The activation process of the α1B-adrenergic receptor: Potential role of protonation and hydrophobicity of a highly conserved aspartate

Proceedings of the National Academy of Sciences of the United States of America

Volumn 94, Issue 3, 1997, Pages 808-813

  Scheer, Alexander ^a   Fanelli, Francesca ^b   Costa, Tommaso ^c   De Benedetti, Pier G ^b   Cotecchia, Susanna ^a  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^c ISTITUTO SUPERIORE DI SANITÀ   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; ADRENERGIC RECEPTOR ALPHA(1B); ALPHA 1 ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; AMINO ACID; ASPARTIC ACID; INOSITOL PHOSPHATE; LIGAND; PRAZOSIN; PROTON; SOLVENT; ALPHA 1B ADRENERGIC RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN;

ANIMAL; ARTICLE; BINDING COMPETITION; BIOSYNTHESIS; CELL STRAIN COS1; CHEMISTRY; COMPUTER SIMULATION; GENETICS; METABOLISM; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; HYDROPHILICITY; HYDROPHOBICITY; LIGAND BINDING; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN STRUCTURE; PROTON TRANSPORT;

ADRENERGIC ALPHA-AGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; AMINO ACIDS; ANIMALS; ASPARTIC ACID; BINDING, COMPETITIVE; COMPUTER SIMULATION; COS CELLS; EPINEPHRINE; INOSITOL PHOSPHATES; LIGANDS; MUTAGENESIS, SITE-DIRECTED; PRAZOSIN; PROTEIN STRUCTURE, TERTIARY; PROTONS; RECEPTORS, ADRENERGIC, ALPHA-1; SOLVENTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0030614337     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.94.3.808     Document Type: Article

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