Adrenomedullin, a multifunctional regulatory peptide

Endocrine Reviews

Volumn 21, Issue 2, 2000, Pages 138-167

  Hinson, Joy Patricia ^a   Kapas, Supriya ^a   Smith, David Michael ^b  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENOMEDULLIN;

ANIMAL CELL; BINDING SITE; CROSS LINKING; DRUG RECEPTOR BINDING; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; METABOLIC REGULATION; MOLECULAR CLONING; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN SYNTHESIS REGULATION; RECEPTOR GENE; REVIEW; SIGNAL TRANSDUCTION;

ADRENOMEDULLIN; AMINO ACID SEQUENCE; ANIMALS; GENE EXPRESSION REGULATION; HUMANS; MOLECULAR SEQUENCE DATA; PEPTIDES; RECEPTORS, PEPTIDE; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION;

EID: 0034453838     PISSN: 0163769X     EISSN: None     Source Type: Journal    
DOI: 10.1210/er.21.2.138     Document Type: Review

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185. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor
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187. Receptor activity modifying proteins regulate the activity of a calcitonin gene-related peptide receptor in rabbit aortic endothelial cells
188. Effect of adrenomedullin on cAMP and cGMP levels in rat cardiac myocytes and nonmyocytes
189. Interaction of adrenomedullin with calcitonin receptor in cultured human breast cancer cells, T 47D
190. Proadrenomedullin N-terminal 20 peptide (PAMP) inhibits proliferation of human neuroblastoma TGW cells
191. The selectivity and structural determinants of peptide antagonists at the CGRP receptor of rat, L6 myocytes
192. Intravenous infusion of adrenomedullin and increase in regional cerebral blood flow and prevention of ischemic brain injury after middle cerebral artery occlusion in rats
193. Adrenomedullin-(22-52) antagonizes vasodilator responses to CGRP but not adrenomedullin in the cat
194. Adrenomedullin-mediated relaxations in veins are endothelium-dependent and distinct from arteries
195. Investigation and characterization of binding sites for islet amyloid polypeptide in rat membranes
196. Autoradiographic studies on the binding sites of I-125-adrenomedullin in rat tissues
197. Autoradiographic evidence that zona glomerulosa and capsular vessels of the human adrenal cortex are provided with different subtypes of adrenomedullin receptors
198. Adrenomedullin in pregnancy
199. Cross-reactivity of amylin with calcitonin-gene-related peptide binding sites in rat liver and skeletal muscle membranes
200. Positive inotropic effects and receptors of calcitonin gene-related peptide (CGRP) in porcine ventricular muscles
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204. A novel putative G protein-coupled receptor highly expressed in lung and testis
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206. Molecular cloning of a novel human receptor gene with homology to the rat adrenomedullin receptor and high expression in heart and immune system
207. Expression of the rat adrenomedullin receptor or a putative human adrenomedullin receptor does not correlate with adrenomedullin binding or functional response
208. Identification of an orphan receptor gene as a type 1 calcitonin gene-related peptide receptor
209. Identification of a protein that confers calcitonin gene-related peptide responsiveness to oocytes by using a cystic fibrosis transmembrane conductance regulator assay
210. Testes exhibit elevated expression of calcitonin gene-related peptide receptor component protein
211. Regional and cellular localization of calcitonin gene-related peptide-receptor component protein mRNA in the guinea-pig central nervous system
212. A new calcitonin-receptor-like sequence in rat pulmonary blood vessels
213. Identification of a seven transmembrane helix receptor for corticotropin-releasing factor and sauvagine in mammalian brain
214. A human orphan calcitonin receptor-like structure
215. A cDNA encoding the calcitonin gene-related peptide type 1 receptor
216. The interaction of CGRP and adrenomedullin with a receptor expressed in the rat pulmonary vascular endothelium
217. Molecular cloning and characterization of the porcine calcitonin gene-related peptide receptor
218. The RAMP2/CRLR complex is a functional adrenomedullin receptor in human endothelial and vascular smooth muscle cells
219. The amino terminus of receptor activity modifying proteins is a critical determinant of glycosylation state and ligand binding of calcitonin receptor-like receptor
220. Amylin receptor is revealed following co-transfection of a calcitonin receptor with receptor activity modifying proteins-1or-3
221. Distribution of novel CGRP(1) receptor and adrenomedullin receptor mRNAs in the rat central nervous system
222. Neuroanatomical localization, pharmacological characterization and functions of CGRP, related peptides and their receptors
223. Cardiac expression of genes encoding putative adrenomedullin/calcitonin gene-related peptide receptors
