Fluticasone propionate increases CD4+CD25+ T regulatory cell suppression of allergen-stimulated CD4+CD25 - T cells by an IL-10-dependent mechanism

Journal of Allergy and Clinical Immunology

Volumn 114, Issue 2, 2004, Pages 296-301

  Dao Nguyen, X ^a   Robinson, Douglas S ^a,b  

^a Leukocyte Biology Section   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

allergy; Corticosteroids; Fluticasone propionate; FP; IL 10; Salmeterol xinfoate; SX; T lymphocytes

Indexed keywords

ALLERGEN; CD4 ANTIGEN; FLUTICASONE PROPIONATE; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR;

ARTICLE; ATOPY; BLOOD SAMPLING; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; INCUBATION TIME; MIXED CELL CULTURE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE; VOLUNTEER;

ALBUTEROL; ALLERGENS; ANDROSTADIENES; ANTIGENS, CD4; HUMANS; INTERLEUKIN-10; LYMPHOCYTE ACTIVATION; RECEPTORS, INTERLEUKIN-2; T-LYMPHOCYTES; T-LYMPHOCYTES, REGULATORY;

EID: 4344696812     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2004.04.048     Document Type: Article

References (29)

1. Larche M., Robinson D.S., Kay A.B. The role of T lymphocytes in the pathogenesis of asthma. J Allergy Clin Immunol. 111:2003;450-463
2. Robinson D.S. Th-2 cytokines in allergic disease. Br Med Bull. 56:2000;956-968
3. Robinson D.S., Hamid Q., Ying S., Tsicopoulos A., Barkans J., Bentley A.M., et al. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl J Med. 326:1992;298-304
4. Durham S.R., Ying S., Varney V.A., Jacobson M.R., Sudderick R.M., Mackay I.S., et al. Cytokine messenger RNA expression for IL-3, IL-4, IL-5, and granulocyte/macrophage-colony-stimulating factor in the nasal mucosa after local allergen provocation: relationship to tissue eosinophilia. J Immunol. 148:1992;2390-2394
5. Thepen T., Langeveld-Wildschut E.G., Bihari I.C., van Wichen D.F., van Reijsen F.C., Mudde G.C., et al. Biphasic response against aeroallergen in atopic dermatitis showing a switch from an initial TH2 response to a TH1 response in situ: an immunocytochemical study. J Allergy Clin Immunol. 97:1996;828-837
6. Maggi E., Biswas P., Del Prete G., Parronchi P., Macchia D., Simonelli C., et al. Accumulation of Th-2-like helper T cells in the conjunctiva of patients with vernal conjunctivitis. J Immunol. 146:1991;1169-1174
7. Lloyd C.M., Gonzalo J.A., Coyle A.J., Gutierrez-Ramos J.C. Mouse models of allergic airway disease. Adv Immunol. 77:2001;263-295
8. British Thoracic Society; Scottish Intercollegiate Guidelines Network. British guideline on the management of asthma. Thorax. 58:(suppl 1):2003;i1-i94
9. Bousquet J., Van Cauwenberge P., Khaltaev N. Allergic rhinitis and its impact on asthma. J Allergy Clin Immunol. 108:(suppl):2001;S147-S334
10. Ellis C., Luger T., Abeck D., Allen R., Graham-Brown R.A., De Prost Y., et al. International Consensus Conference on Atopic Dermatitis II (ICCAD II): clinical update and current treatment strategies. Br J Dermatol. 148:(suppl 63):2003;3-10
11. Leung D.Y., Bloom J.W. Update on glucocorticoid action and resistance. J Allergy Clin Immunol. 111:2003;3-22
12. Robinson D., Hamid Q., Ying S., Bentley A., Assoufi B., Durham S., et al. Prednisolone treatment in asthma is associated with modulation of bronchoalveolar lavage cell interleukin-4, interleukin-5, and interferon-gamma cytokine gene expression. Am Rev Respir Dis. 148:1993;401-406
