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Volumn 15, Issue 6, 2003, Pages 677-682

Toll-like receptors: Balancing host resistance with immune tolerance

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CYTOKINE; LIGAND; RHEUMATOID FACTOR; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG;

EID: 0242556891     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2003.09.002     Document Type: Review
Times cited : (118)

References (59)
  • 1
    • 0024955886 scopus 로고
    • Approaching the asymptote? Evolution and revolution in immunology
    • Janeway C.A. Jr. Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb. Symp. Quant. Biol. 54:1989;1-13.
    • (1989) Cold Spring Harb. Symp. Quant. Biol. , vol.54 , pp. 1-13
    • Janeway Jr., C.A.1
  • 4
    • 0035524488 scopus 로고    scopus 로고
    • Toll-like receptors and innate immunity
    • Medzhitov R. Toll-like receptors and innate immunity. Nat. Rev. Immunol. 1:2001;135-145.
    • (2001) Nat. Rev. Immunol. , vol.1 , pp. 135-145
    • Medzhitov, R.1
  • 7
    • 0037436119 scopus 로고    scopus 로고
    • Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells
    • This study shows the importance of cytokines secreted by DCs in overcoming suppression mediated by Tr cells.
    • Pasare C., Medzhitov R. Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science. 299:2003;1033-1036 This study shows the importance of cytokines secreted by DCs in overcoming suppression mediated by Tr cells.
    • (2003) Science , vol.299 , pp. 1033-1036
    • Pasare, C.1    Medzhitov, R.2
  • 8
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • Banchereau J., Steinman R.M. Dendritic cells and the control of immunity. Nature. 392:1998;245-252.
    • (1998) Nature , vol.392 , pp. 245-252
    • Banchereau, J.1    Steinman, R.M.2
  • 11
    • 0033213590 scopus 로고    scopus 로고
    • Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
    • Takeuchi O., Hoshino K., Kawai T., Sanjo H., Takada H., Ogawa T., Takeda K., Akira S. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity. 11:1999;443-451.
    • (1999) Immunity , vol.11 , pp. 443-451
    • Takeuchi, O.1    Hoshino, K.2    Kawai, T.3    Sanjo, H.4    Takada, H.5    Ogawa, T.6    Takeda, K.7    Akira, S.8
  • 13
    • 0035909372 scopus 로고    scopus 로고
    • Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
    • Alexopoulou L., Holt A.C., Medzhitov R., Flavell R.A. Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3. Nature. 413:2001;732-738.
    • (2001) Nature , vol.413 , pp. 732-738
    • Alexopoulou, L.1    Holt, A.C.2    Medzhitov, R.3    Flavell, R.A.4
  • 15
    • 0038242875 scopus 로고    scopus 로고
    • Toll-like receptor signaling pathways
    • Barton G.M., Medzhitov R. Toll-like receptor signaling pathways. Science. 300:2003;1524-1525.
    • (2003) Science , vol.300 , pp. 1524-1525
    • Barton, G.M.1    Medzhitov, R.2
  • 16
    • 0037177825 scopus 로고    scopus 로고
    • Novel signal transduction pathway utilized by extracellular HSP70: Role of toll-like receptor (TLR) 2 and TLR4
    • Asea A., Rehli M., Kabingu E., Boch J.A., Bare O., Auron P.E., Stevenson M.A., Calderwood S.K. Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4. J. Biol. Chem. 277:2002;15028-15034.
    • (2002) J. Biol. Chem. , vol.277 , pp. 15028-15034
    • Asea, A.1    Rehli, M.2    Kabingu, E.3    Boch, J.A.4    Bare, O.5    Auron, P.E.6    Stevenson, M.A.7    Calderwood, S.K.8
  • 17
    • 0034650427 scopus 로고    scopus 로고
    • Cutting edge: Heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex
    • Ohashi K., Burkart V., Flohe S., Kolb H. Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex. J. Immunol. 164:2000;558-561.
    • (2000) J. Immunol. , vol.164 , pp. 558-561
    • Ohashi, K.1    Burkart, V.2    Flohe, S.3    Kolb, H.4
  • 20
    • 0037928705 scopus 로고    scopus 로고
    • Recombinant human heat shock protein 60 does not induce the release of tumor necrosis factor α from murine macrophages
    • ••].
    • ••].
    • (2003) J. Biol. Chem. , vol.278 , pp. 22523-22529
    • Gao, B.1    Tsan, M.F.2
  • 21
    • 0037414787 scopus 로고    scopus 로고
    • Endotoxin contamination in recombinant human heat shock protein 70 (Hsp70) preparation is responsible for the induction of tumor necrosis factor α release by murine macrophages
    • ••] demonstrate that the ability of HSPs to stimulate TLR4 as reported by studies [16-18] is because of endotoxin contamination. These studies are very important and rule out the possibility of HSPs being endogenous ligands for TLRs.
