Blockade and reversal of spinal morphine tolerance by peptide and non-peptide calcitonin gene-related peptide receptor antagonists

British Journal of Pharmacology

Volumn 131, Issue 5, 2000, Pages 875-884

  Powell, Kelly J ^a   Ma, Weiya ^b   Sutak, Maaja ^a   Doods, Henri ^c   Quirion, Remi ^b   Jhamandas, Khem ^a  

^a QUEEN S UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

Antinociception; Calcitonin gene related peptide; Immunostaining; Morphine tolerance; Spinal cord

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE RECEPTOR; CALCITONIN GENE RELATED PEPTIDE RECEPTOR ANTAGONIST; MORPHINE; N METHYL DEXTRO ASPARTIC ACID; OLCEGEPANT; SUBSTANCE P; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG ANTAGONISM; DRUG RECEPTOR BINDING; DRUG TOLERANCE; IMMUNOHISTOCHEMISTRY; MALE; MORPHINE TOLERANCE; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL ANESTHESIA; SPINAL CORD DORSAL HORN; TAIL FLICK TEST;

EID: 0033707952     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703655     Document Type: Article

References (52)

1. Molecular and cellular mechanisms in opioid tolerance
2. A method for determining loss of pain sensation
3. hGRP8-37, a calcitonin gene-related peptide antagonist revealing calcitonin gene-related peptide receptor heterogeneity in brain and periphery
4. Electrophysiological studies on the effects of intrathecal morphine on nociceptive neurones in the rat dorsal horn
5. Pharmacological profile of BIBN4096BS, the first selective small molecule CGRP antagonist
6. Concurrent spinal infusion of MK801 blocks spinal tolerance and dependence induced by chronic intrathecal morphine in the rat
7. Dextromethorphan attenuates and reverses analgesic tolerance to morphine
8. Calcitonin gene-related peptide immunoreactivity in the spinal cord of man and of eight other species
9. Intrathecal substance P-induced thermal hyperalgesia and spinal release of prostaglandin E2 and amino acids
10. Tachykinin antagonists inhibit the morphine withdrawal response in guinea-pigs
11. The effects of substance P and calcitonin gene-related peptide on the efflux of endogenous glutamate and aspartate from the rat spinal dorsal horn in vitro
12. Blockade of tolerance to morphine but not to kappa opioids by a nitric oxide synthase inhibitor
13. Substance P-(1-7), a substance P metabolite, inhibits withdrawal jumping in morphine-dependent mice
14. Neuropeptide-mediated transmission of nociceptive information and its regulation. Novel mechanisms of analgesics
15. Evidence that substance P and somatostatin transmit separate information related to pain in the spinal dorsal horn
16. Calcitonin gene-related peptide is a potent inhibitor of substance P degradation
17. Determination of cross tolerance in rat spinal cord using intrathecal infusion via sequential mini-osmotic pumps
18. Thermal hyperalgesia in association with the development of morphine tolerance in rats: Roles of excitatory amino acid receptors and protein kinase C
19. Experimental mononeuropathy reduces the antinociceptive effects of morphine: Implications for common intracellular mechanisms involved in morphine tolerance and neuropathic pain
20. Mechanisms of hyperalgesia and morphine tolerance: A current view of their possible interactions
21. Eicosanoid synthesis by spinal cord astrocytes is evoked by substance P; possible implications for nociception and pain
22. Mapping of prostaglandin E2 binding sites in rat brain using quantitative autoradiography
23. Tolerance to the antinociceptive properties of morphine in the rat spinal cord: Alteration of calcitonin gene-related peptide-like immunostaining and receptor binding sites
24. A calcitonin gene-related peptide receptor antagonist prevents the development of tolerance to spinal morphine analgesia
25. Excitatory and inhibitory amino acids and peptide-induced responses in acutely isolated rat spinal dorsal horn neurons
26. mu- and kappa-opioids inhibit K+ evoked glutamate release from rat cerebrocortical slices
27. Calcitonin gene-related peptide promotes mechanical nociception by potentiating release of substance P from the spinal dorsal horn in rats
28. Assembly of an inexpensive tail flick analgesia meter
29. Opioid control of the in vitro release of calcitonin gene-related peptide from primary afferent fibres projecting in the rat cervical cord
30. Comparative effects of cyclo-oxygenase and nitric oxide synthase inhibition on the development and reversal of spinal opioid tolerance
31. Morphine induced calcitonin gene-related peptide increase in cultured dorsal root ganglion neurons
32. Characterization of CGRP1 and CGRP2 receptor subtypes
33. The calcitonin gene-related peptide activates both cAMP and NO pathways to induce relaxation of circular smooth muscle cells of guinea-pig ileum
34. Pharmacological differentiation between responses of rat medullary dorsal horn neurons to noxious mechanical and noxious thermal cutaneous stimuli
35. Dual regulation of adenylate cyclase accounts for narcotic dependence and tolerance
36. Ketamine attenuates and reverses morphine tolerance in rodents
37. Adrenomedullin inhibits feeding in the rat by a mechanism involving calcitonin gene-related peptide receptors
38. Attenuation and reversal of morphine tolerance by the competitive N-methyl-D-aspartate receptor antagonist, LY274614
39. Spinal opioid analgesia: How critical is the regulation of substance P signalling?
40. Inhibition of morphine tolerance and dependence by the NMDA receptor antagonist MK-801
41. Inhibition of opiate tolerance by non-competitive N-methyl-D-aspartate receptor antagonists
42. Neuroanatomical localization, pharmacological characterization and functions of CGRP, related peptides and their receptors
43. Prostaglandin E2 enhances bradykinin-stimulated release of neuropeptides from rat sensory neurons in culture
44. The antinociception produced by intrathecal morphine, calcium, A23187, U50, 488H, [D-Ala2, N-Me-Phe4, Glyol]enkephalin and [D-Pen2, D-Pen5]enkephalin after intrathecal administration of calcitonin gene-related peptide in mice
45. Immunoreactive calcitonin gene-related peptide and substance P coexist in sensory neurons to the spinal cord and interact in spinal behavioral responses of the rat
46. Calcitonin gene-related peptide and its receptors: Molecular genetics, physiology, pathophysiology, and therapeutic potentials
47. The threshold for the depressive effect of intrathecal morphine on the spinal nociceptive flexor reflex is increased during autotomy after sciatic nerve section in rats
48. Chronic catheterization of the subarachnoid space
49. Intrathecal morphine inhibits substance P release from mammalian spinal cord in vivo
50. Quantitative autoradiographic distribution of calcitonin gene-related peptide (hCGRP alpha) binding sites in the rat and monkey spinal cord
51. Receptor for calcitonin gene-related peptide: Localization in the dorsal and ventral spinal cord
52. The calcitonin gene-related peptide antagonist CGRP8-37 increases the latency to withdrawal responses in rats