13. Bentley A.M., Hamid Q., Robinson D.S., Schotman E., Meng Q., Assoufi B., et al. Prednisolone treatment in asthma. Reduction in the numbers of eosinophils, T cells, tryptase-only positive mast cells, and modulation of IL-4, IL-5, and interferon-gamma cytokine gene expression within the bronchial mucosa. Am J Respir Crit Care Med. 153:1996;551-556
14. Sakaguchi S. Regulatory T cells: key controllers of immunologic self-tolerance. Cell. 101:2000;455-458
15. McHugh R.S., Shevach E.M. The role of suppressor T cells in regulation of immune responses. J Allergy Clin Immunol. 110:2002;693-702
16. Maloy K.J., Powrie F. Regulatory T cells in the control of immune pathology. Nat Immunol. 2:2001;816-822
17. Ling E.M., Smith T., Nguyen X.D., Pridgeon C., Dallman M., Arbery J., et al. Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease. Lancet. 363:2004;608-615
18. Bellinghausen I., Klostermann B., Knop J., Saloga J. Human CD4+CD25+ T cells derived from the majority of atopic donors are able to suppress TH1 and TH2 cytokine production. J Allergy Clin Immunol. 111:2003;862-868
19. Jutel M., Akdis M., Budak F., Aebischer-Casaulta C., Wrzyszcz M., Blaser K., et al. IL-10 and TGF-beta cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy. Eur J Immunol. 33:2003;1205-1214
20. Moore K.W., de Waal Malefyt R., Coffman R.L., O'Garra A. Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol. 19:2001;683-765
21. Brinkmann V., Kristofic C. Regulation by corticosteroids of Th1 and Th2 cytokine production in human CD4+ effector T cells generated from CD45RO- and CD45RO+ subsets. J Immunol. 155:1995;3322-3328
22. Visser J., van Boxel-Dezaire A., Methorst D., Brunt T., de Kloet E.R., Nagelkerken L. Differential regulation of interleukin-10 (IL-10) and IL-12 by glucocorticoids in vitro. Blood. 91:1998;4255-4264
23. Richards D.F., Fernandez M., Caulfield J., Hawrylowicz C.M. Glucocorticoids drive human CD8(+) T cell differentiation towards a phenotype with high IL-10 and reduced IL-4, IL-5 and IL-13 production. Eur J Immunol. 30:2000;2344-2354
24. Barrat F.J., Cua D.J., Boonstra A., Richards D.F., Crain C., Savelkoul H.F., et al. In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines. J Exp Med. 195:2002;603-616
25. Eickelberg O., Roth M., Lorx R., Bruce V., Rudiger J., Johnson M., et al. Ligand-independent activation of the glucocorticoid receptor by beta2-adrenergic receptor agonists in primary human lung fibroblasts and vascular smooth muscle cells. J Biol Chem. 274:1999;1005-1010
26. Borish L., Aarons A., Rumbyrt J., Cvietusa P., Negri J., Wenzel S. Interleukin-10 regulation in normal subjects and patients with asthma. J Allergy Clin Immunol. 97:1996;1288-1296
27. John M., Lim S., Seybold J., Jose P., Robichaud A., O'Connor B., et al. Inhaled corticosteroids increase interleukin-10 but reduce macrophage inflammatory protein-1alpha, granulocyte-macrophage colony-stimulating factor, and interferon-gamma release from alveolar macrophages in asthma. Am J Respir Crit Care Med. 157:1998;256-262
28. Woo E.Y., Yeh H., Chu C.S., Schlienger K., Carroll R.G., Riley J.L., et al. Cutting edge: regulatory T cells from lung cancer patients directly inhibit autologous T cell proliferation. J Immunol. 168:2002;4272-4276
29. + T cells from the target organ of patients with rheumatoid arthritis. Eur J Immunol. 33:2003;215-223