Scanning mutagenesis identifies amino acid side chains in transmembrane domain 5 of the M1 muscarinic receptor that participate in binding the acetyl methyl group of acetylcholine

Molecular Pharmacology

Volumn 58, Issue 1, 2000, Pages 175-184

  Allman, Karen ^a,c   Page, Karen M ^b,c   Curtis, Carol A M ^c   Hulme, Edward C ^c  

^a GLAXOSMITHKLINE   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BROMOACETYLCHOLINE; METHYL GROUP; MUSCARINIC M1 RECEPTOR;

ACETYLCHOLINE RELEASE; ALPHA HELIX; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CONFORMATIONAL TRANSITION; LIGAND BINDING; MEMBRANE BINDING; NEUROTRANSMITTER RELEASE; NONHUMAN; PHOSPHOLIPID BILAYER; PRIORITY JOURNAL; PROTEIN DOMAIN; RECEPTOR BINDING; SITE DIRECTED MUTAGENESIS;

EID: 0033932599     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.58.1.175     Document Type: Article

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