Platelet-derived growth factor promotes the expression of peroxisome proliferator-activated receptor γ in vascular smooth muscle cells by a phosphatidylinositol 3-kinase/Akt signaling pathway

Circulation Research

Volumn 89, Issue 11, 2001, Pages 1058-1064

  Fu, Mingui ^a   Zhu, Xiaojun ^a   Wang, Qian ^a   Zhang, Jifeng ^a   Song, Qing ^a   Zheng, Hui ^a   Ogawa, Wataru ^a   Du, Jie ^a   Chen, Yuqing E ^a  

^a MOREHOUSE SCHOOL OF MEDICINE   (United States)

Author keywords

Peroxisome proliferator activated receptor ; Phosphatidylinositol 3 kinase; Platelet derived growth factor; Signaling pathway; Vascular smooth muscle cells

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PLATELET DERIVED GROWTH FACTOR; PROTEIN KINASE B; RECEPTOR SUBUNIT;

ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; NORTHERN BLOTTING; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; VASCULAR SMOOTH MUSCLE; WESTERN BLOTTING;

EID: 0035941410     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/hh2301.099642     Document Type: Article

References (32)

1. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
2. Control of the peroximal β-oxidation pathway by a novel family of nuclear hormone receptors
3. Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor
4. Expression of the peroxisome proliferator-activated receptor γ (PPARγ) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein
5. PPARγ activation in human endothelial cells increases plasminogen activator inhibitor type-1 expression
6. Expression and function of PPARγ in rat and human vascular smooth muscle cells
7. Troglitazone inhibits vascular smooth muscle cell growth and intimal hyperplasia
8. Peroxisome proliferator-activated receptor γ ligands inhibit development of atherosclerosis in LDL receptor-deficient mice
9. Peroxisome proliferator-activated receptor (PPAR)-γ expression in human vascular smooth muscle cells: Inhibition of growth, migration, and c-fos expression by the peroxisome proliferator-activated receptor (PPAR)γ activator troglitazone
10. Peroxisome proliferator-activated receptor γ activators inhibit gene expression and migration in human vascular smooth muscle cells
11. Mechanism of catecholamine-induced proliferation of vascular smooth muscle cells
12. 2+ in activation of mitogen-activated protein kinase and DNA synthesis in vascular smooth muscle cells
13. Platelet-derived growth factor-BB, insulin-like growth factor-I, and phorbol ester activate different signaling pathways for stimulation of vascular smooth muscle cell migration
14. The synergistic effect of PDGF-AA and IGF-I on VSMC proliferation might be explained by the differential activation of their intracellular signaling pathways
15. Regulation of vascular smooth muscle cell apoptosis: Modulation of bad by a phosphatidylinositol 3-kinase-dependent pathway
16. A simplified system for generating recombinant adenoviruses
17. Activation of phosphoinositide 3-kinase by interaction with Ras and by point mutation
18. The organization, promoter analysis, and expression of the human PPARγ gene
19. Peroxisome proliferator-activated receptor gene expression in human tissues: Effects of obesity, weight loss, and regulation by insulin and glucocorticoids
20. Dominant negative forms of Akt (protein kinase B) and atypical protein kinase Cλ do not prevent insulin inhibition of phosphoenolpyruvate carboxykinase gene transcription
21. Angiotensin II induces interleukin-6 transcription in vascular smooth muscle cells through pleiotropic activation of nuclear factor-κB transcription factors
22. Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB
23. PPARγ promotes monocyte/macrophage differentiation and uptake of oxidized LDL
24. Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, β cell dysfunction, and type 2 diabetes
25. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
26. Regulation of cell death protease caspase-9 by phosphorylation
27. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
28. NF-κB is a target of AKT in anti-apoptotic PDGF signalling
29. PPAR-α PPAR-γ activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway
30. The role of PPAR-γ in macrophage differentiation and cholesterol uptake
31. Prostaglandins promote and block adipogenesis through opposing effects on peroxisome proliferator-activated receptor γ
32. Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARγ