Suppression of STAT5 functions in liver, mammary glands, and T cells in cytokine-inducible SH2-containing protein 1 transgenic mice

Molecular and Cellular Biology

Volumn 19, Issue 9, 1999, Pages 6396-6407

  Matsumoto, Akira ^a   Seki, Youichi ^b   Kubo, Masato ^b   Ohtsuka, Satoshi ^a   Suzuki, Asuka ^a   Hayashi, Itsuro ^a   Tsuji, Kohichiro ^c   Nakahata, Tatsutoshi ^c   Okabe, Masaru ^d   Yamada, Shuichi ^d   Yoshimura, Akihiko ^a  

^a KURUME UNIVERSITY   (Japan)

^b TOKYO UNIVERSITY OF SCIENCE   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ACTIN; CYTOKINE; ERYTHROPOIETIN; GROWTH HORMONE; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 3; PROLACTIN; PROTEIN KINASE; STAT5 PROTEIN; T LYMPHOCYTE RECEPTOR DELTA CHAIN; T LYMPHOCYTE RECEPTOR GAMMA CHAIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BREAST DEVELOPMENT; CONTROLLED STUDY; HELPER CELL; IMMEDIATE EARLY GENE; KNOCKOUT MOUSE; LACTATION; LIVER; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MAMMARY GLAND; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PHOSPHORYLATION; T LYMPHOCYTE; TRANSGENIC MOUSE;

EID: 0032772125     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.19.9.6396     Document Type: Article

References (43)

