Alphaviruses induce apoptosis in Bcl-2-overexpressing cells: Evidence for a caspase-mediated, proteolytic inactivation of Bcl-2

EMBO Journal

Volumn 17, Issue 5, 1998, Pages 1268-1278

  Grandgirard, Denis ^a   Studer, Erwin ^a   Monney, Laurent ^b   Belser, Tanja ^b   Fellay, Isabelle ^b   Borner, Christoph ^b   Michel, Marcel R ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY OF FRIBOURG   (Switzerland)

Author keywords

Alphaviruses; Apoptosis; Bax; Bcl 2; Caspase; ICE like protease; Semliki; Sindbis

Indexed keywords

CASPASE; CYSTEINE PROTEINASE; DNA FRAGMENT; ENZYME INHIBITOR; INTERLEUKIN 1BETA CONVERTING ENZYME; PROTEIN BCL 2; UNCLASSIFIED DRUG;

ALPHA VIRUS; AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL TYPE; CELL VIABILITY; CONTROLLED STUDY; EPITOPE MAPPING; GENE OVEREXPRESSION; NONHUMAN; ONCOGENE; PERSISTENT VIRUS INFECTION; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT; SEMLIKI FOREST ALPHAVIRUS; SINDBIS VIRUS; VECTOR CONTROL; VIRUS INFECTION;

AMINO ACID CHLOROMETHYL KETONES; AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CASPASES; CELL LINE; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; ENZYME ACTIVATION; EPITOPES; FIBROBLASTS; GENE EXPRESSION; MICE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; SEMLIKI FOREST VIRUS; SINDBIS VIRUS;

ALPHAVIRUS; ANIMALIA; MURINAE; SEMLIKI FOREST VIRUS; SINDBIS VIRUS;

EID: 0032473496     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/17.5.1268     Document Type: Article

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