-
1
-
-
0031127305
-
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα
-
ALESSIDR, JAMES SR, DOWNES CP, HOLMES AB, GAFFNEY PR, REESE CB, COHEN P: Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα. Curr Biol 7: 261-269, 1997.
-
(1997)
Curr Biol
, vol.7
, pp. 261-269
-
-
Alessi, D.R.1
James, S.R.2
Downes, C.P.3
Holmes, A.B.4
Gaffney, P.R.5
Reese, C.B.6
Cohen, P.7
-
2
-
-
0032560796
-
Akt activation by growth factors is a multiple-step process: The role of the PH domain
-
BELLACOSA A, CHAN TO, AHMED NN, DATTA K, MALSTROM S, STOKOE D, MCCORMICK F, FENG J, TSICHLIS P: Akt activation by growth factors is a multiple-step process: the role of the PH domain. Oncogene 17: 313-325, 1998.
-
(1998)
Oncogene
, vol.17
, pp. 313-325
-
-
Bellacosa, A.1
Chan, T.O.2
Ahmed, N.N.3
Datta, K.4
Malstrom, S.5
Stokoe, D.6
McCormick, F.7
Feng, J.8
Tsichlis, P.9
-
3
-
-
0035210374
-
Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia
-
BERNAL-MIZRACHI E, WEN W, STAHLHUT S, WELLING CM, PERMUTT MA: Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia. J Clin Invest 108: 1631-1638, 2001.
-
(2001)
J Clin Invest
, vol.108
, pp. 1631-1638
-
-
Bernal-Mizrachi, E.1
Wen, W.2
Stahlhut, S.3
Welling, C.M.4
Permutt, M.A.5
-
4
-
-
0035092268
-
Insulin regulation of protein translation repressor 4E-BP1, an eIF4E-binding protein, in renal epithelial cells
-
BHANDARI BK, FELIERS D, DURAISAMY S, STEWART JL, GINGRAS AC, ABBOUD HE, CHOUDHURY GG, SONENBERG N, KASINATH BS: Insulin regulation of protein translation repressor 4E-BP1, an eIF4E-binding protein, in renal epithelial cells. Kidney Int 59: 866-875, 2001.
-
(2001)
Kidney Int
, vol.59
, pp. 866-875
-
-
Bhandari, B.K.1
Feliers, D.2
Duraisamy, S.3
Stewart, J.L.4
Gingras, A.C.5
Abboud, H.E.6
Choudhury, G.G.7
Sonenberg, N.8
Kasinath, B.S.9
-
5
-
-
0033595011
-
Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1
-
BIGGS WH, MEISENHELDER J, HUNTER T, CAVENEE WK, ARDEN KC: Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. Proc Natl Acad Sci USA 96: 7421-7426, 1999.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 7421-7426
-
-
Biggs, W.H.1
Meisenhelder, J.2
Hunter, T.3
Cavenee, W.K.4
Arden, K.C.5
-
7
-
-
0029160069
-
Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
-
BURGERING BM, COFFER PJ: Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature 376: 599-602, 1995.
-
(1995)
Nature
, vol.376
, pp. 599-602
-
-
Burgering, B.M.1
Coffer, P.J.2
-
8
-
-
0032571257
-
Insulin increases the association of Akt-2 with Glut4-containing vesicles
-
CALERA MR, MARTINEZ C, LIU H, JACK AK, BIRNBAUM MJ, PILCH PF: Insulin increases the association of Akt-2 with Glut4-containing vesicles. J Biol Chem 273: 7201-7204, 1998.
-
(1998)
J Biol Chem
, vol.273
, pp. 7201-7204
-
-
Calera, M.R.1
Martinez, C.2
Liu, H.3
Jack, A.K.4
Birnbaum, M.J.5
Pilch, P.F.6
-
9
-
-
0035947744
-
Myocardial Akt activation and gender: Increased nuclear activity in females versus males
-
CAMPER-KIRBY D, WELCH S, WALKER A, SHIRAISHI I, SETCHELL KD, SCHAEFER E, KAJSTURA J, ANVERSA P, SUSSMAN MA: Myocardial Akt activation and gender: increased nuclear activity in females versus males. Circ Res 88: 1020-1027, 2001.
-
(2001)
Circ Res
, vol.88
, pp. 1020-1027
-
-
Camper-Kirby, D.1
Welch, S.2
Walker, A.3
Shiraishi, I.4
Setchell, K.D.5
Schaefer, E.6
Kajstura, J.7
Anversa, P.8
Sussman, M.A.9
-
10
-
-
0034055787
-
Insulin resistance in fat cells from obese Zucker rats - Evidence for an impaired activation and translocation of protein kinase B and glucose transporter 4
-
CARVALHO E, RONDINONE C, SMITH U: Insulin resistance in fat cells from obese Zucker rats - evidence for an impaired activation and translocation of protein kinase B and glucose transporter 4. Mol Cell Biochem 206: 7-16, 2000.
-
(2000)
Mol Cell Biochem
, vol.206
, pp. 7-16
-
-
Carvalho, E.1
Rondinone, C.2
Smith, U.3
-
11
-
-
0035942232
-
Oxidized LDL inhibits vascular endothelial growth factor-induced endothelial cell migration by an inhibitory effect on the Akt/endothelial nitric oxide synthase pathway
-
CHAVAKIS E, DERNBACH E, HERMANN C, MONDORF UF, ZEIHER AM, DIMMELER S: Oxidized LDL inhibits vascular endothelial growth factor-induced endothelial cell migration by an inhibitory effect on the Akt/endothelial nitric oxide synthase pathway. Circulation 103: 2102-2107, 2001.
-
(2001)
Circulation
, vol.103
, pp. 2102-2107
-
-
Chavakis, E.1
Dernbach, E.2
Hermann, C.3
Mondorf, U.F.4
Zeiher, A.M.5
Dimmeler, S.6
-
12
-
-
0034832915
-
1 modulates NOS expression and phosphorylation of Akt/PKB in rat myocytes exposed to hypoxia-reoxygenation
-
1 modulates NOS expression and phosphorylation of Akt/PKB in rat myocytes exposed to hypoxia-reoxygenation. Am J Physiol 281: H1035-H1039, 2001a.
-
(2001)
Am J Physiol
, vol.281
-
-
Chen, H.1
Li, D.2
Saldeen, T.3
Mehta, J.L.4
-
13
-
-
0035448879
-
Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene
-
CHEN WS, XU PZ, GOTTLOB K, CHEN ML, SOKOL K, SHIYANOVA T, RONINSON I, WENG W, SUZUKI R, TOBE K, KADOWAKI T, HAY N: Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes Dev 15: 2203-2208, 2001b.
-
(2001)
Genes Dev
, vol.15
, pp. 2203-2208
-
-
Chen, W.S.1
Xu, P.Z.2
Gottlob, K.3
Chen, M.L.4
Sokol, K.5
Shiyanova, T.6
Roninson, I.7
Weng, W.8
Suzuki, R.9
Tobe, K.10
Kadowaki, T.11
Hay, N.12
-
14
-
-
0030860466
-
Transforming activity and mitosis-related expression of the AKT2 oncogene: Evidence suggesting a link between cell cycle regulation and oncogenesis
-
CHENG JQ, ALTOMARE DA, KLEIN MA, LEE WC, KRUH GD, LISSY NA, TESTA JR: Transforming activity and mitosis-related expression of the AKT2 oncogene: evidence suggesting a link between cell cycle regulation and oncogenesis. Oncogene 14: 2793-2801, 1997.
