Excessive Hexosamines Block the Neuroprotective Effect of Insulin and Induce Apoptosis in Retinal Neurons

Journal of Biological Chemistry

Volumn 276, Issue 47, 2001, Pages 43748-43755

  Nakamura, Makoto ^a   Barber, Alistair J ^a   Antonetti, David A ^a   LaNoue, Kathryn F ^a   Robinson, Katherine A ^b   Buse, Maria G ^b   Gardner, Thomas W ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; ATTENUATION; BIOSYNTHESIS; CELLS; GLUCOSE; NEUROLOGY;

NEUROPROTECTIVE EFFECT;

INSULIN;

AZASERINE; GLUCOSAMINE; GLUCOSE; HEXOSAMINE; INSULIN; INSULIN RECEPTOR; NEUROTROPHIC FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; UNCLASSIFIED DRUG; URIDINE DIPHOSPHATE N ACETYLHEXOSAMINE; ADENOSINE TRIPHOSPHATE; HYPERGLYCEMIC AGENT; NEUROPROTECTIVE AGENT;

ANIMAL CELL; APOPTOSIS; ARTICLE; BIOSYNTHESIS; CELL SURVIVAL; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DIABETIC RETINOPATHY; DOSE RESPONSE; ENZYME PHOSPHORYLATION; GLUCOSE TRANSPORT; GLYCOSYLATION; INSULIN RESISTANCE; MICROANGIOPATHY; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; RETINA NERVE CELL; ANIMAL; CELL LINE; CYTOLOGY; DRUG EFFECT; METABOLISM; NERVE CELL; PHOSPHORYLATION; PROTEIN PROCESSING; RETINA;

ANIMALIA;

ADENOSINE TRIPHOSPHATE; ANIMALS; APOPTOSIS; AZASERINE; CELL LINE; GLUCOSAMINE; GLUCOSE; HEXOSAMINES; INSULIN; INSULIN ANTAGONISTS; NEURONS; NEUROPROTECTIVE AGENTS; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTOR, INSULIN; RETINA;

EID: 0035941260     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M108594200     Document Type: Article

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