Inhibition of interleukin 1β converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 5, 1997, Pages 2007-2012

  Hara, Hideaki ^a   Friedlander, Robert M ^a   Gagliardini, Valeria ^a   Ayata, Cenk ^a   Fink, Klaus ^a   Huang, Zhihong ^a   Shimizu Sasamata, Masao ^a   Yuan, Junying ^a,b   Moskowitz, Michael A ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

caspase inhibitors; infarction; neurological deficit; transient focal ischemia

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; CATHEPSIN B; GLUTAMATE RECEPTOR; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; N METHYL DEXTRO ASPARTIC ACID; PROTEINASE INHIBITOR; CASP3 PROTEIN, MOUSE; CASP3 PROTEIN, RAT; CASPASE; CASPASE 3; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; INTERLEUKIN 1; NEUROTOXIN;

ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; BLOOD PRESSURE; BRAIN BLOOD FLOW; BRAIN ISCHEMIA; CONFERENCE PAPER; CONTROLLED STUDY; DEGENERATIVE DISEASE; ENZYME INHIBITION; HEART RATE; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; STROKE; ANIMAL; ARTICLE; BRAIN; CEREBROVASCULAR DISEASE; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION; GENETICS; METABOLISM; NERVE CELL; REPERFUSION; SPRAGUE DAWLEY RAT; WESTERN BLOTTING;

ANIMALIA;

ANIMALS; BLOTTING, WESTERN; BRAIN; BRAIN ISCHEMIA; CASPASE 1; CASPASE 3; CASPASES; CATHEPSIN B; CEREBROVASCULAR DISORDERS; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; GENE EXPRESSION; INTERLEUKIN-1; MALE; MICE; NEURONS; NEUROTOXINS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GLUTAMATE; REPERFUSION;

EID: 0030614952     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.5.2007     Document Type: Article

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