Ethanol consumption and resistance are inversely related to neuropeptide Y levels

Nature

Volumn 396, Issue 6709, 1998, Pages 366-369

  Thiele, Todd E ^a   Marsh, Donald J ^b   Marie, Linda Ste ^b   Bernstein, Ilene L ^a   Palmiter, Richard D ^b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; HYPNOTIC SEDATIVE AGENT; NEUROPEPTIDE Y;

ANIMAL; ARTICLE; BLOOD; C57BL MOUSE; DRINKING BEHAVIOR; MALE; MOUSE; PHYSIOLOGY; TASTE; TRANSGENIC MOUSE;

ALCOHOL DRINKING; ANIMALS; ETHANOL; HYPNOTICS AND SEDATIVES; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEUROPEPTIDE Y; TASTE;

EID: 0032569940     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/24614     Document Type: Letter

References (30)

1. Carr, L. G. et al.Aquantitative traitlocus foralcohol consumption in selectivelybred ratlines. Alcohol. Clin. Exp. Res. 22, 884-887 (1998).
2. Ehlers, C. L. et al. Neuropeptide Y (NPY) levels in ethanol-naive alcohol preferring and nonpreferring rats and in wistars following ethanol exposure. Alcohol. Clin. Exp. Res. (in the press).
3. Erickson, J. C., Clegg, K. E. and Palmiter, R. D. Sensitivityto leptin and susceptibilityto seizures of mice lacking neuropeptide Y. Nature 381, 415-418 (1996).
4. Colmer, W. F. and Wahlestedt, C. The Biology of Neuropeptide Y and Related Peptides (Humana, Totowa, NJ, 1993).
5. Dumont, Y., Martel, J. C., Fournier, A., St Pierre, S. and Quirion, R. Neuropeptide Y and neuropeptide Y receptor subtypes in brain and peripheral tissues. Prog. Neurobiol. 38, 125-167 (1992).
6. Clark, J. J., Karla, P. S., Crowle, W. R. and Karla, S. P. NeuropeptideYandhumanpancreatic polypeptide stimulate feeding behavior in rats. Endocrinology 115, 427-429 (1984).
7. Levine, A. S. and Morley, J. E. Neuropeptide Y: a potent inducer of consummatory behavior in rats. Peptides 5, 1025-1029 (1984).
8. Woldbye, D. P., Madsen, T. M., Larsen, P. J., Mikkelsen, J. D. and Bolwig, T. G. Neuropeptide Y inhibits hippocampal seizures and wet dog shakes. Brain Res. 737, 162-168 (1996).
9. Woldbye, D. P. et al. Powerful inhibition of kainic acid seizures by neuropeptide Y via Y5-like receptors. NatureMed. 3, 761-764 (1997).
10. Heilig, M., McLeod, S., Koob, G. K. and Britton, K. T. Anxiolytic-like effect ofneuropeptide Y (NPY), but not other peptides in an operant conflict test. Regul. Pept. 41, 61-69 (1992).
11. Heilig, M. et al. Anxiolytic-like action ofneuropeptide Y: mediationbyY1 receptors in amygdala, and dissociation from food intake effects. Neuropsychopharmacol. 8, 357-363 (1993).
12. Yamada, K. et al. Neuropeptide Y reverses corticotropin-releasing hormone- and psychological stress- caused shortening of sodium pentobarbital-induced sleep in rats. Brain Res. 725, 272-275 (1996).
13. Palmiter, R. D., Erickson, J. C., Hollopeter, G., Baraban, S. C. and Schwartz, M. W. Life without neuropeptide Y. Recent Prog. Horm. Res. 53, 163-199 (1998).
14. Li, T.-K., Lumeng, L. and Doolittle, D. P. Selective breeding for alcohol preference and associated responses. Behav. Genet. 23, 163-170 (1993).
15. Kurtz, D. L., Stewart, R. B., Zweifel, M., Li, T.-K. and Froehlich, J. C. Genetic differences in tolerance and sensitization to the sedative/hypnotic effects of alcohol. Pharmacol. Biochem. Behav. 53, 585-591 (1996).
16. Crawley, J. N. et al. Behavioral phenotypes ofinbred mouse strains: implications and recommendations for molecular studies. Psychopharmacol. 132, 107-124 (1997).
17. Belknap, J. K., Crabbe, J. C. and Young, E. R. Voluntary consumption of ethanol in 15 inbred mouse strains. Psychopharmacol. 112, 503-510 (1993).
18. Melo, J. A., Shendure, J., Pociask, K. and Silver, L. M. Identification of sex-specific quantitative trait loci controlling alcohol preference in C57BL/6 mice. Nature Genet. 13, 137-138 (1996).
19. Heilig, M. and Widerlov, E. Neurobiology and clinical aspects of neuropeptide Y. Crit. Rev. Neurobiol. 9, 115-136 (1995).
20. Gerald, C. et al. A receptor subtype involved in neuropeptide-Y-induced food intake. Nature 382, 168-171 (1996).
21. Diamond, I. and Gordon, A. Cellularandmolecular neuroscienceofalcoholism. Physiol. Rev. 77, 1-20 (1997).
22. Lane-Ladd, S. B. et al. CREB (cAMP response element-binding protein) in the locus coeruleus: biochemical, physiological, and behavioral evidence for a role in opiate dependence. J. Neurosci. 17, 7890-7901 (1997).
23. Self, D. W. et al. Involvement of cAMP-dependentproteinkinase inthe nucleus accumbens in cocaine self-administration and relapse of cocaine-seeking behavior. J. Neurosci. 18, 1848-1859 (1998).
24. Moore, M. S. et al. Ethanol intoxication in Drosophila: genetic and pharmacological evidence for regulation bythe cAMP signaling pathway. Cell 93, 997-1007 (1998).
25. Woods, S. C., Seeley, R. J., Porte, D. and Schwartz, M. W. Signals that regulate food intake and energy homeostasis. Science 280, 1378-1383 (1998).
26. Stewart, R. B., Gatto, G. J., Lumeng, L., Li, T.-K. and Murphy, J. M. Comparison of alcohol-preferring (P) andnonpreferring (NP) rats on tests ofanxiety and for the anxiolytic effects ofalcohol. Alcohol 10, 1-10 (1993).
27. Ryabinin, A. E., Criado, J. R., Henriksen, S. J., Bloom, F. E. and Wilson, M. C. Differential sensitivity ofc- Fos expression in hippocampus and other brain regions to moderate and low doses ofethanol. Mol. Psychiat. 2, 32-43 (1997).
28. Wright, J. M., Peoples, R. W. and Weight, F. F. Single-channel and whole-cell analysis of ethanol inhibition ofNMDA-activated currents in cultured mouse cortical and hippocampal neurons. Brain Res. 738, 249-256 (1996).
29. Rodgers, R. J. and Shepherd, J. K. Influence of prior maze experience on behaviour and response to diazepam in the elevated plus-maze and light/dark tests of anxiety in mice. Psychopharmacol. 113, 237-242 (1993).
30. Kim, J. J. et al. Selective enhancement of emotional, but not motor, learning in monoamine oxidase A- deficient mice. Neurobiology 94, 5929-5933 (1997).