1,3-Disubstituted benzazepines as novel, potent, selective neuropeptide Y Y1 receptor antagonists

Journal of Medicinal Chemistry

Volumn 42, Issue 14, 1999, Pages 2621-2632

  Murakami, Yasushi ^a   Hara, Hirokazu ^a   Okada, Tetsuo ^a   Hashizume, Hiroshi ^a   Kii, Makoto ^a   Ishihara, Yasunobu ^a   Ishikawa, Michio ^a   Shimamura, Mayumi ^a   Mihara, Shin Inchi ^a   Kato, Goro ^a   Hanasaki, Kohji ^a   Hagishita, Sanji ^a   Fujimoto, Masafumi ^a  

^a SHIONOGI AND CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 [3 (BENZOTHIAZOL 6 YL)UREIDO] 1 N [3 [N' (3 ISOPROPYLUREIDO)]BENZYL] 2,3,4,5 TETRAHYDRO 1H 1 BENZAPIN 2 ONE; BENZAZEPINE DERIVATIVE; NEUROPEPTIDE Y RECEPTOR ANTAGONIST; NEUROPEPTIDE Y1 RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NEUROBLASTOMA CELL; RECEPTOR BINDING; RECEPTOR BLOCKING; STRUCTURE ACTIVITY RELATION;

ANIMALS; BENZAZEPINES; BENZOTHIAZOLES; CALCIUM; CHO CELLS; CRICETINAE; HISTAMINE RELEASE; HUMANS; PHENYLUREA COMPOUNDS; RADIOLIGAND ASSAY; RATS; RECEPTORS, NEUROPEPTIDE Y; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0033566134     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm990044m     Document Type: Article

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