Transcriptional and DNA Binding Activity of the Foxp1/2/4 Family Is Modulated by Heterotypic and Homotypic Protein Interactions

Molecular and Cellular Biology

Volumn 24, Issue 2, 2004, Pages 809-822

  Li, Shanru ^a   Weidenfeld, Joel ^a   Morrisey, Edward E ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; DNA BINDING PROTEIN; LEUCINE ZIPPER PROTEIN; PROTEIN FOXP1; PROTEIN FOXP2; PROTEIN FOXP4; REGULATOR PROTEIN; REPRESSOR PROTEIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DIMERIZATION; GENE REPRESSION; GENETIC CONSERVATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LUNG DEVELOPMENT; MULTIGENE FAMILY; NERVE CELL DIFFERENTIATION; ONCOGENE C MYB; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN FAMILY; REGULATORY MECHANISM;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CELL LINE; DIMERIZATION; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; LEUCINE ZIPPERS; MACROMOLECULAR SUBSTANCES; MICE; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; MUTAGENESIS; NIH 3T3 CELLS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; REPRESSOR PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TWO-HYBRID SYSTEM TECHNIQUES;

CANIDAE; HOMO;

EID: 0347986673     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.24.2.809-822.2004     Document Type: Article

References (42)

1. Alcorn, J. L., R. E. Hammer, K. R. Graves, M. E. Smith, S. D. Maika, L. F. Michael, E. Gao, Y. Wang, and C. R. Mendelson. 1999. Analysis of genomic regions involved in regulation of the rabbit surfactant protein A gene in transgenic mice. Am. J. Physiol. 277:L349-L361.
2. Ang, S. L., and J. Rossant. 1994. HNF-3 beta is essential for node and notochord formation in mouse development. Cell 78:561-574.
3. Banham, A. H., N. Beasley, E. Campo, P. L. Fernandez, C. Fidler, K. Gatter, M. Jones, D. Y. Mason, J. E. Prime, P. Trougouboff, K. Wood, and J. L. Cordell. 2001. The FOXPI winged helix transcription factor is a novel candidate tumor suppressor gene on chromosome 3p. Cancer Res. 61:8820-8829.
4. Bennett, C. L., J. Christie, F. Ramsdell, M. E. Brunkow, P. J. Ferguson, L. Whitesell, T. E. Kelly, F. T. Saulsbury, P. F. Chance, and H. D. Ochs. 2001, The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat. Genet. 27:20-21.
5. Bohinski, R. J., R. Di Lauro, and J. A. Whitsett. 1994. The lung-specific surfactant protein B gene promoter is a target for thyroid transcription factor 1 and hepatocyte nuclear factor 3, indicating common factors for organ-specific gene expression along the foregut axis. Mol. Cell. Biol. 14:5671-5681.
6. Braun, H., and G. Suske. 1998. Combinatorial action of HNF3 and Sp family transcription factors in the activation of the rabbit uteroglobin/CC10 promoter. J. Biol. Chem. 273:9821-9828.
7. Brunkow, M. E., E. W. Jeffery, K. A. Hjerrild, B. Paeper, L. B. Clark, S. A. Yasayko, J. E. Wilkinson, D. Galas, S. F. Ziegler, and F. Ramsdell. 2001. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat. Genet. 27:68-73.
8. Carlsson, P., and M. Mahlapuu. 2002. Forkhead transcription factors: key players in development and metabolism. Dev. Biol. 250:1-23.
9. Chatila, T. A., F. Blaeser, N. Ho, H. M. Lederman, C. Voulgaropoulos, C. Helms, and A. M. Bowcock. 2000. JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic dysregulation syndrome. J. Clin. Investig. 106:R75-R81.
10. Clark, K. L., E. D. Halay, E. Lai, and S. K. Burley. 1993. Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5. Nature 364:412-420.
