The natriuretic peptide family

Current Opinion in Nephrology and Hypertension

Volumn 5, Issue 1, 1996, Pages 4-11

  Nakao, Kazuwa ^a   Itoh, Hiroshi ^a   Saito, Yoshihiko ^a   Mukoyama, Masashi ^a   Ogawa, Yoshihiro ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ATRIAL NATRIURETIC FACTOR; BRAIN NATRIURETIC PEPTIDE; CLEARANCE RECEPTOR; GUANYLYL CYCLASE A; GUANYLYL CYCLASE B; NATRIURETIC FACTOR; NATRIURETIC PEPTIDE RECEPTOR; NATRIURETIC PEPTIDE TYPE C; PEPTIDE; UNCLASSIFIED DRUG;

BLOOD PRESSURE REGULATION; BODY FLUID; DRUG EFFECT; HOMEOSTASIS; HUMAN; PRIORITY JOURNAL; REVIEW; VASCULARIZATION;

EID: 0029942692     PISSN: 10624821     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041552-199601000-00003     Document Type: Review

References (73)

1. Nakao K, Ogawa Y, Suga S, Imura H: Molecular biology and biochemistry of the natriuretic peptide system I: natriuretic peptides. J Hypertens 1992, 10:907-912.
2. Nakao K, Ogawa Y, Suga S, Imura H: Molecular biology and biochemistry of the natriuretic peptide system II: natriuretic peptide receptors. J Hypertens 1992, 10:1111-1114.
3. Itoh H, Nakao K, Mukoyama M, Yamada T, Hosoda K, Shirakami G, Morii N, Sugawara A, Saito Y, Shono S, et al.: Chronic blockade of endogenous atrial natriuretic polypeptide (ANP) by monoclonal antibody against ANP accelerates the development of hypertension in spontaneously hypertensive and DOCA-salt hypertensive rats. J Clin Invest 1989, 84:145-154.
4. Sano T, Morishita Y, Matsuda Y, Yamada K: Pharmacological profile of HS-142-1, a novel nonpeptide atrial natriuretic peptide antagonist of microbial origin I: selective inhibition of the actions of natriuretic peptides in anesthetized rats. J Pharmacol Exp Ther 1992, 260:825-831.
5. Wada A, Tsutamoto T, Matsuda Y, Kinoshita M: Cardiorenal and neurohumoral effects of endogenous atrial natriuretic peptide in dogs with severe congestive heart failure using a specific antagonist for guanylate cyclase-coupled receptors. Circulation 1994, 89:2232-2240.
6. Nishikimi T, Miura K, Minamino N, Takeuchi K, Takeda T: Role of endogenous atrial natriuretic peptide on systemic and renal hemodynamics in heart failure rats. Am J Physiol 1994, 267:H182-H186.
7. Margulies K, Barclay PL, Burnett JC Jr: The role of neutral endopeptidase in dogs with evolving congestive heart failure. Circulation 1995, 91:2036-2042.
8. Good JM, Peters M, Wilkins M, Jackson N, Oakley CM, Cleland JG: Renal response to candoxatrilat in patients with heart failure. J Am Coll Cardiol 1995, 25:1273-1281.
9. Trippodo NC, Panchal BC, Fox M: Repression of angiotensin II and potentiation of bradykinin contribute to the synergistic effects of dual metalloprotease inhibition in heart failure. J Pharmacol Exp Ther 1995, 272:619-627.
10. Ogawa Y, Nakao K: Brain natriuretic peptide as a cardiac hormone in cardiovascular disorders. In Hypertension: pathophysiology, diagnosis, and management. Vol. 1. Edited by Laragh JH, Brenner BM. New York: Raven Press; 1995:836-840. The significance of BNP as a ventricular hormone was assessed using a molecular biological approach.
11. Tamura N, Ogawa Y, Itoh H, Arai H, Suga S, Nakagawa O, Komatsu Y, Kishimoto I, Takaya K, Yoshimasa T et al.: Molecular cloning of hamster brain and atrial natriuretic peptide cDNAs. Cardiomyopathic hamsters are useful models for brain and atrial natriuretic peptides. J Clin Invest 1994, 94:1059-1068. This paper reports the molecular cloning of hamster BNP and ANP cDNAs, and demonstrates that ventricular expression of the BNP gene is greatly augmented in cardiomyopathic hamsters.
12. Hama N, Itoh H, Shirakami G, Nakagawa O, Suga S, Ogawa Y, Masuda I, Nakanishi K, Yoshimasa T, Hashimoto Y, Yamaguchi M, Hori R, Yasue H, Nakao K: Rapid ventricular induction of brain natriuretic peptide gene expression in experimental acute myocardial infarction. Circulation 1995, 92:1558-1564.
13. LaPointe MC, Sitkins JR: Phorbol ester stimulates the synthesis and secretion of brain natriuretic peptide from neonatal rat ventricular cardiocytes: a comparison with the regulation of atrial natriuretic factor. Mol Endocrinol 1993, 7:1284-1296.
14. Hanford DS, Thuerauf DJ, Murray SF, Glembotski CC: Brain natriuretic peptide is induced by α1-adrenergic agonists as a primary response gene in cultured rat cardiac myocytes. J Biol Chem 1994, 269:26227-26233. This paper describes the differential regulation of the BNP and ANP genes in primary cultures of neonatal rat ventricular cardiocytes, and shows that the BNP gene expression is induced as a primary response gene.
15. Nakagawa O, Ogawa Y, Itoh H, Suga S, Komatsu Y, Kishimoto I, Nishino K, Yoshimasa T, Nakao K: Rapid transcriptional activation and early mRNA turnover of brain natriuretic peptide in cardiocyte hypertrophy. Evidence for brain natriuretic peptide as an 'emergency' cardiac hormone against ventricular overload. J Clin Invest 1995, 96:1280-1287. This paper demonstrates that the BNP gene expression is regulated differently from the ANP gene expression in cultured ventricular cardiocytes, both at the transcriptional and at the post-transcriptional levels. This paper also suggests that BNP is an 'emergency' cardiac hormone against cardiocyte hypertrophy.
16. Grepin C, Dagnino L, Robitaille L, Haberstroh L, Antakly T, Nemer M: A hormone-encoding gene identifies a pathway for cardiac but not skeletal muscle gene transcription. Mol Cell Biol 1994, 14:3115-3129. The first demonstration of the importance of GATA motifs in BNP transcription. This paper also shows that the GATA-dependent pathway is the first mechanism for cardiac-specific transcription.
17. Thuerauf DJ, Hanford DS, Glembotski CC: Regulation of rat brain natriuretic peptide transcription. A potential role for GATA-related transcription factors in myocardial cell gene expression. J Biol Chem 1994, 169:17772-17775. This paper reports the nucleotide sequences of the 2500 base pair rat BNP 5′-flanking region and suggests that the GATA motifs are crucial for BNP transcription in the heart.
18. Ogawa Y, Itoh H, Nakagawa O, Shirakami G, Tamura N, Yoshimasa T, Nagata K, Yoshida N, Nakao K: Characterization of the 5′-flanking region and chromosomal assignment of the human brain natriuretic peptide gene. J Mol Med (in press)
19. Seilhamer JJ, Arfsten A, Miller JA, Lundquist P, Scarborough RM, Lewicki JA, Portor JG: Human and canine gene homologs of porcine brain natriuretic peptide. Biochem Biophys Res Commun 1989, 165:650-658.
20. Steinhelper ME, Cochrane KL, Field LJ: Hypotension in transgenic mice expressing atrial natriuretic factor fusion genes. Hypertension 1990, 16:301-307.
21. Barbee RW, Perry BD, Re RN, Murgo JP, Field LF: Hemodynamics in transgenic mice with overexpression of atrial natriuretic factor. Circ Res 1994, 74:747-751.
22. Field LJ, Veress AT, Steinhelper ME, Cochrane K, Sonnenberg H: Kidney function in ANF-transgenic mice. Effect of blood volume expansion. Am J Physiol 1991, 260:R1-R5.
23. Ogawa Y, Itoh H, Tamura N, Suga S, Yoshimasa T, Uehira M, Matusda S, Shiono S, Nishimoto H, Nakao K: Molecular cloning of the complementary DNA and gene that encode mouse brain natriuretic peptide and generation of transgenic mice that overexpress the brain natriuretic peptide gene. J Clin Invest 1994, 93:1911-1921. This paper reports the molecular cloning of the mouse BNP gene and the generation of transgenic mice which overexpress the BNP gene. This paper demonstrates that BNP is involved in the control of chronic blood pressure.
24. John SWM, Krege JH, Oliver PM, Hagaman JR, Hodgin JB, Pang SC, Flynn TG, Smithies O: Genetic decreases in atrial natriuretic peptide and salt-sensitive hypertension. Science 1995, 267:679-681. The first report of the application of gene targeting methods for research on the natriuretic peptide family. This paper reports the generation of ANP-knockout mice and suggests the possibility that ANP is one of the candidate genes for salt-sensitive hypertension.
25. Sudoh T, Minamino N, Kangawa K, Matsuo H: C-type natriuretic peptide (CNP): a new member of natriuretic peptide family identified in porcine brain. Biochem Biophys Res Commun 1990, 168:863-870.
26. Tawaragi Y, Fuchimura K, Nakazato H, Tanaka S, Minamino N, Kangawa K, Matsuo H: Gene and precursor structure of porcine C-type natriuretic peptide. Biochem Biophys Res Commun 1990, 172:627-632.
27. Tawaragi Y, Fuchimura K, Tanaka S, Minamino N, Kangawa K, Matsuo H: Gene and precursor structures of human C-type natriuretic peptide. Biochem Biophys Res Commun 1991, 171:645-651.
28. Ogawa Y, Nakao K, Nakagawa O, Komatsu Y, Hosoda K, Suga S, Arai H, Nagata K, Yoshida N, Imura H: Human C-type natriuretic peptide: characterization of the gene and peptide. Hypertension 1992, 19:762-765.
29. Ogawa Y, Itoh H, Yoshitake Y, Inoue M, Yoshimasa T, Serikawa T, Nakao K: Molecular cloning and chromosomal assignment of the mouse C-type natriuretic peptide (CNP) gene. Comparison with the human CNP gene. Genomics 1994, 24:383-387. Molecular cloning of the mouse CNP gene and its chromosomal assignment using the polymerase chain reaction-analysed microsatellite length polymorphisms assay in recombinant inbred strains of mice elucidated that the CNP gene was located on mouse chromosome 1; this is in contrast to the localization of the ANP and BNP genes on mouse chromosome 4. The results suggest that CNP, a local regulator or a neuropeptide is functionally and evolutionally distinct from ANP and BNP, which are cardiac hormones.
30. Komatsu Y, Nakao K, Suga S, Ogawa Y, Mukoyama M, Arai H, Shirakami G, Hosoda K, Nakagawa O, Hama N, et al.: C-type natriuretic peptide (CNP) in rats and humans. Endocrinology 1991, 129:1104-1106.
31. Tao H, Zhang LM, Castresana MR, Shillcutt SD, Newman WH: C-type natriuretic peptide but not atrial natriuretic peptide increases cyclic GMP in cerebral arterial smooth muscle cells. Life Science 1995, 56:2357-2365.
32. Goncalves J, Grove KL, Deschepper CF: Generation of cyclic guanosine monophosphate in brain slices incubated with atrial or C-type natriuretic peptides: comparison of the amplitudes and cellular distribution of the responses. Regul Pept 1995, 57:55-63.
33. Stingo AJ, Clavell AL, Aarhus LL, Burnett JC: Cardiovascular and renal actions of C-type natriuretic peptide. Am J Physiol 1992, 262:H308-H312.
34. Hunt PJ, Richards AM, Espiner EA, Nicholls MG, Yandle TG: Bioactivity and metabolism of C-type natriuretic peptide in normal man. J Clin Endocrinol Metab 1994, 78:1428-1435.
35. Cargill RI, Struthers AD, Lipworth BJ: Human C-type natriuretic peptide: effects on the haemodynamic and endocrine responses to angiotensin II. Circ Res 1995, 29:108-111.
36. Itoh H, Pratt RE, Dzau VJ: Atrial natriuretic polypeptide inhibits hypertrophy of vascular smooth muscle cells. J Clin Invest 1990, 86:1690-1697.
37. Itoh H, Pratt RE, Ohno M, Dzau VJ: Atrial natriuretic polypeptide as novel antigrowth factor of endothelial cells. Hypertension 1992, 19:758-761.
38. Furuya M, Yoshida M, Hayashi Y, Ohnuma N, Minamino N, Kangawa K, Matsuo H: C-type natriuretic peptide is a growth inhibitor of rat vascular smooth muscle cells. Biochem Biophys Res Commun 1991, 177:927-931.
39. Suga S, Nakao K, Itoh H, Komatsu Y, Ogawa Y, Hama N, Imura H: Endothelial production of C-type natriuretic peptide and its marked augmentation by transforming growth factor-β: possible existence of 'vascular natriuretic peptide system'. J Clin Invest 1992, 90:1145-1149.
40. Suga S, Itoh H, Komatsu Y, Ogawa Y, Hama N, Yoshimasa T, Nakao K: Cytokine-induced C-type natriuretic peptide (CNP) secretion from vascular endothelial cells. Evidence for CNP as an autocrine/ paracrine regulator from endothelial cells. Endocrinology 1993, 133:3038-3041.