    • ••] demonstrate that the ability of HSPs to stimulate TLR4 as reported by studies [16-18] is because of endotoxin contamination. These studies are very important and rule out the possibility of HSPs being endogenous ligands for TLRs.
    • (2003) J. Biol. Chem. , vol.278 , pp. 174-179
    • Gao, B.1    Tsan, M.F.2
  • 23
    • 0025948793 scopus 로고
    • Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens
    • Hartley S.B., Crosbie J., Brink R., Kantor A.B., Basten A., Goodnow C.C. Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens. Nature. 353:1991;765-769.
    • (1991) Nature , vol.353 , pp. 765-769
    • Hartley, S.B.1    Crosbie, J.2    Brink, R.3    Kantor, A.B.4    Basten, A.5    Goodnow, C.C.6
  • 24
    • 0028064578 scopus 로고
    • Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire
    • Cyster J.G., Hartley S.B., Goodnow C.C. Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire. Nature. 371:1994;389-395.
    • (1994) Nature , vol.371 , pp. 389-395
    • Cyster, J.G.1    Hartley, S.B.2    Goodnow, C.C.3
  • 25
    • 0029550111 scopus 로고
    • Antigen-induced exclusion from follicles and anergy are separate and complementary processes that influence peripheral B cell fate
    • Cyster J.G., Goodnow C.C. Antigen-induced exclusion from follicles and anergy are separate and complementary processes that influence peripheral B cell fate. Immunity. 3:1995;691-701.
    • (1995) Immunity , vol.3 , pp. 691-701
    • Cyster, J.G.1    Goodnow, C.C.2
  • 28
    • 0037383758 scopus 로고    scopus 로고
    • Aire regulates negative selection of organ-specific T cells
    • ••] are very important in understanding how peripheral antigens are represented in the thymus for the purpose of negative selection to ascertain central tolerance.
    • ••] are very important in understanding how peripheral antigens are represented in the thymus for the purpose of negative selection to ascertain central tolerance.
    • (2003) Nat. Immunol. , vol.4 , pp. 350-354
    • Liston, A.1    Lesage, S.2    Wilson, J.3    Peltonen, L.4    Goodnow, C.C.5
  • 29
    • 0027957577 scopus 로고
    • Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28
    • Punt J.A., Osborne B.A., Takahama Y., Sharrow S.O., Singer A. Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28. J. Exp. Med. 179:1994;709-713.
    • (1994) J. Exp. Med. , vol.179 , pp. 709-713
    • Punt, J.A.1    Osborne, B.A.2    Takahama, Y.3    Sharrow, S.O.4    Singer, A.5
  • 30
    • 0030732750 scopus 로고    scopus 로고
    • T cell receptor (TCR)-induced death of immature CD4+CD8+ thymocytes by two distinct mechanisms differing in their requirement for CD28 costimulation: Implications for negative selection in the thymus
    • Punt J.A., Havran W., Abe R., Sarin A., Singer A. T cell receptor (TCR)-induced death of immature CD4+CD8+ thymocytes by two distinct mechanisms differing in their requirement for CD28 costimulation: implications for negative selection in the thymus. J. Exp. Med. 186:1997;1911-1922.
    • (1997) J. Exp. Med. , vol.186 , pp. 1911-1922
    • Punt, J.A.1    Havran, W.2    Abe, R.3    Sarin, A.4    Singer, A.5
  • 31
    • 0029831662 scopus 로고    scopus 로고
    • Differing roles for B7 and intercellular adhesion molecule-1 in negative selection of thymocytes
    • Kishimoto H., Cai Z., Brunmark A., Jackson M.R., Peterson P.A., Sprent J. Differing roles for B7 and intercellular adhesion molecule-1 in negative selection of thymocytes. J. Exp. Med. 184:1996;531-537.
    • (1996) J. Exp. Med. , vol.184 , pp. 531-537
    • Kishimoto, H.1    Cai, Z.2    Brunmark, A.3    Jackson, M.R.4    Peterson, P.A.5    Sprent, J.6
  • 32
    • 0036630358 scopus 로고    scopus 로고
    • The thymus and negative selection
    • Sprent J., Kishimoto H. The thymus and negative selection. Immunol. Rev. 185:2002;126-135.
