Molecular basis of receptor/G protein coupling selectivity studied by coexpression of wild type and mutant m2 muscarinic receptors with mutant Gα(q) subunits

Biochemistry

Volumn 36, Issue 6, 1997, Pages 1487-1495

  Kostenis, Evi ^a   Conklin, Bruce R ^b   Wess, Jürgen ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b GLADSTONE INSTITUTE OF CARDIOVASCULAR DISEASE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; MUSCARINIC M2 RECEPTOR;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; GENE EXPRESSION; GENETIC TRANSFECTION; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN INTERACTION; PROTEIN STRUCTURE;

AMINO ACID SEQUENCE; ANIMALS; COS CELLS; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PHOSPHOPROTEINS; PROTEIN CONFORMATION; RECEPTOR, MUSCARINIC M2; RECEPTOR, MUSCARINIC M3; RECEPTORS, MUSCARINIC; RGS PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0031016906     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi962554d     Document Type: Article

References (42)

1. Altenbach, C., Yang, K., Farrens, D. L., Khorana, H. G., & Hubbell, W. L. (1996) Biochemistry 35, 12470-12478.
2. Baldwin, J. M. (1993) EMBO J. 12, 1693-1703.
3. Berridge, M. J., Dawson, M. C., Downs, C. P., Heslop, J. P., & Irvine, R. F. (1983) Biochem. J. 212, 473-482.
4. Berstein, G., Blank, J. L., Smrcka, A. V., Higashijima, T., Sternweis, P. C., Exton, J. H., & Ross, E. M. (1992) J. Biol. Chem. 267, 8081-8088.
5. Blin, N., Yun, J., & Wess, J. (1995) J. Biol. Chem. 270, 17741-17748.
6. Bonner, T. I., Buckley, N. J., Young, A. C., & Brann, M. R. (1987) Science 237, 527-532.
7. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254.
8. Burstein, E. S., Spalding, T. A., Hill-Eubanks, D., & Brann, M. R. (1995) J. Biol. Chem. 270, 3141-3146.
9. Conklin, B. R., & Bourme, H. R. (1993) Cell 73, 631-641.
10. Conklin, B. R., Farfel, Z., Lustig, K. D., Julius, D., & Bourne, H. R. (1993) Nature 363, 274-276.
11. Conklin, B. R., Herzmark, P., Ishida, S., Voyno-Yasenetskaya, T. A., Sun, Y., Farfel, Z., & Bourne, H. R. (1996) Mol. Pharmacol. 50, 885-890.
12. Cullen, B. R. (1987) Methods Enzymol. 152, 684-704.
13. Dohlman, H. G., Thorner, J., Caron, M. G., & Lefkowitz, R. J. (1991) Annu. Rev. Biochem. 60, 653-688.
14. Dörje, F., Wess, J., Lambrecht, G., Tacke, R., Mutschler, E., & Brann, M. R. (1991) J. Pharmacol. Exp. Ther. 256, 727-733.
15. Dratz, E. A., Furstenau, J. E., Lambert, C. G., Thireault, D. L., Rarick, H., Schepers, T. Pakhlevaniants, S., & Hamm, H. E. (1993) Nature 363, 276-281.
16. Farrens, D. L., Altenbach, C., Yang, K., Hubbell, W. L., & Khoranta H. G. (1996) Science 274, 768-770.
17. Garcia, P. D., Onrust, R., Bell, S. M., Sakmar, T. P., & Bourne, H. R. (1995) EMBO J. 14, 4460-4469.
18. Gudermann, T., Kalkbrenner, F., & Schultz, G. (1996) Annu. Rev. Pharmacol. Toxicol. 36, 429-459.
19. Hedin, K. E., Duerson, K., & Clapham, D. E. (1993) Cell. Signalling 5, 505-518.
20. Higuchi, R. (1989) in PCR Technology (Erlich, H. A., Ed.) pp 61-70, Stockton Press, New York.
21. Lee, C. H., Park, D., Wu, D., Rhee, S. G., & Simon, M. I. (1992) J. Biol. Chem. 267, 16044-16047.
22. Liu, J., Conklin, B. R., Blin, N., Yun, J., & Wess, J. (1995) Proc. Natl. Acad. Sci. U.S.A. 92, 11642-11646.
23. Liu, J., Blin, N., Conklin, B. R., & Wess, J. (1996) J. Biol. Chem. 271, 6172-6178.
24. Martin, E. L., Rens-Domiano, S., Schatz, P. J., & Hamm, H. (1996) J. Biol. Chem. 271, 361-366.
25. Munson, P. J., & Rodbard, D. (1980) Anal. Biochem. 107, 220-239.
26. Neer, E. J. (1995) Cell 80, 249-257.
27. Offermanns, S., & Simon, M. I. (1995) J. Biol. Chem. 270, 15175-15180.
28. Offermanns, S., Wieland, T., Homann, D., Sandmann, J., Bombien, E., Spicher, K., Schultz, G., & Jakobs, K. H. (1994) Mol. Pharmacol. 45, 890-898.
29. Osawa, S., & Weiss, E. R. (1995) J. Biol. Chem. 270, 31052-31058.
30. Parker, E. M., Kameyama, K., Higashijima, T., & Ross, E. M. (1991) J. Biol. Chem. 266, 519-527.
31. Peralta, E. G., Ashkenazi, A., Winslow, J. W., Ramachandran, J., & Capon, D. J. (1988) Nature 334, 434-437.
32. Rens-Domiano, S., & Hamm, H. (1995) FASEB J. 9, 1059-1066.
33. Sanger, F., Nicklen, S., & Coulson, A. R. (1977) Proc. Natl. Acad. Sci. U.S.A. 74, 5463-5467.
34. Savarese, T. M., & Fraser, C. M. (1992) Biochem. J. 283, 1-19.
35. Spiegel, A. M. (1994) in G Proteins (Spiegel, A. M., Jones, T. L. Z., Simonds, W. F., & Weinstein, L. S., Eds.) pp 25-31, R. G. Landes Company, Austin, TX.
36. Strader, C. D., Sigal, I. S., & Dixon, R. A. F. (1989) FASEB J. 3, 1825-1832.
37. Strader, C. D., Fong, T. M., Tola, M. R., Underwood, D., & Dixon, R. A. F. (1994) Annu. Rev. Biochem. 63, 101-132.
38. Subramaniam, S., Gerstein, M., Oesterhelt, D., & Henderson, R. (1993) EMBO J. 12, 1-8.
39. Wedegaertner, P. B., Chu, D. H., Wilson, P. T., Levis, M. J., & Bourne, H. R. (1993) J. Biol. Chem. 268, 25001-25008.
40. Wess, J. (1996) Crit. Rev. Neurobiol. 10, 69-99.
41. West, R. E., Moss, J., Vaughan, M., Liu, T., & Liu, T. Y. (1985) J. Biol. Chem. 260, 14428-14430.
42. Wilkie, T. M., Scherle, P. A., Strathmann, M. P., Slepak, V. Z., & Simon, M. I. (1991) Proc. Natl. Acad. Sci. U.S.A. 88, 10049-10053.