224. Co-expression of prepro-adrenomedullin with a putative adrenomedullin receptor gene in vascular smooth muscle
225. Desensitization of CGRP and adrenomedullin receptors in SK-N-MC cells: Implications for the RAMP hypothesis
226. Down-regulation of adenylate cyclase coupled to adrenomedullin receptor in vascular smooth muscle cells
227. Adrenomedullin increases intracellular Ca2+ and inositol 1,4,5-trisphosphate in human oligodendroglial cell line KG-1C
228. Adrenomedullin binds with high affinity, elevates cyclic AMP, and stimulates c-fos mRNA in C6 glioma cells
229. Cytoprotective effects of adrenomedullin in glomerular cell injury: Central role of cAMP signaling pathway
230. Activation of adenylyl cyclase in human myometrial smooth muscle cells by neuropeptides
231. Adrenomedullin is a potent inhibitor of angiotensin II-induced migration of human coronary artery smooth muscle cells
232. Adrenomedullin as an autocrine/paracrine apoptosis survival factor for rat endothelial cells
233. Adrenomedullin stimulates renin release and renin mRNA in mouse juxtaglomerular granular cells
234. Adrenomedullin stimulates cAMP accumulation and inhibits atrial natriuretic peptide gene expression in cardiomyocytes
235. Actions of adrenomedullin on the rat adrenal cortex
236. Adrenomedullin augments inducible nitric oxide synthase expression in cytokine-stimulated cardiac myocytes
237. Effect of adrenomedullin on cAMP levels along the rat nephron: Comparison with CGRP
238. Adrenomedullin increases inducible nitric oxide synthase in rat vascular smooth muscle cells stimulated with interleukin-1
239. Interaction of adrenomedullin and platelet-derived growth factor on rat mesangial cell production of endothelin
240. Adrenomedullin suppresses mitogenesis in rat mesangial cells via cAMP pathway
241. Adrenomedullin increases cyclic AMP more potently than CGRP and amylin in rat renal tubular basolateral membranes
242. Receptors for adrenomedullin in human vascular endothelial cells
243. Adrenomedullin inhibits the secretion of cytokine-induced neutrophil chemoattractant, a member of the interleukin-8 family, from rat alveolar macrophages
244. Inhibition of endothelin production by adrenomedullin in vascular smooth muscle cells
245. Stimulation of cyclic adenosine monophosphate formation by the novel vasorelaxant peptide adrenomedullin in cultured rat mesangial cells
246. Adrenomedullin acts via stimulation of cyclic AMP and not via calcium signalling in vascular cells in culture
247. Adrenomedullin decreases both cytosolic Ca2+ concentration and Ca(2+)-sensitivity in pig coronary arterial smooth muscle
248. Evidence for cAMP-independent mechanisms mediating the effects of adrenomedullin, a new inotropic peptide
249. Differential inhibition of mesangial MAP kinase cascade by cyclic nucleotides
250. Beraprost sodium, an analogue of prostacyclin, induces the expression of mitogen-activated protein kinase phosphatase and inhibits the proliferation of cultured mesangial cells
251. Adrenomedullin as a novel growth-promoting factor for cultured vascular smooth muscle cells: Role of tyrosine kinase-mediated mitogen-activated protein kinase activation
252. Adrenomedullin synergistically interacts with endogenous vasodilators in rats: A possible role of K-ATP channels
253. Adrenomedullin induces expression of c-fos and AP-1 activity in rat vascular smooth muscle cells and cardiomyocytes
254. Analysis of responses to human synthetic adrenomedullin and calcitonin gene-related peptides in the hindlimb vascular bed of the cat
255. Direct cardiac and vascular actions of adrenomedullin in conscious sheep
256. Vasodilator effects of adrenomedullin on small pulmonary arteries and veins in anaesthetized cats
257. Adrenomedullin: A hypotensive hormone in man
258. Potent and long-lasting vasodilatory effects of adrenomedullin in humans. Comparisons between normal subjects and patients with chronic heart failure
259. ACTH-suppressive and vasodilator actions of adrenomedullin in conscious sheep
260. L-NAME modulates responses to adrenomedullin in the hindquarters vascular bed of the rat
261. Cardiovascular and neurohormonal effects of intravenous adrenomedullin in conscious rabbits
262. Attenuation of adrenomedullin-induced renal vasodilatation by NG-nitro L-arginine but not glibenclamide
263. Mechanisms of adrenomedullin-induced vasodilation in the rat kidney
264. Structure and function of adrenomedullin and PAMP
265. Effects of a synthetic rat adrenomedullin on regional hemodynamics in rats
266. Hemodynamic effects of a novel hypotensive peptide, human adrenomedullin, in rats
267. Effect of chronically infused adrenomedullin in two-kidney, oneclip hypertensive rats
268. Hypotensive effect of chronically infused adrenomedullin in conscious Wistar-Kyoto and spontaneously hypertensive rats
269. Regional haemodynamic effects of human and rat adrenomedullin in conscious rats