-
(1997)
Oncogene
, vol.14
, pp. 2793-2801
-
-
Cheng, J.Q.1
Altomare, D.A.2
Klein, M.A.3
Lee, W.C.4
Kruh, G.D.5
Lissy, N.A.6
Testa, J.R.7
-
15
-
-
1542652475
-
Nitric oxide production and regulation of endothelial nitric-oxide synthase phosphorylation by prolonged treatment with troglitazone: Evidence for involvement of peroxisome proliferator-activated receptor (PPAR) γ-dependent and PPARγ-independent signaling pathways
-
CHO DH, CHOI YJ, JO SA, JO I: Nitric oxide production and regulation of endothelial nitric-oxide synthase phosphorylation by prolonged treatment with troglitazone: evidence for involvement of peroxisome proliferator-activated receptor (PPAR) γ-dependent and PPARγ-independent signaling pathways. J Biol Chem 279: 2499-2506, 2004.
-
(2004)
J Biol Chem
, vol.279
, pp. 2499-2506
-
-
Cho, D.H.1
Choi, Y.J.2
Jo, S.A.3
Jo, I.4
-
16
-
-
0035368548
-
Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKBβ)
-
CHO H, MU J, KIM JK, THORVALDSEN JL, CHU Q, CRENSHAW EB, KAESTNER KH, BARTOLOMEI MS, SHULMAN GI, BIRNBAUM MJ: Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKBβ). Science 292: 1728-1731, 2001.
-
(2001)
Science
, vol.292
, pp. 1728-1731
-
-
Cho, H.1
Mu, J.2
Kim, J.K.3
Thorvaldsen, J.L.4
Chu, Q.5
Crenshaw, E.B.6
Kaestner, K.H.7
Bartolomei, M.S.8
Shulman, G.I.9
Birnbaum, M.J.10
-
17
-
-
0019805712
-
Kidney function and size in normal subjects before and during growth hormone administration for one week
-
CHRISTIANSEN JS, GAMMELGAARD J, ORSKOV H, ANDERSEN AR, TELMER S, PARVING HH: Kidney function and size in normal subjects before and during growth hormone administration for one week. Eur J Clin Invest 11: 487-490, 1981.
-
(1981)
Eur J Clin Invest
, vol.11
, pp. 487-490
-
-
Christiansen, J.S.1
Gammelgaard, J.2
Orskov, H.3
Andersen, A.R.4
Telmer, S.5
Parving, H.H.6
-
18
-
-
0037184318
-
Simvastatin induces activation of the serine-threonine protein kinase AKT and increases survival of isolated human pancreatic islets
-
CONTRERAS JL, SMYTH CA, BILBAO G, YOUNG CJ, THOMPSON JA, ECKHOFF DE: Simvastatin induces activation of the serine-threonine protein kinase AKT and increases survival of isolated human pancreatic islets. Transplantation 74: 1063-1069, 2002.
-
(2002)
Transplantation
, vol.74
, pp. 1063-1069
-
-
Contreras, J.L.1
Smyth, C.A.2
Bilbao, G.3
Young, C.J.4
Thompson, J.A.5
Eckhoff, D.E.6
-
19
-
-
0029587224
-
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
-
CROSS DA, ALESSI DR, COHEN P, ANDJELKOVICH M, HEMMINGS BA: Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378: 785-789, 1995.
-
(1995)
Nature
, vol.378
, pp. 785-789
-
-
Cross, D.A.1
Alessi, D.R.2
Cohen, P.3
Andjelkovich, M.4
Hemmings, B.A.5
-
20
-
-
0034644522
-
Signal transduction by the JNK group of MAP kinases
-
DAVIS RJ: Signal transduction by the JNK group of MAP kinases. Cell 103: 239-252, 2000.
-
(2000)
Cell
, vol.103
, pp. 239-252
-
-
Davis, R.J.1
-
21
-
-
0017071570
-
The effects of glucose and insulin on renal electrolyte transport
-
DEFRONZO RA, GOLDBERG M, AGUS Z: The effects of glucose and insulin on renal electrolyte transport. J Clin Invest 58: 83-90, 1976.
-
(1976)
J Clin Invest
, vol.58
, pp. 83-90
-
-
Defronzo, R.A.1
Goldberg, M.2
Agus, Z.3
-
22
-
-
1842333237
-
Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
-
DEL PESO L, GONZALEZ-GARCIA M, PAGE C, HERRERA R, NUNEZ G: Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt. Science 278: 687-689, 1997.
-
(1997)
Science
, vol.278
, pp. 687-689
-
-
Del Peso, L.1
Gonzalez-Garcia, M.2
Page, C.3
Herrera, R.4
Nunez, G.5
-
23
-
-
0032504745
-
Fluid shear stress stimulates phosphorylation of Akt in human endothelial cells: Involvement in suppression of apoptosis
-
DIMMELER S, ASSMUS B, HERMANN C, HAENDELER J, ZEIHER AM: Fluid shear stress stimulates phosphorylation of Akt in human endothelial cells: involvement in suppression of apoptosis. Circ Res 83: 334-341, 1998.
-
(1998)
Circ Res
, vol.83
, pp. 334-341
-
-
Dimmeler, S.1
Assmus, B.2
Hermann, C.3
Haendeler, J.4
Zeiher, A.M.5
-
24
-
-
0033542476
-
Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
-
DIMMELER S, FLEMING I, FISSLTHALER B, HERMANN C, BUSSE R, ZEIHER AM: Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 399: 601-605, 1999.
-
(1999)
Nature
, vol.399
, pp. 601-605
-
-
Dimmeler, S.1
Fleming, I.2
Fisslthaler, B.3
Hermann, C.4
Busse, R.5
Zeiher, A.M.6
-
25
-
-
0034908652
-
HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway
-
DIMMELER S, AICHER A, VASA M, MILDNER-RIHM C, ADLER K, TIEMANN M, RUTTEN H, FICHTLSCHERER S, MARTIN H, ZEIHER AM: HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway. J Clin Invest 108: 391-397, 2001.
-
(2001)
J Clin Invest
, vol.108
, pp. 391-397
-
-
Dimmeler, S.1
Aicher, A.2
Vasa, M.3
Mildner-Rihm, C.4
Adler, K.5
Tiemann, M.6
Rutten, H.7
Fichtlscherer, S.8
Martin, H.9
Zeiher, A.M.10
-
26
-
-
0036889062
-
Adrenomedullin improves cardiac function and prevents renal damage in streptozotocin-induced diabetic rats
-
DOBRZYNSKI E, MONTANARI D, AGATA J, ZHU J, CHAO J, CHAO L: Adrenomedullin improves cardiac function and prevents renal damage in streptozotocin-induced diabetic rats. Am J Physiol Endocrinol Metab 283: E1291-E1298, 2002.
-
(2002)
Am J Physiol Endocrinol Metab
, vol.283
-
-
Dobrzynski, E.1
Montanari, D.2
Agata, J.3
Zhu, J.4
Chao, J.5
Chao, L.6
-
27
-
-
0032053709
-
Mechanisms and consequences of activation of protein kinase B/Akt
-
DOWNWARD J: Mechanisms and consequences of activation of protein kinase B/Akt. Curr Opin Cell Biol 10: 262-267, 1998.
-
(1998)
Curr Opin Cell Biol
, vol.10
, pp. 262-267
-
-
Downward, J.1
-
28
-
-
0035180299
-
Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site
-
DU XL, EDELSTEIN D, DIMMELER S, JU Q, SUI C, BROWNLEE M: Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site. J Clin Invest 108: 1341-1348, 2001.
-
(2001)
J Clin Invest
, vol.108
, pp. 1341-1348
-
-
Du, X.L.1
Edelstein, D.2
Dimmeler, S.3
Ju, Q.4
Sui, C.5
Brownlee, M.6
-
29
-
-
0032555154
-
Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase
-
ENDRES M, LAUFS U, HUANG Z, NAKAMURA T, HUANG P, MOSKOWITZ MA, LIAO JK: Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase. Proc Natl Acad Sci USA 95: 8880-8885, 1998.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 8880-8885
-
-
Endres, M.1
Laufs, U.2
Huang, Z.3
Nakamura, T.4
Huang, P.5
Moskowitz, M.A.6
Liao, J.K.7
-
30
-
-
0037117639
-
Statin prevents tissue factor expression in human endothelial cells: Role of Rho/Rho-kinase and Akt pathways
-
ETO M, KOZAI T, COSENTINO F, JOCH H, LUSCHER TF: Statin prevents tissue factor expression in human endothelial cells: role of Rho/Rho-kinase and Akt pathways. Circulation 105: 1756-1759, 2002.
