Interaction of amylin with calcitonin gene-related peptide receptors in the microvasculature of the hamster cheek pouch in vivo

British Journal of Pharmacology

Volumn 126, Issue 1, 1999, Pages 280-284

  Brain, Susan D ^a  

^a UNIVERSITY OF SURREY   (United Kingdom)

Author keywords

Amylin; Amylin antagonist; Amylin8 37; Blood flow; CGRP; CGRP antagonist; CGRP8 37; Microvasculature; Sensory nerves; Vasodilation

Indexed keywords

ALPHA CALCITONIN GENE RELATED PEPTIDE; AMYLIN; BETA CALCITONIN GENE RELATED PEPTIDE; CALCITONIN GENE RELATED PEPTIDE DERIVATIVE; CALCITONIN GENE RELATED PEPTIDE RECEPTOR; CALCITONIN GENE RELATED PEPTIDE[8-37]; RECEPTOR SUBTYPE; SUBSTANCE P;

ANIMAL EXPERIMENT; ARTERIOLE; ARTICLE; BLOOD VESSEL DIAMETER; CHEEK POUCH; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; HAMSTER; INTRAVENOUS DRUG ADMINISTRATION; MALE; MICROVASCULATURE; NONHUMAN; PRIORITY JOURNAL; VASODILATATION;

AMYLOID; ANIMALS; ANTI-ULCER AGENTS; ARTERIOLES; CALCITONIN GENE-RELATED PEPTIDE; CHEEK; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MALE; MESOCRICETUS; MIOTICS; PEPTIDE FRAGMENTS; RATS; RECEPTORS, CALCITONIN GENE-RELATED PEPTIDE; RECEPTORS, PEPTIDE; TIME FACTORS; VASODILATION;

EID: 0032945688     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702272     Document Type: Article

References (31)

