BIIE0246: A selective and high affinity neuropeptide Y Y2 receptor antagonist

European Journal of Pharmacology

Volumn 384, Issue 2-3, 1999, Pages

  Doods, Henri ^a   Gaida, Wolfram ^a   Wieland, Heike A ^a   Dollinger, Horst ^a   Schnorrenberg, Gerd ^a   Esser, Franz ^a   Engel, Wolfhard ^a   Eberlein, Wolfgang ^a   Rudolf, Klaus ^a  

^a BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

BIIE0246; Neuropeptidc Y Y2 receptor antagonist; Neuropeptide Y

Indexed keywords

N2 [[1 [2 [4 (5,11 DIHYDRO 6(6H) OXODIBENZ[B,E]AZEPIN 11 YL]PIPERAZINYL] 2 OXOETHYL]CYCLOPENTYL]ACETYL] N [2 (1,2 DIHYDRO 3,5 DIOXO 1,2 DIPHENYL 3H 1,2,4 TRIAZOL 4 YL]ETHYL]ARGINAMIDE; NEUROPEPTIDE Y; NEUROPEPTIDE Y RECEPTOR; NEUROPEPTIDE Y RECEPTOR ANTAGONIST; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

CELL LINE; CONTROLLED STUDY; DOSE RESPONSE; HUMAN; HUMAN CELL; IN VITRO STUDY; ISOTOPE LABELING; NEUROBLASTOMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SHORT SURVEY;

EID: 0033404704     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(99)00650-0     Document Type: Article

References (8)

1. Criscione l., Rigollier P., Batzl-Hartmann C., Rueger H., Stricker-Krongrad A., Wyss P., Brunner L., Whitebread S., Yamaguchi Y., Gerald C., Heurich R.O., Walker M.W., Chiesi M., Schilling W., Hofbauer K.G., Levens N. Food intake in free-feeding and energy-deprived lean rats is mediated by the neuropeptide Y5 receptor. J. Clin. Invest. 102(12):1998;2136-2145.
2. Doods H., Krause J. Different neuropeptide Y receptor subtypes in rat and rabbit vas deferens. Eur. J. Pharmacol. 204:1991;101-103.
3. Gerald C., Walker M.W., Vaysse P.J.-J, He C., Branchek T.A., Weinshank R.L. Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/peptide YY Y2 receptor subtype. J. Biol. Chem. 270(45):1995;26758-26761.
4. Gerald C., Walker M.W., Criscione L., Gustafson E.L., Batzl-Hartmann C., Smith K.E., Vaysse P., Durkin M.M., Laz T.M., Linemeyer D.L., Schaffhauser A.O., Whitebread S., Hofbauer K.G., Taber R.I., Branchek T.A., Weinshank R.L. A receptor subtype involved in neuropeptide-Y-induced food intake. Nature. 381:1996;168-171.
5. Grouzmann E., Buclin T., Martire M., Cannizzaro C., Dorner B., Razaname A., Mutter M. Characterization of a selective antagonist of neuropeptide Y at the Y2 receptor. Synthesis and pharmacological evaluation of a Y2 antagonist. J. Biol. Chem. 272(12):1997;7699-7706.
6. Michel M.C., Beck-Sickinger A., Cox H., Doods H.N., Herzog H., Larhammar D., Quirion R., Schwartz T., Westfall T. XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors. Pharm. Rev. 50(1):1998;143-150.
7. Rudolf K., Eberlein W., Engel W., Wieland H.A., Willim K.D., Entzeroth M., Wienen W., Beck-Sickinger A.G., Doods H.N. The first highly potent and selective non-peptide neuropeptide Y Y1 receptor antagonist: BIBP3226. Eur. J. Pharmacol. 271:1994;R11-R13.
8. Wieland H.A., Engel W., Eberlein W., Rudolf K., Doods H.N. Subtype selectivity of the novel nonpeptide neuropeptide Y Y1 receptor antagonist BIBO3304 and its effect on feeding in rodents. Br. J. Pharmacol. 125:1998;549-555.