-
(2002)
Circulation
, vol.105
, pp. 1756-1759
-
-
Eto, M.1
Kozai, T.2
Cosentino, F.3
Joch, H.4
Luscher, T.F.5
-
31
-
-
0034924522
-
Activation of renal signaling pathways in db/db mice with type 2 diabetes
-
FELIERS D, DURAISAMY S, FAULKNER JL, DUCH J, LEE AV, ABBOUD HE, CHOUDHURY GG, KASINATH BS: Activation of renal signaling pathways in db/db mice with type 2 diabetes. Kidney Int 60: 495-504, 2001.
-
(2001)
Kidney Int
, vol.60
, pp. 495-504
-
-
Feliers, D.1
Duraisamy, S.2
Faulkner, J.L.3
Duch, J.4
Lee, A.V.5
Abboud, H.E.6
Choudhury, G.G.7
Kasinath, B.S.8
-
32
-
-
0030907987
-
PI3K: Downstream AKTion blocks apoptosis
-
FRANKE TF, KAPLAN DR, CANTLEY LC: PI3K: downstream AKTion blocks apoptosis. Cell 88: 435-437, 1997.
-
(1997)
Cell
, vol.88
, pp. 435-437
-
-
Franke, T.F.1
Kaplan, D.R.2
Cantley, L.C.3
-
33
-
-
0032566658
-
Targeting of constitutively active phosphoinositide 3-kinase to GLUT4-containing vesicles in 3T3-L1 adipocytes
-
FREVERT EU, BJORBAEK C, VENABLE CL, KELLER SR, KAHN BB: Targeting of constitutively active phosphoinositide 3-kinase to GLUT4-containing vesicles in 3T3-L1 adipocytes. J Biol Chem 273: 25480-25487, 1998.
-
(1998)
J Biol Chem
, vol.273
, pp. 25480-25487
-
-
Frevert, E.U.1
Bjorbaek, C.2
Venable, C.L.3
Keller, S.R.4
Kahn, B.B.5
-
34
-
-
0035941410
-
Platelet-derived growth factor promotes the expression of peroxisome proliferator-activated receptor gamma in vascular smooth muscle cells by a phosphatidylinositol 3-kinase/Akt signaling pathway
-
FU M, ZHU X, WANG Q, ZHANG J, SONG Q, ZHENG H, OGAWA W, DU J, CHEN YE: Platelet-derived growth factor promotes the expression of peroxisome proliferator-activated receptor gamma in vascular smooth muscle cells by a phosphatidylinositol 3-kinase/Akt signaling pathway. Circ Res 89: 1058-1064, 2001.
-
(2001)
Circ Res
, vol.89
, pp. 1058-1064
-
-
Fu, M.1
Zhu, X.2
Wang, Q.3
Zhang, J.4
Song, Q.5
Zheng, H.6
Ogawa, W.7
Du, J.8
Chen, Y.E.9
-
35
-
-
0033542414
-
Regulation of endothelium-derived nitric oxide production by the protein kinase Akt
-
FULTON D, GRATTON JP, MCCABE TJ, FONTANA J, FUJIO Y, WALSH K, FRANKE TF, PAPAPETROPOULOS A, SESSA WC: Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature 399: 597-601, 1999.
-
(1999)
Nature
, vol.399
, pp. 597-601
-
-
Fulton, D.1
Gratton, J.P.2
McCabe, T.J.3
Fontana, J.4
Fujio, Y.5
Walsh, K.6
Franke, T.F.7
Papapetropoulos, A.8
Sessa, W.C.9
-
36
-
-
0032557564
-
Vascular endothelial growth factor induces expression of the antiapoptotic proteins Bcl-2 and A1 in vascular endothelial cells
-
GERBER HP, DIXIT V, FERRARA N: Vascular endothelial growth factor induces expression of the antiapoptotic proteins Bcl-2 and A1 in vascular endothelial cells. J Biol Chem 273: 13313-13316, 1998.
-
(1998)
J Biol Chem
, vol.273
, pp. 13313-13316
-
-
Gerber, H.P.1
Dixit, V.2
Ferrara, N.3
-
37
-
-
0035149745
-
IGF-I mRNA and signaling in the diabetic retina
-
GERHARDINGER C, MCCLURE KD, ROMEO G, PODESTA F, LORENZI M: IGF-I mRNA and signaling in the diabetic retina. Diabetes 50: 175-183, 2001.
-
(2001)
Diabetes
, vol.50
, pp. 175-183
-
-
Gerhardinger, C.1
McClure, K.D.2
Romeo, G.3
Podesta, F.4
Lorenzi, M.5
-
38
-
-
0036840309
-
Leptin induces endothelial cell migration through Akt, which is inhibited by PPARγ-ligands
-
GOETZE S, BUNGENSTOCK A, CZUPALLA C, EILERS F, STAWOWY P, KINTSCHER U, SPENCER-HANSCH C, GRAF K, NURNBERG B, LAW RE, FLECK E, GRAFE M: Leptin induces endothelial cell migration through Akt, which is inhibited by PPARγ-ligands. Hypertension 40: 748-754, 2002.
-
(2002)
Hypertension
, vol.40
, pp. 748-754
-
-
Goetze, S.1
Bungenstock, A.2
Czupalla, C.3
Eilers, F.4
Stawowy, P.5
Kintscher, U.6
Spencer-Hansch, C.7
Graf, K.8
Nurnberg, B.9
Law, R.E.10
Fleck, E.11
Grafe, M.12
-
39
-
-
0034840860
-
Angiotensin II activates Akt/protein kinase B by an arachidonic acid/redox-dependent pathway and independent of phosphoinositide 3-kinase
-
GORIN Y, KIM NH, FELIERS D, BHANDARI B, CHOUDHURY GG, ABBOUD HE: Angiotensin II activates Akt/protein kinase B by an arachidonic acid/redox-dependent pathway and independent of phosphoinositide 3-kinase. FASEB J 15: 1909-1920, 2001.
-
(2001)
FASEB J
, vol.15
, pp. 1909-1920
-
-
Gorin, Y.1
Kim, N.H.2
Feliers, D.3
Bhandari, B.4
Choudhury, G.G.5
Abboud, H.E.6
-
40
-
-
0031809969
-
Fructose uptake in rat adipocytes: GLUTS expression and the effects of streptozotocin-induced diabetes
-
HAJDUCH E, DARAKHSHAN F, HUNDAL HS: Fructose uptake in rat adipocytes: GLUTS expression and the effects of streptozotocin-induced diabetes. Diabetologia 41: 821-828, 1998.
-
(1998)
Diabetologia
, vol.41
, pp. 821-828
-
-
Hajduch, E.1
Darakhshan, F.2
Hundal, H.S.3
-
41
-
-
0036329397
-
Association of SH2-containing inositol phosphatase 2 with the insulin resistance of diabetic db/db mice
-
HORI H, SASAOKA T, ISHIHARA H, WADA T, MURAKAMI S, ISHIKIM, KOBAYASHI M: Association of SH2-containing inositol phosphatase 2 with the insulin resistance of diabetic db/db mice. Diabetes 51: 2387-2394, 2002.
-
(2002)
Diabetes
, vol.51
, pp. 2387-2394
-
-
Hori, H.1
Sasaoka, T.2
Ishihara, H.3
Wada, T.4
Murakami, S.5
Ishiki, M.6
Kobayashi, M.7
-
42
-
-
13344293711
-
Amelioration of vascular dysfunctions in diabetic rats by an oral PKCb inhibitor
-
ISHII H, JIROUSEK MR, KOYA D, TAKAGI C, XIA P, CLERMONT A, BURSELL S-E, KERN TS, BALLAS LM, HEATH WF, KING GL: Amelioration of vascular dysfunctions in diabetic rats by an oral PKCb inhibitor. Science 272: 728-731, 1996.
