A Pathogenic Presenilin-1 Deletion Causes Abberrant Aβ42 Production in the Absence of Congophilic Amyloid Plaques

Journal of Biological Chemistry

Volumn 276, Issue 10, 2001, Pages 7233-7239

  Steiner, Harald ^a   Revesz, Tamas ^b   Neumann, Manuela ^a   Helmut, Romig ^c   Grim, Melissa G ^a   Pesold, Brigitte ^a,e   Kretzschmar, Hans A ^a   Hardy, John ^d   Holton, Janice L ^b   Baumeister, Ralf ^a   Houlden, Henry ^b   Haass, Christian ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^d MAYO CLINIC   (United States)

^e CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BRAIN; DISEASES; MUTAGENESIS; PATHOLOGY;

NEURODEGENERATION;

GENES;

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; GENOMIC DNA; MESSENGER RNA; NOTCH RECEPTOR; PRESENILIN 1; TAU PROTEIN; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA-PROTEIN (1-42); COMPLEMENTARY DNA; FLAVINE ADENINE NUCLEOTIDE; MEMBRANE PROTEIN; PEPTIDE FRAGMENT; PSEN1 PROTEIN, HUMAN;

ALZHEIMER DISEASE; ARTICLE; AUTOSOMAL DOMINANT DISORDER; CAENORHABDITIS ELEGANS; CONTROLLED STUDY; GENE DELETION; HUMAN; HUMAN CELL; HUMAN TISSUE; NERVE DEGENERATION; NEURITE; NEUROFIBRILLARY TANGLE; NEUROPIL; PARENCHYMA; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; SENILE PLAQUE; SPASTIC PARAPLEGIA; VASCULAR AMYLOIDOSIS; ANIMAL; BIOSYNTHESIS; CELL LINE; CHEMISTRY; FEMALE; GENETICS; IMMUNOHISTOCHEMISTRY; MALE; METABOLISM; MUTATION; PEDIGREE; SERODIAGNOSIS; SIGNAL TRANSDUCTION; TRANSGENIC ANIMAL; WESTERN BLOTTING;

CAENORHABDITIS; CAENORHABDITIS ELEGANS; GOSSYPIUM HIRSUTUM;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; ANIMALS, GENETICALLY MODIFIED; BLOTTING, WESTERN; CAENORHABDITIS ELEGANS; CELL LINE; CEREBRAL AMYLOID ANGIOPATHY; DNA, COMPLEMENTARY; FEMALE; FLAVIN-ADENINE DINUCLEOTIDE; GENE DELETION; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MEMBRANE PROTEINS; MUTATION; PEDIGREE; PEPTIDE FRAGMENTS; PHENOTYPE; POINT MUTATION; PRECIPITIN TESTS; PRESENILIN-1; RECEPTORS, NOTCH; SENILE PLAQUES; SIGNAL TRANSDUCTION;

EID: 0035831499     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M007183200     Document Type: Article

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