Novel analogues of neuropeptide Y with a preference for the Y1-receptor

European Journal of Biochemistry

Volumn 268, Issue 10, 2001, Pages 2828-2837

  Söll, Richard M ^a,b   Dinger, Michaela C ^a   Lundell, Ingrid ^c   Larhammer, Dan ^c   Beck Sickinger, Annette G ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b ETH ZURICH   (Switzerland)

^c UPPSALA UNIVERSITY   (Sweden)

Author keywords

Food intake; Neuropeptides; NPY; Selective ligands; Structure affinity relationship

Indexed keywords

1 NAPHTHALENESULFONIC ACID [4 [(4 AMINO 2 QUINAZOLINYLAMINO)METHYL]CYCLOHEXYLMETHYL]AMIDE; ANTIBIOTIC G 418; GR 231118; LY 357897; N2 DIPHENYLACETYL N (4 UREIDOMETHYLBENZYL)ARGININAMIDE; NALPHA (DIPHENYLACETYL) N (4 HYDROXYBENZYL) DEXTRO ARGININAMIDE; NEUROPEPTIDE Y DERIVATIVE; NEUROPEPTIDE Y RECEPTOR ANTAGONIST; NEUROPEPTIDE Y1 RECEPTOR; NEUROPEPTIDE Y2 RECEPTOR; NEUROPEPTIDE Y5 RECEPTOR; NEUROPEPTIDE Y[6 ARGININE 34 PROLINE]; NEUROPEPTIDE Y[7 PHENYLALANINE 34 PROLINE]; UNCLASSIFIED DRUG;

ALPHA HELIX; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; RECEPTOR AFFINITY;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE; CHICKENS; CIRCULAR DICHROISM; CRICETINAE; CYCLIC AMP; HUMANS; KINETICS; LIGANDS; MOLECULAR SEQUENCE DATA; NEUROPEPTIDE Y; PEPTIDE BIOSYNTHESIS; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, NEUROPEPTIDE Y; SWINE; TRANSFECTION; TUMOR CELLS, CULTURED;

ANIMALIA; MAMMALIA; SUIDAE; TRIXIS;

EID: 0034819277     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.2001.02161.x     Document Type: Article

References (50)

1. Obesity as a medical problem
2. Neuropeptide Y: Direct and indirect action on insulin secretion in the rat
3. Neuropeptide Y feeding receptors: Are multiple subtypes involved?
4. Neuropeptide Y: A novel neuroendocrine peptide in the control of pituitary hormone secretion, and its relation to luteinizing hormone
5. Neuropeptide Y affects secretion of luteinizing hormone and growth hormone in ovariectomized rats
6. Evidence for different pre- and post-junctional receptors for neuropeptide Y and related peptides
7. Modulation of memory processing by neuropeptide Y
8. Neurobehavioral profile of neuropeptide Y
9. In vivo structure activity study supports the existence of heterogeneous neuropeptide Y receptors
10. Central administration of neuropeptide Y induces hypothermia in mice. Possible interaction with central noradrenergic systems
11. Neuropeptide Y stimulates feeding but inhibits sexual behavior in rats
12. Daily changes of neuropeptide Y-like immunoreactivity in the suprachiasmatic nucleus of the rat
13. Central cardiovascular actions of neuropeptide Y
14. Neuropepitde Y in relation to behavior and psychiatric disorders: Some animal and clinical observations
15. Ethanol consumption and resistance are inversely related to neuropeptide Y levels
16. Neuropeptide Y - A novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide
17. Neuropeptide Y1 subtype pharmacology of a recombinantly expressed neuropeptide receptor
18. Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type
19. Cloned human neuropeptide Y receptor couples to two different second messenger systems
20. Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor
21. Expression cloning and pharmacological characterization of a human hippocampal neuropeptide Y/peptide YY Y2 receptor subtype
22. Expression cloning of a human brain neuropeptide Y Y2 receptor
23. A receptor subtype involved in neuropeptide-Y-induced food intake
24. Cloning and expression of a novel neuropeptide Y receptor
25. Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY
26. Cloning and functional expression of a human Y4 subtype receptor for pancreatic polypeptide, neuropeptide Y, and peptide YY
27. XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors
28. Structural characterization and binding sites of G-protein-coupled receptors
29. Food intake in free-feeding and energy-deprived lean rats is mediated by the neuropeptide Y5 receptor
30. Subtype selectivity of the novel nonpeptide neuropeptide Y Y1 receptor antagonist BIBO 3304 and its effect on feeding in rodents
31. De novo design, synthesis, and biological activities of high-affinity and selective non-peptide agonists of the delta-opioid receptor
32. The pharmacology of neuropeptide Y (NPY) receptor-mediated feeding in rats characterizes better Y5 than Y1, but not Y2 or Y4 subtypes
33. The first selective agonist at the neuropeptide Y Y5-receptor increases food intake in rats
34. The first highly potent and selective non-peptide neuropeptide Y Y1 receptor antagonist: BIBP3226
35. Potent and selective 1,2,3-trisubstituted indole NPY Y-1 antagonists
36. High-affinity neuropeptide Y receptor antagonists
37. The neuropeptide Y Y1 antagonist, 1229U91, a potent agonist for the human pancreatic polypeptide-preferring (NPY Y4) receptor
38. 2-36[K4,RYYSA (19-23)]PP a novel Y5-receptor preferring ligand with strong stimulatory effect on food intake
39. Fluorescent labelled analogues of neuropeptide Y for the characterization of cells expressing NPY receptor subtypes
40. The cloned rat pancreatic polypeptide receptor exhibits profound differences to the orthologous receptor
41. The cloned guinea pig pancreatic polypeptide receptor Y4 resembles more the human Y4 than does the rat Y4
42. Calculation of protein conformation from circular dichroism
43. Evolution of neuropeptide Y, peptide YY and pancreatic polypeptide
44. Structure-affinity studies of C-terminally modified analogs of neuropeptide Y led to a novel class of peptidic Y1 receptor antagonist
45. Complete L-alanine scan of neuropeptide Y reveals ligands binding to Y1 and Y2 receptors with distinguished conformations
46. Molecular characterization of the ligand-receptor interaction of the neuropeptide Y family
47. Neuropeptide Y: Y1 and Y2 affinities of the complete series of analogues with single D-residue substitutions
48. A rational approach for the development of reduced-size analogues of neuropeptide Y with high affinity to the Y1 receptor
49. Defining structural requirements for neuropeptide Y receptors using truncated and conformationally restricted analogues
50. [Leu31, Pro34]neuropeptide Y: A specific Y1 receptor agonist