Lipopolysaccharide induces in macrophages the synthesis of the suppressor of cytokine signaling 3 and suppresses signal transduction in response to the activating factor IFN-γ

Journal of Immunology

Volumn 163, Issue 5, 1999, Pages 2640-2647

  Stoiber, Dagmar ^a   Kovarik, Pavel ^a   Cohney, Solomon ^c   Johnston, James A ^c   Steinlein, Peter ^b   Decker, Thomas ^a  

^a Vienna Biocenter   (Austria)

^b RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; LIPOPOLYSACCHARIDE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; NEUTRALIZING ANTIBODY; PROTEIN TYROSINE KINASE; STAT1 PROTEIN; STAT5 PROTEIN; SUPPRESSOR FACTOR;

ARTICLE; DIMERIZATION; ENZYME ACTIVATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MACROPHAGE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE; CELL LINE, TRANSFORMED; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; INTERFERON TYPE II; JANUS KINASE 1; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; PROTEIN-TYROSINE KINASES; PROTEINS; REPRESSOR PROTEINS; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TIME FACTORS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSFECTION; TYROSINE;

EID: 0033197958     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Galanos, C., and M. A. Freudenberg. 1993. Mechanisms of endotoxin shock and endotoxin hypersensitivity. Immunobiology 187:346.
2. Nacy, C. A., and M. S. Meltzer. 1991. T-cell-mediated activation of macrophages. Curr. Opin. Immunol. 3:330.
3. Darnell, J. E., Jr., I. M. Kerr, and G. R. Stark. 1994. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264:1415.
4. Schindler, C., and J. E. Darnell, Jr. 1995. Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu. Rev. Biochem. 64:621.
5. Decker, T., P. Kovarik, and A. Meinke. 1997. Gas elements: a few nucleotides with a major impact on cytokine-induced gene expression. J. Interferon Cytokine Res. 17:121.
6. Baeuerle, P. A., and D. Baltimore. 1996. NF-κB: ten years after. Cell 87:13.
7. Kovarik, P., D. Stoiber, M. Novy, and T. Decker. 1998. Stall combines signals derived from IFN-γ and LPS receptors during macrophage activation. EMBO J. 17:3660.
8. Wen, Z., Z. Zhong, and J. E. Darnell, Jr. 1995. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell 82:241.
9. Starr, R., T. A. Willson, E. M. Viney, L. J. Murray, J. R. Rayner, B. J. Jenkins, T. J. Gonda, W. S. Alexander, D. Metcalf, N. A. Nicola, and D. J. Hilton. 1997. A family of cytokine-inducible inhibitors of signalling. Nature 387:917.
10. Endo, T. A., M. Masuhara, M. Yokouchi, R. Suzuki, H. Sakamoto, K. Mitsui, A. Matsumoto, S. Tanimura, M. Ohtsubo, H. Misawa, et al. 1997. A new protein containing an SH2 domain that inhibits JAK kinases. Nature 387:921.
11. Naka, T., M. Narazaki, M. Hirata, T. Matsumoto, S. Minamoto, A. Aono, N. Nishimoto, T. Kajita, T. Taga, K. Yoshizaki, S. Akira, and T. Kishimoto. 1997. Structure and function of a new STAT-induced STAT inhibitor. Nature 387:924.
12. Nicholson, S. E., and D. J. Hilton. 1998. The SOCS proteins: a new family of negative regulators of signal transduction. J. Leukocyte Biol. 63:665.
13. Yoshimura, A. 1998. The CIS family: negative regulators of JAK-STAT signaling. Cytokine Growth Factor Rev. 9:197.
14. Auernhammer, C. J., C. Bousquet, and S. Melmed. 1999. Autoregulation of pituitary corticotroph SOCS-3 expression: characterization of the murine SOCS-3 promoter. Proc. Natl. Acad. Sci. USA 96:6964.
15. Morgan, C., J. W. Pollard, and E. R. Stanley. 1987. Isolation and characterization of a cloned growth factor dependent macrophage cell line, BAC1.2F5. J. Cell. Physiol. 130:420.