-
(1996)
Science
, vol.272
, pp. 728-731
-
-
Ishii, H.1
Jirousek, M.R.2
Koya, D.3
Takagi, C.4
Xia, P.5
Clermont, A.6
Bursell, S.-E.7
Kern, T.S.8
Ballas, L.M.9
Heath, W.F.10
King, G.L.11
-
43
-
-
0036326005
-
Potentiation of insulin signaling in tissues of Zucker obese rats after acute and long-term treatment with PPARy agonists
-
JIANG G, DALLAS-YANG Q, LIZ, SZALKOWSKI D, LIU F, SHEN X, WU M, ZHOU G, DOEBBER T, BERGER J, MOLLER DE, ZHANG BB: Potentiation of insulin signaling in tissues of Zucker obese rats after acute and long-term treatment with PPARy agonists. Diabetes 51: 2412-2419, 2002.
-
(2002)
Diabetes
, vol.51
, pp. 2412-2419
-
-
Jiang, G.1
Dallas-Yang, Q.2
Li, Z.3
Szalkowski, D.4
Liu, F.5
Shen, X.6
Wu, M.7
Zhou, G.8
Doebber, T.9
Berger, J.10
Moller, D.E.11
Zhang, B.B.12
-
44
-
-
0032719024
-
Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats
-
JIANG ZY, LIN YW, CLEMONT A, FEENER EP, HEIN KD, IGARASHI M, YAMAUCHI T, WHITE MF, KING GL: Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats. J Clin Invest 104: 447-457, 1999.
-
(1999)
J Clin Invest
, vol.104
, pp. 447-457
-
-
Jiang, Z.Y.1
Lin, Y.W.2
Clemont, A.3
Feener, E.P.4
Hein, K.D.5
Igarashi, M.6
Yamauchi, T.7
White, M.F.8
King, G.L.9
-
45
-
-
0036095059
-
Suppression of diabetic retinopathy with angiopoietin-1
-
JOUSSEN AM, POULAKI V, TSUJIKAWA A, QIN W, QAUM T, XU Q, MOROMIZATO Y, BURSELL SE, WIEGAND SJ, RUDGE J, IOFFE E, YANCOPOULOS GD, ADAMIS AP: Suppression of diabetic retinopathy with angiopoietin-1. Am J Pathol 160: 1683-1693, 2002.
-
(2002)
Am J Pathol
, vol.160
, pp. 1683-1693
-
-
Joussen, A.M.1
Poulaki, V.2
Tsujikawa, A.3
Qin, W.4
Qaum, T.5
Xu, Q.6
Moromizato, Y.7
Bursell, S.E.8
Wiegand, S.J.9
Rudge, J.10
Ioffe, E.11
Yancopoulos, G.D.12
Adamis, A.P.13
-
46
-
-
0031028730
-
Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB
-
KAUFFMANN-ZEH A, RODRIGUEZ-VICIANA P, ULRICH E, GILBERT C, COFFER P, DOWNWARD J, EVAN G: Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB. Nature 385: 544-548, 1997.
-
(1997)
Nature
, vol.385
, pp. 544-548
-
-
Kauffmann-Zeh, A.1
Rodriguez-Viciana, P.2
Ulrich, E.3
Gilbert, C.4
Coffer, P.5
Downward, J.6
Evan, G.7
-
47
-
-
0030913673
-
Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway
-
KHWAJA A, RODRIGUEZ-VICIANA P, WENNSTROM S, WARNE PH, DOWNWARD J: Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway. EMBO J 16: 2783-2793, 1997.
-
(1997)
EMBO J
, vol.16
, pp. 2783-2793
-
-
Khwaja, A.1
Rodriguez-Viciana, P.2
Wennstrom, S.3
Warne, P.H.4
Downward, J.5
-
48
-
-
0035133227
-
Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1
-
KIM AH, KHURSIGARA G, SUN X, FRANKE TF, CHAO MV: Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1. Mol Cell Biol 21: 893-901, 2001.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 893-901
-
-
Kim, A.H.1
Khursigara, G.2
Sun, X.3
Franke, T.F.4
Chao, M.V.5
-
49
-
-
0006677050
-
Angiopoietin-1 regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway
-
KIM I, KIM HG, SO JN, KIM JH, KWAK HJ, KOH GY: Angiopoietin-1 regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway. Circ Res 86: 24-29, 2000.
-
(2000)
Circ Res
, vol.86
, pp. 24-29
-
-
Kim, I.1
Kim, H.G.2
So, J.N.3
Kim, J.H.4
Kwak, H.J.5
Koh, G.Y.6
-
50
-
-
0032698470
-
Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes
-
KIM YB, NIKOULINA SE, CIARALDI TP, HENRY RR, KAHN BB: Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes. J Clin Invest 104: 733-741, 1999a.
-
(1999)
J Clin Invest
, vol.104
, pp. 733-741
-
-
Kim, Y.B.1
Nikoulina, S.E.2
Ciaraldi, T.P.3
Henry, R.R.4
Kahn, B.B.5
-
51
-
-
0033046582
-
Glucosamine infusion in rats rapidly impairs insulin stimulation of phosphoinositide 3-kinase but does not alter activation of Akt/protein kinase B in skeletal muscle
-
KIM YB, ZHU JS, ZIERATH JR, SHEN HQ, BARON AD, KAHN BB: Glucosamine infusion in rats rapidly impairs insulin stimulation of phosphoinositide 3-kinase but does not alter activation of Akt/protein kinase B in skeletal muscle. Diabetes 48: 310-320, 1999b.
-
(1999)
Diabetes
, vol.48
, pp. 310-320
-
-
Kim, Y.B.1
Zhu, J.S.2
Zierath, J.R.3
Shen, H.Q.4
Baron, A.D.5
Kahn, B.B.6
-
52
-
-
0022002617
-
Receptors and growth-promoting effects of insulin and insulinlike growth factors on cells from bovine retinal capillaries and aorta
-
KING GL, GOODMAN AD, BUZNEY S, MOSES A, KAHN CR: Receptors and growth-promoting effects of insulin and insulinlike growth factors on cells from bovine retinal capillaries and aorta. J Clin Invest 75: 1028-1036, 1985.
-
(1985)
J Clin Invest
, vol.75
, pp. 1028-1036
-
-
King, G.L.1
Goodman, A.D.2
Buzney, S.3
Moses, A.4
Kahn, C.R.5
-
53
-
-
0029908016
-
Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation
-
KOHN AD, SUMMERS SA, BIRNBAUM MJ, ROTH RA: Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation. J Biol Chem 271: 31372-31378, 1996.
-
(1996)
J Biol Chem
, vol.271
, pp. 31372-31378
-
-
Kohn, A.D.1
Summers, S.A.2
Birnbaum, M.J.3
Roth, R.A.4
-
54
-
-
0031724590
-
Requirement of atypical protein kinase Cλ for insulin stimulation of glucose uptake but not for Akt activation in 3T3-L1 adipocytes
-
KOTANI K, OGAWA W, MATSUMOTO M, KITAMURA T, SAKAUE H, HINO Y, MIYAKE K, SANO W, AKIMOTO K, OHNO S, KASUGA M: Requirement of atypical protein kinase Cλ for insulin stimulation of glucose uptake but not for Akt activation in 3T3-L1 adipocytes. Mol Cell Biol 18: 6971-6982, 1998.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 6971-6982
-
-
Kotani, K.1
Ogawa, W.2
Matsumoto, M.3
Kitamura, T.4
Sakaue, H.5
Hino, Y.6
Miyake, K.7
Sano, W.8
Akimoto, K.9
Ohno, S.10
Kasuga, M.11
-
55
-
-
0030827388
-
Improved glucose tolerance restores insulin-stimulated Akt kinase activity and glucose transport in skeletal muscle from diabetic Goto-Kakizaki rats
-
KROOK A, KAWANO Y, SONG XM, EFENDIC S, ROTH RA, WALLBERG-HENRIKSSON H, ZIERATH JR: Improved glucose tolerance restores insulin-stimulated Akt kinase activity and glucose transport in skeletal muscle from diabetic Goto-Kakizaki rats. Diabetes 46: 2110-2114, 1997.
