Conserved extracellular cysteine pair in the M3 muscarinic acetylcholine receptor is essential for proper receptor cell surface localization but not for G protein coupling

Journal of Neurochemistry

Volumn 72, Issue 6, 1999, Pages 2404-2414

  Zeng, Fu Yue ^a   Soldner, Andrea ^a   Schöneberg, Torsten ^b   Wess, Jürgen ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Disulfide bond; G protein coupled receptors; Muscarinic receptors; Receptor folding; Receptor G protein coupling; Site directed mutagenesis

Indexed keywords

CYSTEINE; MUSCARINIC M3 RECEPTOR;

ACETYLCHOLINE RELEASE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELLULAR DISTRIBUTION; DISULFIDE BOND; GLYCOSYLATION; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN FOLDING; PROTEIN LOCALIZATION; PROTEIN STABILITY; RECEPTOR UPREGULATION; SITE DIRECTED MUTAGENESIS;

ALANINE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; CARBACHOL; CELL MEMBRANE; CONSERVED SEQUENCE; COS CELLS; CYSTEINE; DISULFIDES; GTP-BINDING PROTEINS; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; N-METHYLSCOPOLAMINE; PHOSPHATIDYLINOSITOLS; PROTEIN STRUCTURE, SECONDARY; RADIOLIGAND ASSAY; RATS; RECEPTOR, MUSCARINIC M3; RECEPTORS, MUSCARINIC; RECOMBINANT PROTEINS; TRANSFECTION; TRITIUM;

EID: 0033011632     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1999.0722404.x     Document Type: Article

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