    • I. Caramalho, T. Lopes-Carvalho, D. Ostler, S. Zelenay, M. Haury, and J. Demengeot Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide J Exp Med 197 2003 403 411
    • (2003) J Exp Med , vol.197 , pp. 403-411
    • Caramalho, I.1    Lopes-Carvalho, T.2    Ostler, D.3    Zelenay, S.4    Haury, M.5    Demengeot, J.6
  • 106
    • 0242556891 scopus 로고    scopus 로고
    • Toll-like receptors: Balancing host resistance with immune tolerance
    • C. Pasare, and R. Medzhitov Toll-like receptors: balancing host resistance with immune tolerance Curr Opin Immunol 15 2003 677 682
    • (2003) Curr Opin Immunol , vol.15 , pp. 677-682
    • Pasare, C.1    Medzhitov, R.2
  • 107
    • 3543097547 scopus 로고    scopus 로고
    • Suppressor T cells in human diseases
    • C. Baecher-Allan, and D.A. Hafler Suppressor T cells in human diseases J Exp Med 200 2004 273 276
    • (2004) J Exp Med , vol.200 , pp. 273-276
    • Baecher-Allan, C.1    Hafler, D.A.2
  • 108
    • 1842732224 scopus 로고    scopus 로고
    • Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis
    • V. Viglietta, C. Baecher-Allan, H.L. Weiner, and D.A. Hafler Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis J Exp Med 199 2004 971 979
    • (2004) J Exp Med , vol.199 , pp. 971-979
    • Viglietta, V.1    Baecher-Allan, C.2    Weiner, H.L.3    Hafler, D.A.4
  • 109
    • 2442628376 scopus 로고    scopus 로고
    • Defective suppressor function of human CD4+ CD25+ regulatory T cells in autoimmune polyglandular syndrome type II
    • M.A. Kriegel, T. Lohmann, C. Gabler, N. Blank, J.R. Kalden, and H.M. Lorenz Defective suppressor function of human CD4+ CD25+ regulatory T cells in autoimmune polyglandular syndrome type II J Exp Med 199 2004 1285 1291
    • (2004) J Exp Med , vol.199 , pp. 1285-1291
    • Kriegel, M.A.1    Lohmann, T.2    Gabler, C.3    Blank, N.4    Kalden, J.R.5    Lorenz, H.M.6
  • 110
    • 11244291391 scopus 로고    scopus 로고
    • Functional defect of regulatory CD4(+)CD25+ T cells in the thymus of patients with autoimmune myasthenia gravis
    • A. Balandina, S. Lecart, P. Dartevelle, A. Saoudi, and S. Berrih-Aknin Functional defect of regulatory CD4(+)CD25+ T cells in the thymus of patients with autoimmune myasthenia gravis Blood 105 2005 735 741
    • (2005) Blood , vol.105 , pp. 735-741
    • Balandina, A.1    Lecart, S.2    Dartevelle, P.3    Saoudi, A.4    Berrih-Aknin, S.5
  • 111
    • 3543140687 scopus 로고    scopus 로고
    • Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy
    • M.R. Ehrenstein, J.G. Evans, A. Singh, S. Moore, G. Warnes, and D.A. Isenberg Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy J Exp Med 200 2004 277 285
    • (2004) J Exp Med , vol.200 , pp. 277-285
    • Ehrenstein, M.R.1    Evans, J.G.2    Singh, A.3    Moore, S.4    Warnes, G.5    Isenberg, D.A.6
  • 112
    • 0037261145 scopus 로고    scopus 로고
    • Isolation and functional characterization of regulatory CD25brightCD4+ T cells from the target organ of patients with rheumatoid arthritis
    • D. Cao, V. Malmstrom, C. Baecher-Allan, D. Hafler, L. Klareskog, and C. Trollmo Isolation and functional characterization of regulatory CD25brightCD4+ T cells from the target organ of patients with rheumatoid arthritis Eur J Immunol 33 2003 215 223
    • (2003) Eur J Immunol , vol.33 , pp. 215-223