1. Adams, T. E., J. A. Hansen, R. Starr, N. A. Nicola, D. J. Hilton, and N. Billestrup. 1998. Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling. J. Biol. Chem. 273:1285-1287.
2. Bix, M., Z. E. Wang, B. Thiel, N. J. Schork, and R. M. Locksley. 1998. Genetic regulation of commitment to interleukin 4 production by a CD4(+) T cell-intrinsic mechanism. J. Exp. Med. 188:2289-2299.
3. Cella, N., B. Groner, and N. E. Hynes. 1998. Characterization of Stat5a and Stat5b homodimers and heterodimers and their association with the glucocorticoid receptor in mammary cells. Mol. Cell. Biol. 18:1783-1792.
4. Darnell, J. E., Jr. 1997. STATs and gene regulation. Science 277:1630-1635.
5. Durbin, J. E., R. Hackenmiller, M. C. Simon, and D. E. Levy. 1996. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell 84:443-450.
6. Endo, T. A., M. Masuhara, M. Yokouchi, R. Suzuki, H. Sakamoto, K. Mitsui, A. Matsumoto, S. Tanimura, M. Ohtsuho, H. Misawa, T. Miyazaki, N. Leonor, T. Taniguchi, T. Fujita, Y. Kanakura, S. Komiya, and A. Yoshimura. 1997. A new protein containing an SH2 domain that inhibits JAK kinases. Nature 387:921-924.
7. Feldman, G. M., L. A. Rosenthal, X. Liu, M. P. Hayes, A. Wynshaw-Boris, W. J. Leonard, L. Hennighausen, and D. S. Finbloom. 1997. STAT5a deficient mice demonstrate a defect in granulocyte-macrophage colony-stimulating factor-induced proliferation and gene expression. Blood 90: 1768-1776.
8. Helman, D., Y. Sandowski, Y. Cohen, A. Matsumoto, A. Yoshimura, S. Merchav, and A. Gertler. 1998. Cytokine-inducible SH2 protein (CIS3) and JAK2 binding protein (JAB) abolish prolactin receptor-mediated STAT5 signaling. FEBS Lett. 441:287-291.
9. Ihle, J. N. 1996. STATs: signal transducers and activators of transcription. Cell 84:331-334.
10. Ikawa, M., S. Yamada, T. Nakanishi, and M. Okabe. 1999. Green fluorescent protein (GFP) as a vital marker in mammals. Curr. Top. Dev. Biol. 44:1-20.
11. Imada, K., E. T. Bloom, H. Nakajima, J. A. Horvath-Arcidiacono, G. B. Udy, H. W. Davey, and W. J. Leonard. 1998. Stat5b is essential for natural killer cell-mediated proliferation and cytolytic activity. J. Exp. Med. 188:2067-2074.
12. Jiao, H., K. Berrada, W. Yang, M. Tabrizi, L. C. Platanias, and T. Yi. 1996. Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1. Mol. Cell. Biol. 16:6985-6992.
13. Kaplan, M. H., Y.-L. Sun, T. Hoey, and M. J. Grusby. 1996. Impaired IL-12 responses and enhanced development of Th2 cells in Staff-deficient mice. Nature 382:174-177.
14. Klingmuller, U., U. Lorenz, L. C. Cantley, B. G. Neel, and H. F. Lodish. 1995. Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivalion of JAK2 and termination of proliferative signals. Cell 80:729-738.
15. Kubo, M., J. Ransom, D. Webb, Y. Hashimoto, T. Tada, and T. Nakayama. 1997. T-cell subset-specific expression of the IL-4 gene is regulated by a silencer element and STAT6. EMBO J. 16:4007-4020.
16. Liu, X., G. W. Robinson, and L. Hennighausen. 1996. Activation of Stat5a and Stat5b by tyrosine phosphorylation is tightly linked to mammary gland differentiation. Mol. Endocrinol. 10:1496-1506.
17. Liu, X., G. W. Robinson, K.-U. Wagner, L. Garrett, A. Wynshaw-Boris, and L. Hennighausen. 1997. Stat5a is mandatory for adult mammary gland development and lactogenesis. Genes Dev. 11:179-186.
18. Masuhara, M., H. Sakamoto, A. Matsumoto, R Suzuki, H. Yasukawa, K. Mitsui, T. Wakioka, S. Tanimura, A. Sasaki, H. Misawa, M. Yokouchi, M. Ohtsubo, and A. Yoshimura. 1997. Cloning and characterization of novel CIS family genes. Biochem. Biophys. Res. Commun. 239:439-446.
19. Matsumoto, A., M. Masuhara, K. Mitsui, M. Yokouchi, M. Ohtsubo, H. Misawa, A. Miyajima, and A. Yoshimura. 1997. CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation. Blood 89:3148-3154.
20. Meraz, M. A., J. M. White, K. C. F. Sheehan, E. A. Bach, S. J. Rodig, A. S. Digne, D. H. Kaplan, J. K. Riley, A. C. Greenlund, D. Campbell, K. Carver-Moore, R. N. DuBois, R. Clark, M. Aguet, and R. D. Schreiber. 1996. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell 84:431-442.
21. Moriggl, R., D. J. Topham, S. Teglund, V. Sexl, C. McKay, D. Wang, A. Hoffmeyer, J. van Deursen, M. Y. Sangster, K. D. Bunting, G. C. Grosveld, and J. N. Ihle. 1999. Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. Immunity 10:249-259.
22. Naka, T., M. Narazaki, M. Hirata, T. Matsumoto, S. Minamoto. A. Aono, N. Nishimoto, T. Kajita, T. Taga, K. Yoshizaki, S. Akira, and T. Kishimoto. 1997. Structure and function of a new STAT-induced STAT inhibitor. Nature 387:924-929.