16. Meinke, A., F. Barahmand-pour, S. Wöhrl, D. Stoiber, and T. Decker. 1996. Activation of different Stat5 isoforms contributes to cell-type-restricted signaling in response to interferons. Mol. Cell. Biol. 16:6937.
17. Foey, A. D., S. L. Parry, L. M. Williams, M. Feldmann, B. M. Foxwell, and F. M. Brennan. 1998. Regulation of monocyte IL-10 synthesis by endogenous IL-1 and TNF-α: role of the p38 and p42/44 mitogen-activated protein kinases. J. Immunol. 160:920.
18. Alleva, D. G., S. B. Kaser, M. A. Monroy, M. J. Fenton, and D. I. Beller. 1997. IL-15 functions as a potent autocrine regulator of macrophage proinflammatory cytokine production: evidence for differential receptor subunit utilization associated with stimulation or inhibition. J. Immunol. 159:2941.
19. Wegenka, U. M., C. Lutticken, J. Buschmann, J. Yuan, F. Lottspeich, W. Muller Esterl, C. Schindler, E. Roeb, P. C. Heinrich, and F. Horn. 1994. The interleukin-6-activated acute-phase response factor is antigenically and functionally related to members of the signal transducer and activator of transcription (STAT) family. Mol. Cell. Biol. 14:3186.
20. Gouilleux, F., C. Pallard, I. Dusanter Fourt, H. Wakao, L. A. Haldosen, G. Norstedt, D. Levy, and B. Groner. 1995. Prolactin, growth hormone, erythropoietin and granulocyte-macrophage colony stimulating factor induce MGF-Stat5 DNA binding activity. EMBO J. 14:2005.
21. Eilers, A., M. Baccarini, F. Horn, R. A. Hipskind, C. Schindler, and T. Decker. 1994. A factor induced by differentiation signals in cells of macrophage lineage binds to the γ interferon activation site. Mol. Cell. Biol. 14:1364.
22. Strehlow, I., D. Seegert, C. Frick, F. C. Bange, C. Schindler, E. C. Bottger, and T. Decker. 1993. The gene encoding IFP 53/tryptophanyl-tRNA synthetase is regulated by the gamma-interferon activation factor. J. Biol. Chem. 268:16590.
23. Xie, Q. W., Y. Kashiwabara, and C. Nathan. 1994. Role of transcription factor NF-κB/Rel in induction of nitric oxide synthase. J. Biol. Chem. 269:4705.
24. Caldenhoven, E., P. Coffer, J. Yuan, A. Van de Stolpe, F. Horn, W. Kruijer, and P. T. Van der Saag. 1994. Stimulation of the human intercellular adhesion molecule-1 promoter by interleukin-6 and interferon-γ involves binding of distinct factors to a palindromic response element. J. Biol. Chem. 269:21146.
25. Ledebur, H. C., and T. P. Parks. 1995. Transcriptional regulation of the intercellular adhesion molecule-1 gene by inflammatory cytokines in human endothelial cells: essential roles of a variant NF-κB site and p65 homodimers. J. Biol. Chem. 270:933.
26. Gao, J. J., D. C. Morrison, T. J. Parmely, S. W. Russell, and W. J. Murphy. 1997. An interferon γ activated site (gas) is necessary for full expression of the mouse inos gene in response to interferon y and lipopolysaccharide. J. Biol. Chem. 272:1226.
27. Muhlethaler-Mottet, A., W. Di Berardino, L. A. Otten, and B. Mach. 1998. Activation of the MHC class II transactivator CIITA by interferon-γ requires cooperative interaction between Stal1 and USF-1. Immunity 8:157.
28. Feldman, G. M., E. J. Chuang, and D. S. Finbloom. 1995. IgG immune complexes inhibit IFN-γ-induced transcription of the FcγRI gene in human monocytes by preventing the tyrosine phosphorylation of the p91 (Stat1) transcription factor. J. Immunol. 154:318.
29. Sakamoto, H., H. Yasukawa, M. Masuhara, S. Tanimura, A. Sasaki, K. Yuge, M. Ohtsubo, A. Ohtsuka, T. Fujita, T. Ohta, et al. 1998. A Janus kinase inhibitor, JAB, is an interferon-γ-inducible gene and confers resistance to interferons. Blood 92:1668.
