Receptor autoradiography as mean to explore the possible functional relevance of neuropeptides: Focus on new agonists and antagonists to study natriuretic peptides, neuropeptide Y and calcitonin gene-related peptides

Peptides

Volumn 25, Issue 3, 2004, Pages 365-391

  Dumont, Yvan ^a   Chabot, Jean Guy ^a   Quirion, Remi ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

2n; 3V; 4V; 5n; 7; ac; AcbC; AcbS; accumbens core; accumbens shell; Amy; amygdala; anterior commissure; anterior olfactory nuclei; AO; basolateral amygdaloid nuclei; BL; CA1; facial nucleus; fourth ventricle; optic nerve; third ventricle; trigeminal nucleus

Indexed keywords

1 [1 [3 (3 PIPERIDYL)]PROPYL] 2 [(4 CHLOROPHENOXY)METHYL]INDOL 3 YL 2 (4 PIPERIDYLPIPERIDYL)ETHAN 1 ONE; 1 NAPHTHALENESULFONIC ACID [4 [(4 AMINO 2 QUINAZOLINYLAMINO)METHYL]CYCLOHEXYLMETHYL]AMIDE; 2 [(4 CHLOROPHENOXY)METHYL]BENZIMIDAZOLE; 2 [1 (3 CHLORO 5 ISOPROPOXYCARBONYLAMINOPHENYL)ETHYLAMINO] 6 [2 (5 ETHYL 4 METHYL 2 THIAZOLYL)ETHYL] 4 MORPHOLINOPYRIDINE; 6 (5 ETHYL 1,3 THIAZOL 2 YLTHIOMETHYL) 2 [3 METHOXY 5 (2 PROPENYLOXYCARBONYLAMINO)BENZYLAMINO] 4 MORPHOLINOPYRIDINE; ADRENOMEDULLIN; AMYLIN; ATRIAL NATRIURETIC FACTOR; BENZIMIDAZOLE DERIVATIVE; BIBN 4099BS; BRAIN NATRIURETIC PEPTIDE; BRAIN PEPTIDE; CALCITONIN; CALCITONIN GENE RELATED PEPTIDE; G PROTEIN COUPLED RECEPTOR; GI 264879A; GR 231118; GUANYLATE CYCLASE; GW 438014A; H 409 22; INTERMEDIN; J 104870; JCF 109; L 152 804; LY 357897; MEMBRANE RECEPTOR; N (1 ACETYL 2,3 DIHYDRO 1H INDOL 6 YL) 3 (3 CYANOPHENYL) N [1 (2 CYCLOPENTYLETHYL) 4 PIPERIDINYL]ACRYLAMIDE; N [1 [4 [[[[4 [(DIMETHYLAMINO)METHYL]CYCLOHEXYL]METHYL]AMINO]IMINOMETHYL]BENZYL] 2 OXO 2 (1 PYRROLIDINYL)ETHYL] ALPHA [(2 NAPHTHALENYLSULFONYL)AMINO]BENZENEPROPANAMIDE; N [2 [1,2 DIHYDRO 3,5(4H) DIOXO 1,2 DIPHENYL 1,2,4 TRIAZOL 4 YL]ETHYL] N2 [[1 [2 [4 [5,11 DIHYDRO 6(6H) OXODIBENZ[B,E]AZEPIN 11 YL] 1 PIPERAZINYL] 2 OXOETHYL]CYCLOPENTYL]ACETYL]ARGININAMIDE; N2 DIPHENYLACETYL N (4 UREIDOMETHYLBENZYL)ARGININAMIDE; NALPHA (DIPHENYLACETYL) N (4 HYDROXYBENZYL) DEXTRO ARGININAMIDE; NATRIURETIC FACTOR; NATRIURETIC PEPTIDE TYPE C; NEUROPEPTIDE Y; NEUROPEPTIDE Y RECEPTOR AGONIST; NEUROPEPTIDE Y RECEPTOR ANTAGONIST; NPY 5RA; OLCEGEPANT; PANCREAS POLYPEPTIDE; PEPTIDE YY; PIPERIDINE DERIVATIVE; PYRIDINE DERIVATIVE; RECEPTOR ACTIVITY MODIFYING PROTEIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

AGONIST; AUTORADIOGRAPHY; BRAIN; CELL MEMBRANE; CENTRAL NERVOUS SYSTEM; CLONING; HORMONE RECEPTOR INTERACTION; HUMAN; LIGAND BINDING; MOLECULAR CLONING; NONHUMAN; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN ISOLATION; QUANTITATIVE ANALYSIS; REVIEW;

ANIMALS; BINDING SITES; CALCITONIN; CALCITONIN GENE-RELATED PEPTIDE; HUMANS; NATRIURETIC PEPTIDES; NEUROPEPTIDE Y; RECEPTORS, NEUROPEPTIDE;

EID: 2342486626     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2004.01.013     Document Type: Review

References (417)

1. Aburaya M., Minamino N., Hino J., Kangawa K., Matsuo H. Distribution and molecular forms of brain natriuretic peptide in the central nervous system, heart and peripheral tissue of rat. Biochem. Biophys. Res. Commun. 165:1989;880-887
2. Aicher S.A., Springston M., Berger S.B., Reis D.J., Wahlestedt C. Receptor-selective analogs demonstrate NPY/PYY receptor heterogeneity in rat brain. Neurosci. Lett. 130:1991;32-36
3. Albers H.E., Ferris C.F. Neuropeptide Y: role in light-dark cycle entrainment of hamster circadian rhythms. Neurosci. Lett. 50:1984;163-168
4. Allen J., Novotny J., Martin J., Heinrich G. Molecular structure of mammalian neuropeptide Y: analysis by molecular cloning and computer-aided comparison with crystal structure of avian homologue. Proc. Natl. Acad. Sci. U.S.A. 84:1987;2532-2536
5. Amara S.G., Arriza J.L., Leff S.E., Swanson L.W., Evans R.M., Rosenfeld M.G. Expression in brain of a messenger RNA encoding a novel neuropeptide homologous to calcitonin gene-related peptide. Science. 229:1985;1094-1097
6. Amara S.G., Jonas V., Rosenfeld M.G., Ong E.S., Evans R.M. Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products. Nature. 298:1982;240-244
7. Ammar D.A., Eadie D.M., Wong D.J., Ma Y.Y., Kolakowski L.F. Jr., Yang-Feng T.L., et al. Characterization of the human type 2 neuropeptide Y receptor gene (NPY2R) and localization to the chromosome 4q region containing the type 1 neuropeptide Y receptor gene. Genomics. 38:1996;392-398
8. Anand-Srivastava M.B., Franks D.J., Cantin M., Genest J. Atrial natriuretic factor inhibits adenylate cyclase activity. Biochem. Biophys. Res. Commun. 121:1984;855-862
9. Anand-Srivastava M.B., Sairam M.R., Cantin M. Ring-deleted analogs of atrial natriuretic factor inhibit adenylate cyclase/cAMP system. Possible coupling of clearance atrial natriuretic factor receptors to adenylate cyclase/cAMP signal transduction system. J. Biol. Chem. 265:1990;8566-8572
10. Antunes-Rodrigues J., McCann S.M., Rogers L.C., Samson W.K. Atrial natriuretic factor inhibits dehydration- and angiotensin II-induced water intake in the conscious, unrestrained rat. Proc. Natl. Acad. Sci. U.S.A. 82:1985;8720-8723
11. Antunes-Rodrigues J., McCann S.M., Samson W.K. Central administration of atrial natriuretic factor inhibits saline preference in the rat. Endocrinology. 118:1986;1726-1728
12. Armour S.L., Foord S., Kenakin T., Chen W.J. Pharmacological characterization of receptor-activity-modifying proteins (RAMPs) and the human calcitonin receptor. J. Pharmacol. Toxicol. Methods. 42:1999;217-224
13. Bard J.A., Walker M.W., Branchek T.A., Weinshank R.L. Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY. J. Biol. Chem. 270:1995;26762-26765
14. Baskaya M.K., Suzuki Y., Anzai M., Seki Y., Saito K., Takayasu M., et al. Effects of adrenomedullin, calcitonin gene-related peptide, and amylin on cerebral circulation in dogs. J. Cereb. Blood Flow Metab. 15:1995;827-834
15. Beaumont K., Kenney M.A., Young A.A., Rink T.J. High affinity amylin binding sites in rat brain. Mol. Pharmacol. 44:1993;493-497
16. Beaumont K., Moore C.X., Pittner R.A., Prickett K.S., Gaeta L.S., Rink T.J., et al. Differential antagonism of amylin's metabolic and vascular actions with amylin receptor antagonists. Can. J. Physiol. Pharmacol. 73:1995;1025-1029
17. Beaumont K., Pittner R.A., Moore C.X., Wolfe-Lopez D., Prickett K.S., Young A.A., et al. Regulation of muscle glycogen metabolism by CGRP and amylin: CGRP receptors not involved. Br. J. Pharmacol. 115:1995;713-715
18. Beck-Sickinger A.G., Grouzmann E., Hoffmann E., Gaida W., van Meir E.G., Waeber B., et al. A novel cyclic analog of neuropeptide Y specific for the Y2 receptor. Eur. J. Biochem. 206:1992;957-964
19. Beck-Sickinger A.G., Jung G., Gaida W., Koppen H., Schnorrenberg G., Lang R. Structure/activity relationships of C-terminal neuropeptide Y peptide segments and analogues composed of sequence 1-4 linked to 25-36. Eur. J. Biochem. 194:1990;449-456
20. Belanger S., Ma W., Chabot J.-G., Quirion R. Expression of calcitonin gene-related peptide, substance P and protein kinase C in cultured dorsal root ganglion neurons following chronic exposure to mu, delta and kappa opiates. Neuroscience. 115:2002;441-453
21. Bell D., McDermott B.J. Activity of amylin at CGRP1-preferring receptors coupled to positive contractile response in rat ventricular cardiomyocytes. Regul. Pept. 60:1995;125-133
22. Belloni A.S., Andreis P.G., Meneghelli V., Champion H.C., Kadowitz P.J., Coy D.H., et al. Adrenomedullin and calcitonin gene-related peptide (CGRP) interact with a common receptor of the CGRP1 subtype in the human adrenal zona glomerulosa. Endocr. Res. 25:1999;29-34
23. Berglund M.M., Holmberg S.K., Eriksson H., Gedda K., Maffrand J.P., Serradeil-Le Gal C., et al. The cloned guinea pig neuropeptide Y receptor Y1 conforms to other mammalian Y1 receptors. Peptides. 20:1999;1043-1053
24. Berthiaume N., Claing A., Lippton H., Cadieux A., D'Orleans-Juste P. Rat adrenomedullin induces a selective arterial vasodilation via CGRP1 receptors in the double-perfused mesenteric bed of the rat. Can. J. Physiol. Pharmacol. 73:1995;1080-1083
25. Betsholtz C., Christmanson L., Gebre-Medhin S., Westermark P. Islet amyloid polypeptide - hen or egg in type 2 diabetes pathogenesis? Acta Oncol. 32:1993;149-154
26. Bidzseranova A., Gueron J., Varga J., Telegdy G. Effects of brain natriuretic peptide-32 on the extinction of active avoidance behavior in rats. Transmitter-mediated action. Physiol. Behav. 52:1992;227-229
27. Bidzseranova A., Telegdy G., Penke B. The effects of atrial natriuretic peptide on passive avoidance behaviour in rats. Brain Res. Bull. 26:1991;177-180
28. Biro E., Toth G., Telegdy G. Effect of receptor blockers on brain natriuretic peptide and C-type natriuretic peptide caused anxiolytic state in rats. Neuropeptides. 30:1996;59-65
29. Bitran M., Daniels A.J., Boric M.P. GW1229, a novel neuropeptide Y Y1 receptor antagonist, inhibits the vasoconstrictor effect on neuropeptide Y in the hamster microcirculation. Eur. J. Pharmacol. 319:1997;43-47
30. Block M.H., Boyer S., Brailsford W., Brittain D.R., Carroll D., Chapman S., et al. Discovery and optimization of a series of carbazole ureas as NPY5 antagonists for the treatment of obesity. J. Med. Chem. 45:2002;3509-3523
31. Bonaventure P, Nepomuceno D, Mazur C, Lord B, Rudolph D, Jablonowski JA, et al. Characterization of JNJ-5207787, a small molecule antagonist of the neuropeptide Y Y2 receptor. J Pharmacol Expt Ther 2004, in press.