41. Nazario B, Hu RM, Pedram A, Prins B, Levin ER: Atrial and brain natriuretic peptides stimulate the production and secretion of C-type natriuretic peptide from bovine aortic endothelial cells. J Clin Invest 1995, 95:1151-1157.
42. Komatsu Y, Nakao K, Itoh H, Suga S, Ogawa Y, Imura H: Vascular natriuretic peptide. Lancet 1992, 340:622.
43. Ishizaka Y, Kangawa K, Minamino K, Ishii S, Takano T, Eto T, Matsuo H: Isolation and identification of C-type natriuretic peptide in human monocytic cell line, THP-1. Biochem Biophys Res Commun 1992, 189:697-704.
44. Vollmar AM, Schulz R: Expression and differential regulation of natriuretic peptides in mouse macrophages. J Clin Invest 1995, 95:2442-2450. This study reports gene expression of ANP, BNP and CNP in mouse macrophages and demonstrates the stimulation of ANP and CNP production by lipopolysaccharides.
45. Brandt RR, Heublein DM, Mattingly MT, Pittelkow MR, Burnett JC Jr: Presence and secretion of atrial natriuretic peptide from cultured human aortic endothelial cells. Am J Physiol 1995, 268:H921-H925.
46. Shinomiya M, Tashiro J, Saito Y, Yoshida S, Furuya M, Oka N, Tanaka S, Kangawa K, Matsuo H: C-type natriuretic peptide inhibits intimal thickening of rabbit carotid artery after balloon catheter injury. Biochem Biophys Res Commun 1994, 205:1051-1056.
47. Hama M, Itoh H, Shirakami G, Suga S, Komatsu Y, Yoshimasa T, Tanaka I, Mori K, Nakao K: Detection of C-type natriuretic peptide (CNP) in human circulation and marked increase of plasma CNP level in septic shock patients. Biochem Biophys Res Commun 1994, 198:1177-1182. This study demonstrates the presence of CNP in human plasma, different regulation of plasma CNP level from that of ANP and BNP in human diseases and marked increase in septic shock.
48. Stingo AJ, Clavell AL, Heublein DM, Wei C-M, Pittelkow MR, Burnett JC Jr: Presence of C-type natriuretic peptide in cultured human endothelial cells and plasma. Am J Physiol 1992, 263:H318-H321.
49. Dean AD, Vehaskari VM, Greenwald JE: Synthesis and localization of C-type natriuretic peptide in mammalian kidney. Am J Physiol 1994, 266:F491-F496.
50. Mattingly MT, Brandt RR, Heublein DM, We C-M, Nir A, Burnett JC Jr: Presence of C-type natriuretic peptide in human kidney and urine. Kidney Int 1994, 46:744-747.
51. Totsune K, Takahashi K, Murakami O, Satoh F, Sone M, Mouri T: Elevated plasma C-type natriuretic peptide concentrations in patients with chronic renal failure. Clin Sci 1994, 87:319-322.
52. Chang MS, Lowe DG, Lewis M, Hellmiss R, Chen E, Goeddel DV: Differential activation by atrial and brain natriuretic peptides of two different receptor guanylate cyclases. Nature 1989, 341:68-72.
53. Shulz S, Singh S, Bellet RAT, Singh G, Tubb DJ, Chin H, Garbers DL: The primary structure of plasma membrane guanylate cyclase demonstrates diversity within this new receptor family. Cell 1989, 58:1155-1162.
54. Fuller F, Porter JG, Arfsten AE, Miller J, Shilling JW, Scarborough RM, Lewicki JA, Schenk DB: Atrial natriuretic peptide clearance receptor: complete sequence and functional expression of cDNA clones. J Biol Chem 1988, 263:9395-9401.
55. Chinkers M, Garbers DL: The protein kinase domain of the ANP receptor is required for signaling. Science 1989, 245:1392-1394.
56. Duda T, Sharma RK: ATP bimodal switch that regulates the ligand binding and signal transduction activities of the atrial natriuretic factor receptor guanylate cyclase. Biochem Biophys Res Commun 1995, 209:286-292.
57. Kishimoto I, Nakao K, Suga S, Hosoda K, Yoshimasa T, Itoh H, Imura H: Downregulation of C-receptor by natriuretic peptides via ANP-B receptor in vascular smooth muscle cells. Am J Physiol 1993, 265:H1373-H1379.
