Adrenomedullin inhibits feeding in the rat by a mechanism involving calcitonin gene-related peptide receptors

Endocrinology

Volumn 137, Issue 8, 1996, Pages 3260-3264

  Taylor, G M ^a   Meeran, K ^a   O'Shea, D ^a   Smith, D M ^a   Ghatei, M A ^a   Bloom, S R ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENOMEDULLIN; CALCITONIN GENE RELATED PEPTIDE; CALCITONIN GENE RELATED PEPTIDE DERIVATIVE; CALCITONIN GENE RELATED PEPTIDE RECEPTOR; CALCITONIN GENE RELATED PEPTIDE[8-37]; IODINE 125;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING COMPETITION; CONTROLLED STUDY; DOSE RESPONSE; FEEDING; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING;

EID: 0029997025     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.137.8.8754748     Document Type: Article

References (35)

1. Kitamura K, Kangawa K, Kawamoto M, Ichiki Y, Nakamura S, Matsuo H, Eto T 1993 Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma. Biochem Biophys Res Commun 192:553-560
2. Sakata J, Shimokubo T, Kitamura K, Nishizono M, Iehiki Y, Kangawa K, Matsuo H, Eto T 1994 Distribution and characterization of immunoreactive rat adrenomedullin in tissue and plasma. FEBS Lett 352:105-108
3. Satoh F, Takahashi K, Murakami O, Totsune K, Sone M, Ohneda M, Abe K, Miura Y, Hayashi Y, Sasano H, Mouri T 1995 Adrenomedullin in human brain, adrenal glands and tumor tissues of pheochromocytoma, ganglioneuroblastoma and neuroblastoma. J Clin Endocrinol Metab 80:1750-1752
4. Kitamura K, Sakata J, Kangawa K, Kojima M, Matsuo H, Eto T 1993 Cloning and characterization of cDNA encoding a precursor for human adrenomedullin. Biochem Biophys Res Commun 194:720-725
5. Ichiki Y, Kitamura K, Kangawa K, Kawamoto M, Matsuo H, Eto T 1994 Distribution and characterization of immunoreactive adrenomedullin in human tissue and plasma. FEBS Lett 338:6-10
6. Ishimitsu T, Nishikimi T, Saito Y, Kitamura K, Eto T, Kangawa K, Matsuo H, Omae T, Matsuoka H 1994 Plasma levels of adrenomedullin, a newly identified hypotensive peptide, in patients with hypertension and renal failure. J Clin Invest 94:2158-2161
7. Kitamura K, Ichiki Y, Tanaka M, Kawamoto M, Emura J, Sakakibara S, Kangawa K, Matsuo H, Eto T 1994 Immunoreactive adrenomedullin in human plasma. FEBS Lett 341:288-290
8. Nandha KA, Taylor GM, Smith DM, Owji AA, Byfield PGH, Ghatei MA, Bloom SR 1996 Specific adrenomedullin binding sites and hypotension in the rat systemic vascular bed. Regul Pept 62:145-151
9. Santiago JA, Garrison EA, Ventura VL, Coy DH, Bitar K, Murphy WA, McNamara DB, Kadowitz PJ 1994 Synthetic human adrenomedullin and adrenomedullin 15-52 have potent short-lived vasodilator activity in the hind-limb vascular bed of the cat. Life Sci. 55:PL85-PL90
10. Dewitt BJ, Cheng DY, Caminiti GN, Nossaman BD, Coy DH, Murphy WA, Kadowitz PJ 1994 Comparison of responses to adrenomedullin and calcitonin gene-related peptide in the pulmonary vascular bed of the cat. Eur J Pharmacol 257:303-306
11. Nuki C, Kawasaki H, Kitamura K, Takenaga M, Kangawa K, Eto T, Wada A 1993 Vasodilator effect of adrenomedullin and calcitonin gene-related peptide receptors in rat mesenteric vascular beds. Biochem Biophys Res Commun 196:245-251
12. Entzeroth M, Doods HN, Wieland HA, Wienen W 1994 Adrenomedullin mediates vasodilation via CGRP1 receptors. Life Sci 56:PL19-PL25
13. Gardiner SM, Kemp PA, March JE, Bennett T 1995 Regional haemodynamic effects of human and rat adrenomedullin in conscious rats. Br J Pharmacol 114:584-591
14. Takahashi H, Watanabe TX, Nishimura M, Nakanishi T, Sakamoto M, Yoshimura M, Komiyama Y, Masuda M, Murakami T 1994 Centrally induced vasopressor and sympathetic responses to a novel endogenous peptide, adrenomedullin, in anesthetized rats. Am J Hypertens 7:478-482
15. Sexton PM, McKenzie JS, Mason RT, Moseley JM, Martin TJ, Mendelsohn FA 1986 Localization of binding sites for calcitonin gene-related peptide in rat brain by in vitro autoradiography. Neuroscience 19:1235-1245
16. 125I calcitonin gene-related peptide binding sites in the rat central nervous system. Peptides 6:975-986
17. Tschopp FA, Henke H, Petermann JB, Tobler PH, Janzer R, Hokfelt T, Lundberg JM, Cuello C, Fischer JA 1985 Calcitonin gene-related peptide and its binding sites in the human central nervous system and pituitary. Proc Natl Acad Sci USA 82:248-252
18. Krahn DD, Gosnell BA, Levine AS, Morley JE 1984 Effects of calcitonin gene-related peptide on food intake. Peptides 5:861-864
19. Chance WT, Balasubramaniam A, Zhang FS, Wimalawansa SJ, Fischer JE 1991 Anorexia following the intrahypothalamic administration of amylin. Brain Res 539:352-354
20. Morley JE, Flood JF 1991 Amylin decreases food intake in mice. Peptides 12:865-869
21. Freed WJ, Perlow MJ, Wyatt RJ 1979 Calcitonin: inhibitory effect on eating in rats. Science 206:850-852
22. Chait A, Suaudeau C, de Beaurepaire R 1995 Extensive brain mapping of calcitonin-induced anorexia. Brain Res Bull 36:467-472
23. Plata Salaman CR, Oomura Y 1987 Calcitonin as a feeding suppressant: localization of central action to the cerebral III ventricle. Physiol Behav 40:501-513
24. Rizzo AJ, Goltzman D 1981 Calcitonin receptors in the central nervous system of the rat. Endocrinology 108:1672-1677
25. Sexton PM, Paxinos G, Kenney MA, Wookey PJ, Beaumont K 1994 In vitro autoradiographic localization of amylin binding sites in rat brain. Neuroscience 62:553-567
26. 125I]Bolton Hunter-rat amylin binding sites in the rat brain. J Pharmacol Exp Ther 270:779-787
27. Owji AA, Smith DM, Coppock HA, Morgan DG, Bhogal R, Ghatei MA, Bloom SR 1995 An abundant and specific binding site for the novel vasodilator adrenomedullin in the rat. Endocrinology 136:2127-2134
28. Gornall AG, Bardawill CJ, David MM 1949 Determination of serum proteins by means of the biuret reaction. J Biol Chem 177:751-766
29. Bhogal R, Smith DM, Purkiss P, Bloom SR 1993 Molecular identification of binding sites for Calcitonin gene-related peptide (CGRP) and islet amyloid polypeptide (IAPP) in mammalian lung: species variation and binding of truncated CGRP and IAPP. Endocrinology 133:2351-2361
30. Dennis T, Fournier A, Cadieux A, Pomerleau F, Jolicoeur FB, St Pierre S, Quirion R 1490 hCGRP8-37, a calcitonin gene-related peptide antagonist revealing calcitonin gene-related peptide receptor heterogeneity in brain and periphery. J Pharmacol Exp Ther 254:123-128
31. Ueta Y, Kitamura K, Isse T, Shibuya I, Kabashima N, Yamamoto S, Kangawa K, Matsuo H, Eto T, Yamashita H 1995 Adrenomedullin-immunoreactive neurons in the paraventricular and supraoptic nuclei of the rat. Neurosci Lett 202:37-40
32. Parkes DG, May C N 1995 ACTH-suppresivo and vasodilator actions of adrenomedullin in conscious sheep. J Neuroendocrinol 7:923-929
33. Murphy TC, Samson WK 1995 The novel vasoactive hormone, adrenomedullin, inhibits water drinking in the rat. Endocrinology 136:2459-2463
34. Kapas S, Catt KJ, Clark AJL 1995 Cloning and expression of cDNA encoding a rat adrenomedullin receptor. J Biol Chem 270:25344-25347
35. Harrison JK, Barber CM, Lynch KR 1992 Molecular cloning of a novel rat G-protein-coupled receptor gene expressed prominently in lung, adrenal and liver. FEBS Lett 318:17-22