32. Born W., Fischer J.A., Muff R. Receptors for calcitonin gene-related peptide, adrenomedullin, and amylin: the contributions of novel receptor-activity-modifying proteins. Receptors Channels. 8:2002;201-209
33. Born W., Muff R., Fischer J.A. Functional interaction of G protein-coupled receptors of the adrenomedullin peptide family with accessory receptor-activity-modifying proteins (RAMP). Microsc. Res. Tech. 57:2002;14-22
34. Borowsky B., Walker M.W., Bard J., Weinshank R.L., Laz T.M., Vaysse P., et al. Molecular biology and pharmacology of multiple NPY Y5 receptor species homologs. Regul. Pept. 75/76:1998;45-53
35. Bouali S.M., Fournier A., St Pierre S., Jolicoeur F.B. In vivo central actions of NPY(1-30), an N-terminal fragment of neuropeptide Y. Peptides. 15:1994;799-802
36. Brain S.D., Wimalawansa S., MacIntyre I., Williams T.J. The demonstration of vasodilator activity of pancreatic amylin amide in the rabbit. Am. J. Pathol. 136:1990;487-490
37. Brenner B.M., Ballermann B.J., Gunning M.E., Zeidel M.L. Diverse biological actions of atrial natriuretic peptide. Physiol. Rev. 70:1990;665-699
38. Brown J., Czarnecki A. Autoradiographic localization of atrial and brain natriuretic peptide receptors in rat brain. Am. J. Physiol. 258:1990;R57-R63
39. Brown J., Czarnecki A. Distribution of atrial natriuretic peptide receptor subtypes in rat brain. Am. J. Physiol. 258:1990;R1078-R1083
40. Brown J., Czarnecki A. Receptor subtypes for natriuretic peptides in the brains of hypertensive rats. Am. J. Physiol. 260:1991;R441-R447
41. Burkhoff A., Linemeyer D.L., Salon J.A. Distribution of a novel hypothalamic neuropeptide Y receptor gene and it's absence in rat. Mol. Brain Res. 53:1998;311-316
42. Cabrele C., Langer M., Bader R., Wieland H.A., Doods H.N., Zerbe O., et al. The first selective agonist for the neuropeptide Y Y5 receptor increases food intake in rats. J. Biol. Chem. 275:2000;36043-36048
43. Cabrele C., Wieland H.A., Langer M., Stidsen C.E., Beck-Sickinger A.G. Y-receptor affinity modulation by the design of pancreatic polypeptide/ neuropeptide Y chimera led to Y5-receptor ligands with picomolar affinity. Peptides. 22:2001;365-378
44. Cameron V.A., Cumming S.A., Espiner E.A., Nicholls G., Richards M. C-type natriuretic peptide expression in olfactory regions of rat brain is modulated by acute water deprivation, salt loading and central angiotensin II. Neuroendocrinology. 73:2001;46-53
45. Campbell R.E., Ffrench-Mullen J.M., Cowley M.A., Smith M.S., Grove K.L. Hypothalamic circuitry of neuropeptide Y regulation of neuroendocrine function and food intake via the Y5 receptor subtype. Neuroendocrinology. 74:2001;106-119
46. Chabot J-G, Dumont Y, St Pierre JA, Tong Y, Dore S, Kar S, et al. Anatomical approaches to study G protein-coupled peptide receptors. In: Peppeti P, Muller-Esterl WRD, editors. Peptidergic G protein-coupled receptors. Amsterdam: IOS Press; 1999. p. 11-28.
47. Chakder S., Rattan S. [Tyr0]-calcitonin gene-related peptide 28-37 (rat) as a putative antagonist of calcitonin gene-related peptide responses on opossum internal anal sphincter smooth muscle. J. Pharmacol. Exp. Ther. 253:1990;200-206
48. Chakravarty P., Suthar T.P., Coppock H.A., Nicholl C.G., Bloom S.R., Legon S., et al. CGRP and adrenomedullin binding correlates with transcript levels for calcitonin receptor-like receptor (CRLR) and receptor activity modifying proteins (RAMPs) in rat tissues. Br. J. Pharmacol. 130:2000;189-195
49. Chan-Palay V., Allen Y.S., Lang W., Haesler U., Polak J.M. Cytology and distribution in normal human cerebral cortex of neurons immunoreactive with antisera against neuropeptide Y. J. Comp. Neurol. 238:1985;382-389
50. Chan-Palay V., Kohler C., Haesler U., Lang W., Yasargil G. Distribution of neurons and axons immunoreactive with antisera against neuropeptide Y in the normal human hippocampus. J. Comp. Neurol. 248:1986;360-375
51. Chance W.T., Balasubramaniam A., Zhang F.S., Wimalawansa S.J., Fischer J.E. Anorexia following the intrahypothalamic administration of amylin. Brain Res. 539:1991;352-354
52. Chang M.S., Lowe D.G., Lewis M., Hellmiss R., Chen E., Goeddel D.V. Differential activation by atrial and brain natriuretic peptides of two different receptor guanylate cyclases. Nature. 341:1989;68-72
53. Chantry A., Leighton B., Day A.J. Cross-reactivity of amylin with calcitonin-gene-related peptide binding sites in rat liver and skeletal muscle membranes. Biochem. J. 277:1991;139-143
54. Charles C.J., Richards A.M., Espiner E.A. Central C-type natriuretic peptide but not atrial natriuretic factor lowers blood pressure and adrenocortical secretion in normal conscious sheep. Endocrinology. 131:1992;1721-1726
55. Chen W.J., Armour S., Way J., Chen G., Watson C., Irving P., et al. Expression cloning and receptor pharmacology of human calcitonin receptors from MCF-7 cells and their relationship to amylin receptors. Mol. Pharmacol. 52:1997;1164-1175
56. Chiba T., Yamaguchi A., Yamatani T., Nakamura A., Morishita T., Inui T., et al. Calcitonin gene-related peptide receptor antagonist human CGRP-(8-37). Am. J. Physiol. 256:1989;E331-E335
57. Choksi T., Hay D.L., Legon S., Poyner D.R., Hagner S., Bloom S.R., et al. Comparison of the expression of calcitonin receptor-like receptor (CRLR) and receptor activity modifying proteins (RAMPs) with CGRP and adrenomedullin binding in cell lines. Br. J. Pharmacol. 136:2002;784-792
58. Christopoulos G., Paxinos G., Huang X.F., Beaumont K., Toga A.W., Sexton P.M. Comparative distribution of receptors for amylin and the related peptides calcitonin gene related peptide and calcitonin in rat and monkey brain. Can. J. Physiol. Pharmacol. 73:1995;1037-1041
59. Christopoulos G., Perry K.J., Morfis M., Tilakaratne N., Gao Y., Fraser N.J., et al. Multiple amylin receptors arise from receptor activity-modifying protein interaction with the calcitonin receptor gene product. Mol. Pharmacol. 56:1999;235-242
60. Clark J.T., Kalra P.S., Crowley W.R., Kalra S.P. Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats. Endocrinology. 115:1984;427-429
61. Clark J.T., Kalra P.S., Kalra S.P. Neuropeptide Y stimulates feeding but inhibits sexual behavior in rats. Endocrinology. 117:1985;2435-2442
62. Colmers W.F. Modulation of synaptic transmission in hippocampus by neuropeptide Y: presynaptic actions. Ann. N.Y. Acad. Sci. 611:1990;206-218
63. Colmers W.F., Bleakman D. Effects of neuropeptide Y on the electrical properties of neurons. Trends Neurosci. 17:1994;373-379
64. Colmers W.F., Lukowiak K., Pittman Q.J. Presynaptic action of neuropeptide Y in area CA1 of the rat hippocampal slice. J. Physiol. (Lond.). 383:1987;285-299
65. Conner A.C., Hay D.L., Howitt S.G., Kilk K., Langel U., Wheatley M., et al. Interaction of calcitonin gene-related peptide with its receptors. Biochem. Soc. Trans. 30:2002;451-455
66. Cooper G.J. Amylin compared with calcitonin gene-related peptide: structure, biology, and relevance to metabolic disease. Endocr. Rev. 15:1994;163-201
67. Cooper G.J., Willis A.C., Clark A., Turner R.C., Sim R.B., Reid K.B. Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients. Proc. Natl. Acad. Sci. U.S.A. 84:1987;8628-8632
68. Copp D.H. Endocrine control of calcium homeostasis. J. Endocrinol. 43:1969;137-161
69. Coppock H.A., Owji A.A., Austin C., Upton P.D., Jackson M.L., Gardiner J.V., et al. Rat-2 fibroblasts express specific adrenomedullin receptors, but not calcitonin-gene-related-peptide receptors, which mediate increased intracellular cAMP and inhibit mitogen-activated protein kinase activity. Biochem. J. 338:1999;15-22
70. Coppock H.A., Owji A.A., Bloom S.R., Smith D.M. A rat skeletal muscle cell line (L6) expresses specific adrenomedullin binding sites but activates adenylate cyclase via calcitonin gene-related peptide receptors. Biochem. J. 318:1996;241-245
71. Cox H.M., Tough I.R. Calcitonin gene-related peptide receptors in human gastrointestinal epithelia. Br. J. Pharmacol. 113:1994;1243-1248
72. Criscione L., Rigollier P., Batzl-Hartmann C., Rueger H., Stricker-Krongrad A., Wyss P., et al. Food intake in free-feeding and energy-deprived lean rats is mediated by the neuropeptide Y5 receptor. J. Clin. Invest. 102:1998;2136-2145
73. 125I ] CGRP specific binding sites in porcine tissues J. Recept. Signal. Transduct. Res. 19:1999;803-817
74. Daniels A.J., Chance W.T., Grizzle M.K., Heyer D., Matthews J.E. Food intake inhibition and reduction in body weight gain in rats treated with GI264879A, a non-selective NPY-Y1 receptor antagonist. Peptides. 22:2001;483-491
75. Daniels A.J., Grizzle M.K., Wiard R.P., Matthews J.E., Heyer D. Food intake inhibition and reduction in body weight gain in lean and obese rodents treated with GW438014A, a potent and selective NPY-Y5 receptor antagonist. Regul. Pept. 106:2002;47-54
76. Daniels A.J., Matthews J.E., Slepetis R.J., Jansen M., Viveros O.H., Tadepalli A., et al. High-affinity neuropeptide Y receptor antagonists. Proc. Natl. Acad. Sci. U.S.A. 92:1995;9067-9071
77. de Bold A.J., Borenstein H.B., Veress A.T., Sonnenberg H. A rapid and potent natriuretic response to intravenous injection of atrial myocardial extract in rats. Life Sci. 28:1981;89-94
78. De Quidt M.E., Emson P.C. Distribution of neuropeptide Y-like immunoreactivity in the rat central nervous system - I. Radioimmunoassay and chromatographic characterisation. Neuroscience. 18:1986;527-543
79. De Quidt M.E., Emson P.C. Distribution of neuropeptide Y-like immunoreactivity in the rat central nervous system - II. Immunohistochemical analysis. Neuroscience. 18:1986;545-618
80. Della-Zuana O., Sadlo M., Germain M., Feletou M., Chamorro S., Tisserand F., et al. Reduced food intake in response to CGP 71683A may be due to mechanisms other than NPY Y5 receptor blockade. Int. J. Obest. Relat. Metab. Disord. 25:2001;84-94
81. Dennis T., Fournier A., Cadieux A., Pomerleau F., Jolicoeur F.B., St Pierre S., et al. hCGRP8-37, a calcitonin gene-related peptide antagonist revealing calcitonin gene-related peptide receptor heterogeneity in brain and periphery. J. Pharmacol. Exp. Ther. 254:1990;123-128
82. Dennis T., Fournier A., Guard S., St Pierre S., Quirion R. Calcitonin gene-related peptide (hCGRP alpha) binding sites in the nucleus accumbens. Atypical structural requirements and marked phylogenic differences. Brain Res. 539:1991;59-66
83. Dennis T., Fournier A., St Pierre S., Quirion R. Structure-activity profile of calcitonin gene-related peptide in peripheral and brain tissues. Evidence for receptor multiplicity. J. Pharmacol. Exp. Ther. 251:1989;718-725
84. Doods H. Development of CGRP antagonists for the treatment of migraine. Curr. Opin. Investig. Drugs. 2:2001;1261-1268
85. Doods H., Gaida W., Wieland H.A., Dollinger H., Schnorrenberg G., Esser F., et al. BIIE0246: a selective and high affinity neuropeptide Y Y2 receptor antagonist. Eur. J. Pharmacol. 384:1999;R3-R5
86. Doods H., Hallermayer G., Wu D., Entzeroth M., Rudolf K., Engel W., et al. Pharmacological profile of BIBN4096BS, the first selective small molecule CGRP antagonist. Br. J. Pharmacol. 129:2000;420-423
87. Dore S., Kar S., Quirion R. Insulin-like growth factor I protects and rescues hippocampal neurons against beta-amyloid- and human amylin-induced toxicity. Proc. Natl. Acad. Sci. U.S.A. 94:1997;4772-4777
88. Dove S., Michel M.C., Knieps S., Buschauer A. Pharmacology and quantitative structure-activity relationships of imidazolylpropylguanidines with mepyramine-like substructures as non-peptide neuropeptide Y Y1 receptor antagonists. Can. J. Physiol. Pharmacol. 78:2000;108-115
89. Dumont Y., Cadieux A., Doods H., Fournier A., Quirion R. Potent and selective tools to investigate neuropeptide Y receptors in the central and peripheral nervous systems: BIBO3304 (Y1) and CGP71683A (Y5). Can. J. Physiol. Pharmacol. 78:2000;116-125
90. Dumont Y., Cadieux A., Doods H., Pheng L.H., Abounader R., Hamel E., et al. BIIE0246, a potent and highly selective non-peptide neuropeptide Y Y2 receptor antagonist. Br. J. Pharmacol. 129:2000;1075-1088
91. Dumont Y., Fournier A., Quirion R. Expression and characterization of the neuropeptide Y Y5 receptor subtype in the rat brain. J. Neurosci. 18:1998;5565-5574
92. Dumont Y., Fournier A., St Pierre S., Quirion R. Comparative characterization and autoradiographic distribution of neuropeptide Y receptor subtypes in the rat brain. J. Neurosci. 13:1993;73-86
93. 125I ]peptide YY3-36 as selective Y1 and Y2 radioligands J. Pharmacol. Exp. Ther. 272:1995;673-680
94. 125I ]PYY3-36 binding sites in the rat brain evaluated with two newly developed Y1 and Y2 receptor radioligands Synapse. 22:1996;139-158
95. Dumont Y., Fournier A., St Pierre S., Quirion R. A potent and selective CGRP2 agonist, [Cys(Et)2, 7]hCGRP alpha: comparison in prototypical CGRP1 and CGRP2 in vitro bioassays. Can. J. Physiol. Pharmacol. 75:1997;671-676
96. Dumont Y., Fournier A., St Pierre S., Schwartz T.W., Quirion R. Differential distribution of neuropeptide Y1 and Y2 receptors in the rat brain. Eur. J. Pharmacol. 191:1990;501-503
97. Dumont Y., Jacques D., Bouchard P., Quirion R. Species differences in the expression and distribution of the neuropeptide Y Y1, Y2, Y4 and Y5 receptors in rodents, guinea pig and primates brains. J. Comp. Neurol. 402:1998;372-384
98. Dumont Y, Jacques D, St Pierre JA, Tong Y, Parker R, Herzog H, et al. Neuropeptide Y, peptide YY and pancreatic polypeptide receptor proteins and mRNAs in mammalian brains. In: Quirion R, Bjorklund A, Hokfelt T, editors. Handbook of chemical neuroanatomy, peptide receptor, vol. 16, Part 1. Amsterdam: Elsevier; 2000. p. 375-475.
99. Dumont Y., Martel J.C., Fournier A., St Pierre S., Quirion R. Neuropeptide Y and neuropeptide Y receptor subtypes in brain and peripheral tissues. Prog. Neurobiol. 38:1992;125-167
100. 125I ]-GR231118: a high affinity radioligand to investigate neuropeptide Y Y1 and Y4 receptors Br. J. Pharmacol. 129:2000;37-46
101. Dumont Y, Redrobe JP, Quirion R. Neuropeptide Y receptors. In: Pangalos MN, Davies CH, editors. Understanding G protein-coupled receptors and their role in the CNS molecular and cellular meurobiology series. Oxford, UK: Oxford University Press; 2002. p. 372-401.
102. 3H ]BIBP3226 Neuroreport. 7:1996;901-904
103. Dumont Y., Thakur M., Beck-Sickinger A., Fournier A., Quirion R. Development and characterization of a highly selective neuropeptide Y Y5 receptor agonist radioligand: [(125)I][hPP(1-17), Ala(31), Aib(32)]NPY. Br. J. Pharmacol. 139:2003;1360-1368
104. Eguchi S., Hirata Y., Iwasaki H., Sato K., Watanabe T.X., Inui T., et al. Structure-activity relationship of adrenomedullin, a novel vasodilatory peptide, in cultured rat vascular smooth muscle cells. Endocrinology. 135:1994;2454-2458
105. Eguchi S., Hirata Y., Kano H., Sato K., Watanabe Y., Watanabe T.X., et al. Specific receptors for adrenomedullin in cultured rat vascular smooth muscle cells. FEBS Lett. 340:1994;226-230
106. Elliott R.L., Oliver R.M., Hammond M., Patterson T.A., She L., Hargrove D.M., et al. In vitro and in vivo characterization of 3-[2-[6-(2-tert- butoxyethoxy)pyridin-3-yl]-1H-imidazol-4-yl]benzonitrile hydrochloride salt, a potent and selective NPY5 receptor antagonist. J. Med. Chem. 46:2003;670-673
107. 3H ]BIBP3226 Eur. J. Pharmacol. 278:1995;239-242
108. Entzeroth M., Doods H.N., Wieland H.A., Wienen W. Adrenomedullin mediates vasodilation via CGRP1 receptors. Life Sci. 56:1995;L19-L25
109. Eriksson H., Berglund M.M., Holmberg S.K., Kahl U., Gehlert D.R., Larhammar D. The cloned guinea pig pancreatic polypeptide receptor Y4 resembles more the human Y4 than does the rat Y4. Regul. Pept. 75:1998;29-37
110. Esteban J., Chover A.J., Sanchez P.A., Mico J.A., Gibert-Rahola J. Central administration of neuropeptide Y induces hypothermia in mice. Possible interaction with central noradrenergic systems. Life Sci. 45:1989;2395-2400
111. Eva C., Keinanen K., Monyer H., Seeburg P., Sprengel R. Molecular cloning of a novel G protein-coupled receptor that may belong to the neuropeptide receptor family. FEBS Lett. 271:1990;81-84
112. Eva C., Oberto A., Sprengel R., Genazzani E. The murine NPY-1 receptor gene. Structure and delineation of tissue-specific expression. FEBS Lett. 314:1992;285-288
113. Evans B.N., Rosenblatt M.I., Mnayer L.O., Oliver K.R., Dickerson I.M. CGRP-RCP, a novel protein required for signal transduction at calcitonin gene-related peptide and adrenomedullin receptors. J. Biol. Chem. 275:2000;31438-31443
114. Feletou M., Nicolas J.P., Rodriguez M., Beauverger P., Galizzi J.P., Boutin J.A., et al. NPY receptor subtype in the rabbit isolated ileum. Br. J. Pharmacol. 127:1999;795-801
115. Fischer J.A., Sagar S.M., Martin J.B. Characterization and regional distrigution of calcitonin binding sites in the rat brain. Life Sci. 29:1981;663-671
116. Flood J.F., Hernandez E.N., Morley J.E. Modulation of memory processing by neuropeptide Y. Brain Res. 421:1987;280-290
117. Flood J.F., Mooradian A.D., Morley J.E. Characteristics of learning and memory in streptozotocin-induced diabetic mice. Diabetes. 39:1990;1391-1398
118. Flood J.F., Morley J.E. Differential effects of amylin on memory processing using peripheral and central routes of administration. Peptides. 13:1992;577-580
119. Fluhmann B., Muff R., Hunziker W., Fischer J.A., Born W. A human orphan calcitonin receptor-like structure. Biochem. Biophys. Res. Commun. 206:1995;341-347
120. Francoeur F., Gossard F., Hamet P., Tremblay J. Alternative splicing of natriuretic peptide A and B receptor transcripts in the rat brain. Clin. Exp. Pharmacol. Physiol. Suppl. 22:1995;S172-S174
121. Freed W.J., Perlow M.J., Wyatt R.J. Calcitonin: inhibitory effect on eating in rat. Science. 206:1979;850-852
122. Friedl A., Harmening C., Schmalz F., Schuricht B., Schiller M., Hamprecht B. Elevation by atrial natriuretic factors of cyclic GMP levels in astroglia-rich cultures from murine brain. J. Neurochem. 52:1989;589-597
123. Fuhlendorff J., Gether U., Aakerlund L., Langeland-Johansen N., Thogersen H., Melberg S.G., et al. [Leu31, Pro34]neuropeptide Y: a specific Y1 receptor agonist. Proc. Natl. Acad. Sci. U.S.A. 87:1990;182-186
124. Fujioka H., Okamura T., Toda N. Inhibition by adrenomedullin of amine release from adrenergic nerves in dog mesenteric arteries. Eur. J. Pharmacol. 385:1999;155-161
125. Fuller F., Porter J.G., Arfsten A.E., Miller J., Schilling J.W., Scarborough R.M., et al. Atrial natriuretic peptide clearance receptor. Complete sequence and functional expression of cDNA clones. J. Biol. Chem. 263:1988;9395-9401
126. Gardiner S.M., Compton A.M., Kemp P.A., Bennett T., Bose C., Foulkes R., et al. Antagonistic effect of human alpha-CGRP [8-37] on the in vivo regional haemodynamic actions of human alpha-CGRP. Biochem. Biophys. Res. Commun. 171:1990;938-943
127. Gardiner S.M., March J.E., Kemp P.A., Bennett T. Influence of CGRP (8-37), but not adrenomedullin (22-52), on the haemodynamic responses to lipopolysaccharide in conscious rats. Br. J. Pharmacol. 127:1999;1611-1618
128. Gardner D.G., Vlasuk G.P., Baxter J.D., Fiddes J.C., Lewicki J.A. Identification of atrial natriuretic factor gene transcripts in the central nervous system of the rat. Proc. Natl. Acad. Sci. U.S.A. 84:1987;2175-2179
129. Gehlert D.R., Beavers L.S., Johnson D., Gackenheimer S.L., Schober D.A., Gadski R.A. Expression cloning of a human brain neuropeptide Y Y2 receptor. Mol. Pharmacol. 49:1996;224-228
130. Gehlert D.R., Gackenheimer S.L. Differential distribution of neuropeptide Y Y1 and Y2 receptors in rat and guinea-pig brains. Neuroscience. 76:1997;215-224
131. 125I -labeled peptide YY binding sites in the rat brain Neurochem. Int. 21:1992;45-67
132. 125I ][Leu31, Pro34]peptide YY, is also a high affinity radioligand for human pancreatic polypeptide 1 receptors Eur. J. Pharmacol. 318:1996;485-490
133. Gehlert D.R., Schober D.A., Beavers L., Gadski R., Hoffman J.A., Smiley D.L., et al. Characterization of the peptide binding requirements for the cloned human pancreatic polypeptide-preferring receptor. Mol. Pharmacol. 50:1996;112-118
134. 125I ]Leu31, Pro34-PYY is a high affinity radioligand for rat PP1/Y4 and Y1 receptors: evidence for heterogeneity in pancreatic polypeptide receptors Peptides. 18:1997;397-401
135. Gehlert D.R., Yang P., George C., Wang Y., Schober D., Gackenheimer S., et al. Cloning and characterization of Rhesus monkey neuropeptide Y receptor subtypes. Peptides. 22:2001;343-350
136. Gerald C., Walker M.W., Criscione L., Gustafson E.L., Batzl-Hartmann C., Smith K.E., et al. A receptor subtype involved in neuropeptide-Y-induced food intake. Nature. 382:1996;168-171
137. Gerald C., Walker M.W., Vaysse P.J., He C., Branchek T.A., Weinshank R.L. Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/peptide YY Y2 receptor subtype. J. Biol. Chem. 270:1995;26758-26761
138. Gibson T.R., Wildey G.M., Manaker S., Glembotski C.C. Autoradiographic localization and characterization of atrial natriuretic peptide binding sites in the rat central nervous system and adrenal gland. J. Neurosci. 6:1986;2004-2011
139. Goldring S.R., Gorn A.H., Yamin M., Krane S.M., Wang J.T. Characterization of the structural and functional properties of cloned calcitonin receptor cDNAs. Horm. Metab. Res. 25:1993;477-480
140. Goy M.F., Oliver P.M., Purdy K.E., Knowles J.W., Fox J.E., Mohler P.J., et al. Evidence for a novel natriuretic peptide receptor that prefers brain natriuretic peptide over atrial natriuretic peptide. Biochem. J. 358:2001;379-387
141. Gregor P., Feng Y., DeCarr L.B., Cornfield L.J., McCaleb M.L. Molecular characterization of a second mouse pancreatic polypeptide receptor and its inactivated human homologue. J. Biol. Chem. 271:1996;27776-27781
142. Gregor P., Millham M.L., Feng Y., DeCarr L.B., McCaleb M.L., Cornfield L.J. Cloning and characterization of a novel receptor to pancreatic polypeptide, a member of the neuropeptide Y receptor family. FEBS Lett. 381:1996;58-62
143. Grove K.L., Campbell R.E., Ffrench-Mullen J.M., Cowley M.A., Smith M.S. Neuropeptide Y Y5 receptor protein in the cortical/limbic system and brainstem of the rat: expression on gamma-aminobutyric acid and corticotropin-releasing hormone neurons. Neuroscience. 100:2000;731-740
144. Gutkowska J., Antunes-Rodrigues J., McCann S.M. Atrial natriuretic peptide in brain and pituitary gland. Physiol. Rev. 77:1997;465-515
145. Hall J.M., Brain S.D. Interaction of amylin with calcitonin gene-related peptide receptors in the microvasculature of the hamster cheek pouch in vivo. Br. J. Pharmacol. 126:1999;280-284
146. Hall J.M., Siney L., Lippton H., Hyman A., Kang-Chang J., Brain S.D. Interaction of human adrenomedullin 13-52 with calcitonin gene-related peptide receptors in the microvasculature of the rat and hamster. Br. J. Pharmacol. 114:1995;592-597
147. Han S.P., Naes L., Westfall T.C. Inhibition of periarterial nerve stimulation-induced vasodilation of the mesenteric arterial bed by CGRP (8-37) and CGRP receptor desensitization. Biochem. Biophys. Res. Commun. 168:1990;786-791
148. Harfstrand A. Intraventricular administration of neuropeptide Y (NPY) induces hypotension, bradycardia and bradypnoea in the awake unrestrained male rat. Counteraction by NPY-induced feeding behaviour. Acta Physiol. Scand. 128:1986;121-123
149. Hartter E., Svoboda T., Ludvik B., Schuller M., Lell B., Kuenburg E., et al. Basal and stimulated plasma levels of pancreatic amylin indicate its co-secretion with insulin in humans. Diabetologia. 34:1991;52-54
150. Hay D.L., Howitt S.G., Conner A.C., Doods H., Schindler M., Poyner D.R. A comparison of the actions of BIBN4096BS and CGRP8-37 on CGRP and adrenomedullin receptors expressed on SK-N-MC, L6, Col29 and rat 2 cells. Br. J. Pharmacol. 137:2002;80-86
151. Hay D.L., Howitt S.G., Conner A.C., Schindler M., Smith D.M., Poyner D.R. CL/RAMP2 CL/RAMP3 produce pharmacologically distinct adrenomedullin receptors: a comparison of effects of adrenomedullin22-52, CGRP8-37 and BIBN4096BS. Br. J. Pharmacol. 140:2003;477-486
152. Hay D.L., Poyner D., Dickerson I. CGRP receptor heterogeneity: a role for receptor component protein? Trends Endocrinol. Metab. 14:2002;3-4
153. Heilig M., McLeod S., Brot M., Heinrichs S.C., Menzaghi F., Koob G.F., et al. Anxiolytic-like action of neuropeptide Y: mediation by Y1 receptors in amygdala, and dissociation from food intake effects. Neuropsychopharmacology. 8:1993;357-363
154. Henke H., Sigrist S., Lang W., Schneider J., Fischer J.A. Comparison of binding sites for the calcitonin gene-related peptides I and II in man. Brain Res. 410:1987;404-408
155. Henke H., Tschopp F.A., Fischer J.A. Distinct binding sites for calcitonin gene-related peptide and salmon calcitonin in rat central nervous system. Brain Res. 360:1985;165-171
156. Herzog H., Darby K., Ball H., Hort Y., Beck-Sickinger A., Shine J. Overlapping gene structure of the human neuropeptide Y receptor subtypes Y1 and Y5 suggests coordinate transcriptional regulation. Genomics. 41:1997;315-319
157. Herzog H., Hort Y.J., Ball H.J., Hayes G., Shine J., Selbie L.A. Cloned human neuropeptide Y receptor couples to two different second messenger systems. Proc. Natl. Acad. Sci. U.S.A. 89:1992;5794-5798
158. Hilton J.M., Chai S.Y., Sexton P.M. In vitro autoradiographic localization of the calcitonin receptor isoforms, C1a and C1b, in rat brain. Neuroscience. 69:1995;1223-1237
159. Hilton J.M., Mitchelhill K.I., Pozvek G., Dowton M., Quiza M., Sexton P.M. Purification of calcitonin-like peptides from rat brain and pituitary. Endocrinology. 139:1998;982-992
160. Himeno A., Niwa M., Nakao K., Suga S., Yamashita K., Kataoka Y., et al. C-type natriuretic peptide-22 differentiates between natriuretic peptide receptors in rat choroid plexus and subfornical organ. Eur. J. Pharmacol. 215:1992;337-340
161. Hinson J.P., Kapas S., Smith D.M. Adrenomedullin, a multifunctional regulatory peptide. Endocr. Rev. 21:2000;138-167
162. Hinson J.P., Thomson L.M., Kapas S. Adrenomedullin and CGRP receptors mediate different effects in the rat adrenal cortex. Endocr. Res. 24:1998;725-728
163. Hipskind P.A., Lobb K.L., Nixon J.A., Britton T.C., Bruns R.F., Catlow J., et al. Potent and selective 1, 2, 3-trisubstituted indole NPY Y-1 antagonists. J. Med. Chem. 40:1997;3712-3714
164. Hirata M., Chang C.H., Murad F. Stimulatory effects of atrial natriuretic factor on phosphoinositide hydrolysis in cultured bovine aortic smooth muscle cells. Biochim. Biophys. Acta. 1010:1989;346-351
165. Hirose S., Hagiwara H., Takei Y. Comparative molecular biology of natriuretic peptide receptors. Can. J. Physiol. Pharmacol. 79:2001;665-672
166. Hjelmqvist H., Keil R., Mathai M., Hubschle T., Gerstberger R. Vasodilation and glomerular binding of adrenomedullin in rabbit kidney are not CGRP receptor mediated. Am. J. Physiol. 273:1997;R716-R724
167. Howitt S.G., Poyner D.R. The selectivity and structural determinants of peptide antagonists at the CGRP receptor of rat, L6 myocytes. Br. J. Pharmacol. 121:1997;1000-1004
168. Hu Y., Bloomquist B.T., Cornfield L.J., DeCarr L.B., Flores-Riveros J.R., Friedman L., et al. Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior. J. Biol. Chem. 271:1996;26315-26319
169. Hughes S.R., Brain S.D. A calcitonin gene-related peptide (CGRP) antagonist (CGRP8-37) inhibits microvascular responses induced by CGRP and capsaicin in skin. Br. J. Pharmacol. 104:1991;738-742
170. Husmann K., Born W., Fischer J.A., Muff R. Three receptor-activity- modifying proteins define calcitonin gene-related peptide or adrenomedullin selectivity of the mouse calcitonin-like receptor in COS-7 cells. Biochem. Pharmacol. 66:2003;2107-2115
171. Iitake K., Share L., Crofton J.T., Brooks D.P., Ouchi Y., Blaine E.H. Central atrial natriuretic factor reduces vasopressin secretion in the rat. Endocrinology. 119:1986;438-440
172. Imada T., Takayanagi R., Inagami T. Changes in the content of atrial natriuretic factor with the progression of hypertension in spontaneously hypertensive rats. Biochem. Biophys. Res. Commun. 133:1985;759-765
173. Imaizumi T., Takeshita A., Higashi H., Nakamura M. alpha-ANP alters reflex control of lumbar and renal sympathetic nerve activity and heart rate. Am. J. Physiol. 253:1987;H1136-H1140
174. Inui A., Neuropeptide Y feeding receptors: are multiple subtypes involved? Trends Pharmacol. Sci. 20:1999;43-46
175. Itoh H., Nakao K., Katsuura G., Morii N., Yamada T., Shiono S., et al. Possible involvement of central atrial natriuretic polypeptide in regulation of hypothalamo-pituitary-adrenal axis in conscious rats. Neurosci. Lett. 69:1986;254-258
176. Itoh H., Nakao K., Morii N., Yamada T., Shiono S., Sakamoto M., et al. Central action of atrial natriuretic polypeptide on blood pressure in conscious rats. Brain Res. Bull. 16:1986;745-749
177. Itoh H., Nakao K., Saito Y., Yamada T., Shirakami G., Mukoyama M., et al. Radioimmunoassay for brain natriuretic peptide (BNP) detection of BNP in canine brain. Biochem. Biophys. Res. Commun. 158:1989;120-128
178. Jacques D., Cadieux A., Dumont Y., Quirion R. Apparent affinity and potency of BIBP3226, a non-peptide neuropeptide Y receptor antagonist, on purported neuropeptide Y Y1, Y2 and Y3 receptors. Eur. J. Pharmacol. 278:1995;R3-R5
179. Jacques D., Dumont Y., Fournier A., Quirion R. Characterization of neuropeptide Y receptor subtypes in the normal human brain, including the hypothalamus. Neuroscience. 79:1997;129-148
180. Jacques D, Dumont Y, Van Rossum D, Quirion R. Calcitonin gene-related peptide (CGRP), amylin and adrenomedullin anatomical localization and biological functions in the mammalian and human brains. In: Quirion R, Bjorklund A, Hokfelt T, editors. Handbook of chemical neuroanatomy. Peptide receptor, vol. 16, Part 1. Amsterdam: Elservier; 2000. p. 301-74.
