Differential distribution of neuropeptide Y Y1 and Y2 receptors in rat and guinea-pig brains

Neuroscience

Volumn 76, Issue 1, 1996, Pages 215-224

  Gehlert, D R ^a   Gackenheimer, S L ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

autoradiography; brain; neuropeptide Y receptors; pancreatic polypeptide; peptide YY

Indexed keywords

NEUROPEPTIDE Y1 RECEPTOR; NEUROPEPTIDE Y2 RECEPTOR; RECEPTOR SUBTYPE;

ANIMAL TISSUE; ARTICLE; BRAIN REGION; CONTROLLED STUDY; GUINEA PIG; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; SPECIES DIFFERENCE;

EID: 0030571585     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-4522(96)00340-5     Document Type: Article

References (41)

1. Bard J. A., Walker M. W., Branchek T. A., Weinshank R. L. Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y and peptide YY. J. biol. Chem. 270:1995;26762-26765.
2. Bradford M. M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analyt. Biochem. 72:1976;248-254.
3. Castan I., Valet P., Voisin T., Quideau N., Laburthe M., Lafontan M. Identification and functional studies of a specific peptide YY-preferring receptor in dog adipocytes. Endocrinology. 131:1992;1970-1976.
4. Chronwall B. M., Dimaggio D. A., Massari V. J., Pickel V. M., Ruggerio D. A., O'Donohue T. L. The anatomy of neuropeptide Y-containing neurons in the rat brain. Neuroscience. 15:1985;1159-1181.
5. Colmers W. F., Bleakman D. Effects of neuropeptide Y on the electrical properties of neurons. Trends Neurosci. 17:1994;373-379.
6. Dietl M. M., Palacios J. M. The distribution of cholecystokinin receptors in the vertebrate brain: species differences studied by receptor autoradiography. J. chem. Neuroanat. 2:1989;149-161.
7. Dumont Y., Fournier A., St-Pierre S., Quirion R. Comparative characterization and autoradiographic distribution of neuropeptide Y receptor subtypes in the rat brain. J. Neurosci. 13:1993;73-86.
8. 2 radioligands. J. Pharmac. exp. Ther. 272:1995;673-680.
9. 2 receptors in rat brain. Eur. J. Pharmac. 191:1990;501-503.
10. 1 receptor agonist. Proc. natn. Acad. Sci. U.S.A. 87:1990;182-186.
11. 34)-Peptide YY binds to receptors for neuropeptide Y (Y-1) and pancreatic polypeptide. Soc. Neurosci. Abstr. 25:1995;1593.
12. Gehlert D. R. Subtypes of receptors for neuropeptide Y: implications for the targeting of therapeutics. Life Sci. 55:1994;551-562.
13. Gehlert D. R., Beavers L., Johnson D., Gackenheimer S. L., Schober D. A., Gadski R. A. Expression cloning of a human brain neuropeptide Y Y2 receptor. Molec. Pharmac. 49:1996;224-228.
14. 125I-labelled peptide YY binding sites in the rat brain. Neurochem. Int. 21:1992;45-67.
15. Gerald C., Walker M. W., Vaysse P. J.-J., He C., Branchek T. A., Weinshank R. L. Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/peptide YY Y2 receptor subtype. J. biol. Chem. 270:1995;26758-26761.
16. Grundemar L., Håkanson R. Neuropeptide Y effector systems: perspectives for drug development. Trends pharmac. Sci. 15:1994;153-159.
17. Heilig M., McLeod S., Brot M., Heinrichs S. C., Menzaghi F., Koob G. F., Britton K. T. Anxiolytic-like action of neuropeptide Y: mediation by Y1 receptors in amygdala, and dissociation from food intake effects. Neuropsychopharmacology. 8:1993;357-363.
18. Herzog H., Hort Y. J., Ball H. J., Hayes G., Shine J., Selbie L. A. Cloned human neuropeptide Y receptor couples to two different second messenger systems. Proc. natn. Acad. Sci. U.S.A. 89:1992;5794-5798.
19. Herzog H., Hort Y. J., Shine J., Selbie L. A. Molecular cloning, characterization, and localization of the human homolog to the reported bovine NPY Y3 receptor: lack of NPY binding and activation. DNA Cell Biol. 12:1993;465-471.
20. Kalra S. P., Dube M. G., Fournier A., Kalra P. S. Structure-function analysis of stimulation of food intake by neuropeptide Y: effects of receptor agonists. Physiol. Behav. 50:1991;5-9.
21. Kalra S. P., Fuentes M., Fournier A., Parker S. L., Crowley W. R. Involvement of the Y-1 receptor subtype in the regulation of luteinizing hormone secretion by neuropeptide Y in rats. Endocrinology. 130:1992;3323-3330.