    • (2002) Immunol. Rev. , vol.185 , pp. 126-135
    • Sprent, J.1    Kishimoto, H.2
  • 33
    • 0026559329 scopus 로고
    • Cells that present both specific ligand and costimulatory activity are the most efficient inducers of clonal expansion of normal CD4 T cells
    • Liu Y., Janeway C.A. Jr. Cells that present both specific ligand and costimulatory activity are the most efficient inducers of clonal expansion of normal CD4 T cells. Proc. Natl. Acad. Sci. U.S.A. 89:1992;3845-3849.
    • (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 3845-3849
    • Liu, Y.1    Janeway Jr., C.A.2
  • 34
    • 0042971652 scopus 로고    scopus 로고
    • Tolerogenic dendritic cells
    • This review summarizes and explains the recent advances about the tolerogenic role of dendritic cells.
    • Steinman R.M., Hawiger D., Nussenzweig M.C. Tolerogenic dendritic cells. Annu. Rev. Immunol. 21:2003;685-711 This review summarizes and explains the recent advances about the tolerogenic role of dendritic cells.
    • (2003) Annu. Rev. Immunol. , vol.21 , pp. 685-711
    • Steinman, R.M.1    Hawiger, D.2    Nussenzweig, M.C.3
  • 38
    • 0037987977 scopus 로고    scopus 로고
    • Characterization of dendritic cells that induce tolerance and T regulatory 1 cell differentiation in vivo
    • ••] show a previously unappreciated role for dendritic cells in induction and differentiation of tolerogenic or suppressor T cells.
    • ••] show a previously unappreciated role for dendritic cells in induction and differentiation of tolerogenic or suppressor T cells.
    • (2003) Immunity , vol.18 , pp. 605-617
    • Wakkach, A.1    Fournier, N.2    Brun, V.3    Breittmayer, J.P.4    Cottrez, F.5    Groux, H.6
  • 40
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Sakaguchi S., Sakaguchi N., Asano M., Itoh M., Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155:1995;1151-1164.
    • (1995) J. Immunol. , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 43
    • 0037385314 scopus 로고    scopus 로고
    • An essential role for scurfin in CD4+CD25+ T regulatory cells
    • ••] demonstrate the importance of transcription factor foxp3 in the development of Tr cells.
    • ••] demonstrate the importance of transcription factor foxp3 in the development of Tr cells.
    • (2003) Nat. Immunol. , vol.4 , pp. 337-342
    • Khattri, R.1    Cox, T.2    Yasayko, S.A.3    Ramsdell, F.4
  • 44
    • 0029788211 scopus 로고    scopus 로고
    • Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation
    • Asano M., Toda M., Sakaguchi N., Sakaguchi S. Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation. J. Exp. Med. 184:1996;387-396.
    • (1996) J. Exp. Med. , vol.184 , pp. 387-396
    • Asano, M.1    Toda, M.2    Sakaguchi, N.3    Sakaguchi, S.4
  • 45
    • 0028037782 scopus 로고
    • Regulatory T cell clones induced by oral tolerance: Suppression of autoimmune encephalomyelitis
    • Chen Y., Kuchroo V.K., Inobe J., Hafler D.A., Weiner H.L. Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science. 265:1994;1237-1240.
    • (1994) Science , vol.265 , pp. 1237-1240
    • Chen, Y.1    Kuchroo, V.K.2    Inobe, J.3    Hafler, D.A.4    Weiner, H.L.5
  • 47
    • 0037061453 scopus 로고    scopus 로고
    • Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors
    • This is a landmark study that demonstrates the pathological consequences of TLR signaling in B cells.
    • Leadbetter E.A., Rifkin I.R., Hohlbaum A.M., Beaudette B.C., Shlomchik M.J., Marshak-Rothstein A. Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature. 416:2002;603-607 This is a landmark study that demonstrates the pathological consequences of TLR signaling in B cells.
    • (2002) Nature , vol.416 , pp. 603-607
    • Leadbetter, E.A.1    Rifkin, I.R.2    Hohlbaum, A.M.3    Beaudette, B.C.4    Shlomchik, M.J.5    Marshak-Rothstein, A.6
  • 48
    • 0037501347 scopus 로고    scopus 로고
    • Resistance to CpG DNA-induced autoimmunity through tolerogenic B cell antigen receptor ERK signaling
    • This study is important to understand how self-reactive B cells prevent TLR driven differentiation into plasma cells.
    • Rui L., Vinuesa C.G., Blasioli J., Goodnow C.C. Resistance to CpG DNA-induced autoimmunity through tolerogenic B cell antigen receptor ERK signaling. Nat. Immunol. 4:2003;594-600 This study is important to understand how self-reactive B cells prevent TLR driven differentiation into plasma cells.
