Mutant presenilins specifically elevate the levels of the 42 residue β-amyloid peptide in vivo: Evidence for augmentation of a 42-specific γ secretase

Human Molecular Genetics

Volumn 13, Issue 2, 2004, Pages 159-170

  Jankowsky, Joanna L ^a,f   Fadale, Daniel J ^b   Anderson, Jeffrey ^c   Xu, Guilian M ^a   Gonzales, Victoria ^a   Jenkins, Nancy A ^d   Copeland, Neal G ^d   Lee, Michael K ^a   Younkin, Linda H ^b   Wagner, Steven L ^c,e   Younkin, Steven G ^b   Borchelt, David R ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MAYO CLINIC   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

^e Neurogenetics Inc   (United States)

^f CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; BETA SECRETASE 1; GAMMA SECRETASE; PRESENILIN 1; PRESENILIN 2; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CARBOXY TERMINAL SEQUENCE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; FAMILIAL DISEASE; HYPOTHESIS; IN VIVO STUDY; MISSENSE MUTATION; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; ONSET AGE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; REVIEW; SENILE PLAQUE; STEADY STATE; TRANSGENIC MOUSE;

AGE OF ONSET; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; BRAIN; CELLS, CULTURED; ENDOPEPTIDASES; HUMANS; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; MUTATION, MISSENSE; PEPTIDE FRAGMENTS; PRESENILIN-1;

ANIMALIA; MUS MUSCULUS;

EID: 1642555780     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/ddh019     Document Type: Review

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