23. Nakajima, H., X.-W. Liu, A. Wynshaw-Boris, L. A. Rosenthal, K. Imada, D. S. Finbloom, L. Hennighausen, and W. J. Leonard. 1997. An indirect effect of Stat5a in IL-2-induced proliferation: a critical role for Stat5a in IL-2-mediated IL-2 receptor a chain induction. Immunity 7:691-701.
24. Niwa, H., K. Yamamura, and J. Miyazaki. 1991. Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 108:193-199.
25. Norstedt, G., and R. Palmiter. 1984. Secretory rhythm of growth hormone regulates sexual differentiation of mouse liver. Cell 36:805-812.
26. O'Shea, J. J. 1997. Jaks, STATs, cytokine signal transduction, and immunoregulation: are we there yet? Immunity 7:1-11.
27. Ripperger, J. A., S. Fritz, K. Richter, G. M. Hocke, F. Lottspeich, and G. H. Fey. 1995. Transcription factors Stat3 and Stat5b are present in rat liver nuclei late in an acute phase response and bind interleukin-6 response elements. J. Biol. Chem. 270:29998-30006.
28. Sakamoto, H., H. Yasukawa, M. Masuhara, S. Tanimura, A. Sasaki, K. Yuge, M. Ohtsubo, S. Ohtsuka, T. Fujita, T. Ohta, Y. Furukawa, S. Iwase, H. Yamada, and A. Yoshimura. 1998. A Janus kinase inhibitor, JAB, is an interferon-γ inducible gene and confers resistance to interferons. Blood 92:1668-1676.
29. Shimoda, K., J. van Deursen, M. Y. Sangster, S. R. Sarawar, R. T. Carson, R. A. Tripp. C. Chu, F. W. Quelle, T. Nosaka, D. A. Vignali, P. C. Doherty, G. Grosveld, W. E. Paul, and J. N. Ihle. 1996. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature 380:630-633.
30. Shultz, L. D., P. A. Schweitzer, T. V. Rajan, T. Yi, J. N. Ihle, R. J. Matthews, M. L. Thomas, and D. R. Beier. 1993. Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene. Cell 73:1445-1454.
31. Starr, R., T. A. Willson, E. M. Viney, L. J. Murray, J. R. Rayner, B. J. Jenkins, T. J. Gonda, W. S. Alexander, D. Metcalf, N. A. Nicola, and D. J. Hilton. 1997. A family of cytokine-inducible inhibitors of signalling. Nature 387:917-921.
32. Suzuki, R., H. Sakamoto, H. Yasukawa, M. Masuhara, T. Wakioka, A. Sasaki, K. Yuge, S. Komiya, A. Inoue, and A. Yoshimura. 1998. CIS3 and JAB have different regulatory roles in interleukin-6 mediated differentiation and STAT3 activation in M1 leukemia cells. Oncogene 17:2271-2278.
33. Takeda, K., T. Tanaka, W. Shi, M. Matsumoto, M. Minami. S. Kashiwamura, K. Nakanishi, N. Yoshida, T. Kishimoto, and S. Akira. 1996. Essential role of State in IL-4 signalling. Nature 380:627-630.
34. Takeda, K., K. Noguchi, W. Shi, T. Tanaka, M. Matsumoto, N. Yoshida, T. Kishimoto, and S. Akira. 1997. Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. Proc. Natl. Acad. Sci. USA 94:3801-3804.
35. Teglund, S., C. McKay, E. Schuetz, J. M. van Deursen, D. Straopodis, D. Wang, M. Brown, S. Bodner, G. Grosveld, and J. N. Ihle. 1998. Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. Cell 93:841-852.
36. Udy, G. B., R. P. Towers, R. G. Snell, R. J. Wilkins, S.-H. Park, P. A. Ram, D. J. Waxman, and H. W. Davey. 1997. Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression. Proc. Natl. Acad. Sci. USA 94:7239-7242.
37. Verdier, F., S. Chretien, O. Muller, P. Varlet, A. Yoshimura, S. Gisselbrecht, C. Lacombe, and P. Mayeux. 1998. Proteasomes regulate erythropoietin receptor and signal transducer and activator of transcription 5 (STAT5) activation. Possible involvement of the ubiquitinated CIS protein. J. Biol. Chem. 273:28185-28190.
38. Welte, T., D. Leitenberg, B. N. Dittel, B. K. al-Ramadi, B. Xie, Y. E. Chin, C. A. Janeway, Jr., A. L. M. Bothwell, K. Bottomly, and X. Y. Fu. 1999. STAT5 interaction with the T cell receptor complex and stimulation of T cell proliferation. Science 283:222-225.
39. Yamashita, M., K. Hashimoto, M. Kimura, M. Kubo, and T. Nakayama. 1998. Requirement for p56 (lck) tyrosine kinase activation in Th subset differentiation. Int. Immunol. 10:577-591.
40. Yasukawa, H., H. Misawa, H. Sakamoto, M. Masuhara, A. Sasaki, T. Wakioka, A. Ohtsuka, T. Imaizumi, T. Matsuda, J. N. Ihle, and A. Yoshimura. 1999. The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop. EMBO J. 18:1309-1320.
41. Yoshimura, A., T. Ohkubo, T. Kiguchi, N. A. Jenkins, D. J. Gilbert, N. G. Copeland, T. Hara, and A. Mivajima. 1995. A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors. EMBO J. 14:2816-2826.
42. Yoshimura, A., M. Ichihara, I. Kinjyo, M. Moriyama, N. G. Copeland, D. J. Gilbert, N. A. Jenkins, T. Hara, and A. Miyajima. 1996. Mouse oncostatin M: an immediate early response gene induced by multiple cytokines through the JAKs/STAT5 pathway. EMBO J. 15:1055-1063.
43. Yoshimura, A. 1998. The CIS/JAB family: novel negative regulators of JAK signaling pathways. Leukemia 12:1851-1857.