-
1
-
-
0034076189
-
Mechanisms of angiogenesis and arteriogenesis
-
(2000)
Nat Med
, vol.6
, pp. 389-395
-
-
Carmeliet, P.1
-
5
-
-
0001582482
-
Molecular cloning of the Akt oncogene and its human homologues AKT1 and AKT2: Amplification of AKT1 in a primary human gastric adenocarcinoma
-
(1987)
Proc Natl Acad Sci U S A
, vol.84
, pp. 5034-5047
-
-
Staal, S.P.1
-
7
-
-
0026006501
-
Molecular cloning and characterisation of a novel putative protein-serine kinase related to the cAMP-dependent and protein kinase C families
-
(1991)
Eur J Biochem
, vol.201
, pp. 475-481
-
-
Coffer, P.J.1
Woodgett, J.R.2
-
14
-
-
0031053360
-
Akt signaling: Linking membrane events to life and death decisions
-
(1997)
Science
, vol.275
, pp. 628-630
-
-
Hemmings, B.A.1
-
17
-
-
0035793574
-
p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils
-
(2001)
J Biol Chem
, vol.276
, pp. 3517-3523
-
-
Rane, M.J.1
Coxon, P.Y.2
Powell, D.W.3
Webster, R.4
Klein, J.B.5
Pierce, W.6
Ping, P.7
McLeish, K.R.8
-
18
-
-
0033594480
-
PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2
-
(1999)
Curr Biol
, vol.9
, pp. 393-404
-
-
Balendran, A.1
Casamayor, A.2
Deak, M.3
Paterson, A.4
Gaffney, P.5
Currie, R.6
Downes, C.P.7
Alessi, D.R.8
-
20
-
-
0035947744
-
Myocardial Akt activation and gender: Increased nuclear activity in females versus males
-
(2001)
Circ Res
, vol.88
, pp. 1020-1027
-
-
Camper-Kirby, D.1
Welch, S.2
Walker, A.3
Shiraishi, I.4
Setchell, K.D.5
Schaefer, E.6
Kajstura, J.7
Anversa, P.8
Sussman, M.A.9
-
22
-
-
0028963084
-
Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor
-
(1995)
Science
, vol.267
, pp. 2003-2006
-
-
Yao, R.1
Cooper, G.M.2
-
23
-
-
0029079275
-
The protein kinase encoded by the Akt protooncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
-
(1995)
Cell
, vol.81
, pp. 727-736
-
-
Franke, T.F.1
Yang, S.I.2
Chan, T.O.3
Datta, K.4
Kazlauskas, A.5
Morrison, D.K.6
Kaplan, D.R.7
Tsichlis, P.N.8
-
24
-
-
0031053586
-
Regulation of neuronal survival by the serine-threonine protein kinase Akt
-
(1997)
Science
, vol.275
, pp. 661-665
-
-
Dudek, H.1
Datta, S.R.2
Franke, T.F.3
Birnbaum, M.J.4
Yao, R.5
Cooper, G.M.6
Segal, R.A.7
Kaplan, D.R.8
Greenberg, M.E.9
-
27
-
-
0032493029
-
Genetic analysis of protein kinase B (AKT) in Drosophila
-
(1998)
Curr Biol
, vol.8
, pp. 599-602
-
-
Staveley, B.E.1
Ruel, L.2
Jin, J.3
Stambolic, V.4
Mastronardi, F.G.5
Heitzler, P.6
Woodgett, J.R.7
Manoukian, A.S.8
-
28
-
-
0035448879
-
Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene
-
(2001)
Genes Dev
, vol.15
, pp. 2203-2208
-
-
Chen, W.S.1
Xu, P.Z.2
Gottlob, K.3
Chen, M.L.4
Sokol, K.5
Shiyanova, T.6