181. Jacques D., Tong Y., Dumont Y., Shen S.H., Quirion R. Expression of the neuropeptide Y Y1 receptor mRNA in the human brain: an in situ hybridization study. Neuroreport. 7:1996;1053-1056
182. Jansen I. Characterization of calcitonin gene-related peptide (CGRP) receptors in guinea pig basilar artery. Neuropeptides. 21:1992;73-79
183. Jansen-Olesen I., Mortensen A., Edvinsson L. Calcitonin gene-related peptide is released from capsaicin-sensitive nerve fibres and induces vasodilatation of human cerebral arteries concomitant with activation of adenylyl cyclase. Cephalalgia. 16:1996;310-316
184. Jaszberenyi M., Bujdoso E., Telegdy G. Effects of C-type natriuretic peptide on pituitary-adrenal activation in rats. Neuroreport. 9:1998;2601-2603
185. Jhamandas J.H., Harris K.H., Cho C., Fu W., MacTavish D. Human amylin actions on rat cholinergic basal forebrain neurons: antagonism of beta-amyloid effects. J. Neurophysiol. 89:2003;2923-2930
186. Jin H.K., Chen Y.F., Yang R.H., Meng Q.C., Oparil S. Impaired release of atrial natriuretic factor in NaCl-loaded spontaneously hypertensive rats. Hypertension. 11:1988;739-744
187. Jolicoeur F.B., Bouali S.M., Fournier A., St Pierre S. Mapping of hypothalamic sites involved in the effects of NPY on body temperature and food intake. Brain Res. Bull. 36:1995;125-129
188. Jolicoeur F.B., Bouali S.M., Michaud J.N., Menard D., Fournier A., St Pierre S. Structure-activity analysis of the motor effects of neuropeptide Y. Brain Res. Bull. 37:1995;1-4
189. Jolicoeur F.B., Menard D., Fournier A., St Pierre S. Structure-activity analysis of CGRP's neurobehavioral effects. Ann. N.Y. Acad. Sci. 657:1992;155-163
190. Jolicoeur F.B., Michaud J.N., Rivest R., Menard D., Gaudin D., Fournier A., et al. Neurobehavioral profile of neuropeptide Y. Brain Res. Bull. 26:1991;265-268
191. Juaneda C., Dumont Y., Chabot J., Quirion R. Autoradiographic distribution of adrenomedullin receptors in the rat brain. Eur. J. Pharmacol. 421:2001;R1-R2
192. Juaneda C., Dumont Y., Chabot J.-G., Fournier A., Quirion R. Adrenomedullin receptor binding sites in rat brain and peripheral tissues. Eur. J. Pharmacol. 474:2003;165-174
193. Juaneda C., Dumont Y., Quirion R. The molecular pharmacology of CGRP and related peptide receptor subtypes. Trends Pharmacol. Sci. 21:2000;432-438
194. Kalra S.P., Crowley W.R. Differential effects of pancreatic polypeptide on luteinizing hormone release in female rats. Neuroendocrinology. 38:1984;511-513
195. Kanatani A., Ishihara A., Iwaasa H., Nakamura K., Okamoto O., Hidaka M., et al. L-152, 804: orally active and selective neuropeptide Y Y5 receptor antagonist. Biochem. Biophys. Res. Commun. 272:2000;169-173
196. Kanatani A., Kanno T., Ishihara A., Hata M., Sakuraba A., Tanaka T., et al. The novel neuropeptide Y Y(1) receptor antagonist J-104870: a potent feeding suppressant with oral bioavailability. Biochem. Biophys. Res. Commun. 266:1999;88-91
197. Kanatsuka A., Makino H., Ohsawa H., Tokuyama Y., Yamaguchi T., Yoshida S., et al. Secretion of islet amyloid polypeptide in response to glucose. FEBS Lett. 259:1989;199-201
198. Kanatsuka A., Makino H., Yamaguchi T., Ohsawa H., Tokuyama Y., Saitoh T., et al. Islet amyloid polypeptide/amylin in pancreatic beta-cell line derived from transgenic mouse insulinoma. Diabetes. 41:1992;1409-1414
199. Kaneko T., Shirakami G., Nakao K., Nagata I., Nakagawa O., Hama N., et al. C-type natriuretic peptide (CNP) is the major natriuretic peptide in human cerebrospinal fluid. Brain Res. 612:1993;104-109
200. Kapas S., Martinez A., Cuttitta F., Hinson J.P. Local production and action of adrenomedullin in the rat adrenal zona glomerulosa. J. Endocrinol. 156:1998;477-484
201. 125I ]neuropeptide Y receptor binding sites in rat spinal cord and the effects of neonatal capsaicin, dorsal rhizotomy and peripheral axotomy Brain Res. 574:1992;333-337
202. Kashiba H., Ueda Y. Acupuncture to the skin induces release of substance P and calcitonin gene-related peptide from peripheral terminals of primary sensory neurons in the rat. Am. J. Chin. Med. 19:1991;189-197
203. Kashiwagi M., Katafuchi T., Kato A., Inuyama H., Ito T., Hagiwara H., et al. Cloning and properties of a novel natriuretic peptide receptor, NPR-D. Eur. J. Biochem. 233:1995;102-109
204. Kask A., Harro J., von Horsten S., Redrobe J.P., Dumont Y., Quirion R. The neurocircuitry and receptor subtypes mediating anxiolytic-like effects of neuropeptide Y. Neurosci. Biobehav. Rev. 26:2002;259-283
205. Katafuchi T., Hamano K., Kikumoto K., Minamino N. Identification of second and third calcitonin receptor-stimulating peptides in porcine brain. Biochem. Biophys. Res. Commun. 308:2003;445-451
206. Katafuchi T., Kikumoto K., Hamano K., Kangawa K., Matsuo H., Minamino N. Calcitonin receptor-stimulating peptide, a new member of the calcitonin gene-related peptide family. Its isolation from porcine brain, structure, tissue distribution, and biological activity. J. Biol. Chem. 278:2003;12046-12054
207. Katsuura G., Nakamura M., Inouye K., Kono M., Nakao K., Imura H. Regulatory role of atrial natriuretic polypeptide in water drinking in rats. Eur. J. Pharmacol. 121:1986;285-287
208. Kawata M., Nakao K., Morii N., Kiso Y., Yamashita H., Imura H., et al. Atrial natriuretic polypeptide: topographical distribution in the rat brain by radioimmunoassay and immunohistochemistry. Neuroscience. 16:1985;521-546
209. Kawata M., Ueda S., Nakao K., Morii N., Kiso Y., Imura H., et al. Immuohistochemical demonstration of alpha-atrial natriretic plypeptide- containing neurons in the rat brain. Histochemistry. 83:1985;1-3
210. Kellner M., Diehl I., Knaudt K., Schule C., Jahn H., Wiedemann K. C-type natriuretic peptide exerts stimulatory effects on the corticotropin-releasing hormone-induced secretion of hormones in normal man. Eur. J. Endocrinol. 136:1997;388-393
211. Kennedy S.P., Sun D., Oleynek J.J., Hoth C.F., Kong J., Hill R.J. Expression of the rat adrenomedullin receptor or a putative human adrenomedullin receptor does not correlate with adrenomedullin binding or functional response. Biochem. Biophys. Res. Commun. 244:1998;832-837
212. King P.J., Williams G., Doods H., Widdowson P.S. Effect of a selective neuropeptide Y Y2 receptor antagonist, BIIE0246 on neuropeptide Y release. Eur. J. Pharmacol. 396:2000;R1-R3
213. Kitamura K., Kangawa K., Kawamoto M., Ichiki Y., Nakamura S., Matsuo H., et al. Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma. Biochem. Biophys. Res. Commun. 192:1993;553-560
214. Kojima M., Minamino N., Kangawa K., Matsuo H. Cloning sequence analysis of a cDNA encoding a precursor for rat C-type natriuretic peptide (CNP). FEBS Lett. 276:1990;209-213
215. Koller K.J., Lowe D.G., Bennett G.L., Minamino N., Kangawa K., Matsuo H., et al. Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP). Science. 252:1991;120-123
216. Komatsu K., Tanaka I., Funai T., Ichiyama A., Yoshimi T. Increased level of atrial natriuretic peptide messenger RNA in the hypothalamus and brainstem of spontaneously hypertensive rats. J. Hypertens. 10:1992;17-23
217. Komatsu Y., Nakao K., Suga S., Ogawa Y., Mukoyama M., Arai H., et al. C-type natriuretic peptide (CNP) in rats and humans. Endocrinology. 129:1991;1104-1106
218. Konrad E.M., Thibault G., Schiffrin E.L. Atrial natriuretic factor binding sites in rat area postrema: autoradiographic study. Am. J. Physiol. 263:1992;R747-R755
219. Kopp J., Xu Z.Q., Zhang X., Pedrazzini T., Herzog H., Kresse A., et al. Expression of the neuropeptide Y Y1 receptor in the CNS of rat and of wild-type and Y1 receptor knock-out mice. Focus on immunohistochemical localization(1). Neuroscience. 111:2002;443-532
220. Krahn D.D., Gosnell B.A., Levine A.S., Morley J.E. Effects of calcitonin gene-related peptide on food intake. Peptides. 5:1984;861-864
221. Krause J., Eva C., Seeburg P.H., Sprengel R. Neuropeptide Y1 subtype pharmacology of a recombinantly expressed neuropeptide receptor. Mol. Pharmacol. 41:1992;817-821
222. Kuestner R.E., Elrod R.D., Grant F.J., Hagen F.S., Kuijper J.L., Matthewes S.L., et al. Cloning and characterization of an abundant subtype of the human calcitonin receptor. Mol. Pharmacol. 46:1994;246-255
223. Kuhn M. Structure, regulation, and function of mammalian membrane guanylyl cyclase receptors, with a focus on guanylyl cyclase-A. Circ. Res. 93:2003;700-709
224. Kuwasako K., Kitamura K., Nagoshi Y., Eto T. Novel calcitonin-(8-32)- sensitive adrenomedullin receptors derived from co-expression of calcitonin receptor with receptor activity-modifying proteins. Biochem. Biophys. Res. Commun. 301:2003;460-464
225. Larhammar D. Evolution of neuropeptide Y, peptide YY and pancreatic polypeptide. Regul. Pept. 62:1996;1-11
226. Larhammar D. Structural diversity of receptors for neuropeptide Y, peptide YY and pancreatic polypeptide. Regul. Pept. 65:1996;165-174
227. Larhammar D., Blomqvist A.G., Yee F., Jazin E., Yoo H., Wahlestedt C. Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type. J. Biol. Chem. 267:1992;10935-10938
228. Larhammar D., Wraith A., Berglund M.M., Holmberg S.K., Lundell I. Origins of the many NPY-family receptors in mammals. Peptides. 22:2001;295-307
229. Larsen P.J., Sheikh S.P., Jakobsen C.R., Schwartz T.W., Mikkelsen J.D. Regional distribution of putative NPY Y1 receptors and neurons expressing Y1 mRNA in forebrain areas of the rat central nervous system. Eur. J. Neurosci. 5:1993;1622-1637
230. Lecklin A., Lundell I., Salmela S., Mannisto P.T., Beck-Sickinger A.G., Larhammar D. Agonists for neuropeptide Y receptors Y(1) and Y(5) stimulate different phases of feeding in guinea pigs. Br. J. Pharmacol. 139:2003;1433-1440
231. Lin H.Y., Harris T.L., Flannery M.S., Aruffo A., Kaji E.H., Gorn A., et al. Expression cloning of an adenylate cyclase-coupled calcitonin receptor. Science. 254:1991;1022-1024
232. Lorenzo A., Razzaboni B., Weir G.C., Yankner B.A. Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus. Nature. 368:1994;756-760
233. Luebke A.E., Dahl G.P., Roos B.A., Dickerson I.M. Identification of a protein that confers calcitonin gene-related peptide responsiveness to oocytes by using a cystic fibrosis transmembrane conductance regulator assay. Proc. Natl. Acad. Sci. U.S.A. 93:1996;3455-3460
234. Lundell I., Blomqvist A.G., Berglund M.M., Schober D.A., Johnson D., Statnick M.A., et al. Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY. J. Biol. Chem. 270:1995;29123-29128
235. Lundell I., Eriksson H., Marklund U., Larhammar D. Cloning and characterization of the guinea pig neuropeptide Y receptor Y5. Peptides. 22:2001;357-363
236. Lundell I., Statnick M.A., Johnson D., Schober D.A., Starback P., Gehlert D.R., et al. The cloned rat pancreatic polypeptide receptor exhibits profound differences to the orthologous receptor. Proc. Natl. Acad. Sci. U.S.A. 93:1996;5111-5115
237. Lutz T.A., Rossi R., Althaus J., Del Prete E., Scharrer E. Amylin reduces food intake more potently than calcitonin gene-related peptide (CGRP) when injected into the lateral brain ventricle in rats. Peptides. 19:1998;1533-1540
238. Lutz T.A., Senn M., Althaus J., Del Prete E., Ehrensperger F., Scharrer E. Lesion of the area postrema/nucleus of the solitary tract (AP/NTS) attenuates the anorectic effects of amylin and calcitonin gene-related peptide (CGRP) in rats. Peptides. 19:1998;309-317
239. Lutz T.A., Tschudy S., Rushing P.A., Scharrer E. Amylin receptors mediate the anorectic action of salmon calcitonin (sCT). Peptides. 21:2000;233-238
240. 125I -neuropeptide Y imply receptor heterogeneity J. Neurosci. 9:1989;2607-2619
241. Ma W., Chabot J.-G., Powell K.J., Jhamandas K., Dickerson I.M., Quirion R. Localization and modulation of calcitonin gene-related peptide-receptor component protein-immunoreactive cells in the rat central and peripheral nervous systems. Neuroscience. 120:2003;677-694
242. Ma W., Zheng W.H., Kar S., Quirion R. Morphine treatment induced calcitonin gene-related peptide and substance P increases in cultured dorsal root ganglion neurons. Neuroscience. 99:2000;529-539
243. Maack T. Receptors of atrial natriuretic factor. Annu. Rev. Physiol. 54:1992;11-27
244. Maack T., Suzuki M., Almeida F.A., Nussenzveig D., Scarborough R.M., McEnroe G.A., et al. Physiological role of silent receptors of atrial natriuretic factor. Science. 238:1987;675-678
245. MacKerell A.D. Jr. Molecular modeling and dynamics of neuropeptide Y. J. Comput. Aided Mol. Des. 2:1988;55-63
246. Maggi C.A., Chiba T., Giuliani S. Human alpha-calcitonin gene-related peptide-(8-37) as an antagonist of exogenous and endogenous calcitonin gene-related peptide. Eur. J. Pharmacol. 192:1991;85-88
247. Malmstrom R.E., Alexandersson A., Balmer K.C., Weilitz J. In vivo characterization of the novel neuropeptide Y Y1 receptor antagonist H 409/22. J. Cardiovasc. Pharmacol. 36:2000;516-525
248. Malmstrom R.E., Hokfelt T., Bjorkman J.A., Nihlen C., Bystrom M., Ekstrand A.J., et al. Characterization and molecular cloning of vascular neuropeptide Y receptor subtypes in pig and dog. Regul. Pept. 75:1998;55-70
249. 125I ]peptide YY receptor sites Neuroscience. 36:1990;255-283
250. Martel J.C., St Pierre S., Quirion R. Neuropeptide Y receptors in rat brain: autoradiographic localization. Peptides. 7:1986;55-60
251. Maton P.N., Pradhan T., Zhou Z.C., Gardner J.D., Jensen R.T. Activities of calcitonin gene-related peptide (CGRP) and related peptides at the CGRP receptor. Peptides. 11:1990;485-489
252. Matsumoto M., Nomura T., Momose K., Ikeda Y., Kondou Y., Akiho H., et al. Inactivation of a novel neuropeptide Y/peptide YY receptor gene in primate species. J. Biol. Chem. 271:1996;27217-27220
253. May P.C., Boggs L.N., Fuson K.S. Neurotoxicity of human amylin in rat primary hippocampal cultures: similarity to Alzheimer's disease amyloid-beta neurotoxicity. J. Neurochem. 61:1993;2330-2333
254. McLatchie L.M., Fraser N.J., Main M.J., Wise A., Brown J., Thompson N., et al. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature. 393:1998;333-339
255. McLean L.R., Buck S.H., Krstenansky J.L. Examination of the role of the amphipathic alpha-helix in the interaction of neuropeptide Y and active cyclic analogues with cell membrane receptors and dimyristoylphosphatidylcholine. Biochemistry. 29:1990;2016-2022
256. McNally J.J., Youngman M.A., Lovenberg T.W., Nepomuceno D., Wilson S., Dax S.L. N-Acylated alpha-(3-pyridylmethyl)-beta-aminotetralin antagoinists of the human neuropeptide Y Y5 receptor. Bioorg. Med. Chem. Lett. 10:2000;1641-1643
257. McNally J.J., Youngman M.A., Lovenberg T.W., Nepomuceno D.H., Wilson S.J., Dax S.L. N-(sulfonamido)alkyl[tetrahydro-1H-benzo[e]indol-2-yl]amines: potent antagonists of human neuropeptide Y Y5 receptor. Bioorg. Med. Chem. Lett. 10:2000;213-216
258. Menard D.P., Van Rossum D., Kar S., Jolicoeur F.B., Jhamandas K., Quirion R. Tolerance to the antinociceptive properties of morphine in the rat spinal cord: alteration of calcitonin gene-related peptide-like immunostaining and receptor binding sites. J. Pharmacol. Exp. Ther. 273:1995;887-894
259. Menard D.P., Van Rossum D., Kar S., Quirion R. Alteration of calcitonin gene related peptide and its receptor binding sites during the development of tolerance to mu and delta opioids. Can. J. Physiol. Pharmacol. 73:1995;1089-1095
260. Menard D.P., Van Rossum D., Kar S., St Pierre S., Sutak M., Jhamandas K., et al. A calcitonin gene-related peptide receptor antagonist prevents the development of tolerance to spinal morphine analgesia. J. Neurosci. 16:1996;2342-2351
261. Michel M.C., Beck-Sickinger A., Cox H., Doods H.N., Herzog H., Larhammar D., et al. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors. Pharmacol. Rev. 50:1998;143-150
262. Mimeault M., Fournier A., Dumont Y., St Pierre S., Quirion R. Comparative affinities and antagonistic potencies of various human calcitonin gene-related peptide fragments on calcitonin gene-related peptide receptors in brain and periphery. J. Pharmacol. Exp. Ther. 258:1991;1084-1090
263. Mimeault M., Quirion R., Dumont Y., St Pierre S., Fournier A. Structure-activity study of hCGRP8-37, a calcitonin gene-related peptide receptor antagonist. J. Med. Chem. 35:1992;2163-2168
264. Minamino N., Aburaya M., Ueda S., Kangawa K., Matsuo H. The presence of brain natriuretic peptide of 12, 000 daltons in porcine heart. Biochem. Biophys. Res. Commun. 155:1988;740-746
265. Minamino N., Kangawa K., Matsuo H. N-terminally extended form of C-type natriuretic peptide (CNP-53) identified in porcine brain. Biochem. Biophys. Res. Commun. 170:1990;973-979
266. Misono K.S. Natriuretic peptide receptor: structure and signaling. Mol. Cell Biochem. 230:2002;49-60
267. Mollereau C., Gouarderes C., Dumont Y., Kotani M., Detheux M., Doods H., et al. Agonist and antagonist activities on human NPFF(2) receptors of the NPY ligands GR231118 and BIBP3226. Br. J. Pharmacol. 133:2001;1-4
268. Mollereau C., Mazarguil H., Marcus D., Quelven I., Kotani M., Lannoy V., et al. Pharmacological characterization of human NPFF(1) and NPFF(2) receptors expressed in CHO cells by using NPY Y(1) receptor antagonists. Eur. J. Pharmacol. 451:2002;245-256
269. Montkowski A., Jahn H., Strohle A., Poettig M., Holsboer F., Wiedemann K. C-type natriuretic peptide exerts effects opposing those of atrial natriuretic peptide on anxiety-related behaviour in rats. Brain Res. 792:1998;358-360
270. Moreno M.J., Terron J.A., Stanimirovic D.B., Doods H., Hamel E. Characterization of calcitonin gene-related peptide (CGRP) receptors and their receptor-activity-modifying proteins (RAMPs) in human brain microvascular and astroglial cells in culture. Neuropharmacology. 42:2002;270-280
271. Morfis M., Christopoulos A., Sexton P.M. RAMPs: 5 years on, where to now? Trends Pharmacol. Sci. 24:2003;596-601
272. Morii N., Nakao K., Itoh H., Sugawara A., Sakamoto M., Yamada T., et al. Increased tissue level of atrial natriuretic polypeptide in the hypothalamus and septum of spontaneously hypertensive rats. J. Hypertens. Suppl. 4:1986;S309-S312
273. Morley J.E., Flood J.F. Psychosocial aspects of diabetes mellitus in older persons. J. Am. Geriatr. Soc. 38:1990;605-606
274. Morley J.E., Flood J.F. Amylin decreases food intake in mice. Peptides. 12:1991;865-869
275. Morley J.E., Flood J.F., Horowitz M., Morley P.M., Walter M.J. Modulation of food intake by peripherally administered amylin. Am. J. Physiol. 267:1994;R178-R184
