Pharmacological characterization of receptor-activity-modifying proteins (RAMPs) and the human calcitonin receptor

Journal of Pharmacological and Toxicological Methods

Volumn 42, Issue 4, 1999, Pages 217-224

  Armour, Susan L ^a   Foord, Steve ^b   Kenakin, Terry ^a   Chen, Wen Ji ^a  

^a GLAXOSMITHKLINE   (United States)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Adrenomedullin; Amylin; Calcitonin receptor; Calcitonin receptor like receptor; CGRP (calcitonin gene related peptide); Melanophore; RAMP (receptor activity modifying protein)

Indexed keywords

AMYLIN; CALCITONIN GENE RELATED PEPTIDE; CALCITONIN RECEPTOR; COMPLEMENTARY DNA; MELATONIN; RECEPTOR ACTIVITY MODIFYING PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; MELANOPHORE; NONHUMAN; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION; XENOPUS LAEVIS;

AMYLOID; ANIMAL; ANTI-ULCER AGENTS; CALCITONIN; HUMAN; MEMBRANE PROTEINS; RATS; RECEPTORS, CALCITONIN; SIGNAL TRANSDUCTION; XENOPUS;

MELANOPHORA; XENOPUS LAEVIS;

EID: 0033303252     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1056-8719(00)00074-5     Document Type: Article

References (37)

1. A cDNA encoding the calcitonin gene-related peptide type 1 receptor
2. Some quantitative uses of drug antagonists
3. Effector pathway-dependent relative efficacy at serotonin type 2A and 2C receptors; evidence for agonist-directed trafficking of receptor stimulus
4. Differential opioid agonist regulation of the mouse mu opioid receptor
5. Expression cloning and receptor pharmacology of human calcitonin receptors from MCF-7 cells and their relationship to amylin receptors
6. Multiple amylin receptors arise from receptor activity modifying protein interaction with the calcitonin receptor gene product
7. The amylin super-family; a novel grouping of biologically active polypeptides related to the insulin A-chain
8. Ramps; accessory proteins for seven transmembrane domain receptors
9. A human orphan calcitonin receptor-like structure
10. The amino terminus of receptor activity modifying proteins is a critical determinant of glycosylation state and ligand binding of calcitonin-like receptor
11. Cloning, characterization, and expression of a human calcitonin receptor from an ovarian carcinoma cell line
12. Pigment dispersion in frog melanophores can be induced by a phorbol ester or stimulation of a recombinant receptor that activates phospholipase C
13. A rapid bioassay for platelet-derived growth factor beta-receptor tyrosine kinase function
14. Creation and functional screening of a multi-use peptide library
15. Discovery and structure-function analysis of α-melanocyte-stimulating hormone antagonists
16. Cloning and characterization of an endothelin-3 specific receptor (ETC receptor) from Xenopus laevis dermal melanophores
17. Morphine activates opioid receptors without causing their rapid internalization
18. 2-adrenergic receptor-Gs complex; evidence for agonist-specific states
19. Tools for investigating functional interactions between ligands and G-protein-coupled receptors
20. Expression cloning of an adenylate cyclase-coupled calcitonin receptor
21. 2 and affinity constants for pharmacological competitive antagonists be estimated?
22. RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor
23. Functional expression of recombinant G-protein-coupled receptors monitored by video imaging of pigment movement in melanophores
24. A new calcitonin-receptor-like sequence in rat pulmonary blood vessels
25. Inhibition of inositol phosphate second messenger formation by intracellular loop one of human calcitonin receptor. Expression and mutational analysis of synthetic receptor genes
26. A method for evaluating the effects of ligands upon Gs protein-coupled receptors using a recombinant melanophore-based bioassay
27. Functional expression and characterization of human D2 and D3 dopamine receptors
28. Agonist-specific coupling of a cloned Drosophila octopamine/tyramine receptor to multiple second messenger systems
29. Differential signal transduction by five splice variants of the PACAP receptor
30. Selection of distinct conformational states of the 5HT3 receptor by full and partial agonists
31. The presence of islet amyloid polypeptide/calcitonin gene-related peptide/salmon calcitonin binding sites in the rat nucleus accumbens
32. The pharmacology of amylin receptors in the rat nucleus accumbens; effects of receptor/G-protein interactions on ligand affinity
33. Contribution of serine residues to constitutive and agonist-induced signaling via the D2S dopamine receptor; evidence for multiple, agonist-specific active conformation
34. μ- Opioid receptor phosphorylation, desensitization, and ligand efficacy