    • (2003) Nat. Immunol. , vol.4 , pp. 594-600
    • Rui, L.1    Vinuesa, C.G.2    Blasioli, J.3    Goodnow, C.C.4
  • 49
    • 0031821875 scopus 로고    scopus 로고
    • CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production
    • Thornton A.M., Shevach E.M. CD4+CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188:1998;287-296.
    • (1998) J. Exp. Med. , vol.188 , pp. 287-296
    • Thornton, A.M.1    Shevach, E.M.2
  • 50
    • 0034020702 scopus 로고    scopus 로고
    • How can dendritic cells cause autoimmune disease?
    • Drakesmith H., Chain B., Beverley P. How can dendritic cells cause autoimmune disease? Immunol. Today. 21:2000;214-217.
    • (2000) Immunol. Today , vol.21 , pp. 214-217
    • Drakesmith, H.1    Chain, B.2    Beverley, P.3
  • 54
    • 0032494191 scopus 로고    scopus 로고
    • Interleukin 6 dependence of anti-DNA antibody production: Evidence for two pathways of autoantibody formation in pristane-induced lupus
    • Richards H.B., Satoh M., Shaw M., Libert C., Poli V., Reeves W.H. Interleukin 6 dependence of anti-DNA antibody production: evidence for two pathways of autoantibody formation in pristane-induced lupus. J. Exp. Med. 188:1998;985-990.
    • (1998) J. Exp. Med. , vol.188 , pp. 985-990
    • Richards, H.B.1    Satoh, M.2    Shaw, M.3    Libert, C.4    Poli, V.5    Reeves, W.H.6
  • 55
    • 0032534730 scopus 로고    scopus 로고
    • IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: Roles of IL-6 in the activation and differentiation of autoreactive T cells
    • Samoilova E.B., Horton J.L., Hilliard B., Liu T.S., Chen Y. IL-6-deficient mice are resistant to experimental autoimmune encephalomyelitis: roles of IL-6 in the activation and differentiation of autoreactive T cells. J. Immunol. 161:1998;6480-6486.
    • (1998) J. Immunol. , vol.161 , pp. 6480-6486
    • Samoilova, E.B.1    Horton, J.L.2    Hilliard, B.3    Liu, T.S.4    Chen, Y.5
  • 57
    • 0037450804 scopus 로고    scopus 로고
    • Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide
    • Caramalho I., Lopes-Carvalho T., Ostler D., Zelenay S., Haury M., Demengeot J. Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide. J. Exp. Med. 197:2003;403-411.
    • (2003) J. Exp. Med. , vol.197 , pp. 403-411
    • Caramalho, I.1    Lopes-Carvalho, T.2    Ostler, D.3    Zelenay, S.4    Haury, M.5    Demengeot, J.6
  • 58
    • 0037136284 scopus 로고    scopus 로고
    • Bacteria-triggered CD4(+) T regulatory cells suppress Helicobacter hepaticus-induced colitis
    • This study is an important example of how bacteria can activate regulatory T cells, complementing findings in [57], which shows that TLRs are expressed on, and activate, Tr cells.
    • Kullberg M.C., Jankovic D., Gorelick P.L., Caspar P., Letterio J.J., Cheever A.W., Sher A. Bacteria-triggered CD4(+) T regulatory cells suppress Helicobacter hepaticus-induced colitis. J. Exp. Med. 196:2002;505-515 This study is an important example of how bacteria can activate regulatory T cells, complementing findings in [57], which shows that TLRs are expressed on, and activate, Tr cells.
    • (2002) J. Exp. Med. , vol.196 , pp. 505-515
    • Kullberg, M.C.1    Jankovic, D.2    Gorelick, P.L.3    Caspar, P.4    Letterio, J.J.5    Cheever, A.W.6    Sher, A.7
  • 59
    • 0037148511 scopus 로고    scopus 로고
    • Pathogen-specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates interleukin 10 production by dendritic cells: A novel strategy for evasion of protective T helper type 1 responses by Bordetella pertussis
    • McGuirk P., McCann C., Mills K.H. Pathogen-specific T regulatory 1 cells induced in the respiratory tract by a bacterial molecule that stimulates interleukin 10 production by dendritic cells: a novel strategy for evasion of protective T helper type 1 responses by Bordetella pertussis. J. Exp. Med. 195:2002;221-231.
    • (2002) J. Exp. Med. , vol.195 , pp. 221-231
    • Mcguirk, P.1    Mccann, C.2    Mills, K.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.