Transmembrane Domains 4 and 7 of the M1 Muscarinic Acetylcholine Receptor are Critical for Ligand Binding and the Receptor Activation Switch

Journal of Biological Chemistry

Volumn 276, Issue 36, 2001, Pages 34098-34104

  Lu, Zhi Liang ^a   Saldanha, Jose W ^a   Hulme, Edward C ^a  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CHEMICAL ACTIVATION; CHEMICAL BONDS; CONFORMATIONS; GROUND STATE; SUBSTITUTION REACTIONS;

TRANSMEMBRANE DOMAINS;

BIOCHEMISTRY;

CHOLINERGIC RECEPTOR; G PROTEIN COUPLED RECEPTOR; MUSCARINIC M1 RECEPTOR; MUSCARINIC RECEPTOR; ACETYLCHOLINE; ALANINE; LIGAND; PHENYLALANINE;

ALPHA HELIX; AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; GENE REARRANGEMENT; HUMAN; HUMAN CELL; LIGAND BINDING; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; RECEPTOR AFFINITY; RECEPTOR UPREGULATION; SITE DIRECTED MUTAGENESIS; ANIMAL; CELL STRAIN COS1; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; GENETIC TRANSFECTION; GENETICS; MUTATION; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE; RAT; SIGNAL TRANSDUCTION;

ACETYLCHOLINE; ALANINE; ANIMALS; BINDING SITES; COS CELLS; DOSE-RESPONSE RELATIONSHIP, DRUG; LIGANDS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; PHENYLALANINE; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTOR, MUSCARINIC M1; RECEPTORS, MUSCARINIC; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 0035823524     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M104217200     Document Type: Article

References (39)

1. Lu, Z. L., and Hulme, E. C. (1999) J. Biol. Chem. 274, 7309-7315
2. Allman, K., Page, K. M., Curtis, C. A., and Hulme, E. C. (2000) Mol. Pharmacol. 58, 175-184
3. Ward, S. D. C., Curtis, C. A., and Hulme, E. C. (1999) Mol. Pharmacol. 56, 1031-1041
4. Palczewski, K., Kumasaka, T., Hori, T., Behnke, C. A., Motoshima, H., Fox, B. A., Le Trong, I., Teller, D. C., Okada, T., Stenkamp, R. E., Yamamoto, M., and Miyano, M. (2000) Science 289, 739-745
5. Unger, V. M., Hargrave, P. A., Baldwin, J. M., and Schertler, G. F. X. (1997) Nature 389, 203-206
6. Borhan, B., Souto, M. L., Imai, H., Shichida, Y., and Nakanishi, K. (2000) Science 288, 2209-2212
7. Waugh, D. J. J., Zhao, M. M., Zuscik, M. J., and Perez, D. M. (2000) J. Biol. Chem. 275, 11698-11705
8. Heitz, F., Holzwarth, J. A., Gies, J.-P., Pruss, R. M., Trumpp-Kallmeyer, S., Hibert, M. F., and Guenet, C. (1999) Eur. J. Pharmacol. 380, 183-195
9. Feng, Y.-H., and Karnik, S. S. (1999) J. Biol. Chem. 274, 35546-35552
10. Matsui, H., Lazareno, S., and Birdsall, N. J. M. (1995) Mol. Pharmacol. 47, 88-98
11. Wess, J., Maggio, R., Palmer, J. R., and Vogel, Z. (1992) J. Biol. Chem. 267, 19313-19319
12. Zhou, W., Flanagan, C., Ballesteros, J. A., Konvicka, K., Davidson, J. S., Weinstein, H., Millar, R. P., and Sealfon, S. C. (1994) Mol. Pharmacol. 45, 165-170
13. Lu, Z. L., and Hulme, E. C. (2000) J. Biol. Chem. 275, 5682-5686
14. Wang, J., Zheng, J., Anderson, J. L., and Toews, M. L. (1997) Mol. Pharmacol. 52, 306-313
15. Audoly, L., and Breyer, R. M. (1997) Mol. Pharmacol. 51, 61-68
16. Rosendorff, A., Ebersole, B. J., and Sealfon, S. C. (2000) Brain Res. Mol. Brain Res. 84, 90-96
17. Perlman, J. H., Colson, A., Wang, W., Bence, K., Osman, R., and Gershengorn, M. C. (1997) J. Biol. Chem. 272, 11937-11942
18. Lu, Z. L., Curtis, C. A., Jones, P. G., Pavia, J., and Hulme, E. C. (1997) Mol. Pharmacol. 51, 234-241
19. Jones, P. G., Curtis, C. A. M., and Hulme, E. C. (1995) Eur. J. Pharmacol. 288, 251-257
20. Hulme, E. C., and Lu, Z. L. (1998) J. Physiol. (Paris) 92, 269-274
21. Sussman, J. L., Lin, D., Jiang, J., Manning, N. O., Prilusky, J., Ritter, O., and Aboral, E. E. (1998) Acta Crystallogr. Sect. D Biol. Crystallogr. 54, 1078-1084
22. Sali, A., and Blundell, T. L. (1993) J. Mol. Biol. 234, 779-815
23. Brooks, B. R., Bruccoleri, R. E., Olafson, B. D., States, D. J., Swaminathan, S., and Karplus, M. (1983) J. Comp. Chem. 4, 187-217
24. Hulme, E. C., Lu, Z. L., Ward, S. D. C., Allman, K., and Curtis, C. A. M. (1999) Eur. J. Pharmacol. 375, 247-260
25. Savarese, T. M., Wang, C. D., and Fraser, C. M. (1992) J. Biol. Chem. 267, 11439-11448
26. Wess, J., Nanavati, S., Vogel, Z., and Maggio, R. (1993) EMBO J. 12, 331-338
27. Furukawa, H., Haga, T., Muto, Y., Yokoyama, T., Hamada, T., and Hirota, H. (2001) Life Sci. 68, 2621
28. Barlow, R. B. (1964) Introduction to Chemical Pharmacology, pp. 185-240, 2nd Ed., Methuen & Co Ltd., London
29. Schulman, J. R., Sabio, M. L., and Disch, R. L. (1983) J. Med. Chem. 26, 817-823
30. Elling, C. E., Thirstrup, K., Holst, B., and Schwartz, T. W. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 12322-12327
31. Holst, B., Elling, C. E., and Schwartz, T. W. (2000) Mol. Pharmacol. 58, 263-270
32. Gerber, B. O., Meng, E. C., Dötsch, V., Baranski, T. J., and Bourne, H. R. (2001) J. Biol. Chem. 276, 3394-3400
33. Robinson, P. R., Cohen, G. B., Zhukovsky, E. A., and Oprian, D. D. (1992) Neuron 9, 719-725
34. Jakubik, J., El-Fakahany, E. E., and Tucek, S. (2000) J. Biol. Chem. 275, 18836-18844
35. Spalding, T. A., Burstein, E. S., Henderson, S. C., Ducote, K. R., and Brann, M. R. (1998) J. Biol. Chem. 273, 21563-21568
36. Konvicka, K., Guarnieri, F., Ballesteros, J. A., and Weinstein, H. (1998) Biophys. J. 75, 601-611
37. Abdulaev, N. G., and Ridge, K. D. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 12854-12859
38. Farrens, D. L., Altenbach, C., Yang, K., Hubbell, W., and Khorana, H. G. (1996) Science 274, 768-770
39. Hibert, M. F., Trumpp-Kallmeyer, S., Hoflack, J., and Bruinvels, A. (1993) Trends Pharmacol. Sci. 14, 7-12