Activation of guanosine 5′-[γ-35S]thio-triphosphate binding through M1 muscarinic receptors in transfected Chinese hamster ovary cell membranes: 1. Mathematical analysis of catalytic G protein activation

Molecular Pharmacology

Volumn 59, Issue 4, 2001, Pages 875-885

  Waelbroeck, Magali ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); GUANOSINE DIPHOSPHATE; MUSCARINIC RECEPTOR; RECEPTOR SUBTYPE;

ANIMAL CELL; ARTICLE; CATALYSIS; CHO CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; GENETIC TRANSFECTION; HUMAN; MATHEMATICAL ANALYSIS; MATHEMATICAL MODEL; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0035064796     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.59.4.875     Document Type: Article

References (32)

1. Solubilization and characterization of guanine nucleotide-sensitive muscarinic agonist binding sites from rat myocardium
2. 1
3. 1 muscarinic cholinergic receptor. Steady-state balance of receptor-mediated activation and GTPase-activating protein-promoted deactivation
4. The binding of agonists to brain muscarinic receptors
5. Signal transduction by G proteins: 1994 Edition
6. 35S]GTPγS binding to rat cerebellar membranes correlates with agonist-induced decreases in GDP affinity
7. Mechanism of adenylate cyclase activation through the β-adrenergic receptor: Catecholamine-induced displacement of bound GDP by GTP
8. 50) of an enzymatic reaction
9. (q)
10. Drug efficacy at guanine nucleotide-binding regulatory protein-linked receptors: Thermodynamic interpretation of negative antagonism and of receptor activity in the absence of ligand
11. A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled β-adrenergic receptor
12. The influence of bound GDP on the kinetics of guanine nucleotide binding to G Proteins
13. Reconstitution of resolved muscarinic cholinergic receptors with purified GTP-binding proteins
14. o)
15. Functional reconstitution of purified muscarinic receptors and inhibitory guanine nucleotide regulatory protein
16. The many faces of G protein signaling
17. Activation of solubilized G-proteins by muscarinic acetylcholine receptors
18. Two populations of binding sites for muscarinic antagonists in the rat heart
19. sα activation of adenylyl cyclase
20. i-proteins in membranes of HL-60 cells
21. 4
22. Interpretation of relative potencies, relative efficacies and apparent affinity constants of agonist drugs estimated from concentration-response curves
23. The kinetics of competitive radioligand binding predicted by the law of mass action
24. (q) promoted by receptor and GTPase-activating proteins
25. βγ subunits of guanine nucleotide-binding proteins and regulation of spontaneous receptor activity: Thermodynamic model for the interaction between receptors and guanine nucleotide-binding protein subunits
26. Kinetics versus equilibrium: The importance of GTP in GPCR activation
27. 1 muscarinic receptors in transfected Chinese hamster ovary cell membranes: 2. Testing the "two-states" model of receptor activation
28. act?
29. Determination of the association and dissociation rate constants of muscarinic antagonists on rat pancreas: Rank order of potency varies with time
30. Rat cardiac muscarinic receptors. I. Effects of guanine nucleotides on high- and low-affinity binding sites
31. Measurement of receptor-stimulated guanosine 5′-O-(γ- Thio)triphosphate binding by G proteins