Roninson, I.7
Weng, W.8
Suzuki, R.9
Tobe, K.10
Kadowaki, T.11
Hay, N.12
-
31
-
-
0033582929
-
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
-
(1999)
Cell
, vol.96
, pp. 857-868
-
-
Brunet, A.1
Bonni, A.2
Zigmond, M.J.3
Lin, M.Z.4
Juo, P.5
Hu, L.S.6
Anderson, M.J.7
Arden, K.C.8
Blenis, J.9
Greenberg, M.E.10
-
50
-
-
0033522927
-
Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner
-
(1999)
J Biol Chem
, vol.274
, pp. 16349-16354
-
-
Fujio, Y.1
Walsh, K.2
-
51
-
-
0034737422
-
Angiopoietin-1 inhibits endothelial cell apoptosis via the Akt/survivin pathway
-
(2000)
J Biol Chem
, vol.275
, pp. 9102-9105
-
-
Papapetropoulos, A.1
Fulton, D.2
Mahboubi, K.3
Kalb, R.G.4
O'Connor, D.S.5
Li, F.6
Altieri, D.C.7
Sessa, W.C.8
-
54
-
-
0033615069
-
The Akt kinase signals directly to endothelial nitric oxide synthase
-
(1999)
Curr Biol
, vol.9
, pp. 845-848
-
-
Michell, B.J.1
Griffiths, J.E.2
Mitchelhill, K.I.3
Rodríguez-Crespo, I.4
Tiganis, T.5
Bozinovski, S.6
De Montellano, P.R.7
Kemp, B.E.8
Pearson, R.B.9
-
55
-
-
0035853775
-
Sphingosine 1-phosphate and activation of endothelial nitric-oxide synthase, differential regulation of Akt and MAP kinase pathways by EDG and bradykinin receptors in vascular endothelial cells
-
(2001)
J Biol Chem
, vol.276
, pp. 12420-12426
-
-
Igarashi, J.1
Bernier, S.G.2
Michel, T.3
-
56
-
-
0035374461
-
Sphingosine 1-phosphate activates Akt, nitric oxide production, and chemotaxis through a Gi protein/phospho-inositide 3-kinase pathway in endothelial cells
-
(2001)
J Biol Chem
, vol.276
, pp. 19672-19677
-
-
Morales-Ruiz, M.1
Lee, M.J.2
Zollner, S.3
Gratton, J.P.4
Scotland, R.5
Shiojima, I.6
Walsh, K.7
Hla, T.8
Sessa, W.C.9
-
57
-
-
0035092841
-
Mitogenic and antiapoptotic actions of hepatocyte growth factor through ERK, Stat3, and Akt in endothelial cells
-
(2001)
Hypertension
, vol.37
, pp. 581-586
-
-
Nakagami, H.1
Morishita, R.2
Yamamoto, K.3
Taniyama, Y.4
Aoki, M.5
Matsumoto, K.6
Nakamura, T.7
Kaneda, Y.8
Horiuchi, M.9
Ogihara, T.10
-
61
-
-
0037155131
-
Hydrogen peroxide activates endothelial nitric-oxide synthase through coordinated phoshorylation and dephosphorylation via a phosphoinositide 3-kinase-dependent signaling pathway
-
(2002)
J Biol Chem
, vol.277
, pp. 6017-6024
-
-
Thomas, S.R.1
Chen, K.2
Keaney, J.F.J.3
-
62
-
-
0036108564
-
Acute cardiovascular protective effects of corticosteroids are mediated by non-transcriptional activation of endothelial nitric oxide synthase
-
(2002)
Nat Med
, vol.8
, pp. 473-479
-
-
Hafezi-Moghadam, A.1
Simoncini, T.2
Yang, E.3
Limbourg, F.P.4
Plumier, J.C.5
Rebsamen, M.C.6
Hsieh, C.M.7
Chui, D.S.8
Thomas, K.L.9
Prorock, A.J.10
Laubach, V.E.11
Moskowitz, M.A.12
French, B.A.13
Ley, K.14
Liao, J.K.15
-
72
-
-
0030022917
-
Effects of vascular endothelial growth factor on hemodynamics and cardiac performance
-
(1996)
J Cardiovasc Pharmacol
, vol.27
, pp. 838-844
-
-
Yang, R.1
Thomas, G.R.2
Bunting, S.3
Ko, A.4
Ferrara, N.5
Keyt, B.6
Ross, J.7
Jin, H.8
-
75
-
-
0033542414
-
Regulation of endothelium-derived nitric oxide production by the protein kinase Akt
-
(1999)
Nature
, vol.399
, pp. 597-601
-
-
Fulton, D.1
Gratton, J.P.2
McCabe, T.J.3
Fontana, J.4
Fujio, Y.5
Walsh, K.6
Franke, T.F.7
Papapetropoulos, A.8
Sessa, W.C.9
-
78
-
-
0033857388
-
Acute modulation of endothelial Akt/PKB activity alters nitric oxide-dependent vasomotor activity in vivo
-
(2000)
J Clin Invest
, vol.106
, pp. 493-499
-
-
Luo, Z.1
Fujio, Y.2
Kureishi, Y.3
Rudic, R.D.4
Daumerie, G.5
Fulton, D.6
Sessa, W.C.7
Walsh, K.8
-
79
-
-
0037013179
-
Functional reconstitution of endothelial nitric oxide synthase reveals the importance of serine 1179 in endothelium-dependent vasomotion
-
(2002)
Circ Res
, vol.90
, pp. 904-910
-
-
Scotland, R.S.1
Morales-Ruiz, M.2
Chen, Y.3
Yu, J.4
Rudic, R.D.5
Fulton, D.6
Gratton, J.P.7
Sessa, W.C.8
-
80
-
-
0035816724
-
Adrenomedullin induces endothelium-dependent vasorelaxation via the Phosphatidylinositol 3-Kinase/Akt-dependent pathway in rat aorta
-
(2001)
Circ Res
, vol.89
, pp. 63-70
-
-
Nishimatsu, H.1
Suzuki, E.2
Nagata, D.3
Moriyama, N.4
Satonaka, H.5
Walsh, K.6
Sata, M.7
Kangawa, K.8
Matsuo, H.9
Goto, A.10
Kitamura, T.11
Hirata, Y.12
-
83
-
-
0029664995
-
Acylation targets endothelial nitric-oxide synthase to plasmalemmal caveolae
-
(1996)
J Biol Chem
, vol.271
, pp. 6518-6522
-
-
Shaul, P.W.1
Smart, E.J.2
Robinson, L.J.3
German, Z.4
Yuhanna, I.S.5
Ying, Y.6
Anderson, R.G.7
Michel, T.8
-
87
-
-
0035964954
-
Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice
-
(2001)
Science
, vol.293
, pp. 2449-2452
-
-
Drab, M.1
Verkade, P.2
Elger, M.3
Kasper, M.4
Lohn, M.5
Lauterbach, B.6
Menne, J.7
Lindschau, C.8
Mende, F.9
Luft, F.C.10
Schedl, A.11
Haller, H.12
Kurzchalia, T.V.13
-
94
-
-
0037013152
-
Domain mapping studies reveal that the M domain of hsp90 serves as a molecular scaffold to regulate Akt-dependent phosphorylation of endothelial nitric oxide synthase and NO release
-
(2002)
Circ Res
, vol.90
, pp. 866-873
-
-
Fontana, J.1
Fulton, D.2
Chen, Y.3
Fairchild, T.A.4
McCabe, T.J.5
Fujita, N.6
Tsuruo, T.7
Sessa, W.C.8
-
96
-
-
0033826581
-
The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals
-
(2000)
Nat Med
, vol.6
, pp. 1004-1010
-
-
Kureishi, Y.1
Luo, Z.2
Shiojima, I.3
Bialik, A.4
Fulton, D.5
Lefer, D.J.6
Sessa, W.C.7
Walsh, K.8
-
98
-
-
0033615537
-
Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate
-
(1999)
Cell
, vol.99
, pp. 301-312
-
-
Lee, M.J.1
Thangada, S.2
Claffey, K.P.3
Ancellin, N.4
Liu, C.H.5
Kluk, M.6
Volpi, M.7
Sha'afi, R.I.8
Hla, T.9
-
103
-
-
0034635452
-
Central role for G protein-coupled phosphoinositide 3-kinase γ in inflammation
-
(2000)
Science
, vol.287
, pp. 1049-1053
-
-
Hirsch, E.1
Katanaev, V.L.2
Garlanda, C.3
Azzolino, O.4
Pirola, L.5
Silengo, L.6
Sozzani, S.7
Mantovani, A.8
Altruda, F.9
Wymann, M.P.10
-
105
-
-
0034635264
-
Function of PI3Kγ in thymocyte development, T cell activation, and neutrophil migration
-
(2000)
Science
, vol.287
, pp. 1040-1046
-
-
Sasaki, T.1
Irie-Sasaki, J.2
Jones, R.G.3
Oliveira-dos-Santos, A.J.4
Stanford, W.L.5
Bolon, B.6
Wakeham, A.7
Itie, A.8
Bouchard, D.9
Kozieradzki, I.10
Joza, N.11
Mak, T.W.12
Ohashi, P.S.13
Suzuki, A.14
Penninger, J.M.15
-
107
-
-
0035827310
-
Rho proteins, PI 3-kinases, and monocyte/macrophage motility
-
(2001)
FEBS Lett
, vol.498
, pp. 168-171
-
-
Ridley, A.J.1
-
109
-
-
0034799675
-
Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement
-
(2001)
J Clin Invest
, vol.108
, pp. 689-701
-
-
Garcia, J.G.1
Liu, F.2
Verin, A.D.3
Birukova, A.4
Dechert, M.A.5
Gerthoffer, W.T.6
Bamberg, J.R.7
English, D.8
-
110
-
-
0035840155
-
Rho family GTPases regulate VEGF-stimulated endothelial cell motility
-
(2001)
Exp Cell Res
, vol.269
, pp. 73-87
-
-
Soga, N.1
Namba, N.2
McAllister, S.3
Cornelius, L.4
Teitelbaum, S.L.5
Dowdy, S.F.6
Kawamura, J.7
Hruska, K.A.8
-
112
-
-
17944363486
-
Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis
-
(2001)
Mol Cell
, vol.8
, pp. 693-704
-
-
Lee, M.J.1
Thangada, S.2
Paik, J.H.3
Sapkota, G.P.4
Ancellin, N.5
Chae, S.S.6
Wu, M.7
Morales-Ruiz, M.8
Sessa, W.C.9
Alessi, D.R.10
Hla, T.11
-
121
-
-
0028910272
-
Beneficial effects of cholesterol-lowering therapy on the coronary endothelium in patients with coronary artery disease
-
(1995)
N Engl J Med
, vol.332
, pp. 481-487
-
-
Treasure, C.B.1
Klein, J.L.2
Weintraub, W.S.3
Talley, J.D.4
Stillabower, M.E.5
Kosinski, A.S.6
Zhang, J.7
Boccuzzi, S.J.8
Cedarholm, J.C.9
Alexander, R.W.10
-
125
-
-
0035514486
-
Endothelial nitric oxide synthase is essential for the HMG-CoA reductase inhibitor cerivastatin to promote collateral growth in response to ischemia
-
(2001)
FASEB J
, vol.15
, pp. 2530-2532
-
-
Sata, M.1
Nishimatsu, H.2
Suzuki, E.3
Sugiura, S.4
Yoshizumi, M.5
Ouchi, Y.6
Hirata, Y.7
Nagai, R.8
-
127
-
-
0034908652
-
HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway
-
(2001)
J Clin Invest
, vol.108
, pp. 391-397
-
-
Dimmeler, S.1
Aicher, A.2
Vasa, M.3
Mildner-Rihm, C.4
Adler, K.5
Tiemann, M.6
Rutten, H.7
Fichtlscherer, S.8
Martin, H.9
Zeiher, A.M.10
-
128
-
-
0034898468
-
HMG-CoA reductase inhibitor mobilizes bone marrow-derived endothelial progenitor cells
-
(2001)
J Clin Invest
, vol.108
, pp. 399-405
-
-
Llevadot, J.1
Murasawa, S.2
Kureishi, Y.3
Uchida, S.4
Masuda, H.5
Kawamoto, A.6
Walsh, K.7
Isner, J.M.8
Asahara, T.9
-
130
-
-
0035093931
-
Safety profiles for the HMG-CoA reductase inhibitors: Treatment and trust
-
(2001)
Drugs
, vol.61
, pp. 197-206
-
-
Davidson, M.H.1
-
133
-
-
0035957682
-
Inhibition of endothelial cell migration by cerivastatin, an HMG-CoA reductase inhibitor: Contribution to its anti-angiogenic effect
-
(2001)
FEBS Lett
, vol.495
, pp. 159-166
-
-
Vincent, L.1
Chen, W.2
Hong, L.3
Mirshahi, F.4
Mishal, Z.5
Mirshahi-Khorassani, T.6
Vannier, J.P.7
Soria, J.8
Soria, C.9
-
134
-
-
0036120428
-
Cerivastatin, an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme a reductase, inhibits endothelial cell proliferation induced by angiogenic factors in vitro and angiogenesis in in vivo models
-
(2002)
Arterioscler Thromb Vasc Biol
, vol.22
, pp. 623-629
-
-
Vincent, L.1
Soria, C.2
Mirshahi, F.3
Opolon, P.4
Mishal, Z.5
Vannier, J.P.6
Soria, J.7
Hong, L.8
-
135
-
-
0034116167
-
Pravastatin: An antithrombotic effect independent of the cholesterol-lowering effect
-
(2000)
Thromb Haemost
, vol.83
, pp. 688-692
-
-
Dangas, G.1
Smith, D.A.2
Unger, A.H.3
Shao, J.H.4
Meraj, P.5
Fier, C.6
Cohen, A.M.7
Fallon, J.T.8
Badimon, J.J.9
Ambrose, J.A.10
-
136
-
-
0242390332
-
An inhibitory role of the phosphatidylinositol 3-kinase-signaling pathway in vascular endothelial growth factor-induced tissue factor expression
-
(2001)
J Biol Chem
, vol.276
, pp. 33428-33434
-
-
Blum, S.1
Issbruker, K.2
Willuweit, A.3
Hehlgans, S.4
Lucema, M.5
Mechtcheriakova, D.6
Walsh, K.7
Von der Ahe, D.8
Hofer, E.9
Clauss, M.10
-
144
-
-
14344279280
-
A cardiac myocyte vascular endothelial growth factor paracrine pathway is required to maintain cardiac function
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 5780-5785
-
-
Giordano, F.J.1
Gerber, H.P.2
Williams, S.P.3
VanBruggen, N.4
Bunting, S.5
Ruiz Lozano, P.6
Gu, Y.7
Nath, A.K.8
Huang, Y.9
Hickey, R.10
Dalton, N.11
Peterson, K.L.12
Ross J., Jr.13
Chien, K.R.14
Ferrara, N.15
-
145
-
-
0036269886
-
Myogenic Akt signaling regulates blood vessel recruitment during myofiber growth
-
(2002)
Mol Cell Biol
, vol.22
, pp. 4803-4814
-
-
Takahashi, A.1
Kureishi, Y.2
Yang, J.3
Luo, Z.4
Guo, K.5
Mukhopadhyay, D.6
Ivashchenko, Y.7
Branellec, D.8
Walsh, K.9
|