276. Muff R., Born W., Fischer J.A. Calcitonin, calcitonin gene-related peptide, adrenomedullin and amylin: homologous peptides, separate receptors and overlapping biological actions. Eur. J. Endocrinol. 133:1995;17-20
277. Muff R., Born W., Fischer J.A. Receptors for calcitonin, calcitonin gene related peptide, amylin, and adrenomedullin. Can. J. Physiol. Pharmacol. 73:1995;963-967
278. Muff R., Buhlmann N., Fischer J.A., Born W. An amylin receptor is revealed following co-transfection of a calcitonin receptor with receptor activity modifying proteins-1 or -3. Endocrinology. 140:1999;2924-2927
279. Muller D., Olcese J., Mukhopadhyay A.K., Middendorff R. Guanylyl cyclase-B represents the predominant natriuretic peptide receptor expressed at exceptionally high levels in the pineal gland. Mol. Brain Res. 75:2000;321-329
280. Murakami Y., Hara H., Okada T., Hashizume H., Kii M., Ishihara Y., et al. 1, 3-Disubstituted benzazepines as novel, potent, selective neuropeptide Y Y1 receptor antagonists. J. Med. Chem. 42:1999;2621-2632
281. Murakami Y., Kato Y., Tojo K., Inoue T., Yanaihara N., Imura H. Stimulation of growth hormone secretion by central administration of atrial natriuretic polypeptide in the rat. Endocrinology. 122:1988;2103-2108
282. Nakamura M., Aoki Y., Hirano D. Cloning and functional expression of a cDNA encoding a mouse type 2 neuropeptide Y receptor. Biochim. Biophys. Acta. 1284:1996;134-137
283. Nakamura M., Sakanaka C., Aoki Y., Ogasawara H., Tsuji T., Kodama H., et al. Identification of two isoforms of mouse neuropeptide Y-Y1 receptor generated by alternative splicing. Isolation, genomic structure, and functional expression of the receptors. J. Biol. Chem. 270:1995;30102-30110
284. Nakamura M., Yokoyama M., Watanabe H., Matsumoto T. Molecular cloning, organization and localization of the gene for the mouse neuropeptide Y-Y5 receptor. Biochim. Biophys. Acta. 1328:1997;83-89
285. Nakao K., Itoh H., Saito Y., Mukoyama M., Ogawa Y. The natriuretic peptide family. Curr. Opin. Nephrol. Hypertens. 5:1996;4-11
286. Nakao K., Morii N., Itoh H., Yamada T., Shiono S., Sugawara A., et al. Atrial natriuretic polypeptide in brain - implication of central cardiovascular control. Klin. Wochenschr. 65(Suppl. 8):1987;103-108
287. Nakao K., Ogawa Y., Suga S., Imura H. Molecular biology and biochemistry of the natriuretic peptide system. I: Natriuretic peptides. J. Hypertens. 10:1992;907-912
288. Nandha K.A., Taylor G.M., Smith D.M., Owji A.A., Byfield P.G., Ghatei M.A., et al. Specific adrenomedullin binding sites and hypotension in the rat systemic vascular bed. Regul. Pept. 62:1996;145-151
289. Nishikimi T., Horio T., Yoshihara F., Nagaya N., Matsuo H., Kangawa K. Effect of adrenomedullin on cAMP and cGMP levels in rat cardiac myocytes and nonmyocytes. Eur. J. Pharmacol. 353:1998;337-344
290. Nonoguchi H., Sands J.M., Knepper M.A. Atrial natriuretic factor inhibits vasopressin-stimulated osmotic water permeability in rat inner medullary collecting duct. J. Clin. Invest. 82:1988;1383-1390
291. Norman M.H., Chen N., Chen Z., Fotsch C., Hale C., Han N., et al. Structure-activity relationships of a series of Pyrrolo[3, 2-d]pyrimidine derivatives and related compounds as neuropeptide Y5 receptor antagonists. J. Med. Chem. 43:2000;4288-4312
292. Ohyama Y., Miyamoto K., Saito Y., Minamino N., Kangawa K., Matsuo H. Cloning and characterization of two forms of C-type natriuretic peptide receptor in rat brain. Biochem. Biophys. Res. Commun. 183:1992;743-749
293. Owji A.A., Smith D.M., Coppock H.A., Morgan D.G., Bhogal R., Ghatei M.A., et al. An abundant and specific binding site for the novel vasodilator adrenomedullin in the rat. Endocrinology. 136:1995;2127-2134
294. Parker E.M., Babij C.K., Balasubramaniam A., Burrier R.E., Guzzi M., Hamud F., et al. GR231118 (1229U91) and other analogues of the C-terminus of neuropeptide Y are potent neuropeptide Y Y1 receptor antagonists and neuropeptide Y Y4 receptor agonists. Eur. J. Pharmacol. 349:1998;97-105
295. Pinto A., Sekizawa K., Yamaya M., Ohrui T., Jia Y.X., Sasaki H. Effects of adrenomedullin and calcitonin gene-related peptide on airway and pulmonary vascular smooth muscle in guinea-pigs. Br. J. Pharmacol. 119:1996;1477-1483
296. Potter E.K., Barden J.A., McCloskey M.J., Selbie L.A., Tseng A., Herzog H., et al. A novel neuropeptide Y analog, N-acetyl [Leu28, Leu31]neuropeptide Y-(24-36), with functional specificity for the presynaptic (Y2) receptor. Eur. J. Pharmacol. 267:1994;253-262
297. Powell K.J., Ma W., Sutak M., Doods H., Quirion R., Jhamandas K. Blockade and reversal of spinal morphine tolerance by peptide and non-peptide calcitonin gene-related peptide receptor antagonists. Br. J. Pharmacol. 131:2000;875-884
298. Powell K.J., Quirion R., Jhamandas K. Inhibition of neurokinin-1- substance P receptor and prostanoid activity prevents and reverses the development of morphine tolerance in vivo and the morphine-induced increase in CGRP expression in cultured dorsal root ganglion neurons. Eur. J. Neurosci. 18:2003;1572-1583
299. Poyner D. Pharmacology of receptors for calcitonin gene-related peptide and amylin. Trends Pharmacol. Sci. 16:1995;424-428
300. Poyner D., Marshall I. CGRP receptors: beyond the CGRP(1)-CGRP(2) subdivision? Trends Pharmacol. Sci. 22:2001;223
301. Poyner D.R., Sexton P.M., Marshall I., Smith D.M., Quirion R., Born W., et al. International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors. Pharmacol. Rev. 54:2002;233-246
302. Poyner D.R., Soomets U., Howitt S.G., Langel U. Structural determinants for binding to CGRP receptors expressed by human SK-N-MC and Col 29 cells: studies with chimeric and other peptides. Br. J. Pharmacol. 124:1998;1659-1666
303. Poyner D.R., Taylor G.M., Tomlinson A.E., Richardson A.G., Smith D.M. Characterization of receptors for calcitonin gene-related peptide and adrenomedullin on the guinea-pig vas deferens. Br. J. Pharmacol. 126:1999;1276-1282
304. Quirion R. Atrial natriuretic factors and the brain. Can. J. Physiol. Pharmacol. 66:1988;253-254
305. Quirion R. Atrial natriuretic factors and the brain: an update. Trends Neurosci. 11:1988;58-62
306. Quirion R. Receptor sites for atrial natriuretic factors in brain and associated structures: an overview. Cell Mol. Neurobiol. 9:1989;45-55
307. Quirion R., Dalpe M., Dam T.V. Characterization and distribution of receptors for the atrial natriuretic peptides in mammalian brain. Proc. Natl. Acad. Sci. U.S.A. 83:1986;174-178
308. Quirion R., Dalpe M., De Lean A., Gutkowska J., Cantin M., Genest J. Atrial natriuretic factor (ANF) binding sites in brain and related structures. Peptides. 5:1984;1167-1172
309. Quirion R., Dalpe M., Delean A. Characterization, distribution and plasticity of atrial natriuretic factor binding sites in brain. Can. J. Physiol. Pharmacol. 66:1988;280-287
310. Quirion R., Martel J.C., Dumont Y., Cadieux A., Jolicoeur F., St Pierre S., et al. Neuropeptide Y receptors: autoradiographic distribution in the brain and structure-activity relationships. Ann. N.Y. Acad. Sci. 611:1990;58-72
311. Quirion R., Van Rossum D., Dumont Y., St Pierre S., Fournier A. Characterization of CGRP1 and CGRP2 receptor subtypes. Ann. N.Y. Acad. Sci. 657:1992;88-105
312. Redrobe J.P., Dumont Y., Fournier A., Quirion R. The neuropeptide Y (NPY) Y1 receptor subtype mediates NPY-induced antidepressant-like activity in the mouse forced swimming test. Neuropsychopharmacology. 26:2002;615-624
313. Redrobe J.P., Dumont Y., Quirion R. Neuropeptide Y (NPY) and depression: from animal studies to the human condition. Life Sci. 71:2002;2921-2937
314. Redrobe J.P., Dumont Y., St Pierre J.A., Quirion R. Multiple receptors for neuropeptide Y in the hippocampus: putative roles in seizures and cognition. Brain Res. 848:1999;153-166
315. Reidelberger R.D., Kelsey L., Heimann D. Effects of amylin-related peptides on food intake, meal patterns, and gastric emptying in rats. Am. J. Physiol. 282:2002;R1395-R1404
316. Renshaw D., Thomson L.M., Michael G.J., Carroll M., Kapas S., Hinson J.P. Adrenomedullin receptor is found exclusively in noradrenaline-secreting cells of the rat adrenal medulla. J. Neurochem. 74:2000;1766-1772
317. Riediger T., Rauch M., Schmid H.A. Actions of amylin on subfornical organ neurons and on drinking behavior in rats. Am. J. Physiol. 276:1999;R514-R521
318. Riediger T., Schmid H.A., Young A.A., Simon E. Pharmacological characterisation of amylin-related peptides activating subfornical organ neurones. Brain Res. 837:1999;161-168
319. Rist B., Entzeroth M., Beck-Sickinger A.G. From micromolar to nanomolar affinity: a systematic approach to identify the binding site of CGRP at the human calcitonin gene-related peptide 1 receptor. J. Med. Chem. 41:1998;117-123
320. Rist B., Lacroix J.S., Entzeroth M., Doods H.N., Beck-Sickinger A.G. CGRP 27-37 analogues with high affinity to the CGRP1 receptor show antagonistic properties in a rat blood flow assay. Regul. Pept. 79:1999;153-158
321. Roh J, Chang CL, Bhalla A, Klein C, Hsu SYT. Intermedin is a calcitonin/CGRP family peptide acting through the CRLT/RAMP receptor complexes. J Biol Chem 2003, in press.
322. Rorabaugh B.R., Scofield M.A., Smith D.D., Jeffries W.B., Abel P.W. Functional calcitonin gene-related peptide subtype 2 receptors in porcine coronary arteries are identified as calcitonin gene-related peptide subtype 1 receptors by radioligand binding and reverse transcription-polymerase chain reaction. J. Pharmacol. Exp. Ther. 299:2001;1086-1094
323. Rose P.M., Fernandes P., Lynch J.S., Frazier S.T., Fisher S.M., Kodukula K., et al. Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor. J. Biol. Chem. 270:1995;22661-22664
324. Rosenfeld M.G., Mermod J.J., Amara S.G., Swanson L.W., Sawchenko P.E., Rivier J., et al. Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing. Nature. 304:1983;129-135
325. Rovero P., Giuliani S., Maggi C.A. CGRP antagonist activity of short C-terminal fragments of human alpha CGRP, CGRP(23-37) and CGRP(19-37). Peptides. 13:1992;1025-1027
326. Rudolf K., Eberlein W., Engel W., Wieland H.A., Willim K.D., Entzeroth M., et al. The first highly potent and selective non-peptide neuropeptide Y Y1 receptor antagonist: BIBP3226. Eur. J. Pharmacol. 271:1994;R11-R13
327. Rueeger H., Rigollier P., Yamaguchi Y., Schmidlin T., Schilling W., Criscione L., et al. Design, synthesis and SAR of a series of 2-substituted 4-amino-quinazoline neuropeptide Y Y5 receptor antagonists. Bioorg. Med. Chem. Lett. 10:2000;1175-1179
328. Saavedra J.M. Atrial natriuretic peptide (6-33) binding sites: decreased number and affinity in the subfornical organ of spontaneously hypertensive rats. J. Hypertens. Suppl. 4:1986;S313-S316
329. Saavedra J.M. Regulation of atrial natriuretic peptide receptors in the rat brain. Cell Mol. Neurobiol. 7:1987;151-173
330. Saavedra JM. Brain endothelin and natriuretic peptide receptors. In: Quirion R, Bjorklund A, Hokfelt T, editors. Handbook of chemical neuroanatomy. Peptide receptors, vol. 16, Part I. Amsterdam: Elservier; 2000. p. 125-62.
331. Saavedra J.M., Israel A., Kurihara M., Fuchs E. Decreased number and affinity of rat atrial natriuretic peptide (6-33) binding sites in the subfornical organ of spontaneously hypertensive rats. Circ. Res. 58:1986;389-392
332. Samson W.K. Dehydration-induced alterations in rat brain vasopressin and atrial natriuretic factor immunoreactivity. Endocrinology. 117:1985;1279-1281
333. Samson W.K., Aguila M.C., Bianchi R. Atrial natriuretic factor inhibits luteinizing hormone secretion in the rat: evidence for a hypothalamic site of action. Endocrinology. 122:1988;1573-1582
334. Samson W.K., Aguila M.C., Martinovic J., Antunes-Rodrigues J., Norris M. Hypothalamic action of atrial natriuretic factor to inhibit vasopressin secretion. Peptides. 8:1987;449-454
335. Samson W.K., Bianchi R., Mogg R. Evidence for a dopaminergic mechanism for the prolactin inhibitory effect of atrial natriuretic factor. Neuroendocrinology. 47:1988;268-271
336. Samson W.K., Skala K.D., Huang F.L. CNP-22 stimulates, rather than inhibits, water drinking in the rat: evidence for a unique biological action of the C-type natriuretic peptides. Brain Res. 568:1991;285-288
337. Scarborough R.M., Schenk D.B., McEnroe G.A., Arfsten A., Kang L.L., Schwartz K., et al. Truncated atrial natriuretic peptide analogs. Comparison between receptor binding and stimulation of cyclic GMP accumulation in cultured vascular smooth muscle cells. J. Biol. Chem. 261:1986;12960-12964
338. Schober D.A., Gackenheimer S.L., Gehlert D.R. Pharmacological characterization of neuropeptide Y-(2-36) binding to neuropeptide Y Y1 and Y2 receptors. Eur. J. Pharmacol. 318:1996;307-313
339. Schober D.A., Gackenheimer S.L., Heiman M.L., Gehlert D.R. Pharmacological characterization of (125)I-1229U91 binding to Y1 and Y4 neuropeptide Y/peptide YY receptors. J. Pharmacol. Exp. Ther. 293:2000;275-280
340. Schober D.A., Van Abbema A.M., Smiley D.L., Bruns R.F., Gehlert D.R. The neuropeptide Y Y1 antagonist, 1229U91, a potent agonist for the human pancreatic polypeptide-preferring (NPY Y4) receptor. Peptides. 19:1998;537-542
341. Schulz S., Singh S., Bellet R.A., Singh G., Tubb D.J., Chin H., et al. The primary structure of a plasma membrane guanylate cyclase demonstrates diversity within this new receptor family. Cell. 58:1989;1155-1162
342. Serradeil-Le Gal C., Valette G., Rouby P.E., Pellet A., Oury-Donat F., Brossard G., et al. SR 120819A, an orally-active and selective neuropeptide Y Y1 receptor antagonist. FEBS Lett. 362:1995;192-196
343. Sexton P.M. Central nervous system binding sites for calcitonin and calcitonin gene-related peptide. Mol. Neurobiol. 5:1991;251-273
344. Sexton P.M., Hilton J.M. Biologically active salmon calcitonin-like peptide is present in rat brain. Brain Res. 596:1992;279-284
345. Sexton P.M., Houssami S., Hilton J.M., O'Keeffe L.M., Center R.J., Gillespie M.T., et al. Identification of brain isoforms of the rat calcitonin receptor. Mol. Endocrinol. 7:1993;815-823
346. Sexton P.M., Paxinos G., Kenney M.A., Wookey P.J., Beaumont K. In vitro autoradiographic localization of amylin binding sites in rat brain. Neuroscience. 62:1994;553-567
347. Shigeri Y., Ishikawa M., Ishihara Y., Fujimoto M. A potent nonpeptide neuropeptide Y Y1 receptor antagonist, a benzodiazepine derivative. Life Sci. 63:1998;PL151-PL160
348. Silvestre R.A., Salas M., Degano P., Peiro E., Marco J. Reversal of the inhibitory effects of calcitonin gene-related peptide (CGRP) and amylin on insulin secretion by the 8-37 fragment of human CGRP. Biochem. Pharmacol. 45:1993;2343-2347
349. Silvestre R.A., Salas M., Rodriguez-Gallardo J., Garcia-Hermida O., Fontela T., Marco J. Effect of (8-32) salmon calcitonin, an amylin antagonist, on insulin, glucagon and somatostatin release: study in the perfused pancreas of the rat. Br. J. Pharmacol. 117:1996;347-350
350. Simard J., Hubert J.F., Labrie F., Israel-Assayag E., Heisler S. Atrial natriuretic factor-induced cGMP accumulation in rat anterior pituitary cells in culture is not coupled to hormonal secretion. Regul. Pept. 15:1986;269-278
351. Simpson P.J., Miller I., Moon C., Hanlon A.L., Liebl D.J., Ronnett G.V. Atrial natriuretic peptide type C induces a cell-cycle switch from proliferation to differentiation in brain-derived neurotrophic factor- or nerve growth factor-primed olfactory receptor neurons. J. Neurosci. 22:2002;5536-5551
352. Soll R.M., Dinger M.C., Lundell I., Larhammer D., Beck-Sickinger A.G. Novel analogues of neuropeptide Y with a preference for the Y1-receptor. Eur. J. Biochem. 268:2001;2828-2837
353. Solomon T.E. Pancreatic polypeptide, peptide YY, and neuropeptide Y family of regulatory peptides. Gastroenterology. 88:1985;838-841
354. Sone M., Takahashi K., Satoh F., Murakami O., Totsune K., Ohneda M., et al. Specific adrenomedullin binding sites in the human brain. Peptides. 18:1997;1125-1129
355. St Pierre J.A., Dumont Y., Nouel D., Herzog H., Hamel E., Quirion R. Preferential expression of the neuropeptide Y Y1 over the Y2 receptor subtype in cultured hippocampal neurons and cloning of the rat Y2 receptor. Br. J. Pharmacol. 123:1998;183-194
356. Stangl D., Muff R., Schmolck C., Fischer J.A. Photoaffinity labeling of rat calcitonin gene-related peptide receptors and adenylate cyclase activation: identification of receptor subtypes. Endocrinology. 132:1993;744-750
357. Stanley B.G., Leibowitz S.F. Neuropeptide Y: stimulation of feeding and drinking by injection into the paraventricular nucleus. Life Sci. 35:1984;2635-2642
358. Stanley B.G., Magdalin W., Seirafi A., Nguyen M.M., Leibowitz S.F. Evidence for neuropeptide Y mediation of eating produced by food deprivation and for a variant of the Y1 receptor mediating this peptide's effect. Peptides. 13:1992;581-587
359. Statnick M.A., Schober D.A., Gehlert D.R. Identification of multiple neuropeptide Y receptor subtypes in the human frontal cortex. Eur. J. Pharmacol. 332:1997;299-305
360. Sudoh T., Kangawa K., Minamino N., Matsuo H. A new natriuretic peptide in porcine brain. Nature. 332:1988;78-81
361. Sudoh T., Minamino N., Kangawa K., Matsuo H. Brain natriuretic peptide-32: N-terminal six amino acid extended form of brain natriuretic peptide identified in porcine brain. Biochem. Biophys. Res. Commun. 155:1988;726-732
362. Sudoh T., Minamino N., Kangawa K., Matsuo H. C-type natriuretic peptide (CNP): a new member of natriuretic peptide family identified in porcine brain. Biochem. Biophys. Res. Commun. 168:1990;863-870
363. Takayanagi R., Snajdar R.M., Imada T., Tamura M., Pandey K.N., Misono K.S., et al. Purification and characterization of two types of atrial natriuretic factor receptors from bovine adrenal cortex: guanylate cyclase-linked and cyclase-free receptors. Biochem. Biophys. Res. Commun. 144:1987;244-250
364. Tanaka I., Inagami T. Release of immunoreactive atrial natriuretic factor from rat hypothalamus in vitro. Eur. J. Pharmacol. 122:1986;353-355
365. Tang W., Paulding W.R., Sumners C. ANP receptors in neurons and astrocytes from spontaneously hypertensive rat brain. Am. J. Physiol. 265:1993;C106-C112
366. Tatemoto K. Neuropeptide Y: complete amino acid sequence of the brain peptide. Proc. Natl. Acad. Sci. U.S.A. 79:1982;5485-5489
367. Tatemoto K., Carlquist M., Mutt V. Neuropeptide Y - a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide. Nature. 296:1982;659-660
368. Taylor G.M., Meeran K., O'Shea D., Smith D.M., Ghatei M.A., Bloom S.R. Adrenomedullin inhibits feeding in the rat by a mechanism involving calcitonin gene-related peptide receptors. Endocrinology. 137:1996;3260-3264
369. Telegdy G., Kokavszky K., Nyerges A. Action of C-type natriuretic peptide (CNP) on passive avoidance learning in rats: involvement of transmitters. Eur. J. Neurosci. 11:1999;3302-3306
370. Thiele T.E., Marsh D.J., Marie L., Bernstein I.L., Palmiter R.D. Ethanol consumption and resistance are inversely related to neuropeptide Y levels. Nature. 396:1998;366-369
371. Thiriet N., Jouvert P., Gobaille S., Solov'eva O., Gough B., Aunis D., et al. C-type natriuretic peptide (CNP) regulates cocaine-induced dopamine increase and immediate early gene expression in rat brain. Eur. J. Neurosci. 14:2001;1702-1708
372. Tilakaratne N., Christopoulos G., Zumpe E.T., Foord S.M., Sexton P.M. Amylin receptor phenotypes derived from human calcitonin receptor/RAMP coexpression exhibit pharmacological differences dependent on receptor isoform and host cell environment. J. Pharmacol. Exp. Ther. 294:2000;61-72
373. Tomlinson A.E., Poyner D.R. Multiple receptors for calcitonin gene-related peptide and amylin on guinea-pig ileum and vas deferens. Br. J. Pharmacol. 117:1996;1362-1368
374. Tremblay J., Desjardins R., Hum D., Gutkowska J., Hamet P. Biochemistry and physiology of the natriuretic peptide receptor guanylyl cyclases. Mol. Cell Biochem. 230:2002;31-47
375. Trinh T., Dumont Y., Quirion R. High levels of specific neuropeptide Y/pancreatic polypeptide receptors in the rat hypothalamus and brainstem. Eur. J. Pharmacol. 318:1996;R1-R3
376. Tsagarakis S., Rees L.H., Besser G.M., Grossman A. Neuropeptide-Y stimulates CRF-41 release from rat hypothalami in vitro. Brain Res. 502:1989;167-170
377. Tschopp F.A., Henke H., Petermann J.B., Tobler P.H., Janzer R., Hokfelt T., et al. Calcitonin gene-related peptide and its binding sites in the human central nervous system and pituitary. Proc. Natl. Acad. Sci. U.S.A. 82:1985;248-252
378. Tsutsumi K., Niwa M., Kawano T., Ibaragi M., Ozaki M., Mori K. Atrial natriuretic polypeptides elevate the level of cyclic GMP in the rat choroid plexus. Neurosci. Lett. 79:1987;174-178
379. Tucker H.M., Rydel R.E., Wright S., Estus S. Human amylin induces "apoptotic" pattern of gene expression concomitant with cortical neuronal apoptosis. J. Neurochem. 71:1998;506-516
380. Ueda S., Sudoh T., Fukuda K., Kangawa K., Minamino N., Matsuo H. Identification of alpha atrial natriuretic peptide [4-28] and [5-28] in porcine brain. Biochem. Biophys. Res. Commun. 149:1987;1055-1062
381. Uehara Y., Shimizu H., Shimomura Y., Kobayashi I., Kobayashi S. Rat brain natriuretic peptide (BNP) reduces water intake following dehydration. Neuropeptides. 17:1990;107-110
382. Van Rossum D., Hanisch U.K., Quirion R. Neuroanatomical localization, pharmacological characterization and functions of CGRP, related peptides and their receptors. Neurosci. Biobehav. Rev. 21:1997;649-678
383. 125I ]BHrAMY) specific binding sites in the rat brain Can. J. Physiol. Pharmacol. 73:1995;1084-1088
384. 125I ]Bolton Hunter-rat amylin binding sites in the rat brain J. Pharmacol. Exp. Ther. 270:1994;779-787
385. 125I -Tyr]hCGRP8-37, in rat brain and peripheral tissues J. Pharmacol. Exp. Ther. 269:1994;846-853
386. Verheggen R., Bumann K., Kaumann A.J. BIBN4096BS is a potent competitive antagonist of the relaxant effects of alpha-CGRP on human temporal artery: comparison with CGRP(8-37). Br. J. Pharmacol. 136:2002;120-126
387. Vezzani A., Sperk G., Colmers W.F. Neuropeptide Y: emerging evidence for a functional role in seizure modulation. Trends Neurosci. 22:1999;25-30
388. Vine W., Smith P., LaChappell R., Rink T.J., Young A.A. Lactate production from the rat hindlimb is increased after glucose administration and is suppressed by a selective amylin antagonist: evidence for action of endogenous amylin in skeletal muscle. Biochem. Biophys. Res. Commun. 216:1995;554-559
389. Wahlestedt C., Yanaihara N., Hakanson R. Evidence for different pre- and post-junctional receptors for neuropeptide Y and related peptides. Regul. Pept. 13:1986;307-318
390. Wang F., Millet I., Bottomly K., Vignery A. Calcitonin gene-related peptide inhibits interleukin 2 production by murine T lymphocytes. J. Biol. Chem. 267:1992;21052-21057
391. Weinberg D.H., Sirinathsinghji D.J., Tan C.P., Shiao L.L., Morin N., Rigby M.R., et al. Cloning and expression of a novel neuropeptide Y receptor. J. Biol. Chem. 271:1996;16435-16438
392. Weiser T., Wieland H.A., Doods H.N. Effects of the neuropeptide Y Y(2) receptor antagonist BIIE0246 on presynaptic inhibition by neuropeptide Y in rat hippocampal slices. Eur. J. Pharmacol. 404:2000;133-136
393. Westermark P., Wernstedt C., Wilander E., Sletten K. A novel peptide in the calcitonin gene related peptide family as an amyloid fibril protein in the endocrine pancreas. Biochem. Biophys. Res. Commun. 140:1986;827-831
394. Whitcomb D.C., Puccio A.M., Vigna S.R., Taylor I.L., Hoffman G.E. Distribution of pancreatic polypeptide receptors in the rat brain. Brain Res. 760:1997;137-149
395. Whitcomb D.C., Taylor I.L., Vigna S.R. Characterization of saturable binding sites for circulating pancreatic polypeptide in rat brain. Am. J. Physiol. 259:1990;G687-G691
396. Wieland H.A., Engel W., Eberlein W., Rudolf K., Doods H.N. Subtype selectivity of the novel nonpeptide neuropeptide Y Y1 receptor antagonist BIBO3304 and its effect on feeding in rodents. Br. J. Pharmacol. 125:1998;549-555
397. Wildey G.M., Glembotski C.C. Cross-linking of atrial natriuretic peptide to binding sites in rat olfactory bulb membranes. J. Neurosci. 6:1986;3767-3776
398. Wimalawansa S.J. Amylin, calcitonin gene-related peptide, calcitonin, and adrenomedullin: a peptide superfamily. Crit. Rev. Neurobiol. 11:1997;167-239
399. Wisskirchen F.M., Burt R.P., Marshall I. Pharmacological characterization of CGRP receptors mediating relaxation of the rat pulmonary artery and inhibition of twitch responses of the rat vas deferens. Br. J. Pharmacol. 123:1998;1673-1683
400. Wisskirchen F.M., Gray D.W., Marshall I. Receptors mediating CGRP-induced relaxation in the rat isolated thoracic aorta and porcine isolated coronary artery differentiated by h(alpha) CGRP(8-37). Br. J. Pharmacol. 128:1999;283-292
401. Wolak M.L., DeJoseph M.R., Cator A.D., Mokashi A.S., Brownfield M.S., Urban J.H. Comparative distribution of neuropeptide Y Y1 and Y5 receptors in the rat brain by using immunohistochemistry. J. Comp. Neurol. 464:2003;285-311
402. Woodard G.E., Zhao J., Rosado J.A., Brown J. Differences between natriuretic peptide receptors in the olfactory bulb and hypothalamus from spontaneously hypertensive and normotensive rat brain. Neurosci. Res. 47:2003;421-429
403. Wookey P.J., Tikellis C., Du H.C., Qin H.F., Sexton P.M., Cooper M.E. Amylin binding in rat renal cortex, stimulation of adenylyl cyclase, and activation of plasma renin. Am. J. Physiol. 270:1996;F289-F294
404. Wraith A., Tornsten A., Chardon P., Harbitz I., Chowdhary B.P., Andersson L., et al. Evolution of the neuropeptide Y receptor family: gene and chromosome duplications deduced from the cloning and mapping of the five receptor subtype genes in pig. Genome Res. 10:2000;302-310
405. Wu D., Doods H., Arndt K., Schindler M. Development and potential of non-peptide antagonists for calcitonin gene-related peptide (CGRP) receptors: evidence for CGRP receptor heterogeneity. Biochem. Soc. Trans. 30:2002;468-473
406. 2, 7]hCGRP-preferring receptor. Eur. J. Pharmacol. 400:2000;313-319
407. Yan H., Yang J., Marasco J., Yamaguchi K., Brenner S., Collins F., et al. Cloning and functional expression of cDNAs encoding human and rat pancreatic polypeptide receptors. Proc. Natl. Acad. Sci. U.S.A. 93:1996;4661-4665
408. Yeung V.T., Ho S.K., Nicholls M.G., Cockram C.S. Adrenomedullin, a novel vasoactive hormone, binds to mouse astrocytes and stimulates cyclic AMP production. J. Neurosci. Res. 46:1996;330-335
409. Young A.A., Gedulin B., Gaeta L.S., Prickett K.S., Beaumont K., Larson E., et al. Selective amylin antagonist suppresses rise in plasma lactate after intravenous glucose in the rat. Evidence for a metabolic role of endogenous amylin. FEBS Lett. 343:1994;237-241
410. Youngman M.A., McNally J.J., Lovenberg T.W., Reitz A.B., Willard N.M., Nepomuceno D.H., et al. alpha-Substituted N-(sulfonamido)alkyl-beta- aminotetralins: potent and selective neuropeptide Y Y5 receptor antagonists. J. Med. Chem. 43:2000;346-350
411. Zarrinmayeh H., Nunes A.M., Ornstein P.L., Zimmerman D.M., Arnold M.B., Schober D.A., et al. Synthesis and evaluation of a series of novel 2-[(4-chlorophenoxy)methyl]benzimidazoles as selective neuropeptide Y Y1 receptor antagonists. J. Med. Chem. 41:1998;2709-2719
412. Zarrinmayeh H., Zimmerman D.M., Cantrell B.E., Schober D.A., Bruns R.F., Gackenheimer S.L., et al. Structure-activity relationship of a series of diaminoalkyl substituted benzimidazole as neuropeptide Y Y1 receptor antagonists. Bioorg. Med. Chem. Lett. 9:1999;647-652
413. Zimmerman D.M., Cantrell B.E., Smith E.C., Nixon J.A., Bruns R.F., Gitter B., et al. Structure-activity relationships of a series of 1-substituted-4- methylbenzimidazole neuropeptide Y-1 receptor antagonists. Bioorg. Med. Chem. Lett. 8:1998;473-476
414. Zimmermann U., Fischer J.A., Frei K., Fischer A.H., Reinscheid R.K., Muff R. Identification of adrenomedullin receptors in cultured rat astrocytes and in neuroblastboma × glioma hybrid cells (NG108-15). Brain Res. 724:1996;238-245
415. Zorad S., Tsutsumi K., Bhatia A.J., Saavedra J.M. Localization and characteristics of atrial natriuretic peptide receptors in prenatal and postnatal rat brain. Eur. J. Pharmacol. 241:1993;195-200
416. Zorad S., Tsutsumi K., Saavedra J.M. Selective localization of C atrial natriuretic peptide receptors in the rat brain. Brain Res. 570:1992;149-153
417. Zumpe E.T., Tilakaratne N., Fraser N.J., Christopoulos G., Foord S.M., Sexton P.M. Multiple ramp domains are required for generation of amylin receptor phenotype from the calcitonin receptor gene product. Biochem. Biophys. Res. Commun. 267:2000;368-372