11. Clevidence, D. E., D. G. Overdier, R. S. Peterson, A. Porcella, H. Ye, K. E. Paulson, and R. H. Costa. 1994. Members of the HNF-3/forkhead family of transcription factors exhibit distinct cellular expression patterns in lung and regulate the surfactant protein B promoter. Dev. Biol. 166:195-209.
12. Deconinck, A. E., P. E. Mead, S. G. Tevosian, J. D. Crispino, S. G. Katz, L. I. Zon, and S. H. Orkin. 2000. FOG acts as a repressor of red blood cell development in Xenopus. Development 127:2031-2040.
13. Dressel, U., P. J. Bailey, S. C. Wang, M. Downes, R. M. Evans, and G. E. Muscat. 2001. A dynamic role for HDAC7 in MEF2-mediated muscle differentiation. J. Biol. Chem. 276:17007-17013.
14. Enard, W., M. Przeworski, S. E. Fisher, C. S. Lai, V. Wiebe, T. Kitano, A. P. Monaco, and S. Paabo. 2002. Molecular evolution of FOXP2, a gene involved in speech and language. Nature 418:869-872.
15. Fox, A. H., C. Liew, M. Holmes, K. Kowalski, J. Mackay, and M. Crossley. 1999. Transcriptional cofactors of the FOG family interact with GATA proteins by means of multiple zinc fingers. EMBO J. 18:2812-2822.
16. Hildebrand, J. D., and P. Soriano. 2002. Overlapping and unique roles for C-terminal binding protein I (CtBP1) and CtBP2 during mouse development. Mol. Cell. Biol. 22:5296-5307.
17. Ikeda, K., J. R. Shaw-White, S. E. Wert, and J. A. Whitsett. 1996. Hepatocyte nuclear factor 3 activates transcription of thyroid transcription factor 1 in respiratory epithelial cells. Mol. Cell. Biol. 16:3626-3636.
18. Kaplan, W., P. Husler, H. Klump, J. Erhardt, N. Sluis-Cremer, and H. Dirr. 1997. Conformational stability of pGEX-expressed Schistosoma japonicum glutathione S-transferase: a detoxification enzyme and fusion-protein affinity tag. Protein Sci. 6:399-406.
19. Kloetzli, J. M., I. A. Fontaine-Glover, E. R. Brown, M. Kuo, and P. A. Labosky. 2001. The winged helix gene, Foxb1, controls development of mammary glands and regions of the CNS that regulate the milk-ejection reflex. Genesis 29:60-71.
20. Lai, C. S., S. E. Fisher, J. A. Hurst, F. Vargha-Khadem, and A. P. Monaco. 2001. A forkhead-domain gene is mutated in a severe speech and language disorder. Nature 413:519-523.
21. Lu, M. M., S. Li, H. Yang, and E. E. Morrisey. 2002. Foxp4: a novel member of the Foxp subfamily of winged-helix genes co-expressed with Foxp1 and Foxp2 in pulmonary and gut tissues. Gene Expr. Patterns 2:223-228.
22. Monaghan, A. P., K. H. Kaestner, E. Grau, and G. Schutz. 1993. Postimplantation expression patterns indicate a role for the mouse forkhead/HNF-3 alpha, beta and gamma genes in determination of the definitive endoderm, chordamesoderm and neuroectoderm. Development 119:567-578.
23. Morrisey, E. E., H. S. Ip, Z. Tang, and M. S. Parmacek. 1997. GATA-4 activates transcription via two novel domains that are conserved within the GATA-4/5/6 subfamily. J. Biol. Chem. 272:8515-8524.
24. Morrisey, E. E., Z. Tang, K. Sigrist, M. M. Lu, F. Jiang, H. S. Ip, and M. S. Parmacek. 1998. GATA6 regulates HNF4 and is required for differentiation of visceral endoderm in the mouse embryo. Genes Dev. 12:3579-3590.
25. Peng, H., G. E. Begg, D. C. Schultz, J. R. Friedman, D. E. Jensen, D. W. Speicher, and F. J. Rauscher III. 2000. Reconstitution of the KRAB-KAP-1 repressor complex: a model system for defining the molecular anatomy of RING-B box-coiled-coil domain-mediated protein-protein interactions. J. Mol. Biol. 295:1139-1162.