-
(1997)
Diabetes
, vol.46
, pp. 2110-2114
-
-
Krook, A.1
Kawano, Y.2
Song, X.M.3
Efendic, S.4
Roth, R.A.5
Wallberg-Henriksson, H.6
Zierath, J.R.7
-
56
-
-
0031852665
-
Insulin-stimulated Akt kinase activity is reduced in skeletal muscle from NIDDM subjects
-
KROOK A, ROTH RA, JIANG XJ, ZIERATH JR, WALLBERG-HENRIKSSON H: Insulin-stimulated Akt kinase activity is reduced in skeletal muscle from NIDDM subjects. Diabetes 47: 1281-1286, 1998.
-
(1998)
Diabetes
, vol.47
, pp. 1281-1286
-
-
Krook, A.1
Roth, R.A.2
Jiang, X.J.3
Zierath, J.R.4
Wallberg-Henriksson, H.5
-
57
-
-
0033826581
-
The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals
-
KUREISHI Y, LUO Z, SHIOJIMA I, BIALIK A, FULTON D, LEFER DJ, SESSA WC, WALSH K: The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals. Nat Med 6: 1004-1010, 2000.
-
(2000)
Nat Med
, vol.6
, pp. 1004-1010
-
-
Kureishi, Y.1
Luo, Z.2
Shiojima, I.3
Bialik, A.4
Fulton, D.5
Lefer, D.J.6
Sessa, W.C.7
Walsh, K.8
-
58
-
-
0035654625
-
Effects of streptozocin diabetes and diabetes treatment by islet transplantation on in vivo insulin signaling in rat heart
-
LAVIOLA L, BELSANTI G, DAVALLI AM, NAPOLI R, PERRINI S, WEIR GC, GIORGINO R, GIORGINO F: Effects of streptozocin diabetes and diabetes treatment by islet transplantation on in vivo insulin signaling in rat heart. Diabetes 50: 2709-2720, 2001.
-
(2001)
Diabetes
, vol.50
, pp. 2709-2720
-
-
Laviola, L.1
Belsanti, G.2
Davalli, A.M.3
Napoli, R.4
Perrini, S.5
Weir, G.C.6
Giorgino, R.7
Giorgino, F.8
-
59
-
-
0030984321
-
New insights into the role and mechanism of glycogen synthase activation by insulin
-
LAWRENCE JC, ROACH PJ: New insights into the role and mechanism of glycogen synthase activation by insulin. Diabetes 46: 541-547, 1997.
-
(1997)
Diabetes
, vol.46
, pp. 541-547
-
-
Lawrence, J.C.1
Roach, P.J.2
-
60
-
-
0036897343
-
Rapid nontranscriptional activation of endothelial nitric oxide synthase mediates increased cerebral blood flow and stroke protection by corticosteroids
-
LIMBOURG FP, HUANG Z, PLUMIER JC, SIMONCINI T, FUJIOKA M, TUCKERMANN J, SCHUTZ G, MOSKOWITZ MA, LIAO JK: Rapid nontranscriptional activation of endothelial nitric oxide synthase mediates increased cerebral blood flow and stroke protection by corticosteroids. J Clin Invest 110: 1729-1738, 2002.
-
(2002)
J Clin Invest
, vol.110
, pp. 1729-1738
-
-
Limbourg, F.P.1
Huang, Z.2
Plumier, J.C.3
Simoncini, T.4
Fujioka, M.5
Tuckermann, J.6
Schutz, G.7
Moskowitz, M.A.8
Liao, J.K.9
-
61
-
-
0033857388
-
Acute modulation of endothelial Akt/PKB activity alters nitric oxide-dependent vasomotor activity in vivo
-
LUO Z, FUJIO Y, KUREISHI Y, RUDIC RD, DAUMERIE G, FULTON D, SESSA WC, WALSH K: Acute modulation of endothelial Akt/PKB activity alters nitric oxide-dependent vasomotor activity in vivo. J Clin Invest 106: 493-499, 2000.
-
(2000)
J Clin Invest
, vol.106
, pp. 493-499
-
-
Luo, Z.1
Fujio, Y.2
Kureishi, Y.3
Rudic, R.D.4
Daumerie, G.5
Fulton, D.6
Sessa, W.C.7
Walsh, K.8
-
62
-
-
0035449121
-
Another activation switch for endothelial nitric oxide synthase: Why does it have to be so complicated?
-
MARLETTA MA: Another activation switch for endothelial nitric oxide synthase: why does it have to be so complicated? Trends Biochem Sci 26: 519-521, 2001.
-
(2001)
Trends Biochem Sci
, vol.26
, pp. 519-521
-
-
Marletta, M.A.1
-
63
-
-
0026684462
-
Impaired endothelium-dependent and independent vasodilation in patients with type II (non-insulin-dependent) diabetes mellitus
-
MCVEIGH GE, BRENNAN GM, JOHNSTON GD, MCDERMOTT BJ, MCGRATH LT, ANDREWS JW, HAYES JR: Impaired endothelium-dependent and independent vasodilation in patients with type II (non-insulin-dependent) diabetes mellitus. Diabetologia 35: 771-776, 1992.
-
(1992)
Diabetologia
, vol.35
, pp. 771-776
-
-
McVeigh, G.E.1
Brennan, G.M.2
Johnston, G.D.3
McDermott, B.J.4
McGrath, L.T.5
Andrews, J.W.6
Hayes, J.R.7
-
65
-
-
0036594230
-
Insulin signalling in skeletal muscle of subjects with or without Type II-diabetes and first degree relatives of patients with the disease
-
MEYER MM, LEVIN K, GRIMMSMANN T, BECK-NIELSEN H, KLEIN HH: Insulin signalling in skeletal muscle of subjects with or without Type II-diabetes and first degree relatives of patients with the disease. Diabetologia 45: 813-822, 2002a.
-
(2002)
Diabetologia
, vol.45
, pp. 813-822
-
-
Meyer, M.M.1
Levin, K.2
Grimmsmann, T.3
Beck-Nielsen, H.4
Klein, H.H.5
-
66
-
-
0036723741
-
Troglitazone treatment increases protein kinase B phosphorylation in skeletal muscle of normoglycemic subjects at risk for the development of type 2 diabetes
-
MEYER MM, LEVIN K, GRIMMSMANN T, PERWITZ N, EIRICH A, BECK-NIELSEN H, KLEIN HH: Troglitazone treatment increases protein kinase B phosphorylation in skeletal muscle of normoglycemic subjects at risk for the development of type 2 diabetes. Diabetes 51: 2691-2697, 2002b.
-
(2002)
Diabetes
, vol.51
, pp. 2691-2697
-
-
Meyer, M.M.1
Levin, K.2
Grimmsmann, T.3
Perwitz, N.4
Eirich, A.5
Beck-Nielsen, H.6
Klein, H.H.7
-
67
-
-
0029973474
-
Accelerated death of retinal microvascular cells in human and experimental diabetic retinopathy
-
MIZUTANI M, KERN TS, LORENZI M: Accelerated death of retinal microvascular cells in human and experimental diabetic retinopathy. J Clin Invest 97: 2883-2890, 1996.
-
(1996)
J Clin Invest
, vol.97
, pp. 2883-2890
-
-
Mizutani, M.1
Kern, T.S.2
Lorenzi, M.3
-
68
-
-
0035658486
-
Normal Akt/PKB with reduced PI3K activation in insulin-resistant mice
-
NADLER ST, STOEHR JP, RABAGLIA ME, SCHUELER KL, BIRNBAUM MJ, ATTIE AD: Normal Akt/PKB with reduced PI3K activation in insulin-resistant mice. Am J Physiol 281: E1249-E1254, 2001.