1. AIYAR, N., BAKER, E., MARTIN, J., PATEL, A., STADEL, J.M., WILLETTE, R.N. & BARONE, F.C. (1995). Differential calcitonin-gene-related peptide (CGRP) and amylin binding sites in nucleus accumbens and lung - potential models for studying CGRP/amylin receptor subtypes. J. Neiirochein., 65, 1131-1138.
2. BASKAYA, M.K., SUSUKI, Y., ANZAI, M., SEKI, Y., SAITO, K., TAKAYASU, M., SHIBUYA, M. & SUGITA, K. (1995). Effects of adrenomedullin, calcitonin gene-related peptide, and amylin on cerebral circulation in dogs. J. Cerebral Blood Flow and Metabolism, 15,827-834.
3. BEAUMONT, K., MOORE, C.X., PITTNER, R.A., PRICKETT, K.S., GAETA, L.S.L., RINK, T.J. & YOUNG, A.A. (1995). Differential antagonism of amylin1 s metabolic and vascular actions with amylin receptor antagonists. Can. J. Pharm. Phannacol., 73, 1025-1029.
4. BRAIN, S.D., WILLIAMS, T.J., TIPPINS, J.R., MORRIS, H.R. & MACINTYRE, I. (1985). Calcitonin gene-related peptide is a potent vasodilator. Nature, 313, 54-56.
5. CASTILLO, M.J., SCHEEN, A.J. & LEFEBVRE, P.J. (1995). Amylin/islet amyloid polypeptide: biochemistry, physiology, pathophysiology. Diabetes & Métabolisme, 21, 3-25.
6. CHIN, S.Y., HALL, J.M., BRAIN, S.D. & MORTON, I.K.M. (1994). Vasodilator responses to calcitonin gene-related peptide (CGRP) and amylin in the rat isolated perfused kidney are mediated via CGRP, receptors. J. Phannacol. Exp. Tlier., 269, 989-992.
7. CLAING, A., TÉLÉMAQUE., CADIEUX, A., FOURNIER, A., REGOLI, D. & D1 ORLÉANS-JUSTE, P. (1992). Nonadrenergic and noncholinergic arterial dilatation and venoconstriclion are mediated by calcitonin gene-related peptidei and neurokinin-1 receptors, respectively, in the mesenteric vasculature of the rat after perivascular nerve stimulation. J. Phannacol. Exp. Tlier., 263, 1226-1232.
8. DEEMS, R.O., CARDINAUX, F., DEACON, R.W. & YOUNG, D.A. (1991). Amylin or CGRP(8-37) fragments reverse amylininduced inhibition of l4C-glycogen accumulation. Bioclieni. Biophys. Res. Commun., 181, 116-120.
9. DENNIS, T., FOURNIER, A., CADIEUX, A., POMERLEAU, F., JOLICOEUR, F.B., ST, PIERRE, S. & QU1RION, R. (I990). hCGRPg-37, a calcitonin gene-related peptide antagonist revealing calcitonin gene-related peptide receptor heterogeneity in brain and periphery. J. Phannacol. Exp. Thcr., 25-1, 123-128.
10. DENNIS, T., FOURNIER, A., ST. PIERRE, S. & QUIRION, R. (1989). Structure-activity profile of calcitonin gene-related peptide in peripheral and brain tissues. Evidence for receptor multiplicity. J. Phannacol Exp. Tlier., 251, 718-725.
11. DULING, B.R. (1973). The preparation and use of the hamster cheek pouch for studies of the microcirculation. Aficrovasc. Res., 5, 423-429.
12. ESCOTT, K.J. & BRAIN, S.D. (1993). Effect of a calcitonin generelated peptide antagonist (CGRPg-37) on skin vasodilatation and oedema induced by stimulation of the rat saphenous nerve. Br, J. Phannacol., 110, 772-776.
13. GIULIANI, S., WIMILAWANSKI, S.J. & MAGGI, C.A. (1992). Involvement of multiple receptors in the biological effects of calcitonin gene-related peptide and amylin in rat and guinea-pig preparations. Br. J. pharmacol., 107, 510-514.
14. HALL, J.M. & BRAIN, S.D. (1993). Quantification of the vasodilator effects of CGRP, amylin and [Cys(ACM2-7]-hCGRP on the microvasculature of the hamster cheek pouch in vivo. Neuropeptittes, 24, 207.
15. HALL, J.M. & BRAIN, S.D. (1994). Inhibition of NK, tachykinin receptor mediated, nitric oxide dependent vasodilatation by SR140333 in the hamster cheek pouch microvasculature in v/i-o. Br. J. Phannacol., 113, 522-526.
16. HALL, J.M. & BRAIN, S.D. (1996). Pharmacology of calcitonin generelated peptide. In: Neurogenic Inflammation, CRC Press, Boca Raton, New York, Tokyo, Gcppetti, P and Holzer, P (eds), ch. 9, pp 101-114.
17. HALL, J.M., SINEY, L., LIPPTON, H., HYMAN, A., KANG-CHANG, 3. & BRAIN, S.D. (1995). Interaction of human adrenomedullin-sj with calcitonin gene-related peptide receptors in the microvasculature of the rat and hamster. Br. J. Pharmacol., 114, 592-597.
18. HALL, J.M. & SMITH, D.M. (1998). Calcitonin gene-related peptide a new concept in receptor-ligand specificity? Trends Pharmacol. Sei. 19,303-305.
19. HOLZER, P. (1988). Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. Neurosci., 24, 739-768.
20. MCLATCHIE, L.M., FRASER, N.J., MAIN, M.J., WISE, A., BROWN, J., THOMPSON, N., SOLARI, R., LEE, M.G. & FOORD, S.M. (1998). RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature, 393, 333-339.
21. MUFF, R., BORN, V. & FISCHER, J.A. (1995). Receptors for calcitonin, calcitonin gene-related peptide, amylin, and adrenomedullin. Can. J. Physlol. Pharmacol., 73, 963-967.
22. MULDER, H., LECKSTRÖM., UDDMAN, R., EKBLAD, E., WESTERMARK, P. & SUNDLER, F. (1995). Islet amyloid polypeptide (amylin) is expressed in sensory neurons. J. Neiirochein., 15, 7625-7632.
23. MULDER, H., ZHANG, Y.Z., DANIELSEN, N. & SUNDLER, F. (1997). Islet amyloid polypeptide and calcitonin gene-related peptide expression are up-regulated in lumbar dorsal root ganglia after unilateral adjuvant-induced inflammation in the rat paw. Afol. Brain Res., 50, 127-135.
24. POYNER, D. (1992). Calcitonin gene-related peptide: multiple actions, multiple receptors. Pharmac. Ther., 56, 23-51.
25. POYNER, D. (1995). Pharmacology of receptors for calcitonin generelated peptide and amylin. Trends Pharmacol. Sei., 16,424-428.
26. SHEYKHADE, M. & BERG NYBORG, C.B. (1998). Characterization of calcitonin gene-related peptide (CORP) receptors in inlramural coronary arteries from male and female Sprague Dawley rats. Br. J. Pharmacol., 123, 1464- 1470.
27. TOMLINSON, A.E. & POYNER, D.R. (1996). Multiple receptors for calcitonin gene-related peptide and amylin on guinea-pig ileum and vas deferens. Br. J. Pharmacol., 117, 1362-1368.
28. VEALE, P.R., BIIOGAL, R., MORGAN, D.G.A., SMITH, D.M. & BLOOM, S.R. (1994). The presence of islet amyloid polypeptide/ calcitonin gene-related peptide/salmon calcitonin binding sites in the rat nucleus accumbens. Eur. J. Pharmacol., 262, 133-141.
29. VINE, W., BEAUMONT, K., GEDULIN, B., PITTNER, R., MOORE, C.X., RINK, T.J. & YOUNG, A.A. (1996). Comparison of the in vitro and m vivo pharmacology of adrenomedullin, calcitonin gene-related peptide and amylin in rats. Eur. J. Pharmacol., 314, 115-121.
30. WANG, Z-L., BENNET, W.M., BYFIELD, P.G.H., SMITH, D.M. & BLOOM, S.R. (1993). Influence of islet amyloid polypeptide and the 8-37 fragment of islet amyloid polypeptide on insulin release from perfused rat islets. Diabetes, 42, 330-335.
31. WISSKIRCHEN, F.M., BURT, R.P. & MARSHALL, I. (1998). Pharmacological characterization of CORP receptors mediating relaxation of the rat pulmonary artery and inhibition of twitch responses of the rat vas deferens. Br. J. Pharmacol., 123, 16731683.