22. 1 subtype pharmacology of a recombinantly expressed neuropeptide receptor. Molec. Pharmac. 41:1992;817-821.
23. Larhammar D., Blomquist A. G., Söderberg C. Evolution of neuropeptide Y and its related peptides. Comp. Biochem. Physiol. 106C:1993;743-752.
24. Larhammar D., Blomquist A. G., Yee F., Jazin E., Yoo H., Wahlestedt C. Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 subtype. J. biol. Chem. 267:1992;10935-10938.
25. Larsen P. J., Sheikh S. P., Jakobsen C. R., Schwartz T. W., Mikkelsen J. D. Regional distribution of putative NPY Y1 receptors and neurons expressing Y1 mRNA in forebrain areas of the rat central nervous system. Eur. J. Neurosci. 5:1993;1622-1637.
26. Lundell I., Blomqvist A. G., Berglund M., Schober D. A., Johnson D., Statnick M. A., Gadski R., Gehlert D. R., Larhammar D. Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY. J. biol. Chem. 270:1995;29123-29128.
27. Lundell I., Statnick M. A., Johnson D., Schober D. A., Starbäck P., Gehlert D. R., Larhammar D. The cloned rat pancreatic polypeptide receptor exhibits profound differences to theorthologus human receptor. Proc. natn. Acad. Sci. U.S.A. 93:1996;5111-5115.
28. I]Bolton-Hunter neuropeptide Y binding sites in the forebrain of various mammalian species. Brain Res. 419:1987;403-407.
29. O'Donohue T. L., Chronwall B. M., Pruss R. M., Mezey E., Kiss J. Z., Eiden L. E., Massari V. J., Tessel R. E., Pickel V. M., Dimaggio D. A., Hotchkiss A. J., Crowley W. R., Zukowska-Grojec Z. Neuropeptide Y and peptide YY in neuronal and endocrine systems. Peptides. 6:1985;755-768.
30. Paxinos G. and Watson C. (1986) The Rat Brain in Stereotaxic Coordinates. Academic, Sydney.
31. Rose P. M., Fernandes P., Lynch J. S., Frazier S. T., Fisher S. M., Kodukula K., Kienzle B., Seethala R. Cloning and expression of a cDNA encoding a human type 2 neuropeptide Y receptor. J. biol. Chem. 270:1995;22661-22664.
32. Sahu A., Kalra S. P. Neuropeptidergic regulation of feeding behaviour of neuropeptide Y. Trends Endocr. Metab. 4:1993;217-224.
33. Stanley B. G., Magdalin W., Seirafi A., Nguyen M. M., Leibowitz S. F. Evidence for neuropeptide Y mediation of eating produced by food deprivation and for a variant of the Y1 receptor mediating this peptide's effect. Peptides. 13:1992;581-587.
34. Stanley B. G., Magdalin W., Seirafi A., Thomas W. J., Leibowitz S. F. The perifornical area: the major focus of (a) patchily distributed hypothalamic neuropeptide Y-sensitive feeding system(s). Brain Res. 604:1993;304-317.
35. Voisin T., Bens M., Cluzeaud F., Vandewalle A., Laburthe M. Peptide YY receptors in the proximal tubule PKSV-PCT cell line derived from transgenic mice. J. biol. Chem. 268:1993;20547-20554.
36. Wahlestedt C., Edvinsson L., Ekblad E. and Håkanson R. (1987) Effects of neuropeptide Y at sympathetic neuroeffector junctions: existence of Y1- and Y2-receptors. In Neuronal Messengers in Vascular Function (eds Nobin A., Owman C. and Arneklo-Nobin B.), pp. 231-241. Elsevier, Amsterdam.
37. Wahlestedt C., Regunathan S., Håkanson R. Identification of cultured cells selectively expressing Y1-, Y2-, or Y3-type receptors for neuropeptide Y/peptide YY. Life Sci. 50:1992;PL7-PL14.
38. Wahlestedt C., Reis D. J. Neuropeptide Y-related peptides and their receptors: are the receptors potential therapeutic drug targets? A. Rev. Pharmac. Toxic. 32:1993;309-352.
39. Wahlestedt C., Yanaihara N., Håkanson R. Evidence for different pre- and post-junctional receptors for neuropeptide Y and related peptides. Regul. Pept. 13:1986;307-318.
40. Whitcomb D. C., Taylor I. L., Vigna S. R. Characterization of saturable binding sites for circulating pancreatic polypeptide in rat brain. Am. J. Physiol. 259:1990;G687-G691.
41. Widdowson P. S. Quantitative receptor autoradiography demonstrates a differential distribution of neuropeptide-Y Y1 and Y2 receptor subtypes in human and rat brain. Brain Res. 631:1993;27-38.