-
(2001)
Am J Physiol
, vol.281
-
-
Nadler, S.T.1
Stoehr, J.P.2
Rabaglia, M.E.3
Schueler, K.L.4
Birnbaum, M.J.5
Attie, A.D.6
-
69
-
-
0035941260
-
Excessive hexosamines block the neuroprotective effect of insulin and induce apoptosis in retinal neurons
-
NAKAMURA M, BARBER AJ, ANTONETTI DA, LANOUE KF, ROBINSON KA, BUSE MG, GARDNER TW: Excessive hexosamines block the neuroprotective effect of insulin and induce apoptosis in retinal neurons. J Biol Chem 276: 43748-43755, 2001.
-
(2001)
J Biol Chem
, vol.276
, pp. 43748-43755
-
-
Nakamura, M.1
Barber, A.J.2
Antonetti, D.A.3
Lanoue, K.F.4
Robinson, K.A.5
Buse, M.G.6
Gardner, T.W.7
-
70
-
-
0034643340
-
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
-
NISHIKAWA T, EDELSTEIN D, DU XL, YAMAGISHI S, MATSUMURA T, KANEDA Y, YOREK MA, BEEBE D, OATES PJ, HAMMES HP, GIARDINO I, BROWNLEE M: Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 404: 787-790, 2000.
-
(2000)
Nature
, vol.404
, pp. 787-790
-
-
Nishikawa, T.1
Edelstein, D.2
Du, X.L.3
Yamagishi, S.4
Matsumura, T.5
Kaneda, Y.6
Yorek, M.A.7
Beebe, D.8
Oates, P.J.9
Hammes, H.P.10
Giardino, I.11
Brownlee, M.12
-
71
-
-
0036318323
-
High-salt diet enhances insulin signaling and induces insulin resistance in Dahl salt-sensitive rats
-
OGIHARA T, ASANO T, ANDO K, SAKODA H, ANAI M, SHOJIMA N, ONO H, ONISHI Y, FUJISHIRO M, ABE M, FUKUSHIMA Y, KIKUCHI M, FUJITA T: High-salt diet enhances insulin signaling and induces insulin resistance in Dahl salt-sensitive rats. Hypertension 40: 83-89, 2002.
-
(2002)
Hypertension
, vol.40
, pp. 83-89
-
-
Ogihara, T.1
Asano, T.2
Ando, K.3
Sakoda, H.4
Anai, M.5
Shojima, N.6
Ono, H.7
Onishi, Y.8
Fujishiro, M.9
Abe, M.10
Fukushima, Y.11
Kikuchi, M.12
Fujita, T.13
-
72
-
-
0028124189
-
Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin
-
OKADA T, KAWANO Y, SAKAKIBARA T, HAZEKI O, UI M: Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin. J Biol Chem 269: 3568-3573, 1994.
-
(1994)
J Biol Chem
, vol.269
, pp. 3568-3573
-
-
Okada, T.1
Kawano, Y.2
Sakakibara, T.3
Hazeki, O.4
Ui, M.5
-
73
-
-
0036020941
-
NF-κB as a therapeutic target in cancer
-
ORLOWSKIRZ, BALDWIN AS: NF-κB as a therapeutic target in cancer. Trends Mol Med 8: 385-9, 2002.
-
(2002)
Trends Mol Med
, vol.8
, pp. 385-389
-
-
Orlowski, R.Z.1
Baldwin, A.S.2
-
74
-
-
0033517189
-
NF-κB activation by tumour necrosis factor requires the Akt serine-threonine kinase
-
OZES ON, MAYO LD, GUSTIN JA, PFEFFER SR, PFEFFER LM, DONNER DB: NF-κB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature 401: 82-85, 1999.
-
(1999)
Nature
, vol.401
, pp. 82-85
-
-
Ozes, O.N.1
Mayo, L.D.2
Gustin, J.A.3
Pfeffer, S.R.4
Pfeffer, L.M.5
Donner, D.B.6
-
75
-
-
0035836770
-
A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1
-
OZES ON, AKCA H, MAYO LD, GUSTIN JA, MAEHAMA T, DIXON JE, DONNER DB: A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1. Proc Natl Acad Sci USA 98: 4640-4645, 2001.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 4640-4645
-
-
Ozes, O.N.1
Akca, H.2
Mayo, L.D.3
Gustin, J.A.4
Maehama, T.5
Dixon, J.E.6
Donner, D.B.7
-
76
-
-
0035831556
-
Phosphatidylinositol 3-kinase/Akt activity regulates c-FLIP expression in tumor cells
-
PANKA DJ, MANO T, SUHARA T, WALSH K, MIER JW: Phosphatidylinositol 3-kinase/Akt activity regulates c-FLIP expression in tumor cells. J Biol Chem 276: 6893-6896, 2001.
-
(2001)
J Biol Chem
, vol.276
, pp. 6893-6896
-
-
Panka, D.J.1
Mano, T.2
Suhara, T.3
Walsh, K.4
Mier, J.W.5
-
77
-
-
0030885575
-
Thiazolidinediones block tumor necrosis factor-α-induced inhibition of insulin signaling
-
PERALDI P, XU M, SPIEGELMAN BM: Thiazolidinediones block tumor necrosis factor-α-induced inhibition of insulin signaling. J Clin Invest 100: 1863-1869, 1997.
-
(1997)
J Clin Invest
, vol.100
, pp. 1863-1869
-
-
Peraldi, P.1
Xu, M.2
Spiegelman, B.M.3
-
78
-
-
0033546439
-
Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B
-
RENA G, GUO S, CICHY SC, UNTERMAN TG, COHEN P: Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B. J Biol Chem 274: 17179-17183, 1999.
-
(1999)
J Biol Chem
, vol.274
, pp. 17179-17183
-
-
Rena, G.1
Guo, S.2
Cichy, S.C.3
Unterman, T.G.4
Cohen, P.5
-
79
-
-
0033517190
-
NF-κB is a target of AKT in anti-apoptotic PDGF signalling
-
ROMASHKOVA JA, MAKAROV SS: NF-κB is a target of AKT in anti-apoptotic PDGF signalling. Nature 401: 86-90, 1999.
-
(1999)
Nature
, vol.401
, pp. 86-90
-
-
Romashkova, J.A.1
Makarov, S.S.2
-
80
-
-
0032765342
-
Impaired glucose transport and protein kinase B activation by insulin, but not okadaic acid, in adipocytes from subjects with type II diabetes mellitus
-
RONDINONE CM, CARVALHO E, WESSLAU C, SMITH UP: Impaired glucose transport and protein kinase B activation by insulin, but not okadaic acid, in adipocytes from subjects with Type II diabetes mellitus. Diabetologia 42: 819-825, 1999.
-
(1999)
Diabetologia
, vol.42
, pp. 819-825
-
-
Rondinone, C.M.1
Carvalho, E.2
Wesslau, C.3
Smith, U.P.4
-
81
-
-
0034718540
-
Modulation of Akt kinase activity by binding to Hsp90
-
SATO S, FUJITA N, TSURUO T: Modulation of Akt kinase activity by binding to Hsp90. Proc Natl Acad Sci USA 97: 10832-10837, 2000.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 10832-10837
-
-
Sato, S.1
Fujita, N.2
Tsuruo, T.3
-
82
-
-
0033852661
-
Role of the hexosamine biosynthetic pathway in diabetic nephropathy
-
SCHLEICHER ED, WEIGERT C: Role of the hexosamine biosynthetic pathway in diabetic nephropathy. Kidney Int 58 (Suppl 77): S13-S18, 2000.
-
(2000)
Kidney Int
, vol.58
, Issue.SUPPL. 77
-
-
Schleicher, E.D.1
Weigert, C.2
-
83
-
-
0036073640
-
Rapid effects of glucose on the insulin signaling of endothelial NO generation and epithelial Na transport
-
SCHNYDER B, PITTET M, DURAND J, SCHNYDER-CANDRIAN S: Rapid effects of glucose on the insulin signaling of endothelial NO generation and epithelial Na transport. Am J Physiol 282: E87-E94, 2002.