26. Pettigrew, N. E., and R. F. Colman. 2001. Heterodimers of glutathione S-transferase can form between isoenzyme classes pi and mu. Arch. Biochem. Biophys. 396:225-230.
27. Postigo, A. A., and D. C. Dean. 1999. ZEB represses transcription through interaction with the corepressor CtBP. Proc. Natl. Acad. Sci. USA 96:6683-6688.
28. Riley, L. G., G. B. Ralston, and A. S. Weiss. 1996. Multimer formation as a consequence of separate homodimerization domains: the human c-Jun leucine zipper is a transplantable dimerization module. Protein Eng. 9:223-230.
29. Sasaki, H., and B. L. Hogan. 1994. HNF-3 beta as a regulator of floor plate development. Cell 76:103-115.
30. Sawaya, P. L., and D. S. Luse. 1994. Two members of the HNF-3 family have opposite effects on a lung transcriptional element; HNF-3 alpha stimulates and HNF-3 beta inhibits activity of region I from the Clara cell secretory protein (CCSP) promoter. J. Biol. Chem. 269:22211-22216.
31. Sawaya, P. L., B. R. Stripp, J. A. Whitsett, and D. S. Luse. 1993. The lung-specific CC10 gene is regulated by transcription factors from the AP-1, octamer, and hepatocyte nuclear factor 3 families. Mol. Cell. Biol. 13:3860-3871.
32. Schaeper, U., J. M. Boyd, S. Verma, E. Uhlmann, T. Subramanian, and G. Chinnadurai. 1995. Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus EIA involved in negative modulation of oncogenic transformation. Proc. Natl. Acad. Sci. USA 92:10467-10471.
33. Shu, W., H. Yang, L. Zhang, M. M. Lu, and E. E. Morrisey. 2001. Characterization of a new subfamily of winged-helix/forkhead (Fox) genes that are expressed in the lung and act as transcriptional repressors. J. Biol. Chem. 276:27488-27497.
34. Svensson, E. C., G. S. Huggins, F. B. Dardik, C. E. Polk, and J. M. Leiden. 2000. A functionally conserved N-terminal domain of the friend of GATA-2 (FOG-2) protein represses GATA4-dependent transcription. J. Biol. Chem. 275:20762-20769.
35. Turner, J., and M. Crossley. 2001. The CtBP family: enigmatic and enzymatic transcriptional co-repressors. Bioessays 23:683-690.
36. Weldenfeld, J., W. Shu, L. Zhang, S. E. Millar, and E. E. Morrisey. 2002. The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium. J. Biol. Chem. 277:21061-21070.
37. Weinstein, D. C., A. Ruiz i Altaba, W. S. Chen, P. Hoodless, V. R. Prezioso, T. M. Jessell, and J. E. Darnell, Jr. 1994. The winged-helix transcription factor HNF-3 beta is required for notochord development in the mouse embryo. Cell 78:575-588.
38. Xuan, S., C. A. Baptista, G. Balas, W. Tao, V. C. Soares, and E. Lai. 1995. Winged helix transcription factor BF-1 is essential for the development of the cerebral hemispheres. Neuron 14:1141-1152.
39. Zhang, C. L., T. A. McKinsey, J. R. Lu, and E. N. Olson. 2001. Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor. J. Biol. Chem. 276:35-39.
40. Zhang, J., B. A. Hug, E. Y. Huang, C. W. Chen, V. Gelmetti, M. Maccarana, S. Minucci, P. G. Pelicci, and M. A. Lazar. 2001. Oligomerization of ETO is obligatory for corepressor interaction. Mol. Cell. Biol. 21:156-163.
41. Zhang, J., D. M. Webb, and O. Podlaha. 2002. Accelerated protein evolution and origins of human-specific features: Foxp2 as an example. Genetics 162:1825-1835.
42. Zhou, L., C. R. Dey, S. E. Wert, C. Yan, R. H. Costa, and J. A. Whitsett. 1997. Hepatocyte nuclear factor-3β limits cellular diversity in the developing respiratory epithelium and alters lung morphogenesis in vivo. Dev. Dyn. 210:305-314.