From micromolar to nanomolar affinity: A systematic approach to identify the binding site of CGRP at the human calcitonin gene-related peptide 1 receptor

Journal of Medicinal Chemistry

Volumn 41, Issue 1, 1998, Pages 117-123

  Rist, Beate ^a   Entzèroth, Michael ^b   Beck Sickinger, Annette G ^a  

^a ETH ZURICH   (Switzerland)

^b BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENOMEDULLIN; AMYLIN; CALCITONIN GENE RELATED PEPTIDE; CALCITONIN GENE RELATED PEPTIDE RECEPTOR; CALCITONIN GENE RELATED PEPTIDE[27-37]; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CALCIUM METABOLISM; DRUG CONFORMATION; DRUG RECEPTOR BINDING; DRUG STABILITY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; RECEPTOR AFFINITY; RECEPTOR DENSITY; VASODILATATION;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CALCITONIN GENE-RELATED PEPTIDE; CELL MEMBRANE; HUMANS; KINETICS; MICROCHEMISTRY; MOLECULAR SEQUENCE DATA; NEUROBLASTOMA; OLIGOPEPTIDES; PEPTIDE FRAGMENTS; RATS; RECEPTORS, CALCITONIN GENE-RELATED PEPTIDE; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0031940701     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970533r     Document Type: Article

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