Phe310 in transmembrane VI of the α(1B)-adrenergic receptor is a key switch residue involved in activation and catecholamine ring aromatic bonding

Journal of Biological Chemistry

Volumn 274, Issue 23, 1999, Pages 16320-16330

  Chen, Songhai ^a   Xu, Ming ^a   Lin, Fang ^a   Lee, Darren ^a   Riek, Peter ^a   Graham, Robert M ^a,b  

^a VICTOR CHANG CARDIAC RESEARCH INSTITUTE   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENERGIC RECEPTOR; ALPHA 1 ADRENERGIC RECEPTOR; CATECHOLAMINE; MEMBRANE RECEPTOR; ADRENALIN; ADRENERGIC RECEPTOR ALPHA(1B); DRUG DERIVATIVE; N METHYLPHENYLETHANOLAMINE; N-METHYLPHENYLETHANOLAMINE; PHENETHYLAMINE; PHENETHYLAMINE DERIVATIVE; PHENYLALANINE; PHENYLETHANOLAMINE; TYROSINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; IMMUNOBLOTTING; ISOMERISM; LIGAND BINDING; NONHUMAN; PEPTIDE MAPPING; PHARMACOPHORE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; RECEPTOR BINDING; RECEPTOR INTRINSIC ACTIVITY; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; AMINO ACID SEQUENCE; ANIMAL; CATTLE; CELL STRAIN COS1; CHEMICAL STRUCTURE; CHEMISTRY; HAMSTER; HUMAN; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY; RAT; SEQUENCE ALIGNMENT;

ANIMALIA;

2-HYDROXYPHENETHYLAMINE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; CATECHOLAMINES; CATTLE; COS CELLS; CRICETINAE; EPINEPHRINE; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PHENETHYLAMINES; PHENYLALANINE; PROTEIN STRUCTURE, SECONDARY; RATS; RECEPTORS, ADRENERGIC, ALPHA-1; SEQUENCE ALIGNMENT; STRUCTURE-ACTIVITY RELATIONSHIP; TYROSINE;

EID: 0033522643     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.23.16320     Document Type: Article

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