-
(2002)
Am J Physiol
, vol.282
-
-
Schnyder, B.1
Pittet, M.2
Durand, J.3
Schnyder-Candrian, S.4
-
85
-
-
0032560521
-
Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway
-
SCOTT PH, BRUNN GJ, KOHN AD, ROTH RA, LAWRENCE JC, Jr: Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway. Proc Natl Acad Sci USA 95: 7772-7777, 1998.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 7772-7777
-
-
Scott, P.H.1
Brunn, G.J.2
Kohn, A.D.3
Roth, R.A.4
Lawrence Jr., J.C.5
-
86
-
-
0034004155
-
Cell cycle regulatory proteins in renal disease: Role in hypertrophy, proliferation, and apoptosis
-
SHANKLAND SJ, WOLF G: Cell cycle regulatory proteins in renal disease: role in hypertrophy, proliferation, and apoptosis. Am J Physiol 278: F515-529, 2000.
-
(2000)
Am J Physiol
, vol.278
-
-
Shankland, S.J.1
Wolf, G.2
-
87
-
-
0036799377
-
PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization
-
SHIN I, YAKES FM, ROJO F, SHIN NY, BAKIN AV, BASELGA J, ARTEAGA CL: PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization. Nat Med 8: 1145-1152, 2002.
-
(2002)
Nat Med
, vol.8
, pp. 1145-1152
-
-
Shin, I.1
Yakes, F.M.2
Rojo, F.3
Shin, N.Y.4
Bakin, A.V.5
Baselga, J.6
Arteaga, C.L.7
-
88
-
-
0037188941
-
Role of Akt signaling in vascular homeostasis and angiogenesis
-
SHIOJIMA I, WALSH K: Role of Akt signaling in vascular homeostasis and angiogenesis. Circ Res 90: 1243-1250, 2002.
-
(2002)
Circ Res
, vol.90
, pp. 1243-1250
-
-
Shiojima, I.1
Walsh, K.2
-
89
-
-
0005828771
-
Muscle fiber type-specific defects in insulin signal transduction to glucose transport in diabetic GK rats
-
SONG XM, KAWANO Y, KROOK A, RYDER JW, EFENDIC S, ROTH RA, WALLBERG-HENRIKSSON H, ZIERATH JR: Muscle fiber type-specific defects in insulin signal transduction to glucose transport in diabetic GK rats. Diabetes 48: 664-670, 1999.
-
(1999)
Diabetes
, vol.48
, pp. 664-670
-
-
Song, X.M.1
Kawano, Y.2
Krook, A.3
Ryder, J.W.4
Efendic, S.5
Roth, R.A.6
Wallberg-Henriksson, H.7
Zierath, J.R.8
-
90
-
-
0001582482
-
Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: Amplification of AKT1 in a primary human gastric adenocarcinoma
-
STAAL SP: Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma. Proc Natl Acad Sci USA 84: 5034-5037, 1987.
-
(1987)
Proc Natl Acad Sci USA
, vol.84
, pp. 5034-5037
-
-
Staal, S.P.1
-
91
-
-
0035653508
-
Insulin signal transduction in skeletal muscle from glucose-intolerant relatives of type 2 diabetic patients
-
STORGAARD H, SONG XM, JENSEN CB, MADSBAD S, BJORNHOLM M, VAAG A, ZIERATH JR: Insulin signal transduction in skeletal muscle from glucose-intolerant relatives of type 2 diabetic patients. Diabetes 50: 2770-2778, 2001.
-
(2001)
Diabetes
, vol.50
, pp. 2770-2778
-
-
Storgaard, H.1
Song, X.M.2
Jensen, C.B.3
Madsbad, S.4
Bjornholm, M.5
Vaag, A.6
Zierath, J.R.7
-
92
-
-
0025813375
-
Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein
-
SUN XJ, ROTHENBERG P, KAHN CR, BACKER JM, ARAKI E, WILDEN PA, CAHILL DA, GOLDSTEIN BJ, WHITE MF: Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature 352: 73-17, 1991.
-
(1991)
Nature
, vol.352
, pp. 73-117
-
-
Sun, X.J.1
Rothenberg, P.2
Kahn, C.R.3
Backer, J.M.4
Araki, E.5
Wilden, P.A.6
Cahill, D.A.7
Goldstein, B.J.8
White, M.F.9
-
93
-
-
0029148591
-
Role of IRS-2 in insulin and cytokine signalling
-
SUN XJ, WANG LM, ZHANG Y, YENUSH L, MYERS MGJ, GLASHEEN E, LANE WS, PIERCE JH, WHITE MF: Role of IRS-2 in insulin and cytokine signalling. Nature 377: 173-177, 1995.
-
(1995)
Nature
, vol.377
, pp. 173-177
-
-
Sun, X.J.1
Wang, L.M.2
Zhang, Y.3
Yenush, L.4
Myers, M.G.J.5
Glasheen, E.6
Lane, W.S.7
Pierce, J.H.8
White, M.F.9
-
94
-
-
0027962499
-
Regulation of fibronectin by insulin-like growth factor-I in cultured rat thoracic aortic smooth muscle cells and glomerular mesangial cells
-
TAMAROGLIO TA, LO CS: Regulation of fibronectin by insulin-like growth factor-I in cultured rat thoracic aortic smooth muscle cells and glomerular mesangial cells. Exp Cell Res 215: 338-346, 1994.
-
(1994)
Exp Cell Res
, vol.215
, pp. 338-346
-
-
Tamaroglio, T.A.1
Lo, C.S.2
-
95
-
-
0035513703
-
Ceramide mediates insulin resistance by tumor necrosis factor-α in brown adipocytes by maintaining Akt in an inactive dephosphorylated state
-
TERUEL T, HERNANDEZ R, LORENZO M: Ceramide mediates insulin resistance by tumor necrosis factor-α in brown adipocytes by maintaining Akt in an inactive dephosphorylated state. Diabetes 50: 2563-2571, 2001.
-
(2001)
Diabetes
, vol.50
, pp. 2563-2571
-
-
Teruel, T.1
Hernandez, R.2
Lorenzo, M.3
-
96
-
-
0035949699
-
AKT plays a central role in tumorigenesis
-
comment
-
TESTA JR, BELLACOSA A: AKT plays a central role in tumorigenesis. [comment]. Proc Natl Acad Sci USA 98: 10983-10985, 2001.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 10983-10985
-
-
Testa, J.R.1
Bellacosa, A.2
-
97
-
-
0036307184
-
Modulation of growth hormone signal transduction in kidneys of streptozotocin-induced diabetic animals: Effect of a growth hormone receptor antagonist
-
THIRONE AC, SCARLETT JA, GASPARETTI AL, ARAUJO EP, LIMA MH, CARVALHO CR, VELLOSO LA, SAAD MJ: Modulation of growth hormone signal transduction in kidneys of streptozotocin-induced diabetic animals: effect of a growth hormone receptor antagonist. Diabetes 51: 2270-2281, 2002.
-
(2002)
Diabetes
, vol.51
, pp. 2270-2281
-
-
Thirone, A.C.1
Scarlett, J.A.2
Gasparetti, A.L.3
Araujo, E.P.4
Lima, M.H.5
Carvalho, C.R.6
Velloso, L.A.7
Saad, M.J.8
-
98
-
-
0037155131
-
Hydrogen peroxide activates endothelial nitric-oxide synthase through coordinated phosphorylation and dephosphorylation via a phosphoinositide 3-kinase-dependent signaling pathway
-
THOMAS SR, CHEN K, KEANEY JF: Hydrogen peroxide activates endothelial nitric-oxide synthase through coordinated phosphorylation and dephosphorylation via a phosphoinositide 3-kinase-dependent signaling pathway. J Biol Chem 277: 6017-6024, 2002.