30. Song, M. M., and K. Shuai. 1998. The suppressor of cytokine signaling (SOCS) 1 and SOCS3 but not SOCS2 proteins inhibit interferon-mediated antiviral and antiproliferative activities. J. Biol. Chem. 273:35056.
31. Klingmuller, U., U. Lorenz, L. C. Cantley, B. G. Neel, and H. F. Lodish. 1995. Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals. Cell 80:729.
32. Bjorbaek, C., J. K. Elmquist, J. D. Frantz, S. E. Shoelson, and J. S. Flier. 1998. Identification of SOCS-3 as a potential mediator of central leptin resistance. Mol. Cell 1:619.
33. Adams, T. E., J. A. Hansen, R. Starr, N. A. Nicola, D. J. Hilton, and N. Billestrup. 1998. Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling. J. Biol. Chem. 273: 1285.
34. Helman, D., Y. Sandowski, Y. Cohen, A. Matsumoto, A. Yoshimura, S. Merchav, and A. Gertler. 1998. Cytokine-inducible SH2 protein (CIS3) and JAK2 binding protein (JAB) abolish prolactin receptor-mediated STAT5 signaling. FEBS Lett. 441:287.
35. Barahmand-pour, F., A. Meinke, A. Eilers, F. Gouilleux, B. Groner, and T. Decker 1995. Colony-stimulating factors and interferon-γ activate a protein related to MGF-Stat 5 to cause formation of the differentiation-induced factor in myeloid cells. FEBS Lett. 360:29.
36. Mellitzer, G., O. Wessely, T. Decker, A. Eilers, M. J. Hayman, and H. Beug. 1996. Activation of Stat 5b in erythroid progenitors correlates with the ability of ErbB to induce sustained cell proliferation. Proc. Natl. Acad. Sci. USA 93:9600.
37. Durbin, J. E., R. Hackenmiller, M. C. Simon, and D. E. Levy. 1996. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell 84:443.
38. Meraz, M. A., J. M. White, K. C. Sheehan, E. A. Bach, S. J. Rodig, A. S. Dighe, D. H. Kaplan, J. K. Riley, A. C. Greenlund, D. Campbell, et al. 1996. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell 84:431.
39. Ito, S., P. Ansari, M. Sakatsume, H. Dickensheets, N. Vasquez, R. P. Donelly, A. C. Larner, and D. S. Finbloom. 1999. Interleukin-10 inhibits expression of both inlerferon-α and interferon-γ-induced genes by suppressing tyrosine phosphorylation of Stat1. Blood 93:1.
40. Weber Nordt, R. M., J. K. Riley, A. C. Greenlund, K. W. Moore, J. E. Darnell, and R. D. Schreiber. 1996. Stat3 recruitment by two distinct ligand-induced, tyrosine-phosphorylated docking sites in the interleukin-10 receptor intracellular domain. J. Biol. Chem. 271:27954.
41. Lehmann, J., D. Seegert, I. Strehlow, C. Schindler, M. L. Lohmann Matthes, and T. Decker. 1994. IL-10-induced factors belonging to the p91 family of proteins bind to IFN-γ-responsive promoter elements. J. Immunol. 153:165.
42. Ziegler-Heitbrock, H. W. 1995. Molecular mechanism in tolerance to lipopolysaccharide. J. Inflamm. 45:13.
43. Ziegler Heitbrock, H. W., A. Wedel, W. Schraut, M. Strobel, P. Wendelgass, T. Sternsdorf, P. A. Bauerle, J. G. Haas, and G. Riethmuller. 1994. Tolerance to lipopolysaccharide involves mobilization of nuclear factor κB with predominance of p50 homodimers. J. Biol. Chem. 269:17001.
44. Yasukawa, H., H. Misawa, H. Sakamoto, M. Masuhara, A. Sasaki, T. Wakioka, S. Ohtsuka, T. Imaizumi, T. Matsuda, J. N. Ihle, and A. Yoshimura. 1999. The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop. EMBO J. 18:1309.
45. Nicholson, S. E., T. A. Willson, A. Farley, R. Starr, J. G. Zhang, M. Baca, W. S. Alexander, D. Metcalf, D. J. Hilton, and N. A. Nicola. 1999. Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction. EMBO J. 18:375.
46. Cohney, S. J., D. Sanden, N. A. Cacalano, A. Yoshimura, A Mui, T. Migone, and J. A. Johnston. 1999. SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses Stat5 phosphorylation and lymphocyte proliferation. Mol. Cell. Biol. 19:4980.