    • Cao, D.1    Malmstrom, V.2    Baecher-Allan, C.3    Hafler, D.4    Klareskog, L.5    Trollmo, C.6
  • 113
    • 15244361536 scopus 로고    scopus 로고
    • CD25brightCD4+ regulatory T cells are enriched in inflamed joints of patients with chronic rheumatic disease
    • D. Cao, R. van Vollenhoven, L. Klareskog, C. Trollmo, and V. Malmstrom CD25brightCD4+ regulatory T cells are enriched in inflamed joints of patients with chronic rheumatic disease Arthritis Res Ther 6 2004 R335 R346
    • (2004) Arthritis Res Ther , vol.6
    • Cao, D.1    Van Vollenhoven, R.2    Klareskog, L.3    Trollmo, C.4    Malmstrom, V.5
  • 114
    • 12144289938 scopus 로고    scopus 로고
    • Epitope-specific immunotherapy induces immune deviation of proinflammatory T cells in rheumatoid arthritis
    • B.J. Prakken, R. Samodal, T.D. Le, F. Giannoni, G.P. Yung, and J. Scavulli Epitope-specific immunotherapy induces immune deviation of proinflammatory T cells in rheumatoid arthritis Proc Natl Acad Sci U S A 101 2004 4228 4233
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 4228-4233
    • Prakken, B.J.1    Samodal, R.2    Le, T.D.3    Giannoni, F.4    Yung, G.P.5    Scavulli, J.6
  • 115
    • 4043102582 scopus 로고    scopus 로고
    • Regulatory cells and infectious agents: Detentes cordiale and contraire
    • B.T. Rouse, and S. Suvas Regulatory cells and infectious agents: detentes cordiale and contraire J Immunol 173 2004 2211 2215
    • (2004) J Immunol , vol.173 , pp. 2211-2215
    • Rouse, B.T.1    Suvas, S.2
  • 116
    • 16844369607 scopus 로고    scopus 로고
    • Natural regulatory T cells in infectious disease
    • Y. Belkaid, and B.T. Rouse Natural regulatory T cells in infectious disease Nat Immunol 6 2005 353 360
    • (2005) Nat Immunol , vol.6 , pp. 353-360
    • Belkaid, Y.1    Rouse, B.T.2
  • 117
    • 7044247947 scopus 로고    scopus 로고
    • An immunomodulatory role for CD4(+)CD25(+) regulatory T lymphocytes in hepatitis C virus infection
    • R. Cabrera, Z. Tu, Y. Xu, R.J. Firpi, H.R. Rosen, and C. Liu An immunomodulatory role for CD4(+)CD25(+) regulatory T lymphocytes in hepatitis C virus infection Hepatology 40 2004 1062 1071
    • (2004) Hepatology , vol.40 , pp. 1062-1071
    • Cabrera, R.1    Tu, Z.2    Xu, Y.3    Firpi, R.J.4    Rosen, H.R.5    Liu, C.6
  • 119
    • 1842455770 scopus 로고    scopus 로고
    • Escape of malaria parasites from host immunity requires CD4+ CD25+ regulatory T cells
    • H. Hisaeda, Y. Maekawa, D. Iwakawa, H. Okada, K. Himeno, and K. Kishihara Escape of malaria parasites from host immunity requires CD4+ CD25+ regulatory T cells Nat Med 10 2004 29 30
    • (2004) Nat Med , vol.10 , pp. 29-30
    • Hisaeda, H.1    Maekawa, Y.2    Iwakawa, D.3    Okada, H.4    Himeno, K.5    Kishihara, K.6
  • 120
    • 18244370760 scopus 로고    scopus 로고
    • Virus-induced dysfunction of CD4+CD25+ T cells in patients with HTLV-I-associated neuroimmunological disease
    • Y. Yamano, N. Takenouchi, H.C. Li, U. Tomaru, K. Yao, and C.W. Grant Virus-induced dysfunction of CD4+CD25+ T cells in patients with HTLV-I-associated neuroimmunological disease J Clin Invest 115 2005 1361 1368
    • (2005) J Clin Invest , vol.115 , pp. 1361-1368
    • Yamano, Y.1    Takenouchi, N.2    Li, H.C.3    Tomaru, U.4    Yao, K.5    Grant, C.W.6


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