-
(2002)
J Biol Chem
, vol.277
, pp. 6017-6024
-
-
Thomas, S.R.1
Chen, K.2
Keaney, J.F.3
-
99
-
-
0033537830
-
Oxidative stress disrupts insulin-induced cellular redistribution of insulin receptor substrate-1 and phosphatidylinositol 3-kinase in 3T3-L1 adipocytes. A putative cellular mechanism for impaired protein kinase B activation and GLUT4 translocation
-
TIROSH A, POTASHNIK R, BASHAN N, RUDICH A: Oxidative stress disrupts insulin-induced cellular redistribution of insulin receptor substrate-1 and phosphatidylinositol 3-kinase in 3T3-L1 adipocytes. A putative cellular mechanism for impaired protein kinase B activation and GLUT4 translocation. J Biol Chem 274: 10595-10602, 1999.
-
(1999)
J Biol Chem
, vol.274
, pp. 10595-10602
-
-
Tirosh, A.1
Potashnik, R.2
Bashan, N.3
Rudich, A.4
-
100
-
-
0030992837
-
Signalling through the lipid products of phosphoinositide-3-OH kinase
-
TOKER A, CANTLEY LC: Signalling through the lipid products of phosphoinositide-3-OH kinase. Nature 387: 673-676, 1997.
-
(1997)
Nature
, vol.387
, pp. 673-676
-
-
Toker, A.1
Cantley, L.C.2
-
101
-
-
0028910272
-
Beneficial effects of cholesterol-lowering therapy on the coronary endothelium in patients with coronary artery disease
-
TREASURE CB, KLEIN JL, WEINTRAUB WS, TALLEY JD, STILLABOWER ME, KOSINSKI AS, ZHANG J, BOCCUZZI SJ, CEDARHOLM JC, ALEXANDER RW: Beneficial effects of cholesterol-lowering therapy on the coronary endothelium in patients with coronary artery disease. N Engl J Med 332: 481-487, 1995.
-
(1995)
N Engl J Med
, vol.332
, pp. 481-487
-
-
Treasure, C.B.1
Klein, J.L.2
Weintraub, W.S.3
Talley, J.D.4
Stillabower, M.E.5
Kosinski, A.S.6
Zhang, J.7
Boccuzzi, S.J.8
Cedarholm, J.C.9
Alexander, R.W.10
-
102
-
-
0035432971
-
Defective insulin-induced GLUT4 translocation in skeletal muscle of high fat-fed rats is associated with alterations in both Akt/protein kinase B and atypical protein kinase C (/) activities
-
TREMBLAY F, LAVIGNE C, JACQUES H, MARETTE A: Defective insulin-induced GLUT4 translocation in skeletal muscle of high fat-fed rats is associated with alterations in both Akt/protein kinase B and atypical protein kinase C (/) activities. Diabetes 50: 1901-1910, 2001.
-
(2001)
Diabetes
, vol.50
, pp. 1901-1910
-
-
Tremblay, F.1
Lavigne, C.2
Jacques, H.3
Marette, A.4
-
103
-
-
0034781057
-
Regulation of pancreatic β-cell growth and survival by the serine/threonine protein kinase Akt1/PKBα
-
TUTTLE RL, GILL NS, PUGH W, LEE JP, KOEBERLEIN B, FURTH EE, POLONSKY KS, NAJI A, BIRNBAUM MJ: Regulation of pancreatic β-cell growth and survival by the serine/threonine protein kinase Akt1/PKBα. Nat Med 7: 1133-1137, 2001.
-
(2001)
Nat Med
, vol.7
, pp. 1133-1137
-
-
Tuttle, R.L.1
Gill, N.S.2
Pugh, W.3
Lee, J.P.4
Koeberlein, B.5
Furth, E.E.6
Polonsky, K.S.7
Naji, A.8
Birnbaum, M.J.9
-
104
-
-
0036091969
-
Leptin effect on endothelial nitric oxide is mediated through Akt-endothelial nitric oxide synthase phosphorylation pathway
-
VECCHIONE C, MAFFEI A, COLELLA S, ARETINI A, POULET R, FRATI G, GENTILE MT, FRATTA L, TRIMARCO V, TRIMARCO B, LEMBO G: Leptin effect on endothelial nitric oxide is mediated through Akt-endothelial nitric oxide synthase phosphorylation pathway. Diabetes 51: 168-173, 2002.
-
(2002)
Diabetes
, vol.51
, pp. 168-173
-
-
Vecchione, C.1
Maffei, A.2
Colella, S.3
Aretini, A.4
Poulet, R.5
Frati, G.6
Gentile, M.T.7
Fratta, L.8
Trimarco, V.9
Trimarco, B.10
Lembo, G.11
-
105
-
-
0035836627
-
PTEN controls tumor-induced angiogenesis
-
WEN S, STOLAROV J, MYERS MP, SU JD, WIGLER MH, TONKS NK, DURDEN DL: PTEN controls tumor-induced angiogenesis. Proc Natl Acad Sci USA 98: 4622-4627, 2001.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 4622-4627
-
-
Wen, S.1
Stolarov, J.2
Myers, M.P.3
Su, J.D.4
Wigler, M.H.5
Tonks, N.K.6
Durden, D.L.7
-
106
-
-
0033864452
-
Cell cycle regulation in diabetic nephropathy
-
WOLF G: Cell cycle regulation in diabetic nephropathy. Kidney Int 58 (Suppl 77): S59-S66, 2000.
-
(2000)
Kidney Int
, vol.58
, Issue.SUPPL. 77
-
-
Wolf, G.1
-
107
-
-
0035793091
-
Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways
-
XIAO GH, JEFFERS M, BELLACOSA A, MITSUUCHI Y, VANDE WOUDE GF, TESTA JR: Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways. Proc Natl Acad Sci USA 98: 247-252, 2001.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 247-252
-
-
Xiao, G.H.1
Jeffers, M.2
Bellacosa, A.3
Mitsuuchi, Y.4
Vande Woude, G.F.5
Testa, J.R.6
-
108
-
-
14944358238
-
Renal cortical expression of Akt and PTEN in Zucker diabetic fatty rats
-
abstract
-
ŽDYCHOVÁ J, PELIKÁNOVÁ T, KAZDOVÁ L, KOMERS R: Renal cortical expression of Akt and PTEN in Zucker diabetic fatty rats. Diabetes Metab 29: 4S297 (abstract), 2003.
-
(2003)
Diabetes Metab
, vol.29
-
-
Ždychová, J.1
Pelikánová, T.2
Kazdová, L.3
Komers, R.4
-
109
-
-
0029789432
-
Insulin-stimulated production of nitric oxide is inhibited by wortmannin. Direct measurement in vascular endothelial cells
-
ZENG G, QUON MJ: Insulin-stimulated production of nitric oxide is inhibited by wortmannin. Direct measurement in vascular endothelial cells. J Clin Invest 98: 894-898, 1996.
-
(1996)
J Clin Invest
, vol.98
, pp. 894-898
-
-
Zeng, G.1
Quon, M.J.2
-
110
-
-
0034603858
-
Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells
-
ZENG G, NYSTROM FH, RAVICHANDRAN LV, CONG LN, KIRBY M, MOSTOWSKI H, QUON MJ: Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells. Circulation 101: 1539-1545, 2000.
-
(2000)
Circulation
, vol.101
, pp. 1539-1545
-
-
Zeng, G.1
Nystrom, F.H.2
Ravichandran, L.V.3
Cong, L.N.4
Kirby, M.5
Mostowski, H.6
Quon, M.J.7
-
111
-
-
0034745353
-
Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells
-
ZHOU BP, LIAO Y, XIA W, SPOHN B, LEE MH, HUNG MC: Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells. Nat Cell Biol 3: 245-252, 2001.
-
(2001)
Nat Cell Biol
, vol.3
, pp. 245-252
-
-
Zhou, B.P.1
Liao, Y.2
Xia, W.3
Spohn, B.4
Lee, M.H.5
Hung, M.C.6
|