58. 2-adrenergic receptor, implicating the augmented biological responsiveness to natriuretic peptides when the sympathetic nervous system is activated.
59. Cao L, Zlock DW, Gardner DG: Differential regulation of natriuretic peptide receptor activity in vascular cells. Hypertension 1994, 24:329-338.
60. Suga S, Nakao K, Hosoda K, Mukoyama M, Ogawa Y, Shirakami G, Arai H, Saito Y, Kambayashi Y, Inouye K, Imura H: Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide. Endocrinology 1992, 130:229-239.
61. Koller KJ, Lowe DG, Bennet GL, Minamino N, Kangawa K, Matsuo H, Goeddel DV: Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP). Science 1991, 252:120-123.
62. 1 kidney epithelial cells. Eur J Pharmacol 1994, 268:443-445.
63. Zhao J, Ardaillou N, Lu CY, Placier S, Pham P, Badre L, Camber J, Ardaillou R: Characterization of C-type natriuretic peptide receptors in human mesangial cells. Kidney Int 1994, 46:717-725.
64. Green DF, Duruibe VA, Blyden G, Laskey RE, Bourgoignie JJ: Uptake of atrial natriuretic peptide and production of cGMP in cultured human glomerular endothelial cells. J Am Soc Nephrol 1994, 5:1091-1098.
65. Suga S, Nakao K, Kishimoto I, Hosoda K, Mukoyama M, Arai H, Shirakami G, Ogawa Y, Komatsu Y, Nakagawa O, Hama N, Imura H: Phenotype-related alteration in expression of natriuretic peptide receptors in aortic smooth muscle cells. Circ Res 1992, 71:34-39.
66. Tremblay J, Huot C, Willenbrock RC, Bayard F, Gossard F, Fujio N, Koch C, Kuchel O, Debinski W, Hamet P: Increased cyclic guanosine monophosphate production and overexpression of atrial natriuretic peptide A-receptor mRNA in spontaneously hypertensive rats. J Clin Invest 1993, 92:2499-2508.
67. Yoshimoto T, Naruse M, Naruse K, Fujimaki Y, Tanabe A, Muraki T, Itakura M, Hagiwara H, Hirose S, Demura H: Modulation of vascular natriuretic peptide receptor gene expression in hypertensive and obese hyperglycemic rats. Endocrinology 1995, 136:2427-2434. This paper demonstrates the upregulation of the ANP-A receptor mRNA expression in the aorta of genetically hypertensive, DOCA-salt hypertensive and genetically hyperglycaemic rats.
68. 1 in cultured aortic smooth muscle cells. Hypertension 1994, 23:908-913.
69. Wei CM, Kim CH, Khraibi AA, Miller VM, Burnett JC Jr: Atrial natriuretic peptide and C-type natriuretic peptide in spontaneously hypertensive rats and their vasorelaxing actions in vitro. Hypertension 1994, 23:903-907.
70. Morishita Y, Sano T, Ando K, Saitoh Y, Kase H, Yamada K, Matsuda Y: Microbial polysaccharide HS-142-1 competitively and selectively inhibits ANP binding to its guanylyl cyclase-containing receptor. Biochem Biophys Res Commun 1991, 176:949-957.
71. Zhang PL, Mackenzie HS, Troy JL, Brenner BM: Effects of an atrial natriuretic peptide receptor antagonist on glomerular hyperfiltration in diabetic rats. J Am Soc Nephrol 1994, 4:1564-1570. This paper shows that a natriuretic peptide receptor antagonist, HS-142-1, ameliorates glomerular hyperfiltration in diabetic rats, demonstrating that intrarenal actions of endogenous natriuretic peptides contribute significantly to glomerular hyperfiltration in experimental diabetes mellitus.
72. Hirata Y, Suzuki Y, Hayakawa H, Suzuki E, Kimura K, Goto A, Kangawa K, Matsuo H, Omata M: Participation of endogenous atrial natriuretic peptide in the regulation of urinary protein excretion in experimental diabetic rats. Clin Sci 1995, 88:413-419.
73. Zhang PL, Mackenzie HS, Troy JL, Brenner BM: Effects of natriuretic peptide receptor inhibition on remnant kidney function in rats. Kidney Int 1994, 46:414-420. A report on the antinatriuretic effects of HS-142-1, an ANP-A-B receptor antagonist, in subtotally nephrectomized rats, showing the functional role of endogenous natriuretic peptides in the compensatory increases in glomerular filtration and sodium excretion of the remnant kidney.