270. Comparison of responses to adrenomedullin and adrenomedullin analogs in the mesenteric vascular bed of the cat
271. Renal responses to intra-arterial administration of adrenomedullin in dogs
272. Autocrine regulation of the renal arterial tone by adrenomedullin
273. Effect of adrenomedullin on renal hemodynamics and functions in dogs
274. Analysis of cardiovascular responses to proadrenomedullin NH2 terminal 20 peptide (PAMP) in the rat and the cat
275. Adrenomedullin dilates the pulmonary vascular bed in vivo
276. Prodepin: A new product of the adrenomedullin (ADM) gene has systemic vasodilator activity
277. Pulmonary vasodilator responses to adrenomedullin are reduced by NOS inhibitors in rats but not in cats
278. Uterine vascular effects of adrenomedullin
279. Effects of adrenomedullin and calcitonin gene-related peptide on contractions of the rat aorta and porcine coronary artery
280. Function of the vascular endothelium after hypothermic storage at four degrees Celsius in a canine tibial perfusion model - The role of adrenomedullin in reperfusion injury
281. Effects of adrenomedullin, calcitonin gene-related peptide, and amylin on cerebral circulation in dogs
282. Effects of adrenomedullin on rat cerebral arterioles
283. Transient vasodilatory effects of adrenomedullin on cerebral parenchymal microvessels in cats
284. Mechanisms of adrenomedullin-induced dilatation of cerebral arterioles
285. Discovery of adrenomedullin in rat ischemic cortex and evidence for its role in exacerbating focal brain ischemic damage
286. Analysis of cardiovascular actions of adrenomedullin and related peptides in the cat and rat
287. Comparison of responses to adrenomedullin and calcitonin gene-related peptide in the feline erection model
288. Adrenomedullin induces penile erection in the cat
289. Comparison of responses to rat and human adrenomedullin in the hindlimb vascular bed of the cat
290. Effects of calcitonin gene-related peptide receptor antagonists on renal actions of adrenomedullin
291. Nitric oxide mediates penile erection in cats
292. Penile erections induced by vasoactive intestinal peptide and sodium nitroprusside
293. Adrenomedullin dilates rat pulmonary artery rings during hypoxia: Role of nitric oxide and vasodilator prostaglandins
294. New peptides, hormones and parturition
295. Inotropic effect of adrenomedullin in the isolated perfused rat heart
296. Negative inotropic effect of adrenomedullin in isolated adult rabbit cardiac ventricular myocytes
297. Adrenomedullin in the adrenal cortex and medulla - Local production, receptor expression and effects of adrenomedullin and the related peptide, PAMP
298. Use of differential display reverse transcription-polymerase chain reaction for discovery of induced adrenomedullin gene expression in focal stroke
299. Adrenomedullin receptor expression in human lung and in pulmonary tumors
300. Adrenotensin: An adrenomedullin gene product contracts pulmonary blood vessels
301. Inhibitory effect of adrenomedullin on rat mesangial cell mitogenesis
302. Adrenomedullin as a novel antiproliferative factor of vascular smooth muscle cells
303. Induction by lysophosphatidylcholine, a major phospholipid component of atherogenic lipoproteins, of human coronary artery smooth muscle cell migration
304. Chronic infusion of adrenomedullin reduces pulmonary hypertension and lessens right ventricular hypertrophy in rats administered monocrotaline
305. Expression of adrenomedullin and its receptor during embryogenesis suggests autocrine or paracrine modes of action
306. Coordinate expression of transforming growth factor-beta 1 and adrenomedullin in rodent embryogenesis
307. Expression of adrenomedullin, a hypotensive peptide, in the trophoblast giant cells at the embryo implantation site in mouse
308. A novel vasoactive peptide, adrenomedullin, inhibits pituitary adrenocorticotropin release
309. Paracrine control of adrenal cortical function by medullary chromaffin cells
310. Intraadrenal interactions in the regulation of adrenocortical steroidogenesis
311. Inhibition of aldosterone production by adrenomedullin, a hypotensive peptide, in the rat
312. Effect of adrenomedullin on aldosterone secretion by dispersed rat adrenal zona glomerulosa cells
313. Alphamelanocyte-stimulating hormone-induced inhibition of angiotensin II receptor-mediated events in the rat adrenal zona glomerulosa
314. Effects of adrenomedullin and proadrenomedullin N-terminal 20 peptide on rat zona glomerulosa cells
315. Effects of adrenomedullin on the human adrenal glands: An in vitro study
316. Adrenomedullin and CGRP receptors mediate different effects in the rat adrenal cortex
317. Adrenomedullin stimulates steroid secretion by the isolated perfused rat adrenal gland in situ: Comparison with calcitonin gene-related peptide effects
318. Adrenomedullin stimulates calcium efflux from adrenal chromaffin cells in culture: Possible involvement of an Na+/Ca2+ exchange mechanism
