Multiple amylin receptors arise from receptor activity-modifying protein interaction with the calcitonin receptor gene product

Molecular Pharmacology

Volumn 56, Issue 1, 1999, Pages 235-242

  Christopoulos, George ^c   Perry, Katie J ^c   Morfis, Maria ^c   Tilakaratne, Nanda ^c   Gao, Yongyi ^c   Fraser, Neil J ^a   Main, Martin J ^a   Foord, Steven M ^a   Sexton, Patrick M ^b  

^a GLAXOSMITHKLINE   (United Kingdom)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMYLIN; CALCITONIN RECEPTOR; GENE PRODUCT; RECEPTOR;

ARTICLE; CELL TRANSPORT; CELLULAR DISTRIBUTION; DNA TRANSFECTION; HUMAN; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; RECEPTOR AFFINITY; RECEPTOR INTRINSIC ACTIVITY;

EID: 0033039911     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.56.1.235     Document Type: Article

References (26)

1. Albrandt K, Brady EM, Moore CX, Mull E, Sierzega ME and Beaumont K (1995) Molecular cloning and functional expression of a third isoform of the human calcitonin receptor and partial characterization of the calcitonin receptor gene. Endocrinology 136:5377-5384.
2. Albrandt K, Mull E, Brady EM, Herich J, Moore CX and Beaumont K (1993) Molecular cloning of two receptors from rat brain with high affinity for salmon calcitonin. FEBS Lett. 325:225-230.
3. Beaumont K, Kenny MA, Young AA and Rink TJ (1993) High affinity amylin binding sites in rat brain. Mol Pharmacol 44:493-497.
4. Chen WJ, Armour S, Way J, Chen G, Watson C, Irving P, Cobb J, Kadwell S, Beaumont K, Rimele T and Kenakin T (1997) Expression cloning and receptor pharmacology of human calcitonin receptors from MCF-7 cells and their relationship to amylin receptors. Mol Pharmacol 52:1164-1175.
5. Christmanson L, Westermark P and Betsholtz C (1994) Islet amyloid polypeptide stimulates cyclic AMP accumulation via the porcine calcitonin receptor. Biochem Biophys Res Commun 208:1226-1235.
6. Devine E and Young AA (1998) Weight gain in male and female mice with amylin gene knockout. Diabetes 47(Suppl):A317.
7. Gebre-Medhin S, Mulder H, Pekny M, Westermark G, Tornell J, Westermark P, Sundler F, Ahren B and Betsholtz C (1998) Increased insulin secretion and glucose tolerance in mice lacking islet amyloid polypeptide. Biochem Biophys Res Commun 250:271-277.
8. Gorn AH, Rudolph SM, Flannery MR, Morton CC, Weremowicz S, Wang TZ, Krane SM and Goldring SR (1995) Expression of two human skeletal calcitonin receptor isoforms cloned from a giant cell tumor of bone. The first intracellular domain modulates ligand binding and signal transduction. J Clin Invest 95:2680-2691.
9. Hanna FW, Smith DM, Johnston CF, Akinsanya KO, Jackson ML, Morgan DG, Bhogal R, Buchanan KD and Bloom SR (1995) Expression of a novel receptor for the calcitonin peptide family and a salmon calcitonin-like peptide in the alphathyrotropin thyrotroph cell line. Endocrinology 136:2377-2382.
10. Houssami S, Findlay DM, Brady CL, Martin TJ, Epand RM, Moore EE, Murayama E, Tamura T, Orlowski RC and Sexton PM (1995) Divergent structural requirements exist for calcitonin receptor binding specificity and adenylate cyclase activation. Mol Pharmacol 47:798-809.
11. Houssami S, Findlay DM, Brady CL, Myers DE, Martin TJ and Sexton PM (1994) Isoforms of the rat calcitonin receptor: Consequences for ligand binding and signal transduction. Endocrinology 135:183-190.
12. Kuestner RE, Elrod RD, Grant FJ, Hagen FS, Kuijper JL, Matthewes SL, O'Hara PJ, Sheppard PO, Stroop SD, Thompson DL, Whitmore T, Findlay DM, Houssami S, Sexton PM and Moore EE (1994) Cloning and characterization of an abundant subtype of the human calcitonin receptor. Mol Pharmacol 46:246-255.
13. McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG and Foord SM (1998) RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature (Lond) 393:333-339.
14. Muff R, Born W and Fischer JA (1995) Calcitonin, calcitonin gene related peptide, adrenomedullin and amylin: Homologous peptides, separate receptors and overlapping biological actions. Eur J Endocrinol 133:17-20
15. Nicholson GC, Moseley JM, Sexton PM, Mendelsohn FA and Martin TJ (1986) Abundant calcitonin receptors in isolated rat osteoclasts. Biochemical and autoradiographic characterization. J Clin Invest 78:355-360.
16. Perry KJ, Quiza M, Myers DE, Morfis M, Christopoulos G and Sexton PM (1997) Characterization of amylin and calcitonin receptor binding in the mouse alphathyroid-stimulating hormone thyrotroph cell line. Endocrinology 138:3486-3496.
17. Pittner RA, Wolfe-Lopez D, Young AA and Beaumont K (1996) Different pharmacological characteristics in L6 and C2C12 muscle cells and intact rat skeletal muscle for amylin, CGRP and calcitonin. Br J Pharmacol 117:847-852.
18. Quiza M, Dowton M, Perry KJ and Sexton PM (1997) Electrophoretic mobility and glycosylation characteristics of heterogeneously expressed calcitonin receptors. Endocrinology 138:530-539.
19. Sexton PM, Houssami S, Brady CL, Myers DE and Findlay DM (1994a) Amylin is an agonist of the renal porcine calcitonin receptor. Endocrinology 134:2103-2107.
20. Sexton PM, Houssami S, Hilton JM, O'Keeffe LM, Center RJ, Gillespie MT, Darcy P and Findlay DM (1993) Identification of brain isoforms of the rat calcitonin receptor. Mol Endocrinol 7:815-821.
21. Sexton PM, Paxinos G, Kenney MA, Wookey PJ and Beaumont K (1994b) In vitro autoradiographic localization of amylin binding sites in rat brain. Neuroscience 62:553-567.
22. Sexton PM and Perry KJ (1996) Amylin receptors in the central nervous system. Recent Res Dev Neurochem 1:157-166.
23. 125I]Bolton Hunter-rat amylin binding sites in the rat brain. J Pharmacol Exp Ther 270:779-787.
24. Wimalawansa SJ (1997) Amylin, calcitonin gene-related peptide, calcitonin, and adrenomedullin: A peptide superfamily. Crit Rev Neurobiol 11:167-239
25. Wookey PJ, Tikellis C, Du HC, Qin HF, Sexton PM and Cooper ME (1996) Amylin binding in rat renal cortex, stimulation of adenylyl cyclase, and activation of plasma renin. Am J Physiol 270:F289-F294.
26. Young AA (1997) Amylin's physiology and its role in diabetes. Curr Opin Endocrinol Diabetes 4:282-290.