319. Effects of adrenomedullin and PAMP on adrenal catecholamine release in dogs
320. Matrix metalloproteases: Variations on a theme
321. The control of blood flow to the placenta
322. Adrenomedullin is widely expressed throughout normal and abnormal reproductive tissues of women - Evidence for cyclic regulation
323. Expression of calcitonin receptor-like receptor and receptor-activity-modifying proteins in human cranial arteries
324. Detect of adrenomedullin, a hypotensive peptide, in amniotic fluid and fetal membranes
325. Immunohistochemical localization of endothelin-1 in placenta and fetal membranes in term and preterm human pregnancy
326. Adrenomedullin attenuates the hypertension in hypertensive pregnant rats induced by N-G-nitro-L-arginine methyl ester
327. Inhibition of nitric oxide synthesis in rats during pregnancy produces signs similar to those of preeclampsia
328. Prolonged blockade of nitric oxide synthesis in gravid rats produces sustained hypertension, proteinuria, thrombocytopenia, and intrauterine growth retardation
329. Preeclampsia-like conditions produced by nitric oxide inhibition: Effects of L-arginine, D-arginine and steroid hormones
330. Adrenomedullin and calcitonin gene-related peptide in the rat isolated kidney and in the anaesthetised rat: In vitro and in vivo effects
331. Renal effects of adrenomedullin in the rat
332. Cardiovascular and renal effects of adrenomedullin in rats with heart failure
333. Beneficial hemodynamic and renal effects of adrenomedullin in an ovine model of heart failure
334. Neutral endopeptidase inhibition potentiates the natriuretic actions of adrenomedullin
335. Role of endopeptidase-24.11 in the inactivation of atrial natriuretic peptide
336. Neutral endopeptidase 24.11: A modulator of natriuretic peptides
337. Mechanism of adrenomedullin-stimulated hyaluronic acid release in rat mesangial cells
338. Central action of adrenomedullin to inhibit gastric emptying in rats
339. Adrenomedullin and regulation of gastric function
340. Neuropeptides, inflammation, and motility
341. Adrenomedullin, amylin, calcitonin gene-related peptide and their fragments are potent inhibitors of gastric acid secretion in rats
342. Adrenomedullin promotes epithelial restitution of rat and human gastric mucosa in vitro
343. Adrenomedullin is a potent stimulator of osteoblastic activity in vitro and in vivo
344. Potentiation of the bronchoprotective effects of vasoactive intestinal peptide, isoprenaline, and theophylline against histamine challenge in anaesthetised guinea pigs by adrenomedullin
345. Augmented adrenomedullin concentrations in right ventricle and plasma of experimental pulmonary hypertension
346. Cytokines and pulmonary fibrosis
347. Antimicrobial activity of adrenomedullin and its gene-related peptides
348. An investigation into the antimicrobial effects of adrenomedullin on members of the skin, oral, respiratory tract and gut microflora
349. Epithelial antibiotics induced at sites of inflammation
350. Paneth cells of the human small intestine express an antimicrobial peptide gene
351. Cardiovascular actions of adrenomedullin in conscious sheep
352. The role of adrenomedullin
353. Hemodynamic, hormonal, and renal effects of intracerebroventricular adrenomedullin in conscious sheep
354. Intracerebroventricular injection of adrenomedullin inhibits vasopressin release in conscious rats
355. The ventral surface of the brain stem: A scarcely explored region of pharmacological sensitivity
356. Distribution of adrenomedullin-like immunoreactivity in the rat central nervous system: A light and electron microscopic study
357. Cardiovascular hormones
358. Anorexia following the intrahypothalamic administration of amylin
359. Amylin decreases food intake in mice
360. Extensive brain mapping of calcitonin-induced anorexia
361. Interrelationships between calcitonin and other modulators of feeding behavior
362. Calcitonin: Inhibitory effect on eating in rats
363. Centrally induced vasopressor and sympathetic responses to a novel endogenous peptide, adrenomedullin, in anesthetized rats
364. The novel vasoactive hormone, adrenomedullin, inhibits water drinking in the rat
365. Adrenomedullin inhibits salt appetite
366. Antisense oligonudeotide treatment reveals a physiologically relevant role for adrenomedullin gene products in sodium intake
367. Effects of centrally or peripherally injected adrenomedullin on reserpine-induced gastric lesions
368. Central mechanisms for the hypertensive effects of preproadrenomedullin-derived peptides in conscious rats
369. Central actions of adrenomedullin on cardiovascular parameters and sympathetic outflow in conscious rats
370. Adrenomedullin microinjection into the area postrema increases blood pressure
371. In vitro recordings from area postrema neurons demonstrate responsiveness to adrenomedullin
372. Cardiovascular and sympathetic effects of proadrenomedullin NH